The Cochrane Library 2001;2. 2005;17(3):60-64. Delaha, E. C. and Garagusi, V. F. Inhibition of mycobacteria by garlic extract (Allium sativum). Antimicrob.Agents Chemother. (Zare 2019) A systematic review of randomized controlled trial data identified 6 studies overall that met inclusion criteria and investigated oral spice supplementation for rheumatoid arthritis. View abstract. View abstract. Br J Urol 1995;76(4):518. View abstract. Xie, W. and Du, L. Diabetes is an inflammatory disease: evidence from traditional Chinese medicines. Gurley BJ, Gardner SF, Hubbard MA. Int.Dent.J. Ekeowa-Anderson, A. L., Shergill, B., and Goldsmith, P. Allergic contact cheilitis to garlic. Chin Med J (Engl.) Chin Med J (Engl.) View abstract. L-arginine. Wiad.Lek. These polysulphides promote the production of H2S in the body. Effect of samgyetang feeding on plasma lipids, glucose, glycosylated hemoglobin, and stress-induced gastric ulcers in mice. View abstract. Nutr Rev 2013;71:282-99. In 5 of the 6 studies, mean patient age ranged from 53 to 60 years and patients were mildly hypercholesterolemic and/or at moderate to high risk for coronary artery disease (CAD); 1 study enrolled patients 8 to 18 years of age with a positive family history. Sobenin, I. Dunstan, J. Adachi, A. View abstract. Atherosclerosis 1981;38:417-21. View abstract. Lawson, L. D. Garlic for total cholesterol reduction. View abstract. Planta Med 2009;75(3):205-210. (Dehghani 2018), A 2013 Cochrane systematic review found little data regarding benefit of garlic in peripheral arterial occlusive disease. (Pocobelli 2010), In a double-blind, randomized, placebo-controlled study of South Korean patients with mild hepatic dysfunction and elevated gamma-glutamyl transpeptidase (GGT) (N=80, with data from 75 patients included in the efficacy analysis), administration of fermented garlic extract (1.5 g/day) for 12 weeks provided a significant decrease in GGT compared to controls, but only in the subgroup of patients who consumed alcohol in the 6 weeks prior to the study (P=0.015). 2006;136(3 Suppl):803S-805S. Kaplan, B., Schewach-Millet, M., and Yorav, S. Factitial dermatitis induced by application of garlic. The investigators cited poor compliance and less tolerability in the 4-capsule group as potential explanations for the superior result in the 2-capsule group. Some of these medicine interactions can be risky. Int J Cancer 1993;55:181-189. Koscielny, J., Schmitt, R., Radtke, H., Latza, R., and Kiesewetter, H. Garlic study vindicated by official investigation. J Nutr. J Med Food 2009;12(3):542-551. Am J Clin Nutr 1981;34(10):2100-2103. Induction of apoptosis by the garlic-derived compound S-allylmercaptocysteine (SAMC) is associated with microtubule depolymerization and c-Jun NH(2)-terminal kinase 1 activation. View abstract. View abstract. Shakeel, M., Trinidade, A., McCluney, N., and Clive, B. Complementary and alternative medicine in epistaxis: a point worth considering during the patient's history. View abstract. Emerg.Med.J. Lau BH. Bleeding may occur. According to the EU Herbal Medicines Agency, garlic can: 3. help prevent hardening of the arteries. View abstract. View abstract. Saravanan, G. and Prakash, J. Combination products containing garlic have also been used. Lipids Health Dis. Atherosclerosis 1997;132:37-42. Sobenin, I. Effects of garlic powder and garlic oil preparations on blood lipids, blood pressure and well-being. Biochem Soc.Trans. Aged garlic extract attenuates gentamicin induced renal damage and oxidative stress in rats. Phytomedicine 1999;6(1):7-11. Gurley BJ, Gardner SF, Hubbard MA, et al. View abstract. Ku DD, Abdel-Razek TT, Dai J, and et al. Planta Med 1999;65:545-8. Ali, M. and Thomson, M. Consumption of a garlic clove a day could be beneficial in preventing thrombosis. View abstract. View abstract. BJOG 2014;121(4):498-506. Trends toward improvement in central hemodynamic measures and lipid levels (ie, total cholesterol, LDL cholesterol) were noted. (Argello-Garca 2018) Allicin 2 mg/kg exerts antimycobacterial activity both in vitro and in vivo. Antimicrob.Agents Chemother 1985;27(4):485-486. Mild GI adverse reactions (eg, bloating, flatulence, nausea) have been commonly reported with use. Allicin is a compound that may help ease inflammation and block free radicals, unstable molecules that harm cells and tissues in your body. The effect of garlic extract on human metabolism of acetaminophen. 1. View abstract. 8-1-2010;75(6):C549-C558. Kiesewetter H, Jung F, Jung EM, et al. Tsai PB, Harnack LJ, Anderson KE, and et al. J Postgrad.Med 1991;37:128-131. For high cholesterol: A dose of 1000 mg to 7200 mg of a specific aged garlic extract (Kyolic, Wakanuga) has been used daily in divided doses for 4-6 months. View abstract. Hypertension and hyperlipidaemia: garlic helps in mild cases. Planta Med 1995;61:356-7.. View abstract. The blood pressure lowering and lipid lowering effect of a garlic preparation in combination with a diuretic. B., Varli, M., Devrim, E., Aras, S., and Durak, I. On the effect of garlic on plasma lipids and lipoproteins in mild hypercholesterolaemia. View abstract. Blood Coagul.Fibrinolysis 2001;12(1):67-74. This information relates to an herbal, vitamin, mineral or other dietary supplement. Hasani-Ranjbar, S., Larijani, B., and Abdollahi, M. A systematic review of the potential herbal sources of future drugs effective in oxidant-related diseases. View abstract. Journal of Natural Remedies 2006;6:19-25. Naganawa, R., Iwata, N., Ishikawa, K., Fukuda, H., Fujino, T., and Suzuki, A. Inhibition of microbial growth by ajoene, a sulfur-containing compound derived from garlic. Ernst, E. Complementary/alternative medicine for hypertension: a mini-review. (Scharbert 2007) In a double-blind, placebo-controlled study of 14 men, garlic did not affect platelet aggregation. JAMA 1-3-2001;285(1):41-42. Ince DI, Sonmez GT, and Ince ML. Pharmacokinetics of vinyldithiins, transformation products of allicin. View abstract. Meher S, Duley L. Garlic for preventing pre-eclampsia and its complications. Ma, J. L., Zhang, L., Brown, L. M., Li, J. Y., Shen, L., Pan, K. F., Liu, W. D., Hu, Y., Han, Z. X., Crystal-Mansour, S., Pee, D., Blot, W. J., Fraumeni, J. F., Jr., You, W. C., and Gail, M. H. Fifteen-year effects of Helicobacter pylori, garlic, and vitamin treatments on gastric cancer incidence and mortality. View abstract. (Gardner 2007), A systematic review and meta-analysis of randomized controlled trials (published through March 10, 2015) investigated the effects of garlic preparations on lipoprotein(a), with 6 trials meeting inclusion criteria (N=286). Ried, K., Frank, O. R., and Stocks, N. P. Aged garlic extract lowers blood pressure in patients with treated but uncontrolled hypertension: a randomised controlled trial. We comply with the HONcode standard for trustworthy health information. View abstract. View abstract. [Postprandial lipemia under treatment with Allium sativum. Zhang XH, Lowe D, Giles P, et al. View abstract. 4-15-1982;35(2):163-164. Lee TY, Lam TH. A comparative study on hypocholesterolaemic effect of allicin, whole germinated seeds of bengal gram and guggulipid of gum gugglu. Antiviral constituents from Allium sativum. View abstract. Acta Toxicol Ther 1990;11(4):365-372. However, no statistical difference was found in triglyceride levels between the 2 groups (SMD, 0.16; 95% CI, 0.87 to 0.55). J Egypt.Soc Parasitol. View abstract. Ter.Arkh. Takeuchi, S., Matsuzaki, Y., Ikenaga, S., Nishikawa, Y., Kimura, K., Nakano, H., and Sawamura, D. Garlic-induced irritant contact dermatitis mimicking nail psoriasis. View abstract. Some people use garlic to prevent colon cancer, rectal cancer, stomach cancer, breast cancer, prostate cancer, multiple myeloma, and lung cancer. Srivastava KC, Bordia A, and Verma SK. Soltani PR. J Pharm.Pharmacol. However, when applied to the skin, garlic might cause skin damage that is similar to a burn. Some don't work well with prescription medicines. Garlic shows promise for improving some cardiovascular risk factors. (Padiyar 2018), Based on data from 4,521 healthy participants enrolled in 20 randomized controlled trials (including 1 study with aged garlic extract), meta-analyses demonstrated that flavonoid-containing supplements were safe and effective in preventing acute respiratory tract infections (ARTIs) compared to controls with a relative risk (RR) of 0.81 (95% CI, 0.74 to 0.89; P<0.001) and low heterogeneity. J Toxicol Sci 1984;9(1):61-75. Some medications that slow blood clotting include aspirin, clopidogrel (Plavix), diclofenac (Voltaren, Cataflam, others), ibuprofen (Advil, Motrin, others), naproxen (Anaprox, Naprosyn, others), dalteparin (Fragmin), enoxaparin (Lovenox), heparin, warfarin (Coumadin), and others. Klin.Med (Mosk) 2007;85(3):25-28. Turner, B., Molgaard, C., and Marckmann, P. Effect of garlic (Allium sativum) powder tablets on serum lipids, blood pressure and arterial stiffness in normo-lipidaemic volunteers: a randomised, double-blind, placebo-controlled trial. 1-15-1993;137(2):155-165. Some medications that are changed by the liver include acetaminophen, chlorzoxazone (Parafon Forte), ethanol, theophylline, and drugs used for anesthesia during surgery such as enflurane (Ethrane), halothane (Fluothane), isoflurane (Forane), and methoxyflurane (Penthrane). View abstract. Neurosurgery 1990;27(4):659. View abstract. View abstract. Am.J Clin Nutr. 2008;39(6):491-494. Dwivedi, C., Rohlfs, S., Jarvis, D., and Engineer, F. N. Chemoprevention of chemically induced skin tumor development by diallyl sulfide and diallyl disulfide. Gerontology 2008;54(3):173-176. Consumption of aqueous garlic extract leads to significant improvement in patients with benign prostate hyperplasia and prostate cancer. Pena, N., Auro, A., and Sumano, H. A comparative trial of garlic, its extract and ammonium-potassium tartrate as anthelmintics in carp. Aged garlic extract with supplement is associated with increase in brown adipose, decrease in white adipose tissue and predict lack of progression in coronary atherosclerosis. View abstract. View abstract. J Nutr 2000;130:2662-5. Buhshan S, Sharma SP, Singh SP, and et al. Fleischauer AT, Poole C, Arab L. Garlic consumption and cancer prevention: meta-analyses of colorectal and stomach cancers. View abstract. This could decrease the effectiveness of some medications used for HIV/AIDS. Tutakne, M. A., Satyanarayanan, G., Bhardwaj, J. R., and Sethi, I. C. Sporotrichosis treated with garlic juice. The recommended dosage of Viagra for erectile dysfunction (ED) is 50 mg, taken as needed about 1 hour before sexual activity. Burnham BE. View abstract. 1997;66(2):398-405. This article looks at research into the health benefits of garlic and the various human conditions that are thought to be . 1994;44(6):734-743. Eur J Clin Pharmacol 1993;45:333-6. View abstract. Bordia A. View abstract. View abstract. Ashraf, M. Z., Hussain, M. E., and Fahim, M. Endothelium mediated vasorelaxant response of garlic in isolated rat aorta: role of nitric oxide. Taking garlic supplements may increase the risk of bleeding. Ishikawa, H., Saeki, T., Otani, T., Suzuki, T., Shimozuma, K., Nishino, H., Fukuda, S., and Morimoto, K. Aged garlic extract prevents a decline of NK cell number and activity in patients with advanced cancer. (Kook 2009) Garlic exerted a hypoglycemic effect in a murine model of type 1 diabetes. View abstract. Seuri, M., Taivanen, A., Ruoppi, P., and Tukiainen, H. Three cases of occupational asthma and rhinitis caused by garlic. Chavan, S. D., Shetty, N. L., and Kanuri, M. Comparative evaluation of garlic extract mouthwash and chlorhexidine mouthwash on salivary Streptococcus mutans count - an in vitro study. View abstract. Br J Cancer 1997;76:678-87. Some medications are changed and broken down by the liver. Clin Exp.Allergy 1993;23(12):1011-1014. The . View abstract. The recommended dose of Viagra is 25-100 mg taken 30 minutes to 4 hours before sexual activity. Silagy CA, Neil HA. See additional information. J Med Food 2006;9(4):537-544. Modulation of lipid profile by fish oil and garlic combination. Some sources suggest that high doses of garlic could be dangerous or even fatal to children. View abstract. View abstract. Headache 2014;54(2):378-82. Vegetables, fruit, and colon cancer in the Iowa Women's Health Study. Comparison of the efficacy and tolerance of a garlic preparation vs. bezafibrate. (Leite 2016, Mousa 2010, Spolarich 2007, Stanger 2012, Ulbricht 2008, Wilson 2018), Antidiabetic drugs: Garlic may enhance the effects of antidiabetes drugs such as metformin. Circulation 1997;96(8S):6-I. Concurrent drug therapy with omeprazole may facilitate sensitization to food allergens.Treudler 2015 Cross-sensitivity to other members of the Liliaceae family, Amaryllis family (Amaryllidaceae), and asparagus may occur.Aibarro 1997, Borelli 2007, Eming 1999, Sanchez-Hernandez 2000, Takeuchi 2011, Treudler 2015 A case of pneumonia induced by black garlic was documented in a 77-year-old female who presented with dyspnea and coughing. Hsu, C. C., Huang, C. N., Hung, Y. C., and Yin, M. C. Five cysteine-containing compounds have antioxidative activity in Balb/cA mice. Rafaat, M. and Leung, A. K. Garlic burns. The dose of your warfarin (Coumadin) might need to be changed. Saleem, S., Ahmad, M., Ahmad, A. S., Yousuf, S., Ansari, M. A., Khan, M. B., Ishrat, T., and Islam, F. Behavioral and histologic neuroprotection of aqueous garlic extract after reversible focal cerebral ischemia. Protective role of natural antioxidant supplementation on testicular tissue after testicular torsion and detorsion. Effect of garlic on blood lipids in patients with coronary heart disease. Indian J Exp Biol 1982;20(7):534-536. Watson CJ, Grando D, Fairley CK, et al. Nutr Res 2003;23:199-204. (3) Cholesterol Health - with Flush-Free Niacin, CoQ10, Red Yeast Rice & Garlic - Support Healthy Cholesterol Levels, Heart Health, and Blood Circulation - Emerald Labs - 90 Vegetable Capsules. Garlic may be used in pregnancy and lactation with caution. View abstract. Garlic's interactions are likely mediated through its impact on P-glycoprotein rather than the CYP-450 systems. 2011;38(3):280-282. Herbal supplements can interact with medicines used to treat heart and blood vessel problems, such as high blood pressure and heart failure. View abstract. 2004;92(4):701-706. Take Away How exactly does garlic work for erectile dysfunction? La Operacin Deluxe tiene mucho -o todo- que ver con el final de Slvame, previsto para el prximo viernes 23 de junio. Takeaway Viagra treats erectile dysfunction (ED) in adults. In studies with a baseline CRP of 2 mg/dL or greater, garlic reduced CRP by 2.44 mg/dL (95% CI, 4.02 to 0.87; P=0.002). View abstract. Bleeding disorder: Garlic, especially fresh garlic, might increase the risk of bleeding. The typicaldose of Viagra is 50 mg. Arch Intern Med 1998;158:1189-94. View abstract. Klin.Med (Mosk) 2001;79(11):55-58. 2009;22:39-48. Asia Pac.J Clin Nutr. View abstract. 2012;110(5):476-481. [638] These chemicals include allicin, diallyl disulfide (DADS), diallyl trisulfide (DATS), and S-allylmercaptocysteine (SAMC). Zheng, W., Blot, W. J., Shu, X. O., Diamond, E. L., Gao, Y. T., Ji, B. T., and Fraumeni, J. F., Jr. A population-based case-control study of cancers of the nasal cavity and paranasal sinuses in Shanghai. View abstract. Atherosclerosis 1977;28(2):155-159. View abstract. View abstract. Sobenin, I. View abstract. Lipids Health Dis. Gebhardt R, Beck H. Differential inhibitory effects of garlic-derived organosulfur compounds on cholesterol biosynthesis in primary rat hepatocyte cultures. 1996;136(1):146-154. Most evidence supporting the use of garlic is for dyslipidemia and hypertension, although evidence shows equivocal or mixed results, partially due to the difficulty in developing a true placebo, as well as poor methodology and a lack of standardization of preparation. 2005;50(7):645-651. Newton, MA: Integrative Medicine Communications, 2000. Planta Med 1986;(3):163-168. Effects garlic on aerobic performance. Heterogeneity exists among trials, along with poor methodology and a lack of standardization of preparations used. Planta Med 1997;63:263-264. Changes in platelet function and susceptibility of lipoproteins to oxidation associated with administration of aged garlic extract. Allium vegetables and reduced risk of stomach cancer. 2004;87(10):1156-1161. 2011;315(2):87-93. Fleischauer AT, Arab L. Garlic and cancer: a critical review of the epidemiologic literature. Arch.Dermatol.Res 1983;275(4):229-234. Garlic contains several sulfur-containing phytochemicals that are metabolized when eaten and can affect cardiovascular health and inflammation. Originally, garlic was used as a performance-enhancer and even given to the first Olympians in Greece, presumably to give them a boost. 2012;8:CD007653. Life Sci 1998;62:71-7. Superko HR, Krauss RM. Rivlin, R. S. Historical perspective on the use of garlic. It is important to fully inform your doctor about the herbal, vitamins, mineral or any other supplements you are taking before any kind of surgery or medical procedure. View abstract. Qureshi AA, Din ZZ, Abuirmeileh N, et al. 2000;17(6):475-476. Diet and other risk factors for laryngeal cancer in Shanghai, China. View abstract. View abstract. 2003;55(2):199-202. Banerjee, S. K., Dinda, A. K., Manchanda, S. C., and Maulik, S. K. Chronic garlic administration protects rat heart against oxidative stress induced by ischemic reperfusion injury. 2009;87(8):633-640. J Altern.Complement Med 2007;13(1):83-95. Clin.Nutr. (Hurley 2010, Smyth 2010), In a study of 60 children 9 to 12 years of age, a 2.5% garlic extract mouthwash (10 mL) used nightly for 15 days reduced salivary Streptococcus mutans counts and prevented buildup of plaque; effects were comparable to mouthwashes containing chlorhexidine gluconate or another natural ingredient, triphala. Avoid combination. View abstract. Russell, J. E. Chinese complementary therapy for stress causing bilateral chemical burns to the feet. Yoshikawa, K., Hadame, K., Saitoh, K., and Hijikata, T. Patch tests with common vegetables in hand dermatitis patients. 2009;23(4):513-518. Scand.J Urol.Nephrol. Ventura P, Girola M, and Lattuada V. [Clinical evaluation and tolerability of a drug with garlic and hawthorn]. Hsing AW, Chokkalingam AP, Gao YT, et al. Garlic Extract Side Effects. Pinto, J. T., Qiao, C., Xing, J., Rivlin, R. S., Protomastro, M. L., Weissler, M. L., Tao, Y., Thaler, H., and Heston, W. D. Effects of garlic thioallyl derivatives on growth, glutathione concentration, and polyamine formation of human prostate carcinoma cells in culture. What medication interactions should I watch for? (Watson 2014), A case report describes a 25-year-old woman with a vaginal infection caused by Ureaplasma spp. View abstract. Lipids 1993;28(5):475-477. McFadden, J. P., White, J. M., Basketter, D. A., and Kimber, I. View abstract. Available for Android and iOS devices. J Ethnopharmacol. People may take PDE5 inhibitors to manage conditions such as erectile dysfunction (ED) or pulmonary hypertension. Garlic powder and plasma lipids and lipoproteins, a multicenter, randomized, placebo-controlled trial. J Nutr. View abstract. Clin Investig 1993;71:383-6. Experientia 2-15-1996;52(2):115-120. View abstract. The plant may produce pink to purple flowers that bloom from July to September in the Northern Hemisphere. View abstract. Anibarro B, Fontela JL, De La Hoz F. Occupational asthma induced by garlic dust. Phytother.Res. For colon cancer and rectal cancer: Capsules containing 2.4 mL of aged garlic extract taken daily for 12 months have been used. AHRQ Publication No. Risk factors for multiple myeloma: a hospital-based case-control study in Northwest China. Clinical assessment of potential cytochrome P450-mediated herb-drug interactions. Gardner CD, Chatterjee L, and Carlson J. Blumenthal M, Goldberg A, Brinckmann J, eds. Tu, H. K., Pan, K. F., Zhang, Y., Li, W. Q., Zhang, L., Ma, J. L., Li, J. Y., and You, W. C. Manganese superoxide dismutase polymorphism and risk of gastric lesions, and its effects on chemoprevention in a Chinese population. Jain, R. C. Anti tubercular activity of garlic oil. The current match involves a Texas lawsuit . Parish, R. A., McIntire, S., and Heimbach, D. M. Garlic burns: a naturopathic remedy gone awry. Sobenin, I. Isolation, physical properties and antibacterial action. No effect of garlic extract supplement on serum lipid levels in hypercholesterolemic subjects. (Gravas 2010, Heck 2000, Hu 2005, Mohammed Abdul 2008), In an in vitro study, analogs of allicin exerted cytotoxic activity against breast cancer cells, with less toxic effects on noncancerous cells. View abstract. Mulrow C, Lawrence V, Ackerman R, et al. A historical perspective on garlic and cancer. The effects of ginkgo and garlic on warfarin use. View abstract. Zinc for the common cold. Thromb.Res 5-1-1986;42(3):303-311. 1993;37(5):316-322. View abstract. Campbell, J. H., Efendy, J. L., Smith, N. J., and Campbell, G. R. Molecular basis by which garlic suppresses atherosclerosis. View abstract. Bakhshi, M., Taheri, J. Sparnins, V. L., Barany, G., and Wattenberg, L. W. Effects of organosulfur compounds from garlic and onions on benzo[a]pyrene-induced neoplasia and glutathione S-transferase activity in the mouse. Lin, M. C., Wang, E. J., Lee, C., Chin, K. T., Liu, D., Chiu, J. F., and Kung, H. F. Garlic inhibits microsomal triglyceride transfer protein gene expression in human liver and intestinal cell lines and in rat intestine. Effect of garlic on lipid profile and psychopathologic parameters in people with mild to moderate hypercholesterolemia. View abstract. View abstract. 2004;18(5):389-394. Hu, J., Nyren, O., Wolk, A., Bergstrom, R., Yuen, J., Adami, H. O., Guo, L., Li, H., Huang, G., Xu, X., and . Food Factors for Cancer Prevention. Urol Res. Life Sci. Contact allergy to garlic used for wound healing. View abstract. Consumption of aqueous garlic extract leads to significant improvement in patients with benign prostate hyperplasia and prostate cancer . Br.J Clin Pract.Suppl 1990;69:20-23. 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