Toxic myocarditis, myocardial hypokinesia, left ventricular thrombosis and myocardial dysfunction were reported in a case of Al phosphide intoxication (Hangouche et al., 2017). Current evidence suggests that Al can induce DNA damage in human breast epithelial cells and subsequently induce proliferation of the cells (Darbre et al., 2013a, b). Eryptotic (apoptotic) injury reduces the erythrocyte aggregate size (Bazzoni et al., 2005) because of the shrinking effect, thereby increasing osmotic resistance (Igbokwe, 2016). Can the controversy of the role of aluminum in Alzheimers be resolved? The largest source of airborne Al-containing particles is the dust from soil and rocks (Lee and Von Lehmden, 1973; Sorenson et al., 1974). If you do not allow these cookies we will not know when you have visited our site, and will not be able to monitor its performance. Bacon R, Tavill A, Brittenham G, Park C, Recknagel R. Hepatic lipid peroxidation in vivo in rats with chronic iron overload. Living in areas where the air is dusty, where aluminum is mined or processed into aluminum metal, near certain hazardous waste sites, or where aluminum is naturally high. Nanomolar aluminum induces pro-inflammatory and pro-apoptotic gene expression in human brain cells in primary culture. Golub MS, Germann SI. Vasanthan S, Joshi P. Effect of aluminum toxicity and. The hepatic toxicity of Al chloride was also reported in pregnant rats and their offspring with observation of decreased fetal weight and size (Mestaghanmi et al., 2003). Exley C, Birchall JD, Price N. Luminum inhibition of hexokinase activity in vitro: A study in biological availability. Industrial release of Al in waste materials into surface waters from processing and manufacturing facilities could be toxic to aquatic life (Filipek et al., 1987; Trieff et al., 1995; His et al., 1996; Gensemer and Playle, 1999). Occasionally, article request options were used to obtain restricted publications and the articles were received from authors. Adjuvant as a source of Al during vaccinations has been receiving attention in research (Malakoff, 2000; Keith et al., 2002; Mitkus et al., 2011; Glanz et al., 2015) and it is presumed that there could be mistakes in adjusting Al content of vaccines to body weights of neonates who stand the risk of Al toxicity from vaccines (Lyons-Weiler and Ricketson, 2018). Evaluation of the effects of aluminum phosphate and calcium phosphate nanoparticles as adjuvants in vaccinated mice. Al absorption from water intake (about 0.3%) is greater than from food (about 0.1%) (Martyn et al., 1989; Steinhausen et al., 2004; Anon, 2008b; Zhou et al., 2008).This was attributed to organic ligands in foods such as phytates and polyphenols that were suggested to form complexes with Al ion and inhibit its absorption (Reto et al., 2007). Sharma DR, Wani WY, Sunkaria A, Kandimalla RJ, Sharma RK, Verma D, Bal A, Gill KD. The Al ion has no physiological role in metabolic processes (Exley and House, 2011) but it can be a metallic toxicant to humans and animals (Becaria et al., 2002) when there is high body burden of the metal after natural or unnatural exposure (Exley, 2013). Chemical composition of green tea (. Zhou Y, Harris WR, Yokel RA. In male and female gerbils (Meriones unguiculatus), Al exposure disrupted prostate development in neonates, with the consequence of adult off-spring having elevated serum testosterone levels with low androgen receptor frequency associated with increased proliferation of cells of the prostate (Gomes et al., 2019). Aluminum is often mixed with small amounts of other metals to form aluminum alloys, which are stronger and harder. Exley C, Price NC, Kelly SM, Birchall JD. Woodson GC. Willhite CC, Karyakina NA, Yokel RA, Yenugadhati N, Wisniewski TM, Arnold IMF, Momoli F, Krewski D. Systematic review of potential health risk posed by pharmaceutical, occupational and consumer exposures to metallic and nanoscale aluminium, aluminum oxides, aluminum hydroxides and its soluble salts. Has the federal government made recommendations to protect human health? Al may decrease ferritin synthesis and increase the expression of transferrin receptors, thereby disrupting the normal synthesis of transferrin receptors with ferritin creating increased free iron levels in the cell, resulting in an increase of oxidative damage via the fenton reaction (Yamanaka et al., 1999). Aluminum, the most abundant metallic element in the earth's crust, is a light metal with excellent heat and electrical conductivity (Keith et al. Smelting aluminum emits greenhouse gases and toxins including carbon dioxide, fluoride, sulphur dioxide, dust, polycyclic aromatic hydrocarbon, and toxic effluents. Day JP, Barker J, Evans LJA, Perks J, Seabright PJ, Ackrill P, Lilley JS, Drumm PV, Newton GWA. Table 1 provides a comparison of 1988 and 2018 national recommended aquatic criteria for aluminum. Wisniewski HM, Sturman JA, Shek JW. Kandimalla R, Vallamkondu J, Corgiat EB, Gill KD. The dynamic chain of Al intake, absorption and elimination determines the level of tissue accumulation and development of toxicosis (Figure 3). Mohammed A, Mayyas I, Elbetieha A, Shoter A, Khamas W, Alnasser Z. Orihuela D. Aluminium effects on thyroid gland function: iodide uptake, hormone biosynthesis and secretion. Browne BA, McColl JG, Driscoll CT. Aluminum speciation using morin: I. morin and its complexes with aluminum. Gonzelez-Suerez I, Lvarez-Hernendez D, Carrillo-Lepez N, Naves-Deaz M, Fernendez-Marten JL, Cannata-Andea JB. Aluminum is found in breast milk, but only a small amount of this aluminum will enter the infant's body through breastfeeding. Pseudohyperparathyroidism syndrome associated with aluminum intoxication in patients with renal failure. A review of metal exposure and its effects on bone health. Aluminium (Al) is the most widely distributed metal in the environment (Delhaize and Ryan, 1995; Ranjbar et al., 2008; Exley and House, 2011) occurring naturally in the trivalent state (Al+3) as silicates, oxides and hydroxides, but may combine with other elements such as chlorine, sulphur, fluorine, as well as form complexes with organic matter (Jones and Bennet, 1986; Ganrot, 1986; Martin, 1992). In Alzheimers disease associated with Al exposure, membrane fluidity increased in platelets and decreased in erythrocytes; and this observation was corroborated by a study where in vitro exposure of membrane suspensions to Al increased fluidity of platelet membranes and decreased the fluidity of erythrocyte membranes (van Rensburg et al., 1992) with consequent effect on the viability of platelets (Neiva et al., 1997) and erythrocytes (Vittori et al., 2002). Colomina MT, Peris-Sampedro F. Aluminum and Alzheimers disease. Biomass yield and phosphorus availability to wheat grown on high phosphorus soils amended with phosphate inactivating residues. See your doctor if: You have concerns about your erections or you're experiencing other sexual problems such as premature or delayed ejaculation Tech. Agency for Toxic Substance and Disease Registration. Aluminum levels in children with chronic renal failure who consume low phosphorus infant formula. Mutagenesis, cell proliferation and impaired mitosis in Al toxicosis are gray areas requiring clarification because of the observed antithesis. Aluminum induces osteoblast apoptosis through oxidative stress-mediated JNK signaling pathway. It is unlikely that Al-containing food additives are intentionally added to the diets of livestock and pets yet, Al contamination of some additives used in livestock and pet food is possible (Burgoin, 1992). The study of these pathologies have received recent attention in epidemiological surveys in regard to some human diseases such as Alzheimers disease, autism, osteoporosis, diabetes mellitus, inflammatory bowel disease and others mentioned in the review. However, other Al compounds may not cause cardiovascular lesion. Subsequently, the search was extended to MEDLINE, PUBMED, PMC Europe, RESEARCHGATE, SCOPUS, SCIENCEDIRECT, SAGE, TANDFONLINE and SPRINGERLINK. Breast cancers and cysts are mammary gland conditions where emerging evidence are suggesting that Al may be involved in their causation (Darbre, 2016). Erythrocyte osmotic fragility decreased (Bazzoni et al., 2005) or increased (Zatta et al., 1989; Hernndez et al., 2008; Al-Qayim et al., 2014; Oztrk and Ozdemir, 2015, Zhang et al., 2016; Cheng et al., 2018) depending on the Al speciation and type of erythrocyte injury. Comparative effects of several chelating agents on the toxicity, distribution, and excretion of aluminum. Aluminum is clearly a valuable material with a gigantic environmental footprint and social costs most people dont see or perhaps even know about. The anthropogenic aluminum release is a result of human activities such as industrial processes resulting in wastewater and solid waste, fossil fuel combustion, manufacturing, aluminum production, and agriculture. Aluminum utensils contribute to aluminum accumulation in patients with renal disease. Xu F, Ren L, Song M, Shao B, Han Y, Cao Z, Li Y. Fas- and mitochondia-mediated signaling pathway involved in osteoblast apoptosis induced by AlCl. Aluminum induced oxidative events and its relation to inflammation: a role for the metal in Alzheimers disease. The Al accumulating in the breast tissue may influence the biological characteristics of breast epithelial cells and carcinogenesis is considered a probable outcome (Pineau et al., 2014). The use of Al cookware, utensils and wrappings can increase the amount of Al in food (Liukkonen-Lilja and Piepponen 1992; Pennington and Schoen, 1995). Aluminum toxicity. Chronic Al exposure in rats disrupted iron homeostasis (Zhang et al., 2010). Various intravenously administered pharmaceutical products were reported to contain 6845977 g/g of Al (Sedman et al., 1985). Menke A, Casagrande S, Geiss L, Cowie CC. In culture, Al induced apoptosis of osteoblasts by inhibiting apoptotic Bcl-2 protein expression and increasing the expression of pro-apoptotic Bax, Bak and Bim proteins (Xu et al., 2018). Xiea CX, Mattsonbc MP, Lovellcd MA, Yokelae RA. Yang X, Yu K, Wang H, Zhang H, Bai C, Song M, Han Y, Shao B, Li Y, Li X. Dose-dependent effects of aluminum on osteocalcin synthesis in osteoblast like ROS 17/2 cells in culture. Boran AM, Al-Khatib AJ, Alanazi BS, Massadeh AM. Recycled cans mainly go to create new cans, greatly the need for mining and refining, as well as reducing the volume of waste in landfills. The migration of Al from cookware into food increases with the acidity of the food and the duration of exposure (Valkonen and Aitio, 1997; Lin et al. In ovo toxico-teratological effects of aluminum on embryonic chick heart and vascularization. Toxicological Profile for Aluminum. Gonzalez MA, Alvarez ML, Pisani GB. Inhibition by nanomolar aluminum and implications for neurodegenerative disease. Domingo JL, Llobet JM, Gomez M, Tomas JM, Corbella J. Nutritional and toxicological effects of short-term ingestion of aluminum by the rat. Additive or synergistic effects of aluminum on the reduction of neural stem cells, cell proliferation and neuroblast differentiation in the dentate gyrus of high-fat diet-fed mice. Contini MC, Ferri A, Bernal CA, Carnovale CE. -Amyloid induces oxidative DNA damage and cell death through activation of c-Jun N terminal kinase. Cytokine expression was accelerated by oxidative cellular injuries to initiate inflammatory processes and alter immune responses that support inflammation and immunosuppression, respectively. Al chlorohydrate in antiperspirant cosmetics and other underarm cosmetic products may be an important source of Al exposure (Pineau et al., 2014; Linhart et al., 2017). Oral Al chloride exposure caused epithelial degeneration, goblet cell proliferation and lymphocyte infiltration in the mucosa of the small intestine of Wistar rats (Buraimoh and Ojo, 2012). On each platform, an article that was found could also have links to related articles and these links were followed to enrich the search outcomes. Filming has already been completed after six weeks, which saw . Brown S, Savory J, Wills MR. Absorption of aluminum from citrate or chloride in everted rat gut sac. Bone impairment caused AlCl. Aluminum disrupts the pro-inflammatory cytokine/neurotrophin balance in primary brain rotation-mediated aggregate cultures: possible role in neurodegeneration. Advances in aluminum hydroxide-based adjuvant research and its mechanism. Acidic drainage from mines or acid rain may cause an increase in the dissolved Al content of the surrounding water bodies (Cronan and Schofield, 1979; Filipek et al., 1987). Taiwo OA, Sircar KD, Slade MD, Cantley LF, Vegso SJ, Rabinowitz PM, Fiellin MG, Cullen MR. Jrup L. Hazards of heavy metal contamination. Yousef MI, Salama AF. Laurel West aluminum industial base residents trace element content in serum and its associated abnormal glucose metabolism (J), Xian dai Yu fang Yi xue (Modern Prev Med). Effects of dietary aluminum excess and manganese deficiency on neurobehavioral endpoints in adult mice. Alter P, Grimm W, Maisch B. Old (18 months of age) rats exposed to Al (100 mg/kg/day) in drinking water with citrate (356 mg/kg/day of citrate) had decreased numbers of synapses and a greater percentage of perforated synapses than controls, but no changes in behavior (Colomina et al., 2002). An experimental animal model of aluminum overload. Evidence of aluminum loading in infants receiving intravenous therapy. Soil and water contamination. The offspring of exposed rats (F0) in a three-generation study belonging to F1 and F2 had decreased testosterone and LH levels, decreased testicular weight, and increase in the production of abnormal immobile spermatozoa, whereas the parental F0 group did not present with such reproductive abnormalities (Muselin et al., 2016). Moghadamnia AA. Rim K. Aluminum leaching using chelating agent as a composition food. Critical Review. The bauxite dissolves. sharing sensitive information, make sure youre on a federal Omar HM, Khadiga AH, Abd-Elghaffar SK, Ahmed EA. Iron overload due to Al exposure has been shown to result in increased lipid peroxidation, DNA lesions, and apoptosis induced by reactive oxygen species (Bacon et al., 1983; Oteiza, 1994; Kell, 2009). Vittori et al. Mouro VGS, Menezes TP, Lima GDA, Domingues RR, Souza AC, Oiveira JA, Matta SLP, Machado-Neves M. How bad is aluminum exposure to reproductive parameters? Obukhova T, Budkar LN, Tereshina LG, Karpova EA. Pineau A, Fauconneau B, Sappino A-P, Deloncle R, Guillard O. Composting Made Easy Tips from an Unlikely Composter, Drought in a Small Town Saving Water before the Drought, Bayer process invented in 1887 by Carl Josef Bayer, U.S. Census Bureau 2012 U.S. population statistics. Chemical aspects of aluminum chelation by desferrioxamine. 1Department of Veterinary Pathology, Faculty of Veterinary Medicine, University of Maiduguri, Maiduguri, Nigeria, 2Department Veterinary Physiology and Biochemistry, Faculty of Veterinary Medicine, University of Maiduguri, Maiduguri, Nigeria. Photomicrograph of pancreas of aluminium chloride-treated rat showing coagulative necrosis of the pancreatic islet tissue with disorganization of its architecture (H & E, x 400) From Igwenagu et al. Sadhana S. S-Allyl-Cysteines reduce amelioration of aluminum induced toxicity in rats. Oral aluminum administration to rats with normal renal function. A critical appraisal. Understanding aspects of aluminum exposure in Alzheimers disease development. Human semen and spermatozoa contain Al and patients with oligospermia had higher Al concentration than healthy individuals (Klein et al., 2014). Hematological changes in rats chronically exposed to oral aluminum. Shaw CA, Li D, Tomljenovic L. Are there negative CNS impacts of aluminum adjuvants used in vaccines and immunotherapy. In the air, aluminum binds to small particles, which can stay suspended for many days. Food or water for livestock could be contaminated with Al when Al sulfate and zeolite are applied to litter and waste lagoons to reduce phosphorus loss from lands fertilized with the wastes and to reduce ammonia fumes in facilities (Moore et al., 1999; Moore et al., 2000; Codling et al., 2002). Sorgdrager B, Looff AJ, Monchy JG, Pal TM, Dubois AE, Rijcken B. Virtually all food, water, air, and soil contain some aluminum. On the whole, it is noted that Al accumulation, which is responsible for Al toxicosis, is enhanced by exposure to Al and its continuous intake, as well as increased intestinal absorption and decreased excretion of the metal (Figure 3). Tissue accumulation of Al is reduced by citrates and fluorides through renal excretion when the transferrin-Al binding capacity of the blood is exceeded (Anon, 2008b). Pettersen JC, Hackett DS, Zwicker GM, Sprague GL. Very little enters your body from aluminum cooking utensils. Biego GH, Joyeux M, Hartemann P, Debry G. Daily intake of essential minerals and metallic micropollutants from foods in France. Cell membrane functions which regulate transmembrane transport of ions are expected to be disrupted when ATPase in cell membrane loses some level of activity during Al exposure. Wesdock JC, Arnold IMF. Stahl T, Taschan H, Brunn H. Aluminium content of selected foods and food products. Greger JL, Sutherland J. Toxicity evaluation of aluminium chloride on adult female mice. Investigation of nine workers with pathologic examination and microanalysis in three of them. Mining, the refining process, and the eventual discarding of aluminum all take a toll on our environment. Burge PS, Scott JA, McCoach J. Effect of sodium fluoride and aluminium chloride on ovary and uterus of mice and their reversal by some antidotes. Huang W, Wang P, Shen T, Hu C, Han Y, Song M, Bian Y, Li Y, Zhu Y. Impairment of erythropoiesis. Fu Y, Jia FB, Wang J, Song M, Liu SM, Li YF, Liu SZ, Bu QW. 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