Kulkarni S, Barbagli G, Kirpekar D et al: Lichen sclerosus of the male genitalia and urethra: Surgical options and results in a multicenter international experience with 215 patients. Ann Intern Med 2011; 155: 529. 126. Ann Chir Gynaecol Suppl 1993; 206: 80. If a patient can forgo clean intermittent catheterization (CIC) without acute urinary retention, a SP tube may be omitted during urethral rest.97-99 This allows the full length of the stricture to develop and accurate determination of definitive treatment options to be made. Int Urol Nephrol 2009; 41: 885. It is more evident in males, where it occurs in the penile/pendulous urethra, near the urethral meatus. World J Urol 2000; 18: 382. Urethroplasty, even in the setting of failed endoscopic management, offers success rates in the range of 80-90%.127 Urethral strictures that have been previously treated with dilation or DVIU are unlikely to be successfully treated with another endoscopic procedure,117 with failure rates of >80%.128 Repeated endoscopic treatment may cause longer strictures and may increase the complexity of subsequent urethroplasty.129 In patients who are unable to undergo, or who prefer to avoid, urethroplasty, repeated endoscopic procedures or intermittent self-catheterization may be considered as palliative measures. 2. 2. a depression on the internal pterygoid process of the sphenoid, giving attachment to the tensor veli palatini muscle. 116. In single-stage procedures, the urethra is augmented in caliber by transferring tissue in the form of a graft or flap. The use of hair-bearing skin for substitution urethroplasty may result in urethral calculi, recurrent UTI and a restricted urinary stream due to hair obstructing the lumen, and therefore should be avoided except in rare cases where no alternative exists.185 Intraurethral hair should be suspected in patients who report these symptoms and have a history of prior tubularized urethroplasty or surgery for proximal hypospadias, in which scrotal skin may have been incorporated into the repair and demonstrate later hair growth. (Moderate Recommendation; Evidence Level: Grade C), Strictures involving the penile urethra are more likely to be related to hypospadias, LS, or iatrogenic etiologies when compared to strictures of the bulbar urethra. Gelman J and Siegel JA: Ventral and dorsal buccal grafting for 1-stage repair of complex anterior urethral strictures. There was statistically significant change in corneal abrasions (P = .03), fossa navicularis strictures (P = .03), and camera-site hernias (P <.001) after a directed intervention adjusted for age . J Urol 2004; 172: 201. Guidelines cannot include evaluation of all data on emerging technologies or management, including those that are FDA-approved, which may immediately come to represent accepted clinical practices. International Urology & Nephrology 2021; 53: 907. Armenakas NA, Morey AF and McAninch JW: Reconstruction of resistant strictures of the fossa navicularis and meatus. When urethral strictures are identified at the time of catheter placement for another surgical procedure, assessment of the need for catheterization should be made. Patients with urethral stricture most commonly present with decreased urinary stream and incomplete bladder emptying but may also demonstrate UTI, epididymitis, rising post-void residual (PVR), or decreased force of ejaculation. When Grade B evidence is used, benefits and risks/burdens appear balanced, the best action also depends on individual patient circumstances and better evidencecould change confidence. 148. Int J Urol 2013; 20: 1199. 185. Santucci R and Eisenberg L: Urethrotomy has a much lower success rate than previously reported. Noll F and Schreiter F: Meshgraft urethroplasty using split-thickness skin graft. Chin Med J (Engl) 2014; 127: 3418. J Urol 2012; 188: 2260. Br J Urol 1998; 81: 735. 65. 180. Breyer BN, Edwards TC, Patrick DL et al: Comprehensive qualitative assessment of urethral stricture disease: Toward the development of a patient centered outcome measure. J Urol 2002; 167: 1715. There are a multitude of different urethroplasty techniques that can be generally divided into tissue transfer-involved procedures and non-tissue transfer-involved procedures. Clinicians should be aware that panurethral strictures are very unlikely to be treated successfully with endoscopic means, which offer only temporary relief of obstruction.26, 100, 101, 105, 117, 119, 137 However, urethroplasty in these instances is also more complicated, time-consuming, and has a higher failure rate as compared to urethroplasty for less complicated strictures.47, 162, 163 Thus, some patients may choose repeat endoscopic treatments, with or without a self-dilation protocol, or a perineal urethrostomy, in order to avoid complex urethral reconstructive surgery. BJU Int 2003; 91: 215. In contrast, the pragmatic design of OPEN and performance at 50 sites across the UK National Health Service should assure greater generalizability. Moncrief T, Gor R, Goldfarb RA et al: Urethral rest with suprapubic cystostomy for obliterative or nearly obliterative urethral strictures: Urethrographic changes and implications for management. 238. Bmj 2016; 355: i4919. Additional information is provided as Clinical Principles and Expert Opinions when insufficient evidence existed. Sa YL, Xu YM, Qian Y et al: A comparative study of buccal mucosa graft and penile pedical flap for reconstruction of anterior urethral strictures. Cialis Together 10mg Tablets - Tadalafil - 4 Tablets. Strictures in the bulbar urethra are more common than other anatomic locations in males; however, certain etiologies are closely associated with an anatomic segment of the urethra.13For example, strictures related to hypospadias and lichen sclerosus ([LS]; previously termed balanitis xerotica obliterans) are generally located in the penile urethra, while traumatic strictures and stenoses tend to be located in the bulbar and posterior urethra. Surgeons may safely remove the urethral catheter within 72 hours following uncomplicated dilation or direct visual internal urethrotomy. 121. Either urethral catheter or suprapubic (SP) cystostomy is a viable option; a urethral catheter is thought to be optimal as it may serve as a stent around which the site of urethra intervention can heal. Khawaja AR, Dar YA, Bashir F et al: Outcome of dorsal buccal graft urethroplasty in female urethral stricture disease (fusd); our institutional experience. The American Urological Association (AUA) categorizes the level of a body of evidence as Grade A (well-conducted and highly-generalizable RCTs or exceptionally strong observational studies with consistent findings); Grade B (RCTs with some weaknesses of procedure or generalizability or moderately strong observational studies with consistent findings); or Grade C (RCTs with serious deficiencies of procedure, generalizability, or extremely small sample sizes or observational studies that are inconsistent, have small sample sizes, or have other problems that potentially confound interpretation of data). These guidelines and best practice statements are not in-tended to provide legal advice about use and misuse of these substances. Gallegos MA and Santucci RA: Advances in urethral stricture management. No studies exist that compare the different treatment strategies for bladder neck contractures after endoscopic prostate procedures. (Expert Opinion). Tausch TJ and Peterson AC: Early aggressive treatment of lichen sclerosus may prevent disease progression. 149. Patients treated with a urethral stent after dilation or internal urethrotomy should be monitored for recurrent stricture and complications. 82. Koraitim MM: The lessons of 145 posttraumatic posterior urethral strictures treated in 17 years. Int Urol Nephrol 1998; 30: 85. Int J Surg 2009; 7: 361. Similar to other types of stricture exact delineation of length and etiology is important for guiding treatment. Helmy TE, Sarhan O, Hafez AT et al: Perineal anastomotic urethroplasty in a pediatric cohort with posterior urethral strictures: Critical analysis of outcomes in a contemporary series. Eur Urol 2008; 53: 420. Urology 2012; 79: 1158. A stricture is essentially a scar that limits urine flow. Prevention of catheter associated urethral injury and traumatic strictures through educational efforts on proper technique of catheter insertion and management after insertion. Urethroplasty is challenging in this population, as patients are more likely to be active tobacco smokers, have a higher body mass index, hypertension, diabetes mellitus, coronary artery disease, and have longer urethral strictures compared to non-LS urethral strictures.212-214 Urethroplasty often requires multiple oral mucosa grafts to reconstruct long-segment strictures, often with a lower success rate compared to non-LS urethral strictures, and thus a comprehensive discussion of the various management strategies is warranted. Zehri AA, Ather MH and Afshan Q: Predictors of recurrence of urethral stricture disease following optical urethrotomy. 167. As individual studies without replication, both OPEN and ROBUST III are at greater risk for bias. The length of urinary catheterization is widely variable, with a shorter recommended time for endoscopic interventions than open urethral reconstruction.28, Urethrography or voiding cystography is typically performed two to three weeks following open urethral reconstruction to assess for complete urethral healing. Indian Journal of Urology 2022; 38: 140. World journal of urology 2017; 35: 839. Common risk factors for developing a urethral stricture in men include a history of hypospadias surgery, urethral catheterization or instrumentation, traumatic injury, transurethral surgery, and prostate cancer treatment.13, 15, 66 The stricture etiology will be idiopathic in many men. BJU Int 2017; 120: 710. 232. Today these evidence-based guidelines statements represent not absolute mandates but provisional proposals for treatment under the specific conditions described in each document. Sharma AK, Chandrashekar R, Keshavamurthy R et al: Lingual versus buccal mucosa graft urethroplasty for anterior urethral stricture: A prospective comparative analysis. J Urol 2000; 163: 1070. (Expert Opinion), When evaluating a patient with a recurrent urethral stricture, a physician who does not perform urethroplasty should consider referral to a surgeon with experience in this technique due to the higher rate of successful treatment compared to repeat endoscopic management. Gupta S, Majumdar B, Tiwari A et al: Sonourethrography in the evaluation of anterior urethral strictures: Correlation with radiographic urethrography. BJU Int 2013; 112: 655. Literature searches were performed on English-language publications using the Pubmed, Embase, and Cochrane databases from 1/1/1990 to 12/1/2015 by the ECRI Institute and were included in a systematic review evidence report. Nasca MR, Innocenzi D and Micali G: Penile cancer among patients with genital lichen sclerosus. The efficacy of injection or balloon-coated anti-proliferative or other pharmacological agents at time of endoscopic treatment for penile urethral stricture, previous failed urethroplasty, posterior urethral stenosis, and bladder neck contracture. 157. To improve the quality of research, the Panel recommends the following: 1. For certain key questions that had little or no evidence from comparative studies, we included case series with 50 or more patients. F1000Res 2016; 5: 2913. Urology 2004; 64: 675. 71. Urology 2011; 77: 1477. Santucci RA, McAninch JW, Mario LA et al: Urethroplasty in patients older than 65 years: Indications, results, outcomes and suggested treatment modifications. Other adjunctive studies may include antegrade cystoscopy, with or without fluoroscopy, and pelvic CT or MRI to assess the proximal extent of the injury, degree of malalignment of the urethra, and length of the defect. Neurourol Urodyn 2021; 40: 986. Surgeons can use a number of diagnostic tests to detect or screen for stricture recurrence following open or endoscopic treatment (see Statements 1 and 2); however, the use of, or combination of, urethrocystoscopy, urethral ultrasound, or RUG appears to provide the most definitive confirmation of stricture recurrence.82, 84, 85, 87-90, 230, 231 No specific urethral lumen diameter, determined endoscopically or radiographically, has been shown to be diagnostic of a stricture recurrence. Pickard R, Goulao B, Carnell S et al: Open urethroplasty versus endoscopic urethrotomy for recurrent urethral stricture in men: The open rct. Hudak SJ, Lubahn JD, Kulkarni S et al: Single-stage reconstruction of complex anterior urethral strictures using overlapping dorsal and ventral buccal mucosal grafts. Urologists play a key role in the initial evaluation of urethral stricture and currently provide all accepted treatments. 69. J Urol 2022; 208: 128. 5. Samaiyar SS, Shukla RC, Dwivedi US et al: Role of sonourethrography in anterior urethral stricture. The presence of voiding symptoms as described above, in combination with reduced peak flow rate for age, place patients at higher probability for urethral stricture, therefore indicating definitive evaluation such as cystoscopy, RUG, VCUG, or ultrasound urethrography. Kumar S, Kapoor A, Ganesamoni R et al: Efficacy of holmium laser urethrotomy in combination with intralesional triamcinolone in the treatment of anterior urethral stricture. 2,3 When there is any history of straddle . J Urol. 118. A similar period of observation is recommended before reassessing a stricture after failure or dilation or DVIU. J Urol 1996; 155: 904. Urology 2011; 77: 1318. Hajebrahimi S, Maroufi H, Mostafaei H et al: Reconstruction of the urethra with an anterior vaginal mucosal flap in female urethral stricture. Katiyar VK, Sood R, Sharma U et al: Critical analysis of outcome between ventral and dorsal onlay urethroplasty in female urethral stricture. Morey AF and McAninch JW: Role of preoperative sonourethrography in bulbar urethral reconstruction. 207. Endoscopic treatments typically offer only temporary relief and necessitate lifelong instrumentation. Radiology 1994; 193: 345. International Urogynecology Journal 2021; 18: 18. Each member of the panel provides an ongoing conflict of interest disclosure to the AUA. Atak M, Tokgoz H, Akduman B et al: Low-power holmium:Yag laser urethrotomy for urethral stricture disease: Comparison of outcomes with the cold-knife technique. History, physical examination, and adjunctive measures (Statements 1 and 2) cannot definitively confirm a urethral stricture. Repeat endoscopic treatment may be necessary for successful outcomes. 19. Mangera A and Chapple C: Management of anterior urethral stricture: An evidence-based approach. Rourke K, McKinny S and St Martin B: Effect of wound closure on buccal mucosal graft harvest site morbidity: Results of a randomized prospective trial. PMCID: PMC3193739 DOI: 10.4103/0970-1591.85442 Abstract Objective: Literature on urethral stricture mainly pertains to bulbar urethral stricture and pelvic fracture urethral distraction defect. Santucci RA, Mario LA and McAninch JW: Anastomotic urethroplasty for bulbar urethral stricture: Analysis of 168 patients. Urol J 2011; 8: 48. Erickson BA, Breyer BN and McAninch JW: Single-stage segmental urethral replacement using combined ventral onlay fasciocutaneous flap with dorsal onlay buccal grafting for long segment strictures. 220. J Urol 1999; 161: 1535. Journal of Urology 2019; 201: 956. European Urology 2021; 11: 11. (Moderate Recommendation; Evidence Level: Grade C). Urology 2014; 83: 648. Murphy GP, Fergus KB, Gaither TW et al: Urinary and sexual function after perineal urethrostomy for urethral stricture disease: An analysis from the turns. Nash PA, McAninch JW, Bruce JE et al: Sono-urethrography in the evaluation of anterior urethral strictures. 27. Research and Reports in Urology 2022; 14: 177. Appendix b: Quality assessment methods for durg class reviews for the drug effectiveness review project. Eur Urol 2008; 53: 828. Broadwin M and Vanni AJ: Outcomes of a urethroplasty algorithm for fossa navicularis strictures. Balshem H, Helfand M, Schunemann HJ et al: Grade guidelines: 3. 56. navicular fossa. While these guidelines do not necessarily establish the standard of care, AUA seeks to recommend and to encourage compliance by practitioners with current best practices related to the condition being treated. Fossa strictures were diagnosed based on acute onset of obstructive voiding symptoms, IPSS and flow pattern changes, and bougie calibration. J Urol 2008; 180: 2479. Badlani GH, Press SM, Defalco A et al: Urolume endourethral prosthesis for the treatment of urethral stricture disease: Long-term results of the north american multicenter urolume trial. Hussain M, Greenwell TJ, Shah J et al: Long-term results of a self-expanding wallstent in the treatment of urethral stricture. Urethroplasty may be offered as the initial treatment for a short bulbar urethral stricture, but the higher success rate of this treatment compared to endoscopic treatment must be weighed against the increased anesthesia requirement and higher morbidity of urethroplasty. 109. (Expert Opinion). 96. Viers BR, Pagliara TJ, Shakir NA et al: Delayed reconstruction of bulbar urethral strictures is associated with multiple interventions, longer strictures and more complex repairs. 66. Additionally, LS is capable of malignant transformation, progressing to squamous cell carcinoma in 2-8% of patients.207, 208 This is important, in that male patients presenting with acquired buried penis also have concomitant urethral strictures in 31-47% of cases, thereby requiring careful evaluation and management.209-211. Meatoplasty, while often reserved for more complicated and long strictures, has a high rate of . Multi-stage procedures use a graft as a urethral substitute for future tubularization. J Urol 2008; 179: 2259. The findings of these two studies, highlight the importance of a patient centered approach to recurrent urethral strictures, challenges inherent in the evidence reviewed in support of this guideline, and opportunities for future directions. 101. Basic science and animal studies using novel graft materials for urethral reconstruction (i.e., stem cells, tissue-engineered scaffolds). Tammela TL, Permi J, Ruutu M et al: Clean intermittent self-catheterization after urethrotomy for recurrent urethral strictures. VUAS or bladder neck reconstruction can be performed robotically or open. 1. the lateral expansion of the urethra of the glans penis. 165. Postprocedural fossa navicularis urethral stricture. J Urol 1993; 150: 1725. J Urol 2007; 178: 2268. Surgeons should offer perineal urethrostomy as a long-term treatment option to patients as an alternative to urethroplasty in patient populations at high risk for failure of urethral reconstruction. Surgeons may reconstruct female urethral strictures using oral mucosal grafts, vaginal flaps, or a combination of these techniques. Patient positioning in the lithotomy (standard, high, or exaggerated) may be limited until orthopedic and lower extremity soft tissues injuries have resolved. Urology 2022; 166: 146. This is thought to maximize success by not underestimating the length of stricture and degree of spongiofibrosis. When no alternative exists, a tubularized flap can be performed with results that are inferior to onlay flaps.183, 184 Currently, available alternatives include combined tissue transfer (e.g., a dorsal buccal graft combined with a ventral skin flap in a single stage), combined dorsal and ventral grafts (e.g., a dorsal graft in the technique of Asopa and a ventral onlay graft), or staged urethroplasty with local skin flaps or oral mucosa grafts. Xu YM, Feng C, Sa YL et al: Outcome of 1-stage urethroplasty using oral mucosal grafts for the treatment of urethral strictures associated with genital lichen sclerosus. Korean J Urol 2013; 54: 710. Geographic setting, socioeconomic factors, and access to healthcare can affect stricture etiology. Urology 2015; 85: 1190. Techniques that involve tissue transfer can be categorized into single-stage and multi-stage procedures. It is important to consider both aesthetic and functional outcomes when reconstructing strictures involving the glanular urethra. 5705185. 231. The anterior urethra includes the bulbar urethra, penile urethra, and fossa navicularis. 200. Further evaluation of alternative sources of autologous graft material. BJU Int 2006; 98: 149. (Conditional Recommendation; Evidence Level: Grade C). Eur Urol 2008; 53: 81. Management of fossa navicularis strictures The correction of strictures involving the fossa navicularis poses a distinct reconstructive challenge. A stricture is primarily a problem of the male urethra, or the tube that carries urine through the prostate and penis. Definitive urethral reconstruction for pelvic fracture urethral injury should be planned only after major injuries stabilize and patients can be safely positioned for urethroplasty. Then it was submitted to the AUA Board of Directors for final approval. Mitterberger M, Christian G, Pinggera GM et al: Gray scale and color doppler sonography with extended field of view technique for the diagnostic evaluation of anterior urethral strictures. Afridi NG, Khan M, Nazeem S et al: Intermittent urethral self dilatation for prevention of recurrent stricture. Prophylactic antibiotic choice and duration should follow AUA Best Practice Policy Statement.27To avoid bacterial resistance, antibiotics should be discontinued after a single dose or within 24 hours. Urethral stricture is a common problem encountered following the treatment of BPH. J Pak Med Assoc 2008; 58: 429. For example, the term "urethral stricture" should be applied to a narrowing of the anterior urethra that restrict the flow of urine. This guideline provides evidence-based guidance to clinicians and patients regarding how to recognize symptoms and signs of a urethral stricture/stenosis, carry out appropriate testing to determine the location and severity of the stricture, and recommend the best options for treatment. 112. Bmj 2011; 343: d5928. 163. Clinicians should use retrograde urethrography with voiding cystourethrogram and/or retrograde + antegrade cystoscopy for preoperative planning of delayed urethroplasty after pelvic fracture urethral injury. Nuss GR, Granieri MA, Zhao LC et al: Presenting symptoms of anterior urethral stricture disease: A disease specific, patient reported questionnaire to measure outcomes. Khan S, Khan RA, Ullah A et al: Role of clean intermittent self catheterisation (cisc) in the prevention of recurrent urethral strictures after internal optical urethrotomy. Review article references were checked to ensure inclusion of all possible relevant studies. A consensus primary outcome measure should be considered for future RCT and registry studies. 186. Hampson LA, Myers JB, Vanni AJ et al: Dorsal buccal graft urethroplasty in female urethral stricture disease: A multi-center experience. Conformance with any clinical guideline does not guarantee a successful outcome. Qu Y, Zhang W, Sun N et al: Immediate or delayed repair of pelvic fracture urethral disruption defects in young boys: Twenty years of comparative experience. Elliott SP, Coutinho K, Robertson KJ et al: One-year results for the robust iii randomized controlled trial evaluating the optilume((r)) drug-coated balloon for anterior urethral strictures. J Urol 1997; 158: 1376. Fossa navicularis magna, or sometimes simply fossa navicularis, is a variant depression on the ventral/inferior surface of the basioccipital portion of the clivus. Sharma G, Sharma S and Parmar K: Buccal mucosa or penile skin for substitution urethroplasty: A systematic review and meta-analysis. J Postgrad Med Inst 2010; 24: 239. Recent Findings In . 179. Introduction-grade evidence profiles and summary of findings tables. 94. 215. (Expert Opinion). Urology 2018; 122: 169. Steenkamp JW, Heyns CF and de Kock ML: Internal urethrotomy versus dilation as treatment for male urethral strictures: A prospective, randomized comparison. Kjaergaard B, Walter S, Bartholin J et al: Prevention of urethral stricture recurrence using clean intermittent self-catheterization. People with this condition can experience symptoms like painful or burning urination, a narrow or fast urinary stream, spraying of urine, difficulty directing the stream and frequent urination. (Conditional Recommendation; Evidence Level: Grade C), Dilation and DVIU have similar success and complication rates and can be used interchangeably for the initial treatment of short urethral strictures. BJU Int 2004; 94: 1037. Liaw A, Rickborn L and McClung C: Incidence of urethral stricture in patients with adult acquired buried penis. Urology 2011; 77: 1232. Kidney Medicine 216.444.6771. Urology 1996; 47: 102. J Urol 2008; 180: 197. Kochakarn W, Muangman V, Viseshsindh V et al: Stricture of the male urethra: 29 years experience of 323 cases. (Clinical Principle), The external manifestations of LS in males can range in severity from mild to aggressive. Int Urol Nephrol 1996; 28: 801. Surgeons may place a suprapubic cystostomy to promote urethral rest prior to definitive urethroplasty in patients dependent on an indwelling urethral catheter or intermittent self-dilation. 213. Surgeons who do not perform urethroplasty should refer patients to surgeons with expertise. Eur Radiol 2004; 14: 137. J Pak Med Assoc 2011; 61: 440. 89. Dubey D, Kumar A, Bansal P et al: Substitution urethroplasty for anterior urethral strictures: A critical appraisal of various techniques. Zhang K, Qi E, Zhang Y et al: Efficacy and safety of local steroids for urethra strictures: A systematic review and meta-analysis. Fenton AS, Morey AF, Aviles R et al: Anterior urethral strictures: Etiology and characteristics. (Clinical Principle). The prostatic urethra extends from the distal bladder neck to the distal end of the veru montanum. And management after insertion of recurrent stricture and complications management of anterior urethral strictures treated in 17 years interest to. Intermittent self-catheterization after urethrotomy for recurrent urethral strictures guarantee a successful outcome with any Clinical guideline does not a. ; 58: 429 the length of stricture and currently provide all accepted treatments as Principles... Following the treatment of BPH Advances in urethral stricture management Urology & Nephrology 2021 ; 18 18... Patients with adult acquired buried penis and Vanni AJ: outcomes of a urethroplasty algorithm for fossa poses. 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