Avoid or Use Alternate Drug. Either increases toxicity of the other by serotonin levels. Minor/Significance Unknown. Effect of interaction is not clear, use caution. Monitor Closely (1)secobarbital and doxepin both increase sedation. dantrolene and doxepin both increase sedation. Modify Therapy/Monitor Closely. papaveretum and doxepin both increase sedation. doxepin, buprenorphine, long-acting injection. Avoid or Use Alternate Drug.trazodone and doxepin both increase serotonin levels. chlordiazepoxide and doxepin both increase sedation. Comment: Barbiturates may increase adverse effects, including respiratory depression, produced by toxic doses of TCAs. bazedoxifene/conjugated estrogens, doxepin. Use Caution/Monitor.Serious - Use Alternative (1)doxepin, midodrine. Monitor Closely (1)dantrolene and doxepin both increase sedation. Avoid or Use Alternate Drug. Use Caution/Monitor. Monitor Closely (1)doxepin and pazopanib both increase QTc interval. Minor (1)pleurisy root decreases effects of doxepin by unspecified interaction mechanism. Monitor Closely (2)solifenacin and doxepin both decrease cholinergic effects/transmission. Use Caution/Monitor. Either increases levels of the other by pharmacodynamic synergism. With therapeutic doses of TCAs, barbiturates increase metabolism and decrease blood concentrations of TCAs. Avoid or Use Alternate Drug. Monitor Closely (1)pregabalin, doxepin. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron. Monitor Closely (1)temazepam and doxepin both increase sedation. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron. Avoid taking selinexor with other medications that may cause dizziness or confusion. Minor/Significance Unknown. Either increases effects of the other by sedation. Monitor Closely (3)asenapine will increase the level or effect of doxepin by affecting hepatic enzyme CYP2D6 metabolism. Use Caution/Monitor. Use Caution/Monitor. Monitor Closely (1)echothiophate iodide increases and doxepin decreases cholinergic effects/transmission. Use Caution/Monitor.donepezil and doxepin both increase QTc interval. Use Caution/Monitor. Effect of interaction is not clear, use caution. Use Caution/Monitor. Mechanism: unknown. lumefantrine will increase the level or effect of doxepin by affecting hepatic enzyme CYP2D6 metabolism. Monitor Closely (1)doxepin and topiramate both increase sedation. Use Caution/Monitor.Serious - Use Alternative (1)doxepin, terbutaline. Avoid or Use Alternate Drug. AUC and Cmax increased by 66% and 69% respectively. Minor/Significance Unknown. buprenorphine buccal and doxepin both increase sedation. cyclobenzaprine and doxepin both decrease cholinergic effects/transmission. Effect of interaction is not clear, use caution. Monitor Closely (1)vecuronium and doxepin both decrease cholinergic effects/transmission. Additive anticholinergic effects. These other dosage forms of doxepin, however, are not FDA-approved for insomnia. desipramine and doxepin both decrease cholinergic effects/transmission. levomilnacipran and doxepin both increase serotonin levels. rifabutin decreases levels of doxepin by increasing metabolism. Continuously monitor vital signs during sedation and recovery period if coadministered. glycopyrronium tosylate topical, doxepin. Doxepin belongs to a . Avoid or Use Alternate Drug.desipramine and doxepin both increase serotonin levels. Avoid or Use Alternate Drug. Use Caution/Monitor. Use Caution/Monitor. Use Caution/Monitor. Comment: Barbiturates may increase adverse effects, including respiratory depression, produced by toxic doses of TCAs. Serious - Use Alternative (1)doxepin, sodium oxybate. Minor/Significance Unknown. fexinidazole and doxepin both increase QTc interval. Avoid or Use Alternate Drug. Minor (1)mestranol, doxepin. doxepin and olodaterol inhaled both increase QTc interval. Modify Therapy/Monitor Closely. Use Caution/Monitor. doxepin decreases effects of brimonidine by pharmacodynamic antagonism. Covering the treated area may increase the absorption of the medication through the skin and increase the risk of side effects.Do not use more of this product, use it more often, or keep using it longer than prescribed by your doctor. Minor/Significance Unknown. Modify Therapy/Monitor Closely. Use Caution/Monitor.Serious - Use Alternative (1)doxepin, dobutamine. Avoid or Use Alternate Drug. Coadministration of drugs that affect the serotonergic neurotransmitter system may result in serotonin syndrome. Do not start, stop, or change the dosage of any medicines without your doctor's approval.Some products that may interact with this drug are: arbutamine, certain drugs for high blood pressure (such as clonidine, guanadrel, guanethidine), thyroid medication.Taking MAO inhibitors with this medication may cause a serious (possibly fatal) drug interaction. With therapeutic doses of TCAs, barbiturates increase metabolism and decrease blood concentrations of TCAs. Avoid or Use Alternate Drug. Use Caution/Monitor.Serious - Use Alternative (2)clomipramine and doxepin both increase QTc interval. Minor/Significance Unknown. stiripentol, doxepin. Estrogens may inhibit hepatic metabolism of tricyclic antidepressants. Use Caution/Monitor. Other (see comment). serdexmethylphenidate/dexmethylphenidate increases effects of doxepin by decreasing metabolism. Avoid or Use Alternate Drug. Mechanism: unspecified interaction mechanism. Comment: Pitolisant increases histamine levels in the brain; therefore, H1 receptor antagonists that cross the blood-brain barrier may reduce the efficacy of pitolisant.doxepin and pitolisant both increase QTc interval. Use Caution/Monitor.Minor (1)secobarbital, doxepin. If clinically appropriate, discontinue drugs that decrease uptake of NE for at least 5 half-lives; may cause false-negative imaging results. Minor (1)estrogens esterified, doxepin. For 2 weeks after abametapir application, avoid taking drugs that are CYP3A4 substrates. Monitor Closely (1)doxepin and rilpivirine both increase QTc interval. Effect of interaction is not clear, use caution. Minor/Significance Unknown. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron. Use Caution/Monitor.desflurane and doxepin both increase QTc interval. Monitor Closely (1)doxepin increases and yohimbine decreases sedation. Avoid or Use Alternate Drug. Limit alcoholic beverages. Minor (1)doxepin increases effects of glyburide by pharmacodynamic synergism. Monitor Closely (1)atropine IV/IM and doxepin both decrease cholinergic effects/transmission. Either increases effects of the other by sedation. If concomitant use is warranted, carefully observe the patient, particularly during treatment initiation, and during dose adjustment of the serotonergic drug. Concomitant use could result in life-threatening serotonin syndrome. Use Caution/Monitor. Minor/Significance Unknown. Ramelteon did not improve global or sleep outcomes in a clinically meaningful. doxepin increases and terbutaline decreases sedation. Use Caution/Monitor. Use Caution/Monitor.Serious - Use Alternative (2)doxepin and trazodone both increase QTc interval. Other (see comment). Modify Therapy/Monitor Closely. Contraindicated. Use lowest dose possible and monitor for respiratory depression and sedation. doxepin and trazodone both decrease cholinergic effects/transmission. Modify Therapy/Monitor Closely. Either increases effects of the other by pharmacodynamic synergism. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron.Minor (1)isoproterenol, doxepin. Minor/Significance Unknown. acrivastine and doxepin both increase sedation. of BZRAs, low-dose doxepin and a DORA are both reasonable options with appropriate pharmacokinetics to . Another brand of sildenafil is Revatio, which is used to treat pulmonary arterial hypertension and improve exercise capacity in men and women. doxepin and pitolisant both increase QTc interval. Effect of interaction is not clear, use caution. IMPORTANT: HOW TO USE THIS INFORMATION: This is a summary and does NOT have all possible information about this product. Use Caution/Monitor. Use Caution/Monitor.Minor (2)doxepin, prochlorperazine. doxepin and dolasetron both increase QTc interval. The objective of this systematic review was to obtain a precise summary of the efficacy and safety of doxepin as a hypnotic. Monitor Closely (1)papaveretum and doxepin both increase sedation. levothyroxine increases effects of doxepin by Other (see comment). Use Caution/Monitor. fesoterodine and doxepin both decrease cholinergic effects/transmission. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron. Exercise extreme caution if vilanterol coadministered with MAOIs or TCAs, or within 2 weeks of discontinuation of these drugs; adrenergic agonist effects on the cardiovascular system may be potentiated. Avoid or Use Alternate Drug. Minor/Significance Unknown. atropine IV/IM and doxepin both decrease cholinergic effects/transmission. Either increases effects of the other by pharmacodynamic synergism. Monitor Closely (1)levothyroxine increases effects of doxepin by Other (see comment). Contraindicated. Avoid or Use Alternate Drug. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron. Monitor Closely (1)oxazepam and doxepin both increase sedation. Drugs that prolong the QTc interval and may potentiate the effects of beta2 agonists on the cardiovascular system; increased risk of ventricular arrhythmias. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron. Use Caution/Monitor. frovatriptan and doxepin both increase serotonin levels. efavirenz and doxepin both increase QTc interval. Avoid or Use Alternate Drug.doxepin and escitalopram both increase QTc interval. Use Caution/Monitor. triprolidine and doxepin both increase sedation. Use Caution/Monitor. pyridostigmine increases and doxepin decreases cholinergic effects/transmission. sevoflurane and doxepin both increase sedation. Use Caution/Monitor.Serious - Use Alternative (1)trifluoperazine and doxepin both increase QTc interval. doxepin and procainamide both increase QTc interval. Sleep medications, like doxepin (Silenor), can cause confusion and increased sleepiness in people over 65 years old. Use Caution/Monitor.prochlorperazine and doxepin both increase sedation. Peginterferon alpha-2b may increase or decrease levels of CYP2D6 substrate. Do not abruptly stop this medication without first talking to your physician. doxepin and ribociclib both increase QTc interval. Modify Therapy/Monitor Closely.Serious - Use Alternative (2)fluoxetine and doxepin both increase serotonin levels. Minor/Significance Unknown. MISSED DOSE: If you miss a dose, apply it as soon as you remember. Avoid or Use Alternate Drug. Monitor Closely (1)doxepin will increase the level or effect of dextroamphetamine transdermal by pharmacodynamic synergism. dicyclomine and doxepin both decrease cholinergic effects/transmission. ECG monitoring is recommended if coadministered. doxepin and entrectinib both increase QTc interval. Coadministration of glycopyrronium tosylate topical with other anticholinergic medications may result in additive anticholinergic adverse effects. Medscape prescription drug monographs are based on FDA-approved labeling information, unless otherwise noted, combined with additional data derived from primary medical literature. Either increases effects of the other by serotonin levels. doxepin and dronedarone both increase QTc interval. Avoid or Use Alternate Drug. Use Caution/Monitor.Serious - Use Alternative (2)doxepin and haloperidol both increase QTc interval. Use Caution/Monitor. Use Caution/Monitor. eletriptan and doxepin both increase serotonin levels. doxepin and romidepsin both increase QTc interval. Doxepin systemic 10 mg (MYLAN 1049 MYLAN 1049). Use Caution/Monitor. Most Monitor Closely (1)hyoscyamine and doxepin both decrease cholinergic effects/transmission. It is not known how this medication decreases itching. methylene blue and doxepin both increase serotonin levels. Either increases effects of the other by pharmacodynamic synergism. Monitor Closely (1)sodium sulfate/potassium sulfate/magnesium sulfate increases effects of doxepin by unknown mechanism. Serious - Use Alternative (1)givosiran will increase the level or effect of doxepin by affecting hepatic enzyme CYP2D6 metabolism. doxepin and dasatinib both increase QTc interval. Avoid or Use Alternate Drug. onabotulinumtoxinA and doxepin both decrease cholinergic effects/transmission. phenobarbital and doxepin both increase sedation. Use Caution/Monitor. Additive anticholinergic effects.doxepin, prochlorperazine. For severe anxiety, your doctor may increase your dosage to 300 mg per day. Use Caution/Monitor. Minor/Significance Unknown. quinidine and doxepin both increase QTc interval. Modify Therapy/Monitor Closely. Modify Therapy/Monitor Closely. Use lowest dose possible and monitor for respiratory depression and sedation. Use Caution/Monitor.doxepin and tapentadol both increase serotonin levels. Monitor Closely (1)doxepin decreases effects of debrisoquine by Other (see comment). Monitor Closely (1)doxepin and meprobamate both increase sedation. Use Caution/Monitor. Monitor Closely (1)elvitegravir/cobicistat/emtricitabine/tenofovir DF increases levels of doxepin by affecting hepatic enzyme CYP2D6 metabolism. Use Caution/Monitor. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron. clomipramine and doxepin both increase sedation. Modify Therapy/Monitor Closely. Use Caution/Monitor. Avoid or Use Alternate Drug. Pharmacotherapy for insomnia in adults. doxepin and formoterol both increase QTc interval. Avoid use with CYP2D6 substrates where minimal increases in concentration of the CYP2D6 substrate may lead to serious or life-threatening toxicities. Use Caution/Monitor. Canada residents can call a provincial poison control center. Other (see comment). Other (see comment). Minor/Significance Unknown. Monitor Closely (1)dexchlorpheniramine and doxepin both increase sedation. Monitor Closely (1)doxepin and vardenafil both increase QTc interval. Avoid or Use Alternate Drug.venlafaxine and doxepin both increase serotonin levels. At the maximum recommended dose, deutetrabenazine does not prolong QT interval to a clinically relevant extent. Either increases levels of the other by pharmacodynamic synergism. Avoid or Use Alternate Drug. Estrogens and progestins may decr tricyclic antidepressant effects, while increasing TCA plasma concentration and adverse effects. Avoid or Use Alternate Drug. Avoid or Use Alternate Drug. Citalopram may increase TCA levels. doxepin increases and methamphetamine decreases sedation. desflurane and doxepin both increase QTc interval. Comment: Amifampridine can cause seizures. Modify Therapy/Monitor Closely. Minor/Significance Unknown. Monitor Closely (1)doxepin increases and midodrine decreases sedation. Use Caution/Monitor. Avoid or Use Alternate Drug.Minor (1)sertraline will increase the level or effect of doxepin by affecting hepatic enzyme CYP2D6 metabolism. Either increases levels of the other by decreasing metabolism. Avoid or Use Alternate Drug. tetrabenazine and doxepin both increase QTc interval. Effect of interaction is not clear, use caution. Effect of interaction is not clear, use caution. Avoid or Use Alternate Drug. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron.Minor (1)serdexmethylphenidate/dexmethylphenidate increases effects of doxepin by decreasing metabolism. Monitor Closely (1)doxepin increases and xylometazoline decreases sedation. doxepin and osimertinib both increase QTc interval. Effect of interaction is not clear, use caution. doxepin and protriptyline both increase serotonin levels. Modify Therapy/Monitor Closely. Monitor Closely (1)huperzine A increases and doxepin decreases cholinergic effects/transmission. Coadministration of drugs that affect the serotonergic neurotransmitter system may result in serotonin syndrome. doxepin and atomoxetine both increase QTc interval. Use Caution/Monitor.orphenadrine and doxepin both increase sedation. This medication is for use on the skin only. Monitor Closely (1)gabapentin enacarbil, doxepin. Use Caution/Monitor. doxepin, remifentanil. Monitor Closely (2)doxepin and trazodone both decrease cholinergic effects/transmission. Use Caution/Monitor. Before using doxepin, report all medications you are currently using to your doctor or pharmacist.Tell your doctor or pharmacist if you are taking other products that cause drowsiness such as opioid pain or cough relievers (such as codeine, hydrocodone), alcohol, marijuana (cannabis), drugs for sleep or anxiety (such as alprazolam, lorazepam, zolpidem), muscle relaxants (such as carisoprodol, cyclobenzaprine), or antihistamines (such as cetirizine, diphenhydramine).Check the labels on all your medicines (such as allergy or cough-and-cold products, diet aids) because they may contain ingredients that cause drowsiness or decongestants/stimulants that could increase your heart rate or blood pressure. Use Caution/Monitor. USES: This medication is used to relieve itching from certain skin conditions (such as atopic dermatitis, eczema, neurodermatitis). 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