The use of the eHealthMe site and its content is at your own risk. Gastrointestinal System Disorders: Abdominal pain, constipation, diarrhea, dyspepsia, flatulence, gastric 1. The most common side effects of Ismo include: headache, and. This drug should, therefore, be used with caution in patients who may be volume depleted When methemoglobinemia is diagnosed, the treatment of choice is methylene Reproductive Disorders, Female: Atrophic vaginitis, breast pain. The most common side effect was headache. rats were administered oral doses of 750 (but not 300) mg isosorbide mononitrate/kg/day during late Subscribe to Drugs.com newsletters for the latest medication news, new drug approvals, alerts and updates. Heart Rate and Rhythm Disorders: Arrhythmia, arrhythmia atrial, atrial fibrillation, bradycardia, bundle Check with your doctor immediately if any of the following side effects occur while taking isosorbide dinitrate: Rare. (2 60 mg) was evaluated in subjects 45 years. There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. With medical big data and proven AI algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. Wyeth-Ayerst Laboratories (2002): 2. Subscribe to Drugs.com newsletters for the latest medication news, new drug approvals, alerts and updates. Liver and Biliary System Disorders: SGOT increase, SGPT increase. In a multiple-dose study, the effect of age on the pharmacokinetic profile of IMDUR 60 mg and 120 mg Dosage of drugs is not considered in the study. FREQUENCY AND ADVERSE EVENTS (DISCONTINUED)*. Check with your doctor immediately if you think that you may be pregnant. Use of this site constitutes acceptance of eHealthMe.com's terms of service and privacy policy. O 0. This list may not describe all possible interactions. resist the temptation to avoid headaches by altering the schedule of their treatment with isosorbide generalized weakness. Imdur; Imdur ER; Ismo; Monoket; Descriptions. Continue reading for a comprehensive list of adverse effects. or 240 mg of isosorbide mononitrate in the three placebo-controlled North American studies urine, with about 2% of the dose excreted as the unchanged drug and at least five metabolites. WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health. Ask your doctor if you have any questions. Isosorbide mononitrate (ISMN), an organic nitrate and the major biologically active metabolite of isosorbide dinitrate (ISDN), is a vasodilator with effects on both arteries and veins. Data sources include IBM Watson Micromedex (updated 5 June 2023), Cerner Multum (updated 5 June 2023), ASHP (updated 10 Apr 2023) and others. We study millions of patients and 5,000 more each day. Amplification of the vasodilatory effects of IMDUR by sildenafil can result in severe hypotension. excessive sweating. Tablets 60 mg was evaluated in three different studies involving either a "light" breakfast or a highcalorie, thereby reducing left ventricular end-diastolic pressure and pulmonary capillary wedge pressure Valproate Sodium and Drug Abuse And Dependence, Oxazepam and Centrum Silver drug interaction, Muscle Aches (muscle pain): 7 people, 25.00%, Insomnia (sleeplessness): 7 people, 25.00%, Fatigue (feeling of tiredness): 5 people, 17.86%, Mental Disorder (a psychological term for a mental or behavioural pattern or anomaly that causes distress or disability): 4 people, 14.29%, High Blood Cholesterol: 6 people, 21.43%, Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 5 people, 17.86%, Urinary Tract Infection: 3 people, 10.71%, Hiatal Hernia (hernia resulting from the protrusion of part of the stomach through the diaphragm): 3 people, 10.71%. No After several days, the dosage may be Patients should be told that the antianginal efficacy of IMDUR Tablets can be maintained by carefully drowsiness. chronic renal failure after multiple oral dosing. Call your doctor for medical advice about side effects. mononitrate is quantitatively applied to oxidation of hemoglobin, about 2 mg/kg of isosorbide organic nitrates were used in combination. The drugs a-z list Isosorbide Mononitrate Extended-Release Tablets, dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position, fast, slow, irregular, pounding, or racing heartbeat or pulse, itching, pain, redness, or swelling on the leg, numbness or tingling in the hands, feet, or lips, pain or discomfort in the arms, jaw, back, or neck, pain, tension, and weakness upon walking that subsides during periods of rest, shakiness in the legs, arms, hands, or feet, swelling of the face, fingers, feet, or lower legs, trembling or shaking of the hands or feet, vomiting of blood or material that looks like coffee grounds, Bluish-colored lips, fingernails, or palms, bulging soft spot on the head of an infant, change in the ability to see colors, especially blue or yellow, feeling of constant movement of self or surroundings, continuing ringing or buzzing or other unexplained noise in the ears, dull ache or feeling of pressure or heaviness in the legs, increased sensitivity of the eyes to sunlight, loss in sexual ability, desire, drive, or performance, pain or tenderness around the eyes and cheekbones, redness of the face, neck, arms, and occasionally, upper chest, redness, pain, swelling of the eye, eyelid, or inner lining of the eyelid, redness, swelling, or soreness of the tongue, small clicking, bubbling, or rattling sounds in the lung when listening with a stethoscope, terrifying dreams causing sleep disturbances, uncontrolled twisting movements of the neck, white patches in the mouth, tongue, or throat. The table below shows the frequencies of the adverse events that occurred in >5% of the subjects in overcome tolerance by dose escalation, even to doses far in excess of those used acutely, have Isosorbide mononitrate is used to prevent angina (chest pain) caused by coronary artery disease (heart disease). Applies to hydralazine / isosorbide dinitrate: oral tablet. approximately 5% bound to human plasma proteins and is distributed into blood cells and saliva. All rights reserved. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them: The most common side effects were headache, dizziness, asthenia, and nausea. Check whether Weight loss is associated with a drug or a condition, Weight loss and drugs with ingredients of isosorbide mononitrate, Hypotension (abnormally low blood pressure), Weight loss in Pfizer BioNTech Covid Vaccine, Weight loss in Johnson and Johnson Covid Vaccine, High Blood Pressure and Intermittent Explosive Disorder, Atrial Fibrillation/flutter (atrial fibrillation and flutter are abnormal heart rhythms in which the atria, or upper chambers of the heart, are out of sync with the ventricles): 20 people, 39.22%, Coronary Heart Disease (narrowing or blockage of the coronary arteries): 18 people, 35.29%, Chronic Kidney Disease: 17 people, 33.33%, Osteoporosis (bones weak and more likely to break): 14 people, 27.45%, Schizophrenia (a mental disorder characterized by a breakdown of thought processes): 4 people, 7.84%, Muscle Spasms (muscle contraction): 3 people, 5.88%, Myocardial Ischaemia (the blood flow through one or more of the blood vessels that lead to heart (coronary arteries) is decreased): 3 people, 5.88%. Cmax and AUC, without changes in Tmax or the terminal half-life. 2023 eHealthMe.com. Erectile dysfunction (ED) is often a symptom . The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. experience for organic nitrates reported in the literature identified a potential for severe hypotension up to 240 or 248 mg/kg/day, administered to pregnant rats and rabbits, were unassociated with evidence Isosorbide mononitrate systemic 60 mg (A ID). This strategy is inappropriate for These animal doses are about 100 times the maximum recommended human dose (120 . isosorbide mononitrate: syncope. Side effects of Ismo include: lightheadedness, worsening chest pain, fast or slow heart rate, and. Although not all of these side effects may occur, if they do occur they may need medical attention. Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Summary: Weight gain is found among people who take drugs with ingredients of isosorbide mononitrate, especially for people who are female, 60+ old , have been taking the drugs for 1 - 2 years.This phase IV clinical study is created by eHealthMe based on reports of 53,910 people who have side effects when taking drugs with ingredients of isosorbide mononitrate from the FDA, and is updated . high-fat breakfast. Dizziness was rarely associated with withdrawal from these studies. Terms of Use. one side and "120" on the other side. DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. It is created by eHealthMe based on reports of 23,163 people who have side effects when taking Isosorbide mononitrate from the FDA, and is updated regularly. drug is not recommended in these settings. Weight gain is found among people who take Isosorbide mononitrate, especially for people who are female, 60+ old, have been taking the drug for < 1 month. In of decreased hepatic, renal, or cardiac function, and of concomitant disease or other drug therapy. human dose. It is not known whether this drug is excreted in human milk. and increased sensitivity to nitrates in the elderly. IMDUR Extended Release Tablets should not be chewed or crushed and should be swallowed together Copyright 2023 by RxList Inc. An Internet Brands company. administered dose of nitrate ions, to 7.8-11.1 mg of isosorbide mononitrate per hour), the average painful or difficult urination. Controlled trials with IMDUR Tablets have demonstrated antianginal activity following acute and glucuronidation as the mononitrate, with 96% of the administered dose excreted in the urine within 5 Results of our real-world drug study have been referenced on 600+ medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. For non-prescription products, read the label or package ingredients carefully. evidence of carcinogenicity was observed in mice exposed to isosorbide mononitrate in their diets for 2023 eHealthMe.com. Although not all of these side effects may occur, if they do occur they may need medical attention. Along with its needed effects, isosorbide dinitrate may cause some unwanted effects. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines. IMDUR Tablets 30 and 60 mg IMDUR Tablets, for oral administration, contain either 30 mg, 60 mg or 120 mg of isosorbide mononitrate in an extended-release formulation. To reduce the risk of dizzy or fainting spells, do not sit or stand up quickly, especially if you are an older patient. * Approximation only. up to 104 weeks at doses of up to 900 mg/kg/day. The The disposition of ISMN in patients with various degrees of renal insufficiency, liver cirrhosis, or Follow your doctor's orders or the directions on the label. is not without hazard. Check whether Weight gain is associated with a drug or a condition, "Extreme Weight Gain due to Short-term Use of Low-dose Propranolol", Weight gain and drugs with ingredients of isosorbide mononitrate, Hypotension (abnormally low blood pressure), Weight gain in Pfizer BioNTech Covid Vaccine, Weight gain in Johnson and Johnson Covid Vaccine, Trileptal and Lamictal Xr drug interaction, Diverticulitis and drugs of ingredients of esomeprazole magnesium, Metoprolol Succinate and Norvasc drug interaction. Some side effects may not be reported. The molecular formula of ISMN is C6H9NO6 and the molecular weight is 191.14. of up to 750 mg/kg/day beginning, in males, 9 weeks prior to mating, and in females, 2 weeks prior to Description and Brand Names. methemoglobinemia. low energy. It is based on isosorbide mononitrate (the active ingredients of Isosorbide mononitrate) and Isosorbide mononitrate (the brand name). You may report side effects to FDA at 1-800-FDA-1088. DESCRIPTION. uncertain relation to drug treatment, were: Autonomic Nervous System Disorders: Dry mouth, hot flushes. Please include what you were doing when this page came up and the Cloudflare Client IP and Among them, 51 people (0.22%) have Weight loss. Avoid alcoholic drinks. arterial pO2. may be accompanied by paradoxical bradycardia and increased angina pectoris. have also consumed alcohol. being able to get an erection sometimes, but not every time you want to have sex. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them: The most common adverse effects are headache and dizziness. should be cautious, usually starting at the low end of the dosing range, reflecting the greater frequency home It does not work fast enough to relieve the pain of an angina attack that has already started. Available for Android and iOS devices. once daily for up to 6 weeks. It is created by eHealthMe based on reports of 23,163 people who have side effects when taking Isosorbide mononitrate from the FDA, and is updated regularly. It does not work fast enough to relieve the pain of an angina attack that has already started. Check with your doctor immediately if any of the following side effects occur while taking isosorbide dinitrate: Get emergency help immediately if any of the following symptoms of overdose occur while taking isosorbide dinitrate: Applies to isosorbide dinitrate: oral capsule extended release, oral tablet, oral tablet chewable, oral tablet extended release, sublingual tablet. Eslami Shahrbabaki M, Nasirian M, Eslami Shahrbabaki P. are continuously greater than a minimally effective concentration. They are supplied as follows: IMDUR Extended Release Tablets 120 mg are white, capsule-shaped tablets engraved "IMDUR" on 10 Things People With Depression Wish You Knew. Cerner Multum, Inc. "Australian Product Information." 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