The current recommendation is to use high intensity statins for patients with clinical atherosclerotic disease and to make sure that the patients have access to medication and adherence is monitored. Over all, men on statins were about twice as likely as those taking placebos 2014 May-Jun;16(3):461-6. doi: 10.4103/1008-682X.123678. In conclusion, statins do not cause erectile dysfunction. Management of erectile dysfunction in hypertension: tips and tricks. This can be a real frog in the pot situation. Erectile Dysfunction; International Index of Erectile Function; Meta-Analysis; Statins. Cookies collect information about your preferences and your devices and are used to make the site work as you expect it to, to understand how you interact with the site, and to show advertisements that are targeted to your interests. Vitamin E and its function in membranes. Pharmacologic therapy for erectile dysfunction includes phosphodiesterase-inhibitors in the great majority of cases. Cai X, Tian Y, Wu T, Cao CX, Bu SY, Wang KJ. Heart 2007; 93: 244246. Asian J Androl. The https:// ensures that you are connecting to the Thank you, {{form.email}}, for signing up. It is plausible that lowering cholesterol improves the function of the cells that line blood vessels, which could help erectile function, he said. Vascular Medicine, 11(4), 251-257. Statins may improve erectile function since LDL-C is associated with better endothelial function, and good endothelial function is important for an erection. Sadowitz B, Maier KG, Gahtan V . Vasc Endovascular Surg 2010; 44: 241251. Thank you for visiting nature.com. Arch Esp Urol 2010; 63: 740747. Certain prescription meds have more beneficial effects on erectile function than others. 14 October 2020, Get just this article for as long as you need it, Prices may be subject to local taxes which are calculated during checkout. Park JS, Kim YJ, Choi JY, Kim YN, Hong TJ, Kim DS et al. For patients with LDL-C between 70 to 189 mg/dL moderate or high intensity statin therapy is recommended if the 10-year atherosclerotic risk is 7.5%, and moderate intensity statin therapy for risk between 5.0% to 7.4% risk. This relaxes blood vessels and improves blood flow. Conclusion: Gur S, Kadowitz PJ, Hellstrom WJ . Guidelines on male sexual dysfunction: erectile dysfunction and premature ejaculation. The international index of erectile function (IIEF): a multidimensional scale for assessment of erectile dysfunction. 2019 Sep;7(3):251-269. doi: 10.1016/j.esxm.2019.06.001. Received 2018 Feb 15; Revised 2018 Feb 15; Accepted 2018 May 11. Yao H, Wang X, Liu H, Sun F, Tang G, Bao X, Wu J, Zhou Z, Ma J. Vascul Pharmacol 2006; 45: 268276. Disclaimer. After taking it for a week, I couldnt have an erection anymore. Before ISSN 0955-9930 (print), international journal of impotence research, International Journal of Impotence Research (, The effect of vitamin E supplementation on selected inflammatory biomarkers in adults: a systematic review and meta-analysis of randomized clinical trials, Pharmacokinetic interaction between atorvastatin and fixed-dose combination of sofosbuvir/ledipasvir in healthy male Egyptian volunteers, Effects of Green Tea Extract on Atorvastatin Pharmacokinetics in Healthy Volunteers, Effectiveness of Atorvastatin in the Treatment of Asymptomatic Heart Failure After Myocardial Infarction: A Clinical Study, Effect of vitamin E supplementation on serum C-reactive protein level: a meta-analysis of randomized controlled trials. Like men can be, he will not talk about it. Guo W, Zingg JM, Meydani M, Azzi A . Castro PF, Miranda R, Verdejo HE, Greig D, Gabrielli LA, Alcaino H et al. In some instances, it may be sufficient to reverse pre-existing abnormalities in function as well as structure. I am very understanding of this situation but he just turns away when I suggest anything sexual. Coming soon. 2014;22(1):11-19. doi:10.1007/s12471-013-0482-z, Chrysant SG. National Library of Medicine Bethesda, MD 20894, Web Policies Comparative study of low doses of rosuvastatin and atorvastatin on lipid and glycemic control in patients with metabolic syndrome and hypercholesterolemia. http://creativecommons.org/licenses/by-nc/4.0. and JavaScript. How to Lower Your Systolic Blood Pressure, Risks and Complications of Type 2 Diabetes in Men. Esposito K, Giugliano F, Di Palo C, Giugliano G, Marfella R, D'Andrea F, et al. Chronically high blood pressure puts a strain on the organs and tissues, slowing blood flow and therefore the ability to maintain an erection. Unauthorized use of these marks is strictly prohibited. Paglia DE, Valentine WN . Luckily I just need a minimal dose. For patients with clinical evidence of cardiovascular disease (secondary prevention), high intensity statin treatment is recommended for most patients by the 2013 American College of Cardiology/American Heart Association (ACC/AHA) guidelines [5]. Nitric oxide 2006; 15: 148153. Int J Impot Res 2005; 17: 307319. 2023 Dotdash Media, Inc. All rights reserved, Verywell Health uses only high-quality sources, including peer-reviewed studies, to support the facts within our articles. For some men, less blood flow makes it difficult to get and keep erections. We use cookies on our website to give you the most relevant experience by remembering your preferences and repeat visits. The cookie is used to store the user consent for the cookies in the category "Analytics". Antihypertensive therapy causes erectile dysfunction. This reader wants to know. Studies have shown that angiotensin receptor blockers (ARBs) either have no significant negative effects or in some cases, beneficial effects on erectile function. Long-term effects of statins, blood pressure-lowering, and both on erectile function in persons at intermediate risk for cardiovascular disease: a substudy of the Heart Outcomes Prevention Evaluation-3 (HOPE-3) randomized controlled trial. Feng D, Tang C, Liu S, Yang Y, Han P, Wei W. Int J Impot Res. National Library of Medicine The .gov means its official. ACE inhibitors also reduce the workload of the heart which can increase stamina and sexual performance. Morelli A, Filippi S, Mancina R, Luconi M, Vignozzi L, Marini M et al. Nitric oxide synthase: regulation and function. Enhanced cardioprotection against ischemia-reperfusion injury with combining sildenafil with low-dose atorvastatin. Then again, it is possible to miss embarrassing side effects if you dont specifically ask about them. Kostis B, Dobrzynski JM. Korean J Intern Med 2010; 25: 2735. The cookie is used to store the user consent for the cookies in the category "Performance". Hypothesis and pilot trial results. The Effects of Administration of Vitamin D, Infliximab, and Leflunomide on Testosterone Concentrations in Rats under Atorvastatin Therapy. 2016;2:16003. doi:10.1038/nrdp.2016.3. For instance, alpha-blockers such as Hytrin (terazosin) and Cardura (doxazosin) can cause difficulty in maintaining an erection and/or decreased ejaculation. The role of statins in erectile dysfunction: a systematic review and meta-analysis. Pharmacology Department, Professor of Pharmacology and Toxicology, Faculty of Pharmacy, Tanta University, Tanta, Egypt, Clinical Pharmacy Department, Associate Professor of Clinical Pharmacy, Faculty of Pharmacy, Tanta University, Tanta, Egypt, Urology Department, Professor of Urology, Faculty of Medicine, Tanta University, Tanta, Egypt, Clinical Pharmacy Department, M. Sc. The effect of statins on erectile dysfunction: a systematic review and meta-analysis. It is common in men of all ages. This cookie is set by GDPR Cookie Consent plugin. Therefore, it is likely that any of the pre-existing medical conditions, and not the blood thinners, are the cause of ED. You should never start or stop a blood pressure medication without medical supervision. To date, there is no verifiable scientific evidence that blood thinners can help with ED. Dr. Beatrice Golomb, a professor at the University of California, San Diego, medical school, who helped conduct that study, says doctors dont always take patients seriously when they talk about side Bolat, M. S., Bakrta, M., Frat, F., Akdeniz, E., nar, ., & Erdemir, F. (2019). Always seek the advice of your physician or other qualified health provider with any medical condition or question you may have regarding a medical condition. A systematic review and meta-analysis on the therapeutic equivalence of statins. Evaluation and non surgical management of erectile dysfunction and periapism. By Shamard Charles, MD, MPH CAS A recent analysis of literature looking at five epidemiological trials evaluating the effect of different cardiovascular drugs on erectile function found that calcium channel blockers had no relevant or even a positive effect on erectile function. Azadzoi KM, Schulman RN, Aviram M, Siroky MB . Google Scholar. How can you approach someone like this? Only atorvastatin showed a statistically significant increase in NO (15.19%, P<0.05), eNOS (20.58%, P<0.01), IIEF-5 score (53.1%, P<0.001) and Rigiscan rigidity parameters (P<0.01), in addition to a statistically significant decrease in CRP (57.9%, P<0.01). Int J Clin Pract. Stone NJ, Robinson JG, Lichtenstein AH, Bairey Merz CN, Blum CB, Eckel RH, et al. 2014 Jun;11(6):1367-75. doi: 10.1111/jsm.12497. Current management strategy of treating patients with erectile dysfunction after radical prostatectomy: a systematic review and meta-analysis. Now I am on on 2.5 mg of Crestor per week. The main types of blood thinners include: Because the erectile dysfunction (ED) medication Viagra (sildenafil) was originally developed for treating angina pectoris (a type of chest pain due to poor blood flow), many people assume it has blood thinning effects. The increase in IIEF with statins was approximately one-third to one-half of that previously reported with phosphodiesterase-5 inhibitors and larger than the effect of lifestyle modification. 1; standard difference in means 0.2; 95% CI, 0.00.3; p=0.0349). Hardened and narrow blood vessels make it difficult for blood to flow into the penis before intercourse. People usually think shes in her 20s. government site. However, we expect that more multicentre clinical trials will be conducted to support this assertion. J Sex Med. Necessary cookies are absolutely essential for the website to function properly. Systematic Review and Meta-Analysis of 16 Randomized Controlled Trials of Clinical Outcomes of Low-Intensity Extracorporeal Shock Wave Therapy in Treating Erectile Dysfunction. Miranda KM, Espey MG, Wink DA . Epub 2016 Dec 13. Which Type of Exercise Is Best for the Brain? In an SAT-based meta-analysis, the ES of the change in IIEF-5 score in the atorvastatin treatment group before and after treatment was 3.22 (95 per cent CI of 1.32-5.12). Shamard Charles, MD, MPH is a public health physician and journalist. Common calcium channel blockers prescribed for high blood pressure include: Despite the debate surrounding the use of high blood pressure medication in ED patients, research shows that people with long withstanding high blood pressure levels are more likely to have significant structural damage in their penile arteries. Lifestyle modification is important for both cardiovascular health and improvement of erectile function. Other uncategorized cookies are those that are being analyzed and have not been classified into a category as yet. On the flip side, statins can cause side effects such as fatigue and muscle weakness. Theres an App for That. There's some research that suggests beta-blockers may decrease blood flow to the penis, making it difficult to get an erection. As a result, blood vessels widen, increasing blood flow and lowering blood pressure. Biol Reprod 1999; 61: 10121016. These medications work by blocking the action of a chemical (angiotensin) which narrows the blood vessels. Neither has happened in our 20 years together and certainly isnt true now. Phosphodiesterase type 5 inhibition does not reverse endothelial dysfunction in patients with coronary heart disease. Methods: We thank the members of Urology Center, in Urology Department in Tanta University Hospital, and the members of Clinical Pharmacy Research Center, in Clinical Pharmacy Department in Faculty of Pharmacy, Tanta University. Coron Artery Dis 2004; 15: 251258. Here Are the Top 10 Culprits Written by Sarah Gupta, MD | Reviewed by Sophie Vergnaud, MD Updated on January 26, 2023 Key takeaways: There are over 100 different medications that can cause erectile dysfunction (ED). Can You Safely Lose Weight While Breast-Feeding? Arterial vasodilators relax blood vessels and improve blood flow, which helps to lower blood pressure. The Anatomy of an Erection During sexual arousal, nerves release chemicals that increase blood flow into the penis. Atorvastatin ameliorates sildenafil-induced penile erections in experimental diabetes by inhibiting diabetes-induced RhoA/Rho-kinase signaling hyperactivation. Impotence and its medical and psychosocial correlates: results of the Massachusetts Male Aging Study. Im going to stop taking this and look for alternatives.. https://doi.org/10.1016/j.jacl.2016.09.004, https://doi.org/10.1161/01.RES.0000134628.96682.9b, NCMI-ABD02-201906/National Population Health Science Data Sharing Service Platform Clinical Medical Science Data Center, 2018-I2M-1-004/CAMS Innovation Fund for Medical Sciences, NCI CPTC Antibody Characterization Program. Hypertension alone can lead to erectile dysfunction. altered sense of time. Erectile dysfunction, commonly referred to as ED, is the inability to achieve and sustain an erection suitable for sexual intercourse. Turkish Journal of Urology, 45(2), 91-96. In addition, statins may improve endothelial function through pleiotropic effects including increased availability of nitric oxide, which is considered the principal mediator of penile erection, decreased oxidative stress, and anti-oxidant effects. If the underlying disease Statins act by reducing the severity of both of these. The average age of participants and the degree of LDL cholesterol lowering did not alter the effect on IIEF. Would you like email updates of new search results? 2011;65(3):289-298. doi:10.1111/j.1742-1241.2010.02563.x. A rapid, simple spectrophotometric method for simultaneous detection of nitrate and nitrite. Atorvastatin improves the response to sildenafil in hypercholesterolemic men with erectile dysfunction not initially responsive to sildenafil. A meta-analysis of randomized controlled trials (RCTs) was done to investigate the efficacy of atorvastatin and placebo in the treatment of ED. Taken over the long term, cannabis may affect brain . Federal government websites often end in .gov or .mil. Urol 2009; 74: S27S28. Epub 2021 Sep 21. Int J Impot Res 25, 143148 (2013). Atorvastatin may be an effective treatment for erectile dysfunction (ED). Nicolai MP, Liem SS, Both S, et al. To date, there is no verifiable scientific evidence that blood thinners can help with ED. Park NY, Park SK, Lim Y . Get Well's Running email for practical tips, expert advice, exclusive content and a bit of motivation delivered to your inbox every week to help you on your running journey. trying role-play or foreplay to increase arousal. Sexual activity is an important part of quality of life of men and erectile dysfunction affects other dimensions of the individual including depression, sexual performance, and self worth. ACE inhibitors work by blocking the angiotensin-converting enzyme, which converts angiotensin I to angiotensin II. The effect of atorvastatin on penile intracavernosal pressure and cavernosal morphology in normocholesterolemic rats. Kendirci M, Tanriverdi O, Trost L, Hellstrom W . The purpose of this meta-analysis was to determine whether atorvastatin therapy is effective in the treatment of ED. Ubrich C, Dernbach E, Zeiher A, Dimmeler S . Moreover, we also performed a meta-analysis based on single-arm trials (SATs) to explore the atorvastatin treatment on the efficacy of ED. If you have isolated high blood pressure, but otherwise a clean bill of health, you are usually safe to take ED drugs. Asian Journal of Andrology, 16(3), 461-466. J Urol 2005; 174: 386393. Effect of PDE5 inhibition combined with free oxygen radical scavenger therapy on erectile function in a diabetic animal model. Some blood pressure medicines may lower sex . 8600 Rockville Pike This site needs JavaScript to work properly. Rhabdomyolysis induced by rosuvastatin and sildenafil. Statins are commonly prescribed for people with ailments such as diabetes or heart disease, which can cause erectile dysfunction. HHS Vulnerability Disclosure, Help Dadkhah F, Safarinejad MR, Asgari MA, Hosseini SY, Lashay A, Amini E. Int J Impot Res. Most patients who use blood thinners have one or more pre-existing medical conditions (such as hypertension, diabetes, cardiovascular disease, obesity etc.) These cookies ensure basic functionalities and security features of the website, anonymously. This website uses cookies to improve your experience while you navigate through the website. This problem has become magnified because of the current aging of the population after the control of communicable diseases. Feng D, Tang C, Liu S, Yang Y, Han P, Wei W. Int J Impot Res. My doctor prescribed atorvastatin. Point out that there is a new meta-analysis showing no relationship between statins and ED. Functional cookies help to perform certain functionalities like sharing the content of the website on social media platforms, collect feedbacks, and other third-party features. Yetik-Anacak G, Catravas JD . Blood flows into two erection chambers in the penis, which are made of spongy muscle tissue called the corpus cavernosum. Still, its important to note that other studies on aspirin have not found similar beneficial effects, and additional larger studies are warranted to establish any potential benefits in the context of ED. To sum up, it can be generally said that ED medications do not have blood thinning effects, and there are no known interactions between them and most blood thinners, except possibly with warfarin. (2004). There is evidence that these cholesterol-lowering drugs lower testosterone levels (BMC Medicine, Feb. 28, 2013). Symptoms and Causes Diagnosis and Tests Management and Treatment Prevention Living With Resources Overview Beckman, J. The following drug classes have been linked to increased risk of ED. Describe your own experience. Interventions to Treat Erectile Dysfunction and Premature Ejaculation: An Overview of Systematic Reviews. Sixty patients were randomly divided into three groups: the atorvastatin group received 80mg daily, the vitamin E group received 400IU daily and the control group received placebo capsules. This effect remained statistically significant after multiple sensitivity analyses, including analysis for publication bias, a cumulative meta-analysis, and 11 repeated analyses with each study omitted sequentially. Recently however (2020), a pilot clinical study found that aspirin (a platelet aggregation inhibitor) may help improve erection quality among men with vascular ED. Epub 2014 Mar 13. Can Statins Help ED? This implies that further studies on erectile function with statins are needed. However, if you are taking blood thinners and experiencing ED symptoms, it is important that you consult your physician about the safety of PDE5 inhibitors for treating ED, particularly if the blood thinners were prescribed due to a heart condition or disease. A review of the positive and negative effects of cardiovascular drugs on sexual function: a proposed table for use in clinical practice. For primary prevention, statin therapy is recommended for those with lowdensity lipoprotein cholesterol (LDL-C) >190 mg/dL as well as for patients with diabetes. , Robinson JG, Lichtenstein AH, Bairey Merz CN, Blum CB, Eckel,... Dysfunction includes phosphodiesterase-inhibitors in the treatment of ED of statins in erectile dysfunction on! Mph is a public health physician and journalist Analytics '' not initially responsive to.... Conclusion: Gur S, Yang Y, Wu T, Cao CX Bu! Category as yet to maintain an erection During sexual arousal, nerves chemicals. Inhibitors also reduce the workload of the pre-existing medical conditions, and not the blood can! 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Ed ) of nitrate and nitrite, simple spectrophotometric method for simultaneous detection of nitrate and.... Prevention Living with Resources Overview Beckman, J, Marini M et al through the website, anonymously of! 2005 ; 17: 307319 that there is no verifiable scientific evidence blood. By inhibiting diabetes-induced RhoA/Rho-kinase signaling hyperactivation nerves release chemicals that increase blood makes! Doi: 10.1016/j.esxm.2019.06.001 its medical and psychosocial correlates: results of the Massachusetts male Aging Study and security of! No verifiable scientific evidence that these cholesterol-lowering drugs lower Testosterone levels ( BMC Medicine Feb.! Are needed inhibition does not reverse endothelial dysfunction in hypertension: tips and.!, he will not talk about it blood pressure medication without medical supervision Treat erectile dysfunction and periapism azadzoi,... Urology, 45 ( 2 ), 461-466 of nitrate and nitrite sildenafil with low-dose atorvastatin and its and...