This issue indicates that atherosclerosis and OA are shared at least in a number of risk factors or pathophysiological processes.18,19 In one study comprised population with advanced KOA, patients with coexistent diabetes and hypertension had greater subchondral bone loss as compared with those without these conditions suggesting a possible association between OA and metabolic abnormalities.20. Login to comment on posts, connect with other members, access special offers and view exclusive content. N Engl J Med. https://doi.org/10.1002/art.1780401106. In addition, the burden of infections over time, compounded by a reduced Th1 response, may foster breakdown of self-tolerance, as infectious agents cannot be cleared as effectively as they would be under normal conditions [36]. Patients who used statins for <1 year had a slightly increased risk compared to those who used statins for 1 year, but this difference did not reach statistical significance in any of the models. 2018;17(3):21525. It may also be the case that having high levels of fat in the blood, which is what causes high cholesterol, may also contribute to a faster progression of osteoarthritis. We represent patients through our popular social media channels, our website CreakyJoints.org, and the 50-State Network, which includes nearly 1,500 trained volunteer patient, caregiver and healthcare activists. Methods Using the OptumLabs Data Warehouse, RA cases were identified as patients aged 18 years with 2 RA diagnoses between January 1, 2010 and June 30, 2019 and 1 prescription fills for methotrexate within 1 year of the first RA diagnosis . A retrospective cohort study comprised 12,980 statin users and 45,997 non-users taking statins for more than 3 months vs. non-users. 2008;359(21):2195207. Markers of atherosclerosis in relation to presence and progression of knee osteoarthritis: a population-based cohort study. PubMed 2005;45(1):89118. 1997;40(11):195561. Rosuvastatin is a prescription drug that is used to treat high cholesterol. For these patients, the periods between each set of start and stop dates were summed to calculate the total duration of statin use. An official website of the United States government. These mediators are released from the local and/or systemic adipose tissues due to damages of joint tissues consequent to trauma and/or overuse.3 Obesity and metabolic syndrome (MetS) as prominent risk factors of OA are highly prevalent in the general population, and supply greater sources of adipokines from adipose tissues and thus provide higher propensity for the development of OA.3,8 Pathophysiology, clinical features and progression of structural changes in OA are linked to release of mediators from adipose tissues.9 Irrespective of inflammation, vascular pathology also plays an important role in the initiation and progression of OA.10, OA is shared with several traditional risk factors of atherosclerosis, such as age, obesity, altered lipid metabolism, and hypercholesterolaemia. Statins block an enzyme the liver needs to make cholesterol. Are Salons and Barbershops the Missing Piece to Facilitate Better Skin and Scalp Health? Is statin use associated with new joint-related symptoms, physical function, and quality of life? Litt JZ. Jones KD, Couldwell WT, Hinton DR, Su YH, He SK, Anker L, et al. Statins have anti-inflammatory/immunomodulatory effects that may be useful in preventing rheumatoid arthritis (RA), but previous observational studies about the risk of RA with statin use yielded conflicting results. Statin use and risk of joint replacement due to osteoarthritis and rheumatoid arthritis: a propensity-score matched longitudinal cohort study, Association of statin use and development and progression of hip osteoarthritis in elderly women. Article Of these, 523,721 had a claim containing an RA code during the study period. At dosages of > 28000 mg spinal DJD reduced further by HR= 0.81(0.680.97). While statins are highly effective and safe for most people, they have been linked to muscle pain, digestive problems and mental fuzziness in some people. stomach pain or gas. Bmj. https://doi.org/10.1371/journal.pone.0193297. While atorvastatin (Lipitor) was linked with a lower risk of worsening pain, rosuvastatin (Crestor) was associated with an increased risk of worsening pain. 2015;33(1):6976. Annu Rev Pharmacol Toxicol. OptumLabs Data Warehouse (OLDW) Descriptions and Citation. Fourteen papers were found to be relevant and were summarised. However, the particular kind of statin may matter. Pattern of risks of rheumatoid arthritis among patients using statins: a cohort study with the clinical practice research datalink. It is a type of statin medication. Because prevalent users had a statin fill within the first 120 days of coverage, the true statin start date was unknown, and it was not possible to determine the total duration of statin use for these patients. Arthritis Rheumatol. 2010;7(9):e1000336. Lancet. Hence, treatment of OA with statins is expected to improve metabolic abnormalities and prevent OA progression. Hence, statin therapy in these populations is widely advised regardless of the presence or absence of OA. Baima B, Sticherling M. Apoptosis in different cutaneous manifestations of lupus erythematosus. Blanco-Colio LM, Villa A, Ortego M, Hernndez-Presa MA, Pascual A, Plaza JJ, et al. Le contenu de ce site Web est titre informatif uniquement et ne constitue pas un avis mdical. The selected articles were categorized according to study designs and the results were presented under subheadings in relation to effects of statins on joint symptoms and function, development, incidence, and progression of OA. Institutional Review Board approval was not required because the data have been de-identified. Heidari B, Javadian Y, Babaei M, Yousef-Ghahari B. Restorative effect of vitamin D deficiency on knee pain and quadriceps in knee osteoarthritis. Cookies policy. PubMed Low vitamin D: There is a possible link between low vitamin D and statin-related muscle pain. There is also an assumed delay between symptom onset and RA diagnosis. Data provided for 2207 participants of the Osteoarthritis Initiative Study with confirmed or suspected knee OA. Is progressive osteoarthritis an atheromatous vascular disease? 1987;40(5):37383. To determine the association of statin use with generalized nodal OA. Youssef S, Stve O, Patarroyo JC, Ruiz PJ, Radosevich JL, Hur EM, et al. N Engl J Med. To assess the effect of age on RA risk, a subgroup analysis was performed observing the risk in patients aged 40 years. To investigate the potential confounding of hyperlipidemia, two analyses were performed. A randomised double-blind placebo-controlled crossover trial of HUMira (adalimumab) for erosive hand OsteoaRthritis - the HUMOR trial. 2012;71(5):64854. https://doi.org/10.1016/S0140-6736(09)60447-5. In summary, the results of this nation-wide study suggest there is no significant increase in the risk of RA occurrence in statin users, adjusting for hyperlipidemia in addition to other relevant confounders. 2008;337(nov06 3):a2286. Lancet. They. However, considering the low prevalence of RA among the general population, a case-control study seemed to have greater power to assess this association compared to alternatives, such as a retrospective cohort study. With the exception of this one similarity, the present study does not seem to clearly support or refute the findings from any prior study that has investigated this topic, as the results have been largely heterogeneous overall. https://doi.org/10.1016/j.autrev.2017.10.013. Comorbidity measures for use with administrative data. Odds ratios for RA risk with statin use were estimated using logistic regression. Statins: a potential role in the management of osteoarthritis? Li GM, Zhao J, Li B, Zhang XF, Ma JX, Ma XL, et al. Statins as antiinflammatory and immunomodulatoragents: a future in rheumatologic therapy? 2018 AHA/ACC/AACVPR/AAPA/ABC/ACPM/ADA/AGS/APhA/ASPC/NLA/PCNA guideline on the management of blood cholesterol: executive summary: a report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines. The tour begins on Aug. 3 in Sterling . fatigue. Sensitivity analyses to assess the stability of findings. Federal government websites often end in .gov or .mil. people: a meta-analysis of individual participant data from 28 randomised controlled trials, The Role of Inflammation in the Pathogenesis of Osteoarthritis. Risk of rheumatoid arthritis diagnosis in statin users in a large nationwide US study. PubMed Central Descriptive statistics were used to summarize the data. 2007;34(5):9648. J Lipid Res. Currently, treatment of osteoarthritis is focused on relieving pain and controlling the associated factors of disease progression and exacerbations. https://doi.org/10.1016/j.atherosclerosis.2004.07.004. Veronese N, Koyanagi A, Stubbs B, Cooper C, Guglielmi G, Rizzoli R, et al. 2009;68(4):54651. Arthritis Rheum. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data. Data from a large population-based clinical database comprised 151,305 participants, who underwent a THA/TKA. Alternatively, two observational studies found no association between statin use and OA.53,54 Similarly, a meta-analysis of 11 observational studies found no significant association between statin use and incident OA. The content of this manuscript is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health. In participants of the Rotterdam Study, over a follow-up duration of 6.5 years, statin use was associated with more than 50% decreased risk of progression of knee OA by OR = 0.43 (0.250.77), but there was no effect on progression of hip OA.56 A few limitations of this study include absence of knee OA at baseline in most participants, loss of a significant number of patients during follow-up period, and availability of final radiographs only for the 38% of the included participants. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. But when calcium leaks from muscle cells unintentionally, it can damage your muscle cells, which can cause muscle pain and weakness. The pain from osteoarthritis comes and goes unpredictably. These blood pressure and migraine-prevention medications are known to cause a five- to seven-pound weight gain, says Dr. Agarwal. However, subgroup analysis showed opposite effects of atorvastatin and rosuvastatin on OA. Now the results of a new study from Italian researchers, published in the journal Arthritis Care & Research, adds to the debate. A month or so later, I had acute joint pain(not muscle) that got to unbearable. This was likely due to the younger age of patients in that study conducted within a military health care system and may explain the result discrepancies with the present study. https://doi.org/10.1164/rccm.201902-0456OC. Cardiovascular risk factors, such as hyperlipidemia, may also play a role, as data has shown that patients who later develop RA tend to have significantly more atherogenic lipid profiles [44]. government site. This causes the liver to remove cholesterol from the blood. After an average period of 8 years, there was a trend toward decreased progression of radiographic hip OA in statin users. La informacin contenida en el sitio web de CreakyJoints Espaol se proporciona nicamente con fines de informacin general. To the authors knowledge, this is the first large case-control study to evaluate the relationship between statin use and RA risk in the US. They researchers surveyed the participants about which statin drugs they were taking. The current body of conflicting data on this topic demonstrates the challenge of performing a retrospective analysis on the relationship between a prescription drug and an unrelated medical disease. The current study was performed in the US, where statins are available via prescription only. Steroid-induced rosacea. Ann Rheum Dis. Cases and controls had equivalent or similar baseline characteristics and comparable distributions of comorbidities (Table 1). These factors as well as hyperlipidaemia itself can influence on OA progression.25. There was no association between statin use with joint pain/stiffness. Of the claims that met the insurance criteria, one was randomly selected as the index date for each patient. Former statin users had an increased risk of RA versus current statin users. CAS Statin use is associated with reduced incidence and progression of knee osteoarthritis in the Rotterdam study. Hoeven TA, Kavousi M, Ikram MA, van Meurs JB, Bindels PJ, Hofman A, et al. A woman has told how she feared she'd never become a mum but gave birth to a boy at age 45 after taking Viagra to get pregnant.. Carin Rockind, 48, welcomed a "miracle" baby after trying to have a . sharing sensitive information, make sure youre on a federal Statin Use and Knee Osteoarthritis Outcomes: A Longitudinal Cohort Study. The scientists who study this put them in a category called muscle-related adverse effects Another common side effect is memory loss. Google Scholar. If youre concerned about your osteoarthritis risk, ask your doctor about which kind of statins might be best to help improve both your heart and joint health. HHS Vulnerability Disclosure, Help MP was involved in the analysis and interpretation of the data and was largely responsible for drafting and revising this manuscript. Statin use was not associated with improvements in knee pain, function or structural progression after a 4 - year follow-up period. The release of endoplasmic and endonuclear antigens into circulation during cell death may induce the production of pathogenic autoantibodies [42, 43]. https://doi.org/10.1146/annurev.pharmtox.45.120403.095748. Finally, duration and intensity assessments were limited by the large number of prevalent statin users in this study. https://doi.org/10.1194/jlr.M010876. When risk estimates were individually adjusted for LDL-C level, they remained unchanged. Therefore, it is possible that a similar change to the statin user definition may have a meaningful impact on risk estimates in other studies. PubMed Duration of statin use was divided into three categories: <1 year, 1 year, or unknown. Wen CY, Chen Y, Tang HL, Yan CH, Lu WW, Chiu KY. Sarmanova A, Doherty M, Kuo C, Wei J, Abhishek A, Mallen C, et al. 1994;37(6):81420. Arnaud C, Braunersreuther V, Mach F. Toward immunomodulatory and anti-inflammatory properties of statins. In a study published in 2012 in Annals of the Rheumatic Diseases, researchers at the Erasmus Medical Centre in Rotterdam, The Netherlands, found that taking statins may help delay the progression of knee OA. Large studies examining the association between statin use and RA risk in the US are lacking. Discrepancies on the risk of development or progression of OA can be attributed to several factors in particular to the study design, patient selection, and variations in methods used for the diagnosis of OA, the type of statins, dosage and duration of treatment and outcome measures. Physical activity and risk of rheumatoid arthritis in women: a population-based prospective study. NSAIDs do this by inhibiting the immune systems ability to regrow bone. Crestor (rosuvastatin calcium) is a type of cholesterol-lowering medicine known as a "statin" (or HMG CoA reductase inhibitor). The pain from osteoarthritis comes and goes unpredictably. 8600 Rockville Pike Beneficial action of statins in patients with rheumatoid arthritis in a large observational cohort. However, this increased risk was eliminated following additional adjustment for hyperlipidemia (OR 0.95, 95% CI 0.901.01). Results were similar in the analysis for the intensity of the most recently filled statin (Table S2). Aitken D, Laslett LL, Pan F, Haugen IK, Otahal P, Bellamy N., et al. Similarly, a decreased risk of radiographic progression of OA was observed in participants of the Osteoarthritis Initiative study. In population of the Rotterdam study, the plasma levels of atherosclerotic markers in women with knee osteoarthritis (KOA) were higher than those without KOA, suggesting an association between atherosclerosis and KOA.15 Also, in participants of the Chingford study, there was an inverse association between HDL cholesterol and radiographic hand OA.16, Vascular pathology impairs blood flow and result in subchondral bone ischemia, osteocyte death and bone resorption with subsequent cartilage degradation.11,17 In postmenopausal women, there is a relationship between atherosclerosis and OA: in particular, hand OA and knee OA. Smeeth L, Douglas I, Hall AJ, Hubbard R, Evans S. Effect of statins on a wide range of health outcomes: a cohort study validated by comparison with randomized trials. To determine the incidence of various musculoskeletal and neoplastic diseases in statin users and nonusers. Zhou M, Guo Y, Wang D, Shi D, Li W, Liu Y, et al. The authors have read and approved the final manuscript. They also lower the risk of heart attack and stroke. Nonetheless, unless a formal analysis with weight analysis is made, a conclusion cannot be drawn. Google Scholar. Studies on the association between using statins and incident osteoarthritis (OA). Structural mechanism for statin inhibition of HMG-CoA reductase. The results on the association between statin therapy and OA vary across various studies. To summarise, data regarding the association between statin therapy and symptoms of osteoarthritis are limited. Elena Myasoedova. https://doi.org/10.1016/S0140-6736(03)12948-0. The distribution of current and former users among cases and controls was similar; there were slightly more former users among RA cases and slightly more current users among controls. https://doi.org/10.1161/ATVBAHA.107.159749. Garcia-Gil M, Reyes C, Ramos R, Sanchez-Santos MT, Prieto-Alhambra D, Spector TD., et al.. Serum Lipid Levels and Risk Of Hand Osteoarthritis: The Chingford Prospective Cohort Study. Study population flow diagram. Van Halm V, Nielen M, Nurmohamed M, Van Schaardenburg D, Reesink H, Voskuyl A, et al. Remnants of suicidal cells fostering systemic autoaggression: apoptosis in the origin and maintenance of autoimmunity. Ann Rheum Dis. 2002;420(6911):7884. Muscle pain doesnt affect everyone taking statins, but for some people, it can be a challenging side effect and ultimately cause them to discontinue taking the drugs. Trends in prescription drug use among adults in the United States from 1999-2012. Elixhauser A, Steiner C, Harris DR, Coffey RM. Photo: Andreas Neumann. In the additional sensitivity analysis for hyperlipidemia, which included only individuals who had laboratory data for LDL-C, 6948 RA cases and 6948 matched controls were identified. "Vitamn C njdete v ovoc, ako s pomarane a jahody, a vitamn E v . Case-control studies are limited in that they cannot be used to calculate incidence and are not suitable to imply causation. Hippisley-Cox J, Coupland C. Unintended effects of statins in men and women in England and Wales: population based cohort study using the QResearch database. RA cases were required to have at least 365 days of medical and pharmacy insurance coverage prior to the first RA diagnosis; patients without this baseline period of coverage were considered prevalent RA patients and were excluded. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. Autoimmun Rev. Verbruggen G, Wittoek R, Vander Cruyssen B, Elewaut D. Tumour necrosis factor blockade for the treatment of erosive osteoarthritis of the interphalangeal finger joints: a double blind, randomised trial on structure modification. EM was highly involved in the conception and design of the work, as well as analysis and interpretation of the results. In hypercholesterolemia patients who took higher cumulative dosage of statin (1190028000 mg) compared with a group taking < 5400 mg), development of spinal DJD reduced significantly by HR = 0.83 (0.700.99). Knee pain is a rare but possible side effect of rosuvastatin. Taking statins increases type 2 diabetes risk by 0.2% for each year that a person takes the medication. 2000;43(8):166372. Lupus. Accessibility CreakyJoints.org n'est pas destin se substituer un avis mdical professionnel, un diagnostic ou un traitement. A blood test can determine the creatine kinase levels in your bloodstream. Strengths of this study include its large and representative sample size with >16,000 RA patients, more than any prior study on this topic. Nature. Esta actitud por parte del paparazzi . By lowering the levels, they help prevent heart attacks and stroke.. Rheumatic disease was omitted from both indices. https://doi.org/10.1016/S0140-6736(04)16449-0. However, more information from prospective studies would be necessary to further understand this relationship. Terms and Conditions, However, synovitis is not the only cause of pain in KOA; obesity, muscle weakness, vitamin D deficiency, and mechanical factors also contribute to the development of pain in KOA which are not responsive to statins.4547 In addition, muscle pain and weakness are adverse effects of statins therapy which have been reported in high percentage of statin users. https://doi.org/10.1111/j.1468-3083.2006.01838.x. For the subset of patients with available laboratory data, the closest LDL-C level measured prior to the index date was used in the analysis. Results from two population-based cohorts of women, Associations between statin use and changes in pain, function and structural progression: a longitudinal study of persons with knee osteoarthritis, Determinants of pain in patients with symptomatic knee osteoarthritis. National Library of Medicine In a person with normal baseline blood glucose levels, statins are highly unlikely to cause . The aim of this study was to investigate whether statin use is associated with a lower risk of radiographic OA (ROA), radiographic symptomatic knee OA, and pain in North American individuals. With over 100 disease education videos produced by the team at Johns Hopkins Rheumatology. Sever PS, Dahlf B, Poulter NR, Wedel H, Beevers G, Caulfield M, et al. Exposure to statins within 1 year and 15 years following THA/TKA reduced risk of revision arthroplasty by HR = 0.82 (0.750.90). 2015;314(17):181831. While statins are generally well-tolerated, they can cause side effects. The definition of statin exposure also varied among studies. Went off med. The premium product BATCH gummies is full-spectrum, vegan-friendly, and made with solely natural components. Statin drugs are widely used to help lower cholesterol levels and prevent heart attacks and heart disease, but these drugs can have wide-ranging impacts throughout your body including your joints. Google Scholar. If you recently began taking a statin to manage your cholesterol and are suffering from joint pain and stiffness, muscle cramps and weakness, or tendon problems, talk to your doctor about your symptoms. Objective To evaluate the association between statin use and the risk of developing rheumatoid arthritis (RA) in a large, US case-control study. The benefits, side effects, and even the worthiness of taking statins have been under constant attack in recent years. WASHINGTON (March 29, 2014) Statins are associated with a significant improvement in erectile function, a fact researchers hope will encourage men who need statins to reduce their risk of heart attack to take them, according to research to be presented at the American College of Cardiology's 63rd Annual Scientific Session. Napumpujte ho antioxidantmi a vitamnmi! However, it is important to consider that many patients receive a hyperlipidemia diagnosis during the initiation of statin treatment, and therefore, any attenuation in risk resulting from hyperlipidemia adjustment may not reflect a true association. Cohort design with a 10-year follow-up period comprised 16,609 cardiovascular patients. 2016;68(11):260311. Journal of the American College of Cardiology. Second, an analysis was performed using a subset of the original population who had laboratory data for lipid levels. Among the 70 remaining studies, 41 were not eligible and removed. The sensitivity of measures such as K-L score or JSN which have been used for the evaluation of radiographic progression in these studies can differently affect outcome measure and lead to contradictories. Intensity classification for various statin medications and dosages, . Patients with an RA diagnostic code and/or DMARD prescription fill (including MTX) any time during their insurance coverage were excluded. https://doi.org/10.1016/j.tcm.2005.07.002. 2003;12(8):60711. The date of the first RA diagnostic code was used as the index date (Fig. However, the association between vascular disease and OA is complex, because the consequences of vascular pathology on OA per se cannot be differentiated from the contribution of individuals risk factors of vascular disease such as diabetes, obesity, hypertension, lipids or from the consequences of metabolic syndrome on OA. In addition, the references of the selected papers and review studies were also searched to find eligible papers. However, several previous studies have considered the impacts of this delay, and the results remained largely unchanged in all studies [18, 19, 21, 22]. However, statins are also known for causing muscle pain as a potential side effect. Prevention of cardiovascular events and death with pravastatin in patients with coronary heart disease and a broad range of initial cholesterol levels. Statin use was not associated with knee pain, function or structural progression after a 4-year follow-up period. Inclusion in an NLM database does not imply endorsement of, or agreement with, Charlson ME, Pompei P, Ales KL, MacKenzie CR. 2015;17(1):17. Founded in 1998, the Arthritis Center at Johns Hopkins is dedicated to providing quality education to patients and healthcare providers alike. 1998;339(19):1349-57. https://doi.org/10.1056/NEJM199811053391902. Efficacy of statins on OA symptoms is expected to be mediated through suppression of synovitis. First, lack of non-statin reference groups: Two prior studies, showing a protective effect of statins against RA, compared statin users depending on persistence with treatment [20] and treatment intensity [22], precluding direct comparison with the current study. Hajian-Tilaki K, Heidari B, Firouzjahi AR. Researchers obtained X-rays of 2,921 participants' knees and hips at baseline and again 6.5 years later to look for signs of osteoarthritis. After adjustment for confounders, statin usage was not associated with nodal OA, hip OA or knee OA, but was associated with lower rate of GOA phenotype. Incidence of musculoskeletal and neoplastic diseases in patients on statin therapy: results of a retrospective cohort analysis. Statins is expected to be relevant and were summarised ( not muscle ) that got unbearable! Clinical database comprised 151,305 participants, who underwent a THA/TKA to cause Guo Y, et al well-tolerated they. Acute joint pain ( not muscle ) that got to unbearable suppression of synovitis in... Van Schaardenburg D, Li W, Liu Y, Wang D, Reesink H, Voskuyl a et... Ra code during the study period populations is widely advised regardless of the selected and. Are Salons and Barbershops the Missing Piece to Facilitate Better Skin and Scalp Health, Laslett LL, F. 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