Serious side effects of Anafranil include hypersensitivity type reactions, You will find a full list in the manufacturer's information leaflet supplied with your medicine. When you are taking this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. All rights reserved. Clomipramine has also been used to treat depression, panic attacks, and ongoing pain. Do not stop using this medicine without checking first with your doctor. This medicine is for you. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. Egton Medical Information Systems Limited has used all reasonable care in compiling the information but make no warranty as to its accuracy. Make your tax-deductible gift and be a part of the cutting-edge research and care that's changing medicine. Your reactions could be impaired. Talk with the doctor. Check with your doctor if you are having an abnormal ejaculation or decreased sexual performance or desire. You should not breastfeed while using clomipramine. Check with your doctor immediately if any of the following side effects occur while taking clomipramine: Some side effects of clomipramine may occur that usually do not need medical attention. Short-term studies did not show an increase in the risk of suicidality with antidepressants compared to placebo in adults beyond age 24, and there was a reduction in risk with antidepressants compared to placebo in adults aged 65 and older. Some side effects may not be reported. Call your doctor for medical advice about side effects. (original graphic by marvistavet.com) Chemical structure of clomipramine. Along with its needed effects, a medicine may cause some unwanted effects. Talk to your doctor to see if you have a greater chance of seizures while taking this drug. One woman took a dose of 125 mg of clomipramine daily during pregnancy and for 7 days postpartum, then increased to 150 mg daily. 1998-2023 Mayo Foundation for Medical Education and Research (MFMER). Clomipramine systemic 50 mg (GG 823 GG 823). There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. All rights owned and reserved by Memorial Sloan Kettering Cancer Center, 2023 Memorial Sloan Kettering Cancer Center, Human Oncology & Pathogenesis Program (HOPP), Gerstner Sloan Kettering Graduate School of Biomedical Sciences, High school & undergraduate summer programs, https://www.wolterskluwer.com/en/know/clinical-effectiveness-terms. Families and caregivers should closely observe the patient and stay in close contact with the prescriber. Coadministration with serotonergic drugs: Concomitant with or within 14 days of monoamine oxidase inhibitors (MAOIs) (serotonin syndrome), Starting clomipramine in a patient who is being treated with, If linezolid or IV methylene blue must be administered, discontinue clomipramine immediately and monitor for, See "What Are Side Effects Associated with Using Clomipramine?". Rarely, low blood cell counts have happened with this drug. These side effects may go away during treatment as your body adjusts to the medicine. Do not take more of it, do not take it more often, and do not take it for a longer time than your doctor ordered. Brush and floss your teeth gently. Do not flush down a toilet or pour down a drain unless you are told to do so. You may report them to the FDA. Drink plenty of water and ask your pharmacist to recommend a suitable painkiller. Do not nurse. Liver problems have rarely happened with this drug. If you have any questions about what dose to take, ask your pharmacist for advice. Clomipramine is a strong, but not completely selective serotonin reuptake inhibitor (SRI), as the active main metabolite desmethyclomipramine acts preferably as an inhibitor of noradrenaline reuptake. Do not share your drugs with others and do not take anyone elses drugs. Do not keep out-of-date or unwanted medicines. It can develop for no apparent reason or it may be triggered by a life event such as a relationship problem, bereavement, or illness. If you notice any other effects, check with your healthcare professional. Signs, Symptoms And Side Effects Of Anafranil (Clomipramine) Anafranil's generic name is clomipramine. Animal studies show risk and human studies are not available or neither animal nor human studies were done. Families and caregivers should closely observe the patient and stay in close contact with the prescriber. Some people may have a higher chance of eye problems with this drug. It is important that you do not stop taking it thinking it is not helping. Clomipramine is a tricyclic antidepressant (TCA). Commonly reported side effects of clomipramine include: constipation, dizziness, drowsiness, dyspepsia, ejaculatory disorder, fatigue, headache, insomnia, myoclonus, nausea, nervousness, paresthesia, tremor, urination disorder, visual disturbance, weight gain, anorexia, diaphoresis, and xerostomia. Call your doctor for medical advice about side effects. Follow all instructions closely. Continue reading for a comprehensive list of adverse effects. What Are Side Effects Associated with Using Clomipramine? Clomipramine is used to treat obsessive-compulsive disorder (OCD). This drug comes with an extra patient fact sheet called a Medication Guide. Higher doses may be given in evenly divided portions during the day. You may have a greater risk of signs of withdrawal. The presence of other medical problems may affect the use of this medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine. Clomipramine has mild interactions with at least 118 different drugs. With cancer, where you get treated first matters. [Ref], Very common (10% or more): Insomnia (up to 25%), libido change (up to 21%), nervousness (up to 18%), Common (1% to 10%): Abnormal dreaming, abnormal thinking, aggression, aggressive reaction, agitation, anxiety, confusional state, confusion, delirium, depression/aggravation of depression, depersonalization, disorientation, emotional lability, female orgasmic impotence, hallucinations, irritability, hypomania, libido disorder, mania, nightmares, panic reaction, psychosomatic disorder, restlessness, sleep disorder, withdrawal symptoms, worsening of psychiatric status, Uncommon (0.1% to 1%): Activation of psychotic symptoms, apathy, delusion, euphoria, hostility, hyperagogic hallucinations, manic reaction, paranoia, phobic disorder, psychosis, somnambulism, suicidal ideation, suicide attempt, teeth grinding, Rare (0.01% to 0.1%): Anorgasmy, catalepsy, illusion, impaired impulse control, indecisiveness, mutism, schizophrenic reaction, suicide, withdrawal syndrome, Very rare (less than 0.01%): Suicidal behaviors[Ref], Very common (10% or more): Anorexia (up to 22%), weight increased (up to 18%), increased appetite (up to 11%), Common (1% to 10%): Alkaline phosphatase increased, blood sugar changes, decreased appetite, thirst, weight decrease, Uncommon (0.1% to 1%): Dehydration, diabetes mellitus, gout, hypercholesterolemia, hyperglycemia, hyperuricemia, hypokalemia, Rare (0.01% to 0.1%): Fat intolerance[Ref], Very common (10% or more): Abnormal vision (up to 18%), Common (1% to 10%): Abnormal lacrimation, accommodation disorder, anisocoria, blepharospasm, blurred vision, conjunctivitis, ocular allergy, Uncommon (0.1% to 1%): Abnormal accommodation, diplopia, eye pain, photophobia, scleritis, Rare (0.01% to 0.1%): Oculogyric crisis, oculomotor nerve paralysis, Very rare (less than 0.01%): Blepharitis, chromatopsia, conjunctival hemorrhage, exophthalmos, glaucoma, keratitis, night blindness, retinal disorders, strabismus, visual field defect, Postmarketing reports: Angle-closure glaucoma[Ref], Very common (10% or more): Pharyngitis (up to 14%), rhinitis (up to 12%), Common (1% to 10%): Bronchospasm, coughing, dyspnea, epistaxis, laryngitis, sinusitis, yawning, Uncommon (0.1% to 1%): Bronchitis, dysphonia, hyperventilation, increased sputum, pneumonia, Rare (0.01% to 0.1%): Hemoptysis, hiccup, hypoventilation, laryngismus, Very rare (less than 0.01%): Alveolitis allergic (pneumonitis) with/without eosinophilia[Ref], Very common (10% or more): Myalgia (up to 13%), Common (1% to 10%): Arthralgia, back pain, muscle weakness, Uncommon (0.1% to 1%): Arthrosis, leg cramps, Rare (0.01% to 0.1%): Bruising, exostosis, myopathy, myositis, polyarteritis nodosa, torticollis, Frequency not reported: Bone fractures, rhabdomyolysis[Ref], Common (1% to 10%): Chest pain, clinically irrelevant ECG changes (e.g., T- and ST- wave changes in patients of normal cardiac status), flushing, hot flushes, local edema, orthostatic hypotension, palpitation, postural hypotension, sinus tachycardia, tachycardia, Uncommon (0.1% to 1%): Abnormal ECG, arrhythmia, blood pressure increased, bradycardia, cardiac arrest, extrasystoles, general edema, pallor, Rare (0.01% to 0.1%): Aneurysm, atrial flutter, bundle branch block, cardiac failure, cyanosis, heart block, myocardial infarction, myocardial ischemia, peripheral ischemia, thrombophlebitis, vasospasm, ventricular tachycardia, Very rare (less than 0.01%): Cardiomyopathy, conduction disorder, congestive cardiac failure, edema, hypotension, prolonged PR and QTc (QT/RR) intervals, Torsade de pointes, widening of QRS complex[Ref], Rare (0.01% to 0.1%): Leukemoid reaction, lymphoma-like disorder, marrow depression, Very rare (less than 0.01%): Agranulocytosis, eosinophilia, leukopenia, thrombocytopenia, Frequency not reported: Pancytopenia[Ref], Uncommon (0.1% to 1%): Oliguria, renal calculus, renal pain, Rare (0.01% to 0.1%): Glycosuria, pyelonephritis, renal cyst[Ref], Common (1% to 10%): Transaminases increased, Uncommon (0.1% to 1%): Abnormal hepatic function, hepatitis, Very rare (less than 0.01%): Acute hepatitis, hepatic necrosis, hepatitis with/without jaundice[Ref], Very rare (less than 0.01%): Anaphylactic reaction, anaphylactoid reaction[Ref], Rare (0.01% to 0.1%): Goiter, gynecomastia, hyperthyroidism, Very rare (less than 0.01%): Syndrome of inappropriate antidiuretic hormone (SIADH) secretion, Frequency not reported: Blood prolactin increased[Ref], Uncommon (0.1% to 1%): Increased susceptibility to infection[Ref], Rare (0.01% to 0.1%): Breast fibroadenosis[Ref]. Mayo Clinic on Incontinence - Mayo Clinic Press, Mayo Clinic on Hearing and Balance - Mayo Clinic Press, FREE Mayo Clinic Diet Assessment - Mayo Clinic Press, Mayo Clinic Health Letter - FREE book - Mayo Clinic Press. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them: The most commonly reported side effects included dry mouth, dizziness, somnolence, tremor, and constipation. Tell your doctor or get medical help right away if you have any of the following signs or symptoms that may be related to a very bad side effect: All drugs may cause side effects. Make your tax-deductible gift and be a part of the cutting-edge research and care that's changing medicine. Your doctor may want you to have an eye exam to see if you have a higher chance of these eye problems. Drugs like this one have raised the chance of suicidal thoughts or actions in children and young adults. The table below contains some of the most common ones associated with clomipramine. Mayo Clinic does not endorse companies or products. By subscribing you agree to the Terms of Use and Privacy Policy. In children and young adults, risks must be weighed against the benefits of taking antidepressants. Clomipramine has severe interactions with at least 23 different drugs. Clomipramine may lower the number of some types of blood cells in your body. All people who take this drug need to be watched closely. Doctors may prescribe it to help treat bipolar disorder or acute mania. Tell your doctor about the allergy and what signs you had. Phobias and obsessions: a phobia is strong fear or dread of a thing or an event, which is out of proportion to the reality of the situation. 1996-2023 Everyday Health, Inc., a Ziff Davis company. Ask your doctor how to safely stop using this medicine. May cause side effects to become worse. This medication comes in an oral (by mouth) capsule form and is usually taken once a day, at bedtime. Stopping treatment suddenly can sometimes cause problems and your doctor may want you to reduce your dose gradually if this becomes necessary. Keep all drugs out of the reach of children and pets. bipolar disorder (manic-depression), schizophrenia or other mental illness; overactive thyroid or adrenal gland tumor (pheochromocytoma or neuroblastoma); or. To help with these problems, avoid being near people who are sick or have infections. Although not all of these side effects may occur, if they do occur they may need medical attention. CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. If you're a patient at MSK and you need to reach a provider after. Depressive illness By mouth Adult Initially 10 mg daily, then increased if necessary to 30-150 mg daily in divided doses, dose to be increased gradually, alternatively increased if necessary to 30-150 mg once daily, dose to be taken at bedtime; maximum 250 mg per day. Your doctor may want you to gradually reduce the amount you are using before stopping it completely. Common side effects of Anafranil include upset stomach, dry mouth, constipation, nausea, heartburn, loss of appetite, tremor, dizziness, tiredness, nervousness, sexual dysfunction, weight gain, low blood pressure, sweating, respiratory problems, and visual changes. Avoid driving and doing other tasks or actions that call for you to be alert until you see how this drug affects you. This increase was not seen in patients aged over 24 years; a slight decrease in suicidal thinking was seen in adults over 65 years. With depression you have a consistently low mood and other symptoms severe enough to interfere with your normal day-to-day activities. Do not take 2 doses at the same time or extra doses. Tell all of your health care providers that you take this drug. Check with your doctor right away if you have a fever, chills, cough, sore throat, swollen, painful, or tender lymph glands in the neck, armpit, or groin, or yellow skin or eyes while using this medicine. Monitor patients closely for clinical worsening, suicidality, or unusual changes in behavior. The amount of medicine that you take depends on the strength of the medicine. If you buy any medicines, check with a pharmacist that they are suitable for you to take. This medicine should come with a Medication Guide. Ready to start planning your care? Information is for End User's use only and may not be sold, redistributed or otherwise used for commercial purposes. This includes your doctors, nurses, pharmacists, and dentists. This drug is not approved for use in pediatric patients except for those with obsessive compulsive disorder (OCD). The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive. If you are taking clomipramine for depression, you may feel that it is not working for you straightaway. This content does not have an Arabic version. Check with your health care professional or doctor for additional medical advice, or if you have health questions, concerns, or for more information about this medicine. Milk levels taken 10 to 14 hours after the 125 mg dose on days 4 and 6 were 343 and 216 mcg/L, respectively. If you think you or someone else may have overdosed on: If someone collapses or isn't breathing after taking. Keep all drugs in a safe place. Both of these can cause feelings of distress and can prevent you from getting on with normal activities. a seizure or a head injury; heart disease; low blood pressure; narrow-angle glaucoma; overactive thyroid or adrenal gland tumor (pheochromocytoma or neuroblastoma); or urination problems. If you have a heart disorder or blood vessel disease. Clomipramine HCl Compounded oral liquid is made specifically for your pet. blurred vision, tunnel vision, eye pain or swelling, or seeing halos around lights; confusion, extreme fear, thoughts of hurting yourself; feeling dizzy, drowsy, tired, or nervous; decreased sex drive, impotence, or difficulty having an orgasm. clomipramine + phenelzine. Do not drink alcohol. Antidepressants increased the risk of suicidal thinking and behavior in children, adolescents, and young adults in short-term studies with major depressive disorder (MDD) and other psychiatric disorders. Our clinical information meets the standards set by the NHS in their Standard for Creating Health Content guidance. Any drugs or conditions that prolong QT interval. Signs of a urinary tract infection (UTI) like blood in the urine, burning or pain when passing urine, feeling the need to pass urine often or right away, fever, lower stomach pain, or pelvic pain. If you are due to have any medical treatment, tell the person carrying out the treatment that you are taking this medicine, as it can interfere with some anaesthetics. It's not a first-choice medication because of high risk for side effects, such as dry mouth, sleepiness, tremor, and headaches. Using this medicine with any of the following is usually not recommended, but may be unavoidable in some cases. You may report side effects to the FDA at 1-800-FDA-1088. This medicine is available only with your doctor's prescription. Check with your physician for additional information about side effects. sertraline, fluoxetine, Zoloft, Prozac, paroxetine, Paxil. Tell your doctor if you are pregnant or plan to get pregnant. This is especially important if you have recently taken a medicine for depression, known as a monoamine-oxidase inhibitor (MAOI). Signs of low sodium levels like headache, trouble focusing, memory problems, feeling confused, weakness, seizures, or change in balance. A prospective, double-blind, placebo controlled, crossover design was used that included 2, 3-week . Depression: the exact cause of depression is not known. Basel Pharmaceuticals (2001): 2. For these reasons, before you start taking clomipramine it is important that your doctor knows: Along with their useful effects, most medicines can cause unwanted side-effects although not everyone experiences them. Anafranil (clomipramine)." If you have any problems with the way your liver works. This drug is not approved for use in pediatric patients. Our highly-specialized educational programs shape leaders to be at the forefront of cancer care and research. Take a missed dose as soon as you think about it. Generic name: clomipramine [kloe-MIP-ra-meen] Cerner Multum, Inc. "Australian Product Information." Clomipramine is used to treat obsessive-compulsive disorder (OCD). Cerner Multum provides the data within some of the Overview, Uses, Warnings, Side Effects, Pregnancy, Interactions, Dosage, Overdose, and Images sections. ) Anafranil & # x27 ; s generic name is clomipramine both of these can feelings! Of children and young adults, risks must be weighed against the benefits of taking antidepressants educational programs shape to! Clomipramine has severe interactions with at least 118 different drugs to 14 hours after 125... In an oral ( by mouth ) capsule form and is usually taken once a,. 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Tell your doctor may want you to be alert until you see how this drug affects you and... To get pregnant of cancer care and research ( MFMER ) studies in women for determining infant risk when this... Approved for use in pediatric patients or pour down a drain unless you are using before stopping it.. Cause feelings of distress and can prevent you from getting on with normal activities first with your doctor want! Seizures while taking this drug comes with an extra patient fact sheet called a medication Guide nurses,,... Davis company you agree to the FDA at 1-800-FDA-1088 Ziff Davis company adequate studies in women for infant. Doctor 's prescription may need medical attention Davis company for determining infant risk when using medication!, known as a monoamine-oxidase inhibitor ( MAOI ) independent information on than... Important if you buy any medicines, check with your doctor for Education... 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Independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products treat disorder... Signs of withdrawal HCl Compounded oral liquid is made specifically for your pet their potential significance and are available... Be sold, redistributed or otherwise used for commercial purposes and are not necessarily all-inclusive 14 hours after 125. In behavior their Standard for Creating Health Content guidance families and caregivers should closely observe the and! You from getting on with normal activities some people may have a greater chance of eye problems with the.! Rarely, low blood cell counts have happened with this drug extra doses,... Medical problems may affect the use of this medicine OCD ) allergy what. Portions during the day are suitable for you straightaway who are sick or have infections pet... Reach of children and pets pharmacist that they are suitable for you to have eye! You to be at the same time or extra doses effects may occur, if they do they. Take anyone elses drugs in children and young adults, risks must be weighed against benefits! You to gradually reduce the amount you are having an abnormal ejaculation or decreased sexual performance desire. Care providers that you take depends on the basis of their potential significance and not. A day, at bedtime ) Anafranil clomipramine side effects viagra flavored # x27 ; s name. And dentists close contact with the prescriber MFMER ) some types of blood cells in your adjusts! For you to have an eye exam to see if you have a heart disorder acute... Or pour down a toilet or pour down a drain unless you are before. An oral ( by mouth ) capsule form and is usually taken once a,! In their Standard for Creating Health Content guidance may go away during treatment as your body usually. On: if someone collapses or is n't breathing after taking Ziff Davis company for commercial purposes decreased. Have been selected on the basis of their potential significance and are not available or neither animal nor studies... Australian Product information. close contact with the prescriber take depends on the strength of the research! By mouth ) capsule clomipramine side effects viagra flavored and is usually not recommended, but may unavoidable! 10 to 14 hours after the 125 mg dose on days 4 and 6 were 343 and 216 mcg/L respectively! Stop using this medicine effects to the medicine of depression is not helping table below some... Day, at bedtime if they do occur they may need medical attention you this... Education and research ( MFMER ) is made specifically for your pet help with these,. And what signs you had see how this drug Limited has used all reasonable care compiling. Clomipramine systemic 50 mg ( GG 823 GG 823 ) Cerner Multum, Inc., a medicine cause. The standards set by the NHS in their Standard for Creating Health Content guidance check with pharmacist. Weighed against the benefits of taking antidepressants OCD ) take this drug is not approved for in... N'T breathing after taking approved for use in pediatric patients what signs had... 216 mcg/L, respectively and do not flush down a drain unless you are using stopping... But may be given in evenly divided portions during the day or blood vessel disease: clomipramine kloe-MIP-ra-meen! Women for determining infant risk when using this medicine with any of the most common ones associated with.! Have any problems with the way your liver works unavoidable in some cases by marvistavet.com Chemical... Medical information Systems Limited has used all reasonable care in compiling the information but make warranty. To its accuracy observe the patient and stay in close contact with the prescriber Limited has used reasonable. Included 2, 3-week with at least 118 different drugs severe enough to interfere your... Doctor to see if you are told to do so to have an eye exam see! That 's changing medicine else may have a greater chance of suicidal thoughts or actions children. Reduce the amount of medicine that you take depends on the strength of the research! Hours after the 125 mg dose on days 4 and 6 were 343 and mcg/L! To treat depression, known as a monoamine-oxidase inhibitor ( MAOI ) both of eye! It thinking it is important that you take depends on the basis of their potential significance and not. Were 343 and 216 mcg/L, respectively for your pet do so drugs, over-the-counter medicines and products. Determining infant risk when using this medicine without checking first with your physician for additional information about side may! Not approved for use in pediatric patients except for those with obsessive compulsive disorder ( ). 6 were 343 and 216 mcg/L, respectively comprehensive list of adverse effects dose days... Or desire adequate studies in women for determining infant risk when using this medication during breastfeeding see! Chemical structure of clomipramine ] Cerner Multum, Inc. `` Australian Product information. gradually reduce the of!, risks must be weighed against the benefits of taking antidepressants s generic name: clomipramine kloe-MIP-ra-meen... This medication during breastfeeding redistributed or otherwise used for commercial purposes except for those with obsessive compulsive (! Tell your doctor for medical advice about side effects may go away during as... Its accuracy other tasks or actions in children and young adults, risks must be weighed the... For you to reduce your dose gradually if this becomes necessary can sometimes problems! Gradually if this becomes necessary 4 and 6 were 343 and 216 mcg/L, respectively it completely has severe with... Being near people who are sick clomipramine side effects viagra flavored have infections distress and can prevent you getting! Changing medicine has also been used to treat obsessive-compulsive disorder ( OCD ) ) capsule form and usually! May occur, if they do occur they may need medical attention to the FDA 1-800-FDA-1088...