Use Caution/Monitor. Avoid or Use Alternate Drug. clomipramine, along with Either increases levels of the other by pharmacodynamic synergism. Use Caution/Monitor. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including: fever, swollen lymph nodes, rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing. Either increases effects of the other by pharmacodynamic synergism. zileuton will increase the level or effect of clomipramine by affecting hepatic enzyme CYP1A2 metabolism. Monitor Closely (2)clomipramine and lithium both increase serotonin levels. If unavoidable, decrease the CYP1A2 substrate dosage in accordance with approved product labeling. rizatriptan and clomipramine both increase serotonin levels. Additive anticholinergic effects. clomipramine, aceclofenac. epinephrine and clomipramine both increase QTc interval. Use combination with caution. Minor (1)nifedipine will increase the level or effect of clomipramine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Monitor Closely.Minor (1)topiramate will decrease the level or effect of clomipramine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Monitor Closely (1)clomipramine and apomorphine both increase sedation. Use Caution/Monitor. Minor/Significance Unknown. Serious - Use Alternative (1)levomilnacipran and clomipramine both increase serotonin levels. amoxapine and clomipramine both increase QTc interval. Monitor Closely (1)hydrocodone, clomipramine. Check the labels on all your medicines (such as cough-and-cold products) because they may contain drowsiness-containing ingredients or decongestants that could increase your heart rate or blood pressure. Avoid or Use Alternate Drug. Use Caution/Monitor.Serious - Use Alternative (1)clomipramine, fenfluramine. Avoid or Use Alternate Drug. Keep all medications away from children and pets.Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Use Caution/Monitor.rifabutin decreases levels of clomipramine by increasing metabolism. cyclobenzaprine and clomipramine both increase sedation. Monitor Closely (1)nilotinib will increase the level or effect of clomipramine by affecting hepatic enzyme CYP2D6 metabolism. celecoxib will increase the level or effect of clomipramine by affecting hepatic enzyme CYP2D6 metabolism. Use Caution/Monitor. Avoid or Use Alternate Drug. Use Caution/Monitor. Minor/Significance Unknown. Mechanism: unspecified interaction mechanism. Monitor Closely (1)trihexyphenidyl and clomipramine both decrease cholinergic effects/transmission. prednisone will decrease the level or effect of clomipramine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. valerian and clomipramine both increase sedation. Use Caution/Monitor. Minimally clinically significant. Avoid or Use Alternate Drug.clomipramine and doxepin both increase serotonin levels. Modify Therapy/Monitor Closely. huperzine A increases and clomipramine decreases cholinergic effects/transmission. Use Caution/Monitor.Minor (1)clomipramine increases levels of atropine IV/IM by unknown mechanism. Avoid or Use Alternate Drug. Monitor Closely (1)valerian and clomipramine both increase sedation. Use Caution/Monitor. Avoid or Use Alternate Drug.clomipramine and lofepramine both increase serotonin levels. Avoid or substitute another drug for these medications when possible. Anxiety symptoms may temporarily worsen when you first start taking clomipramine. Comment: Barbiturates may increase adverse effects, including respiratory depression, produced by toxic doses of TCAs. Use Caution/Monitor. Minor/Significance Unknown. chlorpromazine and clomipramine both increase sedation. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Monitor Closely (2)lasmiditan, clomipramine. Minor/Significance Unknown. amitriptyline and clomipramine both decrease cholinergic effects/transmission. azelastine and clomipramine both increase sedation. Desvenlafaxine inhibits CYP2D6; with higher desvenlafaxine doses (ie, 400 mg) decrease the CYP2D6 substrate dose by up to 50%; no dosage adjustment needed with desvenlafaxine doses <100 mgSerious - Use Alternative (1)clomipramine and desvenlafaxine both increase serotonin levels. Minor/Significance Unknown. Use Caution/Monitor. clomipramine, midodrine. escitalopram and clomipramine both increase serotonin levels. Tecovirimat is a weak inhibitor of CYP2C8 and CYP2C19. clomipramine and nortriptyline both increase sedation. Use Caution/Monitor. Based on the mechanism of action of iobenguane, drugs that reduce catecholamine uptake or that deplete catecholamine stores may interfere with iobenguane uptake into cells, and thus, reduce iobenguane efficacy. Use Caution/Monitor. If concomitant use is warranted, carefully observe the patient, particularly during treatment initiation and dose adjustment. These medications can help prevent suicidal thoughts/attempts and provide other important benefits. Use Caution/Monitor. Either increases toxicity of the other by pharmacodynamic synergism. Use Caution/Monitor. Use Caution/Monitor.Serious - Use Alternative (1)clomipramine, diethylpropion. Use Caution/Monitor. Use Caution/Monitor. Recommended dosage. Monitor Closely (1)diamorphine and clomipramine both increase sedation. Enter your medication into the WebMD interaction checker, Taking Care of Mental Health While Treating HIV, muscle weakness associated with sleeping disease, FDA Labeling for clomipramine HCL on RxList. succinylcholine increases and clomipramine decreases cholinergic effects/transmission. clomipramine and amisulpride both increase QTc interval. Use Caution/Monitor.hydroxyzine and clomipramine both increase QTc interval. Use Caution/Monitor. Monitor Closely (1)clomipramine increases and pirbuterol decreases sedation. clomipramine increases effects of miglitol by pharmacodynamic synergism. Use Caution/Monitor.Serious - Use Alternative (1)clomipramine, dexfenfluramine. Use Caution/Monitor. clomipramine, sodium oxybate. Modify Therapy/Monitor Closely. Avoid or Use Alternate Drug. naratriptan and clomipramine both increase serotonin levels. frovatriptan and clomipramine both increase serotonin levels. Monitor for signs of urinary retention or reduced gastric motility if oliceridine is coadministered with anticholinergics. Monitor Closely (1)clomipramine, etodolac. Clomipramine is used to treat obsessive compulsive disorder (OCD). Avoid or Use Alternate Drug. Use Caution/Monitor. Use Caution/Monitor. Monitor Closely (1)conivaptan will increase the level or effect of clomipramine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. . Monitor Closely (1)osimertinib and clomipramine both increase QTc interval. Use Caution/Monitor. clomipramine, piroxicam. Monitor Closely (1)dipipanone and clomipramine both increase sedation. Monitor Closely (1)clomipramine increases effects of oxymetazoline intranasal by pharmacodynamic synergism. Use Caution/Monitor. Other (see comment). Serious - Use Alternative (1)degarelix and clomipramine both increase QTc interval. Minor/Significance Unknown. tramadol and clomipramine both increase sedation. belladonna alkaloids and clomipramine both decrease cholinergic effects/transmission. Monitor Closely (1)cisatracurium and clomipramine both decrease cholinergic effects/transmission. Use Caution/Monitor. sertraline will increase the level or effect of clomipramine by affecting hepatic enzyme CYP2D6 metabolism. Effect of interaction is not clear, use caution. primidone will decrease the level or effect of clomipramine by affecting hepatic enzyme CYP1A2 metabolism. benperidol and clomipramine both increase sedation. Modify Therapy/Monitor Closely. Modify Therapy/Monitor Closely. Methylene blue may increase serotonin as a result of MAO-A inhibition. amitriptyline and clomipramine both increase serotonin levels. Minor/Significance Unknown. Combination is contraindicated within 2 weeks of MAOI use. Either increases toxicity of the other by sedation. Contraindicated (1)dronedarone will increase the level or effect of clomipramine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. tolterodine and clomipramine both decrease cholinergic effects/transmission. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron. Use Caution/Monitor. thioridazine and clomipramine both increase sedation. zolpidem, clomipramine. Either increases toxicity of the other by pharmacodynamic synergism. fluconazole will increase the level or effect of clomipramine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Minor/Significance Unknown. Effect of interaction is not clear, use caution. Monitor Closely (1)metaxalone and clomipramine both increase sedation. Use Caution/Monitor. Use Caution/Monitor. . chlorzoxazone and clomipramine both increase sedation. Avoid or Use Alternate Drug. Modify Therapy/Monitor Closely. pentobarbital, clomipramine. Monitor Closely (1)triprolidine and clomipramine both increase sedation. Monitor Closely (2)clomipramine and dosulepin both decrease cholinergic effects/transmission. Monitor Closely (2)belladonna and opium and clomipramine both decrease cholinergic effects/transmission. Use Caution/Monitor. Avoid or Use Alternate Drug. Monitor Closely (1)clomipramine, lornoxicam. Additive anticholinergic effects. To help you remember, use it at the same time(s) each day. Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. Avoid or Use Alternate Drug. Effect of interaction is not clear, use caution. triclabendazole will increase the level or effect of clomipramine by affecting hepatic enzyme CYP2C19 metabolism. metaxalone and clomipramine both increase sedation. Ask your doctor when to start or stop taking this medication.The risk of serotonin syndrome/toxicity increases if you are also taking other drugs that increase serotonin. Use Caution/Monitor.Serious - Use Alternative (1)trifluoperazine and clomipramine both increase QTc interval. granisetron and clomipramine both increase QTc interval. OCD is a nervous condition wherein a person has recurring thoughts or ideas or does repetitive things because they are anxious. oxcarbazepine will decrease the level or effect of clomipramine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. sorafenib and clomipramine both increase QTc interval. Use Caution/Monitor. Use Caution/Monitor.Serious - Use Alternative (2)amitriptyline and clomipramine both increase QTc interval. Either increases levels of the other by decreasing metabolism. Use Caution/Monitor. Use Caution/Monitor. Minor/Significance Unknown. Contraindicated. Monitor Closely (1)clomipramine and pazopanib both increase QTc interval. Serious - Use Alternative (1)clomipramine, calcium/magnesium/potassium/sodium oxybates. Minor/Significance Unknown. Mechanism: unspecified interaction mechanism. Either increases effects of the other by pharmacodynamic synergism. Minor/Significance Unknown. Monitor Closely (1)clomipramine and SAMe both increase serotonin levels. Minor (1)clomipramine increases effects of insulin glargine by pharmacodynamic synergism. Other (see comment). Symptoms of overdose may include: fast/irregular heartbeat, severe dizziness, fainting, delirium, seizures, loss of consciousness. Use Caution/Monitor. methocarbamol and clomipramine both increase sedation. Use Caution/Monitor. Monitor Closely (1)clomipramine, meclofenamate. Use Caution/Monitor. Minor/Significance Unknown. Use Caution/Monitor.Serious - Use Alternative (1)promethazine and clomipramine both increase QTc interval. Limit use to patients for whom alternative treatment options are inadequate. clomipramine, levalbuterol. Avoid or Use Alternate Drug. Use Caution/Monitor. Avoid or Use Alternate Drug.buprenorphine transdermal and clomipramine both increase sedation. Use Caution/Monitor. Brand name forms of clomipramine cost between $40 and $70 for the . Modify Therapy/Monitor Closely. cenobamate, clomipramine. Use Caution/Monitor. With therapeutic doses of TCAs, barbiturates increase metabolism and decrease blood concentrations of TCAs. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron. Use Caution/Monitor. Use Caution/Monitor.clomipramine and pentazocine both increase serotonin levels. Estrogens and progestins may decr tricyclic antidepressant effects, while increasing TCA plasma concentration and adverse effects. Estrogens and progestins may decr tricyclic antidepressant effects, while increasing TCA plasma concentration and adverse effects. You may report side effects to FDA at 1-800-FDA-1088 or at www.fda.gov/medwatch.In Canada - Call your doctor for medical advice about side effects. Use Caution/Monitor. Taking MAO inhibitors with this medication may cause a serious (possibly fatal) drug interaction. Serious - Use Alternative (1)clomipramine and dextromethorphan both increase serotonin levels. Minor/Significance Unknown. Use Caution/Monitor. clomipramine increases levels of atomoxetine by affecting hepatic enzyme CYP2D6 metabolism. Avoid or Use Alternate Drug. Clomipramine inhib. Monitor Closely (1)levoketoconazole will increase the level or effect of clomipramine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Avoid coadministration of abiraterone with substrates of CYP2D6. pentobarbital will decrease the level or effect of clomipramine by affecting hepatic enzyme CYP1A2 metabolism. Use Caution/Monitor. Use Caution/Monitor.clomipramine and nortriptyline both increase sedation. Monitor Closely (1)clomipramine and flecainide both increase QTc interval. Use Caution/Monitor. Rolapitant may increase plasma concentrations of CYP2D6 substrates for at least 28 days following rolapitant administration. It helps decrease thoughts that are unwanted or that don't go away (obsessions), and it helps reduce the urge to perform repeated tasks (compulsions such as hand-washing, counting, checking) that. Initiate with lower doses and monitor for signs and symptoms of serotonin syndrome, particularly during initiation or dosage increase. Monitor Closely (1)clomipramine and ergotamine both increase serotonin levels. Profound sedation, respiratory depression, coma, and death may result if coadministered. Effect of interaction is not clear, use caution. It is very important to talk with the doctor about the risks and benefits of antidepressant medication (especially for people younger than 25), even if treatment is not for a mental/mood condition. Minor (1)omeprazole will increase the level or effect of clomipramine by affecting hepatic enzyme CYP2C19 metabolism. Avoid or Use Alternate Drug. Use Caution/Monitor. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron. Adderall (amphetamine / dextroamphetamine), Adderall XR (amphetamine / dextroamphetamine), Fish Oil (omega-3 polyunsaturated fatty acids), Email this report to a friend, doctor, or patient. Other (see comment). Avoid or Use Alternate Drug. Either increases toxicity of the other by pharmacodynamic synergism. Monitor Closely (1)pancuronium and clomipramine both decrease cholinergic effects/transmission. thioridazine will increase the level or effect of clomipramine by affecting hepatic enzyme CYP2D6 metabolism. Either increases toxicity of the other by pharmacodynamic synergism. Clomipramine inhib. Avoid or Use Alternate Drug. Consider reducing the dose of sensitive CYP2C19 substrates, as clinically appropriate, when coadministered with cannabidiol. Monitor Closely (1)oxybutynin topical and clomipramine both decrease cholinergic effects/transmission. Manufacturer advises avoid. Increases risk of hypotension. cigarette smoking will decrease the level or effect of clomipramine by affecting hepatic enzyme CYP1A2 metabolism. Minor/Significance Unknown. Use Caution/Monitor. Avoid or Use Alternate Drug. Monitor Closely (1)teriflunomide decreases levels of clomipramine by affecting hepatic enzyme CYP1A2 metabolism. Either increases toxicity of the other by serotonin levels. Minor (1)ethinylestradiol will increase the level or effect of clomipramine by affecting hepatic enzyme CYP1A2 metabolism. haloperidol will increase the level or effect of clomipramine by affecting hepatic enzyme CYP2D6 metabolism. Effect of interaction is not clear, use caution. Use Caution/Monitor. Use Caution/Monitor. Use Caution/Monitor. clomipramine, clobazam. Allow sufficient washout time of drugs that are known to prolong the QT interval before administering macimorelin. clomipramine, dopamine. Clomipramine inhib. Use Caution/Monitor. ranolazine will increase the level or effect of clomipramine by affecting hepatic enzyme CYP2D6 metabolism. Use Caution/Monitor. Of the total drug interactions, 136 are major, 604 are moderate, and 24 are minor. Use Caution/Monitor. Monitor Closely (3)phenobarbital will decrease the level or effect of clomipramine by affecting hepatic enzyme CYP1A2 metabolism. Either increases toxicity of the other by pharmacodynamic synergism. Serious - Use Alternative (1)ribociclib increases toxicity of clomipramine by QTc interval. Use Caution/Monitor. Either increases effects of the other by sedation. In Canada - Call your doctor for medical advice about side effects. Comment: Increased catecholamine receptor sensitivity; may increase CNS and cardiovascular effects, including arrhythmias. Ask your pharmacist which type of laxative is right for you. asenapine and clomipramine both increase QTc interval. diazepam and clomipramine both increase sedation. Does CBD interact with Ibuprofen? Lonafarnib may increase the AUC and peak concentration of CYP2C19 substrates. To help you remember, use it at the same time(s) each day.Do not suddenly stop taking this medication without consulting your doctor. Either increases toxicity of the other by pharmacodynamic synergism. Serious - Use Alternative (2)clomipramine increases toxicity of umeclidinium bromide/vilanterol inhaled by QTc interval. 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