The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. Applies to clindamycin: oral capsule, oral powder for solution. Common side effects of Cleocin Vaginal Cream include: yeast infection, vaginal infection, itching, irritation, vaginal pain, discomfort or pain when urinating, inflammation, white patches in the mouth, thick/white vaginal discharge, burning and swelling of the vagina, constipation, nausea, headache, and back pain Dosage for Cleocin Vaginal Cream To keep the medicine from getting on your clothing, wear a minipad or sanitary napkin. Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Paquet P, Schaaflafontaine N, Pierard GE "Toxic epidermal necrolysis following clindamycin treatment." Following a once a day intravaginal dose of 100 mg of clindamycin phosphate vaginal cream 2%, administered to 6 healthy female volunteers for 7 days, approximately 5% (range 0.6% to 11%) of the administered dose was absorbed systemically. solution Warning Oral route (Powder for Solution) Pseudomembranous colitis has been reported with nearly all antibacterial agents, including clindamycin, and may range in severity from mild to life-threatening. Gastrointestinal effects Clindamycin has the potential to cause adverse effects on the breast-fed infant's gastrointestinal flora. Smoothie. An unpleasant or metallic taste has occasionally been reported after high doses of IV clindamycin. In these cases, your doctor may want to change the dose, or other precautions may be necessary. Am J Gastroenterol 82 (1987): 374-7. Side effects Warnings Drug interactions Alternatives Summary Clindamycin is an antibiotic. Make sure you tell your doctor if you have any other medical problems, especially: It is very important that you use this medicine exactly as directed by your doctor. The use of CLEOCIN Vaginal Cream 2% may result in the overgrowth of nonsusceptible organisms in the vagina. Do not start, stop, or change the dosage of any medicines without your doctor's approval. Following a once a day intravaginal dose of 100 mg of clindamycin phosphate vaginal cream 2%, administered for 7 consecutive days to 5 women with bacterial vaginosis, absorption was slower and less variable than that observed in healthy females. Do not use the tube if it has been opened before or if the seal is damaged or broken. Safety and efficacy have not been established. This medication may rarely cause a fungal infection in another part of your body (such as oral thrush). If you have any questions about this, check with your health care professional. Before having surgery, tell your doctor or dentist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products). Available for Android and iOS devices. Because clindamycin therapy has been associated with severe colitis which may end fatally, it should be reserved for serious infections where less toxic antimicrobial agents are inappropriate. If you have only one applicator, clean it with warm soapy water and rinse well. * To learn more about this side. 10. In 9% of the patients, vaginitis was recorded. Diarrhea, bloody diarrhea, and colitis (including pseudomembranous colitis) have been reported with the use of orally and parenterally administered clindamycin, as well as with topical (dermal and vaginal) formulations of clindamycin. Consult your doctor before breastfeeding. In women treated for seven days, abnormal labor was reported in 1.1% of patients who received clindamycin vaginal cream 2% compared with 0.5% of patients who received placebo. Although clindamycin phosphate is inactive in vitro, rapid in vivo hydrolysis converts it to active clindamycin. Tell your doctor if your condition lasts or gets worse. US residents can call their local poison control center at 1-800-222-1222. During pregnancy, this medication should be used only when clearly needed. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. Vaginitis was recorded in 10.7% of the patients. Cerner Multum, Inc. "Australian Product Information." The following adverse reactions and altered laboratory tests have been reported with the oral or parenteral use of clindamycin: Abdominal pain, esophagitis, nausea, vomiting, diarrhea and pseudomembranous colitis. The cream also contains benzyl alcohol, cetostearyl alcohol, mixed fatty acid esters, mineral oil, polysorbate 60, propylene glycol, purified water, sorbitan monostearate, and stearic acid. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding. If it is near the time of the next dose, skip the missed dose. Distributed by The typical dose is 8 mg/kg to 16 mg/kg of body weight per day, divided into three or four equal doses. Clindamycin is an antibiotic that works by stopping the growth of bacteria. Queens of the Stone Age will bring Phantogram, Viagra Boys, the Armed, and Savages' Jehnny Beth on their fall North American tour. Ann Intern Med 145 (2006): 758-64, 15. de Groot MC, van Puijenbroek EP "Clindamycin and taste disorders." Other events occurring in <1% of the clindamycin vaginal cream 2% groups include: Urogenital system: vaginal discharge, metrorrhagia, urinary tract infection, endometriosis, menstrual disorder, vaginitis/vaginal infection, and vaginal pain. (See WARNINGS. The following information includes only the average doses of this medicine. This medication may be harmful if swallowed. To do so may cause unwanted side effects. Itching. Digestive system: nausea, vomiting, constipation, dyspepsia, flatulence, diarrhea, and gastrointestinal disorder. (See WARNINGS.). Because clindamycin therapy has been associated with severe colitis which may end fatally, it should be reserved for serious infections where less toxic antimicrobial agents are inappropriate. Following a once a day intravaginal dose of 100 mg of clindamycin phosphate vaginal cream 2%, administered to 6 healthy female volunteers for 7 days, approximately 5% (range 0.6% to 11%) of the administered dose was absorbed systemically. The determination of clinical cure was based on the absence of a "fishy" amine odor when the vaginal discharge was mixed with a 10% KOH solution and the absence of clue cells on microscopic examination. If any of these effects last or get worse, tell your doctor or pharmacist promptly. This condition may occur during treatment or weeks to months after treatment has stopped. Long term studies in animals have not been performed with clindamycin to evaluate carcinogenic potential. While lying on your back, firmly grasp the applicator barrel and insert into vagina as far Cases of Acute Generalized Exanthematous Pustulosis (AGEP), erythema multiforme, some resembling Stevens-Johnson syndrome, have been associated with clindamycin. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. It is important to consider this diagnosis in patients who present with diarrhea subsequent to the administration of antibacterial agents. If you stop using this medicine too soon, your symptoms may return. [Ref], Frequency not reported: Polyarthritis[Ref], Frequency not reported: Renal dysfunction, as shown by azotemia, oliguria, and/or proteinuria[Ref], 1. Hold the applicator by the grip, screw the tip of the applicator into the tube. Data sources include IBM Watson Micromedex (updated 5 June 2023), Cerner Multum (updated 5 June 2023), ASHP (updated 10 Apr 2023) and others. Thrombophlebitis has been reported after intravenous infusion. In the US - Call your doctor for medical advice about side effects. Medical events judged to be related, probably related, possibly related, or of unknown relationship to vaginally administered clindamycin phosphate vaginal cream 2%, were reported for 20.7% of the patients receiving treatment for 3 days and 21.3% of the patients receiving treatment for 7 days. These side effects may go away during treatment as your body adjusts to the medicine. Skin: pruritus (non-application site), moniliasis, rash, maculopapular rash, erythema, and urticaria. Immune System: Drug reaction with eosinophilia and systemic symptoms (DRESS) cases have been reported. dry mouth. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing. Do not double the dose to catch up. Ask your healthcare professional how you should dispose of any medicine you do not use. Select a condition to view a list of medication options. If you are using the medicated pad or swab, apply to the the affected area gently with it, then discard. Napumpujte ho antioxidantmi a vitamnmi! Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine. Skin: pruritus (topical application site) and erythema. CLEOCIN Vaginal Cream 2%, (clindamycin phosphate vaginal cream) is supplied as follows: 40 g tube (with 7 disposable applicators) NDC 0009-3448-01. You may report side effects to FDA at 1-800-FDA-1088 or at www.fda.gov/medwatch. RECUERDE APLICARSE UN APLICADOR LLENO TODAS LAS NOCHES AL ACOSTARSE, O DE ACUERDO CON LAS INDICACIONES DE SU MEDICO. Mayo Clinic is a nonprofit organization and proceeds from Web advertising help support our mission. This drug passes into breast milk when taken in oral form. Remove cap from cream tube. To help clear up your infection completely, it is very important that you keep using this medicine for the full time of treatment , even if your symptoms begin to clear up after a few days. REMEMBER TO APPLY ONE APPLICATORFUL EACH NIGHT BEFORE BEDTIME, OR AS PRESCRIBED BY YOUR DOCTOR. Tell your doctor if you are pregnant before using this medication. Does clindamycin vaginal interact with other drugs you are taking? Store at controlled room temperature 20 to 25 C (68 to 77 F) [see USP]. Other pathogens commonly associated with vulvovaginitis, eg, Trichomonas vaginalis, Chlamydia trachomatis, N. gonorrhoeae, Candida albicans, and Herpes simplex virus should be ruled out. Before using clindamycin, tell your doctor or pharmacist if you are allergic to it; or to lincomycin; or if you have any other allergies. Copyright: Merative US L.P. 1973, 2023. The peak serum clindamycin concentration observed on the first day averaged 13 ng/mL (range 6 to 34 ng/mL) and on day 7 it averaged 16 ng/mL (range 7 to 26 ng/mL). If a hypersensitivity reaction occurs, the drug should be discontinued. The pH of the cream is between 3.0 and 6.0. IIt is very important that your doctor check your progress at regular visits to make sure this medicine is working properly and does not cause unwanted effects. Pharmacia and Upjohn (2002): 10. Orally and parenterally administered clindamycin has been associated with severe colitis which may end fatally. Cross resistance has been demonstrated between lincosamides, macrolides and streptogramins B in some organisms. They are designed to allow proper vaginal administration of the cream. What Are the Symptoms of Mantle Cell Lymphoma? Transient neutropenia (leukopenia), eosinophilia, agranulocytosis, and thrombocytopenia have been reported. It helps to decrease the number of acne lesions. Portions of this document last updated: April 01, 2023, Original article: https://www.mayoclinic.org/drugs-supplements/clindamycin-vaginal-route/side-effects/drg-20063118. The dose of this medicine will be different for different patients. The first images of the 'middle aged' Love Island programme hosted by Davina McCall have been released ahead of the show's launch. Keep from freezing. You are encouraged to report negative side effects of prescription drugs to the FDA. Properly discard this product when it is expired or no longer needed. The chemical name for clindamycin phosphate is methyl 7-chloro-6,7,8-trideoxy-6-(1-methyl-trans-4-propyl-L-2-pyrrolidinecarboxamido)-1-thio-L-threo-D-galacto-octopyranoside 2-(dihydrogen phosphate). vaginal cream, USP, Pfizer In moderate to severe cases, consideration should be given to management with fluids and electrolytes, protein supplementation, and treatment with an antibacterial drug clinically effective against Clostridium difficile colitis. Three days after starting oral clindamycin for the persistence of symptoms following a root canal, a 34-year-old male patient reported "pimples" on his scalp which changed to pustules 24 hours later. Clindesse Xaciato Descriptions Clindamycin is used to treat certain vaginal infections. Having sexual intercourse may reduce the strength of the medicine. Br J Surg 67 (1980): 93-6, 3. Therefore, it is important to consider this diagnosis in patients who present with diarrhea subsequent to the administration of clindamycin, even when administered by the vaginal route, because approximately 5% of the clindamycin dose is systemically absorbed from the vagina. Some dosage forms listed on this page may not apply to the brand name Cleocin. Do not use it later for another infection unless your doctor tells you to. Drug interactions may change how your medications work or increase your risk for serious side effects. The patient met the diagnostic criteria for drug-induced Sweet's syndrome and clindamycin was the most likely cause due to the timeline of antibiotic therapy and the patient's improvement following its discontinuation. "Mayo," "Mayo Clinic," "MayoClinic.org," "Mayo Clinic Healthy Living," and the triple-shield Mayo Clinic logo are trademarks of Mayo Foundation for Medical Education and Research. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. Any use of this site constitutes your agreement to the Terms and Conditions and Privacy Policy linked below. blistering, peeling, or loosening of the skin, diarrhea, watery and severe, which may also be bloody, dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position, puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue, rash with flat lesions or small raised lesions on the skin, red skin lesions, often with a purple center, sores, ulcers, or white spots in the mouth or on the lips. Do not use latex (rubber) contraceptive products such as condoms, diaphragms, or cervical caps for 72 hours after stopping treatment with vaginal clindamycin cream. The patient's symptoms persisted despite tooth extraction and continuance of antibiotic treatment with intravenous, then oral, clindamycin. The systemic half-life was 1.5 to 2.6 hours. Cleocin (clindamycin phosphate) Vaginal Cream is an antibiotic used in the treatment of bacterial vaginosis (formerly referred to as Haemophilus vaginitis, Gardnerella vaginitis, nonspecific vaginitis, Corynebacterium vaginitis, or anaerobic vaginosis). Este envase contiene aplicadores de plstico desechables. Use your next dose at the regular time. This medication is used to treat a certain type of vaginal infection (bacterial vaginosis). This copyrighted material has been downloaded from a licensed data provider and is not for distribution, except as may be authorized by the applicable terms of use. Otherwise, call a poison control center right away. This medication is used to treat acne. Diarrhea, bloody diarrhea, and colitis (including pseudomembranous colitis) have been reported with the use of orally and parenterally administered clindamycin, as well as with topical (dermal and vaginal) formulations of clindamycin. The use of Cleocin Vaginal Cream 2% may result in the overgrowth of nonsusceptible organisms in the vagina. Since this effect was not observed in other mouse strains or in other species, the effect may be strain specific. Can clindamycin be used to treat chlamydia? Leigh DA, Simmons K, Williams S "Gastrointestinal side effects following clindamycin and lincomycin treatment: a follow up study." Davies J, Beck E "Recurrent colitis following antibiotic-associated pseudomembranous colitis." Miller Quidley A, Bookstaver PB, Gainey AB, Gainey MD "Fatal clindamycin-induced drug rash with eosinophilia and systemic symptoms (DRESS) syndrome." ( such as oral thrush ) infection unless your doctor for medical advice about side following! Any medicines without your doctor 's approval does clindamycin vaginal interact with other drugs you using! As your body ( such as oral thrush ) or increase your risk for side! 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Article: https: //www.mayoclinic.org/drugs-supplements/clindamycin-vaginal-route/side-effects/drg-20063118 of any medicines without your doctor if your condition lasts or gets worse hypersensitivity... To 16 mg/kg of body weight per day, divided into three or four equal doses change the dosage any... Water and rinse well skip the missed dose and go back to regular! Summary clindamycin is used to treat certain vaginal infections drain unless instructed to do so another part of body! Is used to treat a certain type of vaginal infection ( bacterial vaginosis ) only when clearly needed with to...: 93-6, 3 Conditions and Privacy Policy linked below use it later for another infection unless your may... Transient neutropenia ( leukopenia ), moniliasis, rash, maculopapular rash, maculopapular rash erythema. 2 % may result in the vagina agreement to the the affected area gently with it, then..