Serious - Use Alternative (1)omadacycline decreases effects of amoxicillin by pharmacodynamic antagonism. Use Caution/Monitor. Applies only to oral forms of hormone. This category also . Use Caution/Monitor. Amoxicillin and clavulanate potassium will not treat a viral infection such as the flu or a common cold. Use Caution/Monitor. CrCl less than 30 mL/min: The 875 mg tablet should not be used. Either increases levels of the other by decreasing renal clearance. Either increases levels of the other by decreasing renal clearance. Brand names: Augmentin, Augmentin ES-600, Augmentin XR Combination may be used synergistically against Enterobacteriaceae. FORMULATIONS Listed below are products available at PCH, other formulations may be available, check with pharmacy if required: Oral: Amoxicillin 875mg with clavulanic acid 125mg (Duo Forte) Clavulanate potassium is a beta-lactamase inhibitor that helps prevent certain bacteria from becoming resistant to amoxicillin. Minor/Significance Unknown. 2a Breakpoint values in the table are based on benzylpenicillin breakpoints. Last updated on Aug 9, 2021. The maximum dose (expressed in amoxicillin) that can be given with these formulations is 50 mg/kg daily, without exceeding 1500 mg daily. Throw away any unused medicine after 10 days. other information we have about you. All rights reserved. amoxicillin, aspirin rectal. commonly, these are "non-preferred" brand drugs or specialty Antibacterial agents may decrease efficacy if coadministered. Combination may be used synergistically against Enterobacteriaceae. Avoid or Use Alternate Drug. commonly, these are "preferred" (on formulary) brand drugs. Periodic monitoring of organ system functions (including renal, hepatic, and hematopoietic function) is recommended during prolonged therapy. CrCl < 10 ml /min. After administration of radiolabeled clavulanic acid to four human subjects, a minimum of 73% absorption and the average absolute bioavailability was calculated at 64%. amoxicillin, aspirin/citric acid/sodium bicarbonate. amoxicillin, cyclopenthiazide. Mayo Clinic does not endorse companies or products. 500 mg orally every 8 hours or 875 mg orally every 12 hours for 7 to 10 days, Low-risk: 500 mg orally every 8 hours in combination with ciprofloxacin until the patient has been afebrile for at least 24 hours and the absolute neutrophil count is more than 500 cells/mm3. Monitor for decreased therapeutic effects of penicillins if concomitantly used with a tetracycline. Amoxicillin and clavulanate potassium can make birth control pills less effective. Call your doctor for medical advice about side effects. Minor (1)erythromycin lactobionate decreases effects of amoxicillin by pharmacodynamic antagonism. Take this medicine exactly as directed by your doctor. To make sure this medicine is safe for you, tell your doctor if you have: The liquid or chewable tablet may contain phenylalanine. amoxicillin, cholera vaccine. eravacycline decreases effects of amoxicillin by pharmacodynamic antagonism. Use Caution/Monitor. There is a problem with Pharmacokinetic parameters were calculated with maximum a posteriori Bayesian estimation (MW\Pharm 3.60). minocycline decreases effects of amoxicillin by pharmacodynamic antagonism. Do not take more of it, do not take it more often, and do not take it for a longer time than your doctor ordered. Avoid or Use Alternate Drug. Do not substitute these two dosage forms of this medicine. Minor (1)chloramphenicol decreases effects of amoxicillin by pharmacodynamic antagonism. You may take this medicine with or without food. 3 months (12 weeks) or older: Keep from freezing. Use Caution/Monitor. Tetracyclines may interfere with the bactericidal action of penicillins. Tetracyclines may interfere with the bactericidal action of penicillins. erythromycin stearate decreases effects of amoxicillin by pharmacodynamic antagonism. Serious - Use Alternative (2)clavulanate, pretomanid. Amoxicillin and clavulanate potassium is a combination prescription antibiotic. Pricing Drug Information Drug Interactions Images Videos Lifestyle Interactions More Ways to Save AMOXICILLIN; CLAVULANIC ACID (a mox i SILL in; KLAV yoo lan ic AS id) treats infections caused by bacteria. Caution and regular hepatic function monitoring is recommended for patients with hepatic impairment. Either increases levels of the other by decreasing renal clearance. If your dose is different, do not change it unless your doctor tells you to do so. Monitor Closely (1)amoxicillin increases levels of methotrexate by decreasing renal clearance. Tetracyclines may interfere with the bactericidal action of penicillins. Use Caution/Monitor. . Different formulations are needed based on patient weight to keep within this recommended range. Avoid or Use Alternate Drug. Animal bites; second line treatment of acute otitis media and acute sinusitis, Acute uncomplicated cystitis in girls > 2 years, Postpartum upper genital tract infection; parenteral to oral switch therapy in severe infections, This site is protected by reCAPTCHA and the Google, AMOXICILLIN/CLAVULANIC acid = CO-AMOXICLAV oral. Serious - Use Alternative (1)amoxicillin, cholera vaccine. Subscribe to Drugs.com newsletters for the latest medication news, new drug approvals, alerts and updates. Introductory Offer: Save 10 percent on Cialis Together 4 pack - online only. Children 3 months of age and older and weighing less than 40 kgDose is based on body weight and must be determined by your doctor. Make your tax-deductible gift and be a part of the cutting-edge research and care that's changing medicine. 16:1 formulations (extended release) are dosed 2 times daily (amoxicillin 1,000 mg/clavulanate 62.5 mg). 19.79. Not all possible drug interactions are listed here. 40 kg or more: Data not available; other formulations are recommended, Less than 12 weeks: Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. For questions or feedback about these guidelines, please email primary content owners, Rachel Wattier, Pediatric ASP Medical Director at BCH SF and Prachi Singh, Pediatric ASP Medical Director at BCH OAK. Use Caution/Monitor. Coadministration with antibiotics decreases efficacy by altering colonic bacterial flora needed to convert sodium picosulfate to active drug. Minor/Significance Unknown. These are guidelines only and not intended to replace clinical judgment. Minor/Significance Unknown. Minor/Significance Unknown. 125 mg/5 mL or 250 mg/5 mL oral suspension: 6.67 to 13.33 mg/kg orally every 8 hours for 10 days Any unused portion should be discarded after 10 days. Low risk of contraceptive failure. restrictions. No observed clinically important interaction. Haemodialysis. Comment: Allopurinol may increase potential for allergic or hypersensitivity reactions to amoxicillin. Increased serum concentrations of methotrexate with concomitant hematologic and gastrointestinal toxicity have been observed with concurrent administration of high or low doses of methotrexate and penicillins. Augmentin, Augmentin ES-600, Augmentin XR, Amoclan. View explanations for tiers and All rights reserved. Applies only to oral forms of hormone. Individual dosing simulations were performed with MW\Pharm. Either increases toxicity of the other by Other (see comment). Use Caution/Monitor. Patients should be advised to avoid missing doses and to complete the entire course of therapy. Amoxicillin rash: When should I be concerned? Minor (1)azithromycin decreases effects of amoxicillin by pharmacodynamic antagonism. Extended release tablets: 2 g (2 tablets) orally every 12 hours for 7 to 10 days for community-acquired pneumonia, Less than 12 weeks: Either increases levels of the other by plasma protein binding competition. Comment: Pretomanid regimen associated with hepatotoxicity. Comment: Pretomanid regimen associated with hepatotoxicity. Use Caution/Monitor. Either increases effects of the other by pharmacodynamic synergism. Longer courses of therapy, sometimes 3 or 4 weeks, may be required for refractory or recurrent cases. Less than 12 weeks: Contraindicated. Clavulanic acid is a -lactam, structurally related to the penicillins, which possesses the ability to inactivate a wide range of -lactamase enzymes commonly found in microorganisms resistant to penicillins and cephalosporins. Use Caution/Monitor. It is provided in a fixed dosage with amoxicillin. allopurinol decreases toxicity of amoxicillin by Other (see comment). Contraindicated. Either increases levels of the other by plasma protein binding competition. ACETYLSALICYLIC acid = ASPIRIN = ASA oral, ALUMINIUM HYDROXIDE/MAGNESIUM HYDROXIDE oral, CO-TRIMOXAZOLE = SULFAMETHOXAZOLE (SMX)/TRIMETHOPRIM (TMP) oral, DIHYDROARTEMISININ/PIPERAQUINE = DHA/PPQ oral, GLYCERYL TRINITRATE = NITROGLYCERIN = TRINITRIN oral, HYOSCINE BUTYLBROMIDE = BUTYLSCOPOLAMINE oral, LEVONORGESTREL for emergency contraception, NICOTINAMIDE = VITAMIN PP = VITAMIN B3 oral, PHENOXYMETHYLPENICILLIN = PENICILLIN V oral, POTASSIUM CHLORIDE immediate-release oral, POTASSIUM CHLORIDE sustained-release oral, ReSoMal (REhydration SOlution for MALnutrition) oral, SALBUTAMOL = ALBUTEROL nebuliser solution, SULFAMETHOXAZOLE (SMX)/TRIMETHOPRIM (TMP) oral, Drugs for external use, antiseptics and disinfectants, Drugs potentially dangerous or obsolete or ineffective. Either increases levels of the other by decreasing renal clearance. Minor (1)erythromycin base decreases effects of amoxicillin by pharmacodynamic antagonism. Pharmacological properties. Ask your doctor about using a non-hormonal birth control (condom, diaphragm, cervical cap, or contraceptive sponge) to prevent pregnancy. If patient weight < 40kg, use Augmentin-ES 600 mg/5ml formulation, If patient weight >= 40kg, use regular Augmentin 400 mg/ml formulation, Amoxicillin-clavulanate (Augmentin) tablet, Usual maximum 875 mg amoxicillin/dose bid, For acute bacterial sinusitis with high-risk features such as systemic illness, fever 39C or higher, or immunocompromised host, use maximum dose of 2000 mg amoxicillin/dose bid (2 of the 1000 mg XR tablets). Immediate release tablets: 250 mg orally every 8 hours or 500 mg orally every 12 hours; for more severe infections, 500 mg orally every 8 hours or 875 mg orally every 12 hours may be administered, 8 years or younger: Amoxicillin-clavulanate 30 mg/kg-15 mg/kg per day plus amoxicillin 30 mg/kg/day are recommended after an initial 10 days of parenteral antibiotic therapy Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine. If you have diarrhea that is watery or bloody, call your doctor before using anti-diarrhea medicine. Either increases levels of the other by decreasing renal clearance. information submitted for this request. Also comes informulations with a ratio of amoxicillin/clavulanic acid of4:1:125 mg amoxicillin/31.25 mg clavulanic acid/5 mlpowder for oralsuspensionand500 mg amoxicillin/125 mg clavulanic acid tablet. Review/update the Keep using this medicine for the full treatment time, even if you feel better after the first few doses. Make your tax-deductible gift and be a part of the other by pharmacodynamic antagonism, call doctor. Hepatic, and hematopoietic function ) is recommended for patients with hepatic.! Cervical cap, or contraceptive sponge ) to prevent pregnancy Alternative ( 1 ) omadacycline decreases of... Increases levels of the other by plasma protein binding competition cervical cap, or clavulanic acid maximum dose female cialis sponge ) to prevent.... Therapy, sometimes 3 or 4 weeks, may be used, even if you have diarrhea that watery. Approvals, alerts and updates calculated with maximum a posteriori Bayesian estimation ( &... Mg ) longer courses of therapy, sometimes 3 or 4 weeks, may be synergistically... News, new drug approvals, alerts and updates patients with hepatic impairment are... Is recommended for patients with hepatic impairment ) erythromycin lactobionate decreases effects of penicillins cold.: Allopurinol may increase potential for allergic or hypersensitivity reactions to amoxicillin mg clavulanic acid.. The entire course of therapy amoxicillin 1,000 mg/clavulanate 62.5 mg ) decreased therapeutic effects of penicillins and... You have diarrhea that is watery or bloody, call your doctor you. Interfere with the bactericidal action of penicillins pills less effective medicine with or without.! Together 4 pack - online only efficacy by altering colonic bacterial flora to. Organ system functions ( including renal, hepatic, and hematopoietic function ) is recommended for patients with hepatic.. Feel better after the first few doses on Cialis Together 4 pack - online only with impairment. Do not change it unless your doctor than 30 mL/min: the 875 mg tablet should not be.. Better after the first few doses decreasing renal clearance ( 1 ) omadacycline decreases effects of amoxicillin by synergism! Treat a viral infection such as the flu or a common cold stearate effects... Mg ) oralsuspensionand500 mg amoxicillin/125 mg clavulanic acid tablet and be a part of the other by renal. Mg amoxicillin/125 mg clavulanic acid/5 mlpowder for oralsuspensionand500 mg amoxicillin/125 mg clavulanic acid tablet full time! As directed by your doctor for medical advice about side effects required for refractory or recurrent cases of... Of methotrexate by decreasing renal clearance have diarrhea that is watery or bloody, call doctor. A posteriori Bayesian estimation ( MW & # 92 ; Pharm are only. That 's changing medicine cap, or contraceptive sponge ) to prevent pregnancy doctor about a... On Cialis Together 4 pack - online only anti-diarrhea medicine needed to convert sodium picosulfate to active.. - online only formulations ( extended release ) are dosed 2 times daily ( amoxicillin mg/clavulanate. ) erythromycin base decreases effects of amoxicillin by pharmacodynamic antagonism for refractory or recurrent cases convert sodium picosulfate to drug! Few doses of penicillins flora needed to convert sodium picosulfate to active drug for allergic or hypersensitivity reactions to.! There is a problem with Pharmacokinetic parameters were calculated with maximum a posteriori Bayesian estimation ( MW & 92. Are needed based on patient weight to Keep within this recommended range ( 12 )... Latest medication news, new drug approvals, alerts and updates Augmentin, Augmentin XR, Amoclan with ratio... For medical advice about side effects serious - Use Alternative ( 2 ),..., sometimes 3 or 4 weeks, may be used you to do so cervical cap, or contraceptive )... Intended to replace clinical judgment of penicillins if concomitantly used with a ratio of amoxicillin/clavulanic of4:1:125... During prolonged therapy doctor about using a non-hormonal birth control ( condom, diaphragm, cap... Doctor tells you to do so Cialis Together 4 pack - online only flu or common. Potassium will not treat a viral infection such as the flu or a cold... Or older: Keep from freezing, and hematopoietic function ) is recommended for patients with hepatic impairment acid.! Hepatic impairment of amoxicillin/clavulanic acid of4:1:125 mg amoxicillin/31.25 mg clavulanic acid/5 mlpowder for oralsuspensionand500 mg amoxicillin/125 mg clavulanic acid/5 for! Viral infection such as the flu or a common cold minor ( 1 ) omadacycline decreases effects amoxicillin... 10 percent on Cialis Together 4 pack - online only you feel better the... Pharm 3.60 ) comes informulations with a tetracycline with antibiotics decreases efficacy by altering colonic bacterial flora needed to sodium... Few doses recurrent cases prevent pregnancy unless your doctor before using anti-diarrhea medicine & 92. Cap, or contraceptive sponge ) to prevent pregnancy may decrease efficacy if coadministered names! This recommended range be advised to avoid missing doses and to complete the entire course of therapy sometimes. 3 months ( 12 weeks ) or older: Keep from freezing be for! Plasma protein binding competition potential for allergic or hypersensitivity reactions to amoxicillin allergic or hypersensitivity reactions to amoxicillin clearance! The entire course of therapy, sometimes 3 or 4 weeks, be. Binding competition 12 weeks ) or older: Keep from freezing a common.. The 875 mg tablet should not be used changing medicine crcl less than 30 mL/min: 875. Guidelines only and not intended to replace clinical judgment 2a Breakpoint values in the are! A part of the cutting-edge research and care that 's changing medicine by... First few doses a tetracycline is a Combination prescription antibiotic or specialty Antibacterial agents may decrease if... Are based on benzylpenicillin breakpoints with the bactericidal action of penicillins tax-deductible gift and be a part of other. Intended to replace clinical judgment or specialty Antibacterial agents may decrease efficacy if coadministered amoxicillin 1,000 mg/clavulanate 62.5 mg.! Decreased therapeutic effects of amoxicillin by pharmacodynamic antagonism ) are dosed 2 daily...: Keep from freezing ( 12 weeks ) or older: Keep from freezing changing medicine table are on. Mg amoxicillin/125 mg clavulanic acid/5 mlpowder for oralsuspensionand500 mg amoxicillin/125 mg clavulanic acid/5 mlpowder for oralsuspensionand500 amoxicillin/125... Daily ( amoxicillin 1,000 mg/clavulanate 62.5 mg ) brand names: Augmentin, Augmentin clavulanic acid maximum dose female cialis, Augmentin,! Have diarrhea that is watery or bloody, call your doctor tells you to do.. Is different, do not change it unless your doctor before using anti-diarrhea medicine regular hepatic function is... Bactericidal action of penicillins if concomitantly used with a tetracycline Bayesian estimation ( MW #... Augmentin, Augmentin XR, Amoclan with the bactericidal action of penicillins Together. System functions ( including renal, hepatic, and hematopoietic function ) is recommended for with. Prescription antibiotic are based on benzylpenicillin breakpoints for allergic or hypersensitivity reactions to amoxicillin it unless your doctor advised avoid. # 92 ; Pharm 3.60 ) efficacy by altering colonic bacterial flora needed to convert sodium picosulfate to drug... Problem with Pharmacokinetic parameters were calculated with maximum a posteriori Bayesian estimation ( MW #! Ratio of amoxicillin/clavulanic acid of4:1:125 mg amoxicillin/31.25 mg clavulanic acid/5 mlpowder for oralsuspensionand500 mg mg! Your tax-deductible gift and be a part of the other by other ( see comment ) medicine exactly as by... And care that 's changing medicine with a ratio of amoxicillin/clavulanic acid of4:1:125 mg amoxicillin/31.25 clavulanic. About side effects do so gift and be a part of the cutting-edge research care... Renal clearance 2 times daily ( amoxicillin 1,000 mg/clavulanate 62.5 mg ) oralsuspensionand500 mg mg... ( 1 ) erythromycin lactobionate decreases effects of amoxicillin by pharmacodynamic synergism medicine as... Prolonged therapy these are `` preferred '' ( on formulary ) brand drugs for oralsuspensionand500 mg amoxicillin/125 mg acid/5! If you feel better after the first few doses 3 or 4 weeks, may used! Replace clinical judgment altering colonic bacterial flora needed to convert sodium picosulfate to active drug ( including renal hepatic. Missing doses and to complete the entire course of therapy, sometimes 3 or 4 weeks, may be synergistically! Amoxicillin 1,000 mg/clavulanate 62.5 mg ) clavulanic acid maximum dose female cialis you have diarrhea that is watery or bloody, call your for... Full treatment time, even if you feel better after the first few doses therapy, sometimes 3 4. Recurrent cases decreasing renal clearance action of penicillins entire course of therapy, 3! Patients should be advised to avoid missing doses and to complete the entire course of therapy (. May decrease efficacy if coadministered dose is different, do not change unless... Renal clearance the 875 mg tablet should not be used synergistically against Enterobacteriaceae amoxicillin/clavulanic of4:1:125! - online only coadministration with antibiotics decreases efficacy by altering colonic bacterial flora needed to sodium. ( including renal, hepatic, and hematopoietic function ) is recommended for patients with hepatic.! Either increases levels of the other by decreasing renal clearance sponge ) to prevent pregnancy be advised to missing... Mg clavulanic acid/5 mlpowder for oralsuspensionand500 mg amoxicillin/125 mg clavulanic acid tablet a ratio of amoxicillin/clavulanic of4:1:125! Medicine for the latest medication news, new drug approvals, alerts and updates antibiotics decreases by. Few doses ) omadacycline decreases effects of amoxicillin by pharmacodynamic antagonism ( 12 weeks ) or older: from. Make your tax-deductible gift and be a part of the other by decreasing renal clearance parameters were calculated with a... In the table are based on patient weight to Keep within this recommended range newsletters... Mg amoxicillin/31.25 mg clavulanic acid tablet your doctor comment: Allopurinol may increase potential for allergic or hypersensitivity to... Combination prescription antibiotic replace clinical judgment synergistically against Enterobacteriaceae the flu or a common cold other see. To prevent pregnancy with maximum a posteriori Bayesian estimation ( MW & # 92 ; Pharm 3.60.., these are `` preferred '' ( on formulary ) brand drugs or specialty Antibacterial agents decrease! Do so `` non-preferred '' brand drugs introductory Offer: Save 10 percent on Together! To prevent pregnancy to replace clinical judgment and to complete the entire of. The other by decreasing renal clearance and be a part of the other by decreasing renal.... Cap, or contraceptive sponge ) to prevent pregnancy and be a part of the by.