Fentanyl: (Major) Reserve concomitant use of opioids and cetirizine for patients in whom alternate treatment options are inadequate. Larger doses or more prolonged use may cause drowsiness and other effects in the infant or decrease the milk supply, particularly in combination with a sympathomimetic such as pseudoephedrine or before lactation is well established. Coadministration may increase the risk of CNS depressant-related side effects. Pentazocine; Naloxone: (Moderate) Concurrent use of cetirizine/levocetirizine with pentazocine should generally be avoided. In combination with sexual stimulation, vardenafil . If you are taking the over-the-counter product to self-treat, read all directions on the product package before taking this medication. In patients with moderate to severe renal impairment (CrCl 31 mL/minute or less) or renal failure, dosage reduction of oral cetirizine is recommended; cetirizine is not appreciably removed during dialysis. Cetirizine hydrochloride caused excessive maternal toxicity at an oral dose in dams that was approximately 180 times the MRHD (on a mg/m. Trospium: (Moderate) Dry mouth and drowsiness may occur in patients receiving cetirizine/levocetirizine; caution may be necessary during concomitant use of cetirizine/levocetirizine with the antimuscarinics. CNS depression is a desired effect of general anesthetics; however, concurrent use with a CNS depressant may prolong recovery. Cetirizine did not alter ritonavir disposition. If concurrent use is necessary, monitor for excessive sedation and somnolence. Monoamine oxidase inhibitors: (Moderate) Monitor for unusual drowsiness and sedation, urinary retention, and reduced gastric motility during coadministration of cetirizine and monoamine oxidase inhibitors (MAOIs). Cetirizine is a known human metabolite of hydroxyzine, and levocetirizine is an enantiomer of cetirizine. Lofexidine: (Moderate) Concurrent use of cetirizine/levocetirizine with lofexidine should generally be avoided. Concomitant use may result in additive anticholinergic adverse effects. Baclofen: (Moderate) Monitor for unusual drowsiness and sedation during coadministration of cetirizine and skeletal muscle relaxants due to the risk for additive CNS depression. Keep in mind 1 level teaspoon equals 5 mL and that teaspoon equals 2.5 mL. If concurrent use is necessary, monitor for excessive sedation and somnolence. If concurrent use is necessary, monitor patients closely. Oxybutynin: (Moderate) Monitor for signs or symptoms of anticholinergic toxicity during concomitant cetirizine and oxybutynin use. Coadministration may increase the risk of CNS depressant-related side effects. Melatonin: (Moderate) Monitor for unusual drowsiness and sedation during coadministration of cetirizine and melatonin due to the risk for additive CNS depression. Tasimelteon: (Moderate) Concurrent use of cetirizine/levocetirizine with tasimelteon should generally be avoided. Hyoscyamine: (Moderate) Monitor for signs or symptoms of anticholinergic toxicity during concomitant cetirizine and hyoscyamine use. See additional information. Entacapone: (Moderate) Caution is recommended during concurrent use of cetirizine or levocetirizine with COMT inhibitors because of the possibility for additive sedative effects. If concomitant use is necessary, consider prescribing naloxone for the emergency treatment of opioid overdose and monitor for signs of urinary retention or reduced gastric motility. If concurrent use is necessary, monitor for excessive sedation and somnolence. Coadministration may increase the risk of CNS depressant-related side effects. IV PushDilution is not necessary.Administer cetirizine injection as an intravenous push over a period of 1 to 2 minutes.The vial is for single-use only; discard any unused portion. See additional information. Codeine: (Major) Reserve concomitant use of opioids and cetirizine for patients in whom alternate treatment options are inadequate. Perampanel: (Moderate) Concurrent use of cetirizine/levocetirizine with perampanel should generally be avoided. Avoid use if there is hypersensitivity to cetirizine or hydroxyzine. Coadministration may increase the risk of CNS depressant-related side effects. How Do Second Generation Antihistamines Work? Use caution during coadministration. Prescribers should re-assess patients for drowsiness or sleepiness regularly throughout treatment, especially since events may occur well after the start of treatment. General anesthetics: (Moderate) Concurrent use of cetirizine/levocetirizine with general anesthetics should generally be avoided. Dronabinol: (Moderate) Additive drowsiness may occur if cetirizine/levocetirizine is administered with other drugs that depress the CNS, including dronabinol. Oxycodone: (Major) Reserve concomitant use of opioids and cetirizine for patients in whom alternate treatment options are inadequate. If concurrent use is necessary, monitor for excessive sedation and somnolence. Olanzapine; Fluoxetine: (Moderate) Monitor for unusual drowsiness and sedation during coadministration of atypical antipsychotics and cetirizine due to the risk for additive CNS depression. COMT inhibitors have also been associated with sudden sleep onset during activities of daily living such as driving, which has resulted in accidents in some cases. 2 drops/day per affected eye for ophthalmic solution. Vardenafil 4 tablets Blister 20 mg. Vardenafil, sold under the brand name Levitra among others, is a medication that is used for treating erectile dysfunction. Concomitant use can increase the risk of hypotension, respiratory depression, profound sedation, coma, and death as well as urinary retention and/or severe constipation, which may lead to paralytic ileus. Cetirizine is a prescription approved by the U.S. Food and Drug Administration (FDA), and over-the-counter antihistamine medication. Squeeze 1 drop into the pouch of each affected eye and gently close eyes. Chlorpheniramine; Dihydrocodeine; Phenylephrine: (Major) Reserve concomitant use of opioids and cetirizine for patients in whom alternate treatment options are inadequate. Limit dosages and durations to the minimum required and monitor patients closely for respiratory depression and sedation. Dopaminergic agents have also been associated with sudden sleep onset during activities of daily living such as driving, which has resulted in accidents in some cases. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Concomitant use may result in additive CNS depression or anticholinergic effects. Limit dosages and durations to the minimum required and monitor patients closely for respiratory depression and sedation. Aspirin, ASA; Oxycodone: (Major) Reserve concomitant use of opioids and cetirizine for patients in whom alternate treatment options are inadequate. If concurrent use is necessary, monitor for excessive anticholinergic effects, sedation, and somnolence. If concurrent use is necessary, monitor for excessive sedation and somnolence. Hydromorphone: (Major) Reserve concomitant use of opioids and cetirizine for patients in whom alternate treatment options are inadequate. Keep a list of all your medications with you, and share the list with your doctor and pharmacist. You should confirm the information on the PDR.net site through independent sources and seek other professional guidance in all treatment and diagnosis decisions. Lorazepam: (Moderate) Concurrent use of cetirizine/levocetirizine with benzodiazepines should generally be avoided. Acetaminophen; Hydrocodone: (Major) Reserve concomitant use of opioids and cetirizine for patients in whom alternate treatment options are inadequate. Molindone: (Moderate) Concurrent use of cetirizine/levocetirizine with molindone should generally be avoided. COMT inhibitors have also been associated with sudden sleep onset during activities of daily living such as driving, which has resulted in accidents in some cases. If it is from a pharmacy or shop, follow the instructions that come with the packet. Lurasidone: (Moderate) Monitor for unusual drowsiness and sedation during coadministration of atypical antipsychotics and cetirizine due to the risk for additive CNS depression. Limit dosages and durations to the minimum required and monitor patients closely for respiratory depression and sedation. Initial release of histamine from mast cells is followed by late-phase reactions involving a number of other cells. If concurrent use is necessary, monitor for excessive sedation and somnolence. Coadministration may increase the risk of CNS depressant-related side effects. If concurrent use is necessary, monitor for excessive sedation and somnolence. In case of overdose, get medical help or contact a Poison Control Center immediately. Cetrizine Tablet provides relief from symptoms such as blocked or runny nose, sneezing, and itchy or watery eyes. Do not blink. Limit dosages and durations to the minimum required and monitor patients closely for respiratory depression and sedation. Concomitant use can increase the risk of hypotension, respiratory depression, profound sedation, coma, and death as well as urinary retention and/or severe constipation, which may lead to paralytic ileus. Pimozide: (Moderate) Concurrent use of cetirizine/levocetirizine with pimozide should generally be avoided. (Moderate) Concurrent use of cetirizine/levocetirizine with barbiturates should generally be avoided. Properly discard this product when it is expired or no longer needed. If concurrent use is necessary, monitor for excessive sedation and somnolence. 0.25 mg/kg/dose PO twice daily may be beneficial for some patients. Copyright(c) 2023 First Databank, Inc. Concomitant use can increase the risk of hypotension, respiratory depression, profound sedation, coma, and death as well as urinary retention and/or severe constipation, which may lead to paralytic ileus. Concomitant use can increase the risk of hypotension, respiratory depression, profound sedation, coma, and death as well as urinary retention and/or severe constipation, which may lead to paralytic ileus. An interaction of cetirizine with pilsicainide has been described in an anecdotal report, a small clinical study, and an in vitro study, (179 AcE). bronchospasm / Rapid / 1.9-3.1myelitis / Delayed / 0-2.0angioedema / Rapid / 0-2.0heart failure / Delayed / 0-2.0visual impairment / Early / 0-2.0ocular hemorrhage / Delayed / 0-2.0ocular hypertension / Delayed / 0-2.0hearing loss / Delayed / 0-2.0seizures / Delayed / Incidence not knownanaphylactoid reactions / Rapid / Incidence not knownglomerulonephritis / Delayed / Incidence not knownsuicidal ideation / Delayed / Incidence not knownhemolytic anemia / Delayed / Incidence not knownfetal death / Delayed / Incidence not known, conjunctival hyperemia / Early / 1.0-7.0dysphonia / Delayed / 0-2.0hyperesthesia / Delayed / 0-2.0ataxia / Delayed / 0-2.0migraine / Early / 0-2.0hypertonia / Delayed / 0-2.0gastritis / Delayed / 0-2.0constipation / Delayed / 0-2.0melena / Delayed / 0-2.0hemorrhoids / Delayed / 0-2.0stomatitis / Delayed / 0-2.0atopic dermatitis / Delayed / 0-2.0furunculosis / Delayed / 0-2.0dyspnea / Early / 0-2.0sinus tachycardia / Rapid / 0-2.0palpitations / Early / 0-2.0hypertension / Early / 0-2.0chest pain (unspecified) / Early / 0-2.0cystitis / Delayed / 0-2.0urinary incontinence / Early / 0-2.0dysuria / Early / 0-2.0urinary retention / Early / 0-2.0hematuria / Delayed / 0-2.0blurred vision / Early / 0-2.0conjunctivitis / Delayed / 0-2.0dehydration / Delayed / 0-2.0diabetes mellitus / Delayed / 0-2.0myasthenia / Delayed / 0-2.0euphoria / Early / 0-2.0depression / Delayed / 0-2.0amnesia / Delayed / 0-2.0vaginitis / Delayed / 0-2.0lymphadenopathy / Delayed / 0-2.0peripheral edema / Delayed / 0-2.0edema / Delayed / 0-2.0elevated hepatic enzymes / Delayed / 0-1.0hot flashes / Early / 0-1.0dyskinesia / Delayed / Incidence not knownmyoclonia / Delayed / Incidence not knownhyperbilirubinemia / Delayed / Incidence not knownhepatitis / Delayed / Incidence not knowncholestasis / Delayed / Incidence not knownhypotension / Rapid / Incidence not knownhallucinations / Early / Incidence not knownthrombocytopenia / Delayed / Incidence not known, headache / Early / 0-14.0drowsiness / Early / 1.9-14.0pharyngitis / Delayed / 2.8-6.2abdominal pain / Early / 4.0-6.0fatigue / Early / 5.9-5.9xerostomia / Early / 5.0-5.0cough / Delayed / 2.8-4.4epistaxis / Delayed / 1.9-3.7diarrhea / Early / 1.9-3.1nausea / Early / 2.0-3.0vomiting / Early / 2.0-3.0paresthesias / Delayed / 0-2.0ptosis / Delayed / 0-2.0hypoesthesia / Delayed / 0-2.0vertigo / Early / 0-2.0dizziness / Early / 2.0-2.0hyperkinesis / Delayed / 0-2.0syncope / Early / 0-2.0tremor / Early / 0-2.0insomnia / Early / 0-2.0weight gain / Delayed / 0-2.0appetite stimulation / Delayed / 0-2.0dental caries / Delayed / 0-2.0flatulence / Early / 0-2.0dyspepsia / Early / 0-2.0tongue discoloration / Delayed / 0-2.0anorexia / Delayed / 0-2.0eructation / Early / 0-2.0acne vulgaris / Delayed / 0-2.0hypertrichosis / Delayed / 0-2.0xerosis / Delayed / 0-2.0photosensitivity / Delayed / 0-2.0urticaria / Rapid / 0-2.0maculopapular rash / Early / 0-2.0hyperkeratosis / Delayed / 0-2.0purpura / Delayed / 0-2.0hyperhidrosis / Delayed / 0-2.0seborrhea / Delayed / 0-2.0rash / Early / 0-2.0pruritus / Rapid / 0-2.0hyperventilation / Early / 0-2.0rhinitis / Early / 0-2.0sinusitis / Delayed / 0-2.0polyuria / Early / 0-2.0increased urinary frequency / Early / 0-2.0xerophthalmia / Early / 0-2.0ocular pain / Early / 0-2.0otalgia / Early / 0-2.0tinnitus / Delayed / 0-2.0polydipsia / Early / 0-2.0arthropathy / Delayed / 0-2.0arthralgia / Delayed / 0-2.0muscle cramps / Delayed / 0-2.0myalgia / Early / 0-2.0agitation / Early / 0-2.0libido decrease / Delayed / 0-2.0anxiety / Delayed / 0-2.0emotional lability / Early / 0-2.0nightmares / Early / 0-2.0menstrual irregularity / Delayed / 0-2.0menorrhagia / Delayed / 0-2.0leukorrhea / Delayed / 0-2.0mastalgia / Delayed / 0-2.0dysmenorrhea / Delayed / 0-2.0fever / Early / 0-2.0malaise / Early / 0-2.0parosmia / Delayed / 0-2.0dysgeusia / Early / 0-2.0flushing / Rapid / 0-2.0asthenia / Delayed / 0-2.0pallor / Early / 0-2.0back pain / Delayed / 0-2.0hypersalivation / Early / Incidence not known. ATX26330: This medicine is a white, pillow, tablet imprinted with "APO" and "10 MG". Limit dosages and durations to the minimum required and monitor patients closely for respiratory depression and sedation. RxList does not provide medical advice, diagnosis or treatment. In clinical trials, drowsiness has been reported in some patients taking cetirizine; therefore patients receiving cetirizine should be advised to avoid driving or operating machinery until the effects of the drug are known. If concurrent use is necessary, monitor for excessive sedation and somnolence. If concurrent use is necessary, monitor for excessive sedation and somnolence. Before taking cetirizine, tell your doctor or pharmacist if you are allergic to it; or to hydroxyzine; or to levocetirizine; or if you have any other allergies. US-based MDs, DOs, NPs and PAs in full-time patient practice can register for free on PDR.net. If concomitant use is necessary, consider prescribing naloxone for the emergency treatment of opioid overdose and monitor for signs of urinary retention or reduced gastric motility. Safety and efficacy have not been established. If concomitant use is necessary, consider prescribing naloxone for the emergency treatment of opioid overdose and monitor for signs of urinary retention or reduced gastric motility. IMPORTANT: HOW TO USE THIS INFORMATION: This is a summary and does NOT have all possible information about this product. Food and Drug Administration ( FDA ), and somnolence drugs that depress the CNS including! At an oral dose in dams that was approximately 180 times the MRHD ( on a mg/m twice daily be... Your medications with you, and itchy or watery eyes Tablet imprinted ``. Occur well after the start of treatment of each affected eye and gently close eyes may recovery. 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