Data sources include IBM Watson Micromedex (updated 5 June 2023), Cerner Multum (updated 5 June 2023), ASHP (updated 10 Apr 2023) and others. Keep it in your carry-on bag. 95% Confidence interval around the success difference [-0.10, +0.16]. (See USP Controlled Room Temperature). If you think youve taken too much of this drug, contact your doctor right away. As with other broad-spectrum antibiotics, prolonged administration of cefuroxime axetil may result in overgrowth of nonsusceptible microorganisms. The duration of therapy for the parenteral dosage of 750 mg to 1.5 g every 8 hours is usually 5 to 10 days. It has been proposed for infections with gram-negative and gram-positive organisms, gonorrhea, and haemophilus. However, this medicine will not work for colds, flu, or other virus infections. The absence of warnings or other information for a given drug does not indicate that the drug or drug combination is safe, effective, or appropriate for all patients or all specific uses. If you are a Mayo Clinic patient, this could information submitted for this request. CAEA4001 and CAEA4002 compared cefuroxime axetil 250 mg twice daily for 5 days, cefuroxime axetil 250 mg twice daily for 10 days, and CECLOR 250 mg 3 times daily for 10 days. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. Oral (tablets): 250 or 500 mg orally every 12 hours for 10 days Complaints about taste (which may impair compliance) occurred in 5% of pediatric patients. Duplex Container: Administer IV; do not use plastic containers in series connections. After you take a dose of cefuroxime, the drug may last up to 6 hours in your body. Redosing may be needed if drug half-life is shortened (e.g., extensive burns) or if prolonged/excessive bleeding during surgery; redosing may not be needed if drug half-life is prolonged (e.g., renal dysfunction). This can cause your body to process drugs more slowly. You can learn more about how we ensure our content is accurate and current by reading our. To ensure adequate serum and tissue drug levels, readministration may be needed if the procedure duration exceeds the recommended redosing interval. Skipping doses or not completing the full course of therapy may: (1) decrease the effectiveness of the immediate treatment, and (2) increase the likelihood that bacteria will develop resistance and will not be treatable by cefuroxime axetil for oral suspension or other antibacterial drugs in the future. The MIC values obtained should be interpreted according to the following criteria: A report of "Susceptible" indicates that the pathogen, if in the blood, is likely to be inhibited by usually achievable concentrations of the antimicrobial compound in blood. All rights reserved. There were no deaths or permanent disabilities in any of the patients in these studies. You can also call Americas Poison Centers at 800-222-1222 or use its online tool. Cefuroxime may cause some side . Drug administered with milk or milk products. Cefuroxime comes with risks if you dont take it as prescribed. Some may be better suited for you than others. CEFUROXIME AXETIL PRODUCTS IS INSTITUTED, CAREFUL INQUIRY SHOULD BE MADE TO DETERMINE WHETHER THE PATIENT HAS HAD PREVIOUS HYPERSENSITIVITY REACTIONS TO CEFUROXIME AXETIL PRODUCTS, OTHER CEPHALOSPORINS, PENICILLINS, OR OTHER DRUGS. SusceptibilityTests: DilutionTechniques: Quantitative methods that are used to determine MICs provide reproducible estimates of the susceptibility of bacteria to antimicrobial compounds. Shake the oral liquid well before each use. In this study each patient had a maxillary sinus aspirate collected by sinus puncture before treatment was initiated for presumptive acute bacterial sinusitis. See additional information. The resulting suspension has a fruity flavor. Persistent infections may require several week of treatment. Always carry your medication with you. Do not double doses. Avoid missing doses and complete the entire course of therapy. Tablets and oral suspension are not bioequivalent; do not substitute on a mg/mg basis. For children: Cefuroxime should not be used in children younger than 3 months of age. Reproduction studies in rats at doses up to 1,000 mg/kg/day (9 times the recommended maximum human dose based on mg/m2) have revealed no impairment of fertility. Cefuroxime Axetil Oral Suspension Prescribing Information. However, sufficient microbiology data were obtained to demonstrate the effectiveness of cefuroxime axetil tablets in treating acute bacterial maxillary sinusitis due only to Streptococcus pneumoniae or non-beta-lactamase-producing Haemophilus influenzae. Perioperative use during open heart surgery has been effective in surgical patients for whom infection at the operative site would present serious risk; for such patients, this drug should be continued for at least 48 hours after the end of surgery. Review/update the Analysis of the submitted clinical data for evaluable patients in the validated patient subset yielded the following results: * 95% confidence interval around the satisfactory difference for Part I (-0.08, +0.05). NOTE: Pseudomonas spp., Campylobacter spp., Acinetobactercalcoaceticus, Legionella spp., and most strains of Serratia spp. Solutions of this drug should not be added to solutions of aminoglycosides due to potential interaction; if concomitant therapy is indicated, each drug can be administered separately. Cefuroxime axetil for oral suspension, USP contains cefuroxime as cefuroxime axetil. When cefuroxime axetil for oral suspension is prescribed to treat a bacterial infection, patients should be told that although it is common to feel better early in the course of therapy, the medication should be taken exactly as directed. In addition to adverse events reported during clinical trials, the following events have been identified during clinical practice in patients treated with cefuroxime tablets or with cefuroxime axetil for oral suspension and were reported spontaneously. Eighteen (18) evaluable patients had Streptococcus pneumoniae as the identified pathogen. For this drug to work well, a certain amount needs to be in your body at all times. Comments: 3 months or older: 50 to 100 mg/kg/day IV or IM in equally divided doses every 6 to 8 hours, Oral (tablets): If you have an allergy to cefuroxime or any other part of Ceftin (cefuroxime oral suspension). This content does not have an English version. Always carry the original prescription-labeled container with you. Last updated on Nov 2, 2021. After constitution/dilution: The manufacturer product information should be consulted regarding stability periods of reconstituted and/or further diluted solutions at room temperature, under refrigeration (5C [41F]), or frozen (-20C [-4F]). Do not keep outdated medicine or medicine no longer needed. As a false-negative result may occur in the ferricyanide test, it is recommended that either the glucose oxidase or hexokinase method be used to determine blood/plasma glucose levels in patients receiving cefuroxime axetil. Eleven U.S. patients (1.2%) discontinued medication due to adverse events thought by the investigators to be possibly, probably, or almost certainly related to drug toxicity. have been shown by in vitro tests to be resistant to cefuroxime and other cephalosporins. If signs of infection observed, specimens for culture and susceptibility testing should be obtained to isolate and identify infecting organisms in order to start appropriate therapy. IM: By deep IM injection into a large muscle mass (such as the gluteus or lateral part of the thigh); aspirate before injecting to avoid inadvertent injection into a blood vessel. Package insert / product label 7 DRUG INTERACTIONS Dosage is based on your medical condition and response to therapy. Shake the oral suspension well before each use and administer with food; discard any remaining oral suspension after 10 days. Cefuroxime oral tablet may be taken with or without food. Store the tablets in a closed container at room temperature, away from heat, moisture, and direct light. Parenteral: 1.5 g IM as a single dose Preoperative dose: 1.5 g IV as a single dose, Redosing interval (from start of preoperative dose): 4 hours. Standard cefuroxime powder should give the following MIC values: DiffusionTechniques: Quantitative methods that require measurement of zone diameters provide estimates of the susceptibility of bacteria to antimicrobial compounds. Patients were randomized in a 1:1 ratio to a 20-day course of treatment with cefuroxime axetil 500 mg twice daily or doxycycline 100 mg 3 times daily. Symptoms of ED include. However, because drugs affect each person differently, we cannot guarantee that this information includes all possible side effects. Comments: Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. Use the higher pediatric parenteral dose (100 mg/kg/day) for more severe or serious infections. Clostridium difficile associated diarrhea (CDAD) has been reported with use of nearly all antibacterial agents, including cefuroxime axetil for oral suspension, and may range in severity from mild diarrhea to fatal colitis. To treat gonorrhea, cefuroxime is taken as a single dose, and to treat Lyme disease, cefuroxime is taken every 12 hours for 20 days. If you have questions about how long cefuroxime lasts in your body, ask your doctor or pharmacist. 2023 Healthline Media LLC. However, because drugs affect each person differently, we cannot guarantee that this list includes all possible dosages. The 30 mcg cefuroxime disk provides the following zone diameters in these laboratory test quality control strains: NOTE: CEFUROXIME AXETIL TABLETS AND CEFUROXIME AXETIL FOR ORAL SUSPENSION ARE NOT BIOEQUIVALENT AND ARE NOT SUBSTITUTABLE ON AMILLIGRAM-PER-MILLIGRAM BASIS (SEE CLINICAL PHARMACOLOGY). Descriptions. Measure the medicine with a marked measuring spoon, oral syringe, or medicine cup. The pharmacokinetics of cefuroxime in the urine of pediatric patients have not been studied at this time. Drugs & Diseases cefuroxime (Rx) Brand and Other Names: Ceftin, Zinacef Classes: Cephalosporins, 2nd Generation Dosing & Uses AdultPediatric Dosage Forms & Strengths oral suspension. Microbiology: The in vivo bactericidal activity of cefuroxime axetil is due to cefuroxime's binding to essential target proteins and the resultant inhibition of cell-wall synthesis. If you become pregnant while taking this drug, contact your doctor right away. It is supplied as follows: The 125 mg/5 mL: is a white to cream colored granular powder forming white to cream colored suspension on constitution with water. The safety and effectiveness of cefuroxime axetil have been established for pediatric patients aged 3 months to 12 years for acute bacterial maxillary sinusitis based upon its approval in adults. Careful medical history is necessary since CDAD has been reported to occur over two months after the administration of antibacterial agents. Medically reviewed by Drugs.com. Villanova, Pa: NCCLS; 1993. Satisfactory clinical outcome includes cure + improvement (Part I) and success + improvement (Part II). IV route may be preferred for patients with bacterial septicemia or other severe or life-threatening infections or for patients who may be poor risks due to lowered resistance, especially if shock is present/impending. To reduce the development of drug-resistant bacteria and maintain the effectiveness of cefuroxime axetil for oral suspension and other antibacterial drugs, cefuroxime axetil for oral suspension should be used only to treat or prevent infections that are proven or strongly suspected to be caused by bacteria. Medically reviewed by Drugs.com. When taken with cefuroxime, oral contraceptives (birth control pills) may not be absorbed well by the body. Disclaimer: Healthline has made every effort to make certain that all information is factually correct, comprehensive, and up-to-date. Infants up to 3 monthsUse and dose must be determined by your doctor. Interpretation involves correlation of the diameter obtained in the disk test with the MIC for cefuroxime. IDSA, American Academy of Neurology (AAN), and American College of Rheumatology (ACR) Recommendations: 500 mg orally twice a day By these procedures, it was possible to confirm the physician diagnosis of early Lyme disease in 281 (79%) of the 355 study patients. If CDAD is suspected or confirmed, ongoing antibiotic use not directed against C. difficile may need to be discontinued. Cefuroxime oral tablet should not be cut or crushed. Take cefuroxime at around the same times every day. Antibiotic resistance refers to bacteria that are no longer contained or killed by antibiotics. The resulting suspension has a fruity flavor. the unsubscribe link in the e-mail. NOTE: Listeria monocytogenes and certain strains of enterococci, e.g., Enterococcus faecalis (formerly Streptococcus faecalis), are resistant to cefuroxime. Comments: SIS and IDSA Recommendations: 1.5 g IV every 8 hours Prophylactic efficacy depends on timing of administration; the preoperative dose should be administered 30 to 60 minutes before surgery to allow enough time to attain effective antibiotic levels in the wound tissues during surgery; dosing should be repeated during prolonged procedures. Cefuroxime also comes as a liquid suspension. The geriatric patients reported somewhat fewer gastrointestinal events and less frequent vaginal candidiasis compared with patients aged 12 to 64 years old; however, no clinically significant differences were reported between the elderly and younger adult patients. Do not take more of it, do not take it more often, and do not take it for a longer time than your doctor ordered. However, this article should not be used as a substitute for the knowledge and expertise of a licensed healthcare professional. Compatible (powder in vials): Sterile Water for Injection; 0.9% Sodium Chloride Injection; 5% Dextrose Injection; 10% Dextrose Injection; 5% Dextrose And 0.9% Sodium Chloride Injection; 5% Dextrose and 0.45% Sodium Chloride Injection; 5% Dextrose and 0.225% Sodium Chloride Injection; 1/6 M Sodium Lactate Injection; Ringer's Injection, USP; Lactated Ringer's Injection, USP; 10% Invert Sugar in Water for Injection; heparin (10 and 50 units/mL) in 0.9% Sodium Chloride Injection; potassium chloride (10 and 40 mEq/L) in 0.9% Sodium Chloride Injection, Incompatible: Sodium Bicarbonate Injection, USP. Oral: For the treatment of uncomplicated skin and skin structure infections due to susceptible strains of S aureus (including beta-lactamase-producing strains) or S pyogenes, Parenteral: For the treatment of skin and skin structure infections due to susceptible strains of S aureus (penicillinase- and non-penicillinase-producing strains), S pyogenes, E coli, Klebsiella species, and Enterobacter species. Fifteen (15) of these 18 patients (83%) had their pathogen (Streptococcus pneumoniae) eradicated. If your symptoms are severe, call 911 or go to the nearest emergency room. Hematologic: Prothrombin time in at-risk patients, including those with renal or liver dysfunction, with poor nutritional state, receiving prolonged antimicrobial therapy, or previously stabilized on anticoagulant therapy (during parenteral therapy), Renal: Renal status, especially in seriously ill patients receiving maximum doses (during therapy); renal function in elderly patients. Efficacy in the treatment of penicillin-resistant strains of S pyogenes was not established in clinical trials. 36 Pharmacokinetics: Approximately 50% of serum cefuroxime is bound to protein. Use: For the treatment of early Lyme disease (erythema migrans) due to susceptible strains of Borrelia burgdorferi This drug is for the treatment of infections due to susceptible strains of the designated bacteria. Cefuroxime axetil is in the crystalline form and has the following structural formula: Cefuroxime axetil for oral suspension USP, when reconstituted with water, provides the equivalent of 125 mg or 250 mg of cefuroxime (as cefuroxime axetil) per 5 mL of suspension. Both forms are taken by swallowing. Fractions of the released cefuroxime axetil were compared . This could result in dangerous side effects. No overall differences in safety or effectiveness were observed between these subjects and younger adult subjects. If concomitant IV therapy with an aminoglycoside is indicated, administer each drug separately. Studies have found that this frequency keeps an effective level of the drug in the body for treating certain bacterial infections. Related/similar drugs Safety: In these clinical trials, 399 patients were treated with cefuroxime axetil for 5 days and 402 patients with cefuroxime axetil for 10 days. Chemically, cefuroxime axetil, the 1-(acetyloxy) ethyl ester of cefuroxime, is (RS)-1- hydroxyethyl (6R,7R)-7-[2-(2-furyl)glyoxylamido]-3-(hydroxymethyl)-8-oxo-5-thia-1- azabicyclo[4.2.0]oct-2-ene-2-carboxylate, 72-(Z)-(O-methyl-oxime), 1-acetate 3-carbamate. Secondary Bacterial Infections of Acute Bronchitis: Four randomized, controlled clinical studies were performed comparing 5 days versus 10 days of cefuroxime axetil for the treatment of patients with secondary bacterial infections of acute bronchitis. This medicine is used alone or in combination with other medicines for treating bacterial infections. 95% Confidence interval around the success difference [-0.061, +0.103]. The area under the curve for the suspension averaged 91% of that for the tablet, and the peak plasma concentration for the suspension averaged 71% of the peak plasma concentration of the tablets. In order to objectively validate the clinical diagnosis of early Lyme disease in these patients, 2 approaches were used: 1) blinded expert reading of photographs, when available, of the pretreatment erythema migrans skin lesion; and 2) serologic confirmation (using enzyme-linked immunosorbent assay [ELISA] and immunoblot assay [Western blot]) of the presence of antibodies specific to Borrelia burgdorferi, the etiologic agent of Lyme disease. Cefuroxime axetil- cefuroxime axetil tablet, film coated. Recommended for surgical prophylaxis for the following procedures: Cardiac: Coronary artery bypass; cardiac device insertion procedures (e.g., pacemaker implantation); ventricular assist devices, Head and neck: Clean with placement of prosthesis (excludes tympanostomy tubes); clean-contaminated cancer surgery; other clean-contaminated procedures (excluding tonsillectomy, functional endoscopic sinus procedures). Food Effect on Pharmacokinetics: All pharmacokinetic and clinical effectiveness and safety studies in pediatric patients using the suspension formulation were conducted in the fed state. Healthline Media does not provide medical advice, diagnosis, or treatment. Theyll let you know if any interact with cefuroxime and adjust your treatment if needed. The axetil moiety is metabolized to acetaldehyde and acetic acid. 95% confidence interval around the satisfactory difference for Part II (-0.13, +0.07). Oral suspension: 15 mg/kg/dose twice daily for 10 days; maximum dose: 500 mg/dose. Oral: For the treatment of uncomplicated endocervical and urethral gonorrhea due to susceptible strains of N gonorrhoeae (penicillinase- and non-penicillinase-producing strains); for the treatment of uncomplicated rectal gonorrhea in females due to susceptible strains of N gonorrhoeae (non-penicillinase-producing strains), Parenteral: For the treatment of uncomplicated gonococcal infections due to susceptible strains of N gonorrhoeae (penicillinase- and non-penicillinase-producing strains), Recommended as an initial IV regimen for empiric treatment of complicated intraabdominal infection, With metronidazole, may be used for initial empiric treatment of mild to moderate community-acquired infection (e.g., perforated or abscessed appendicitis), May be used for initial empiric treatment of mild to moderate community-acquired acute cholecystitis, Recommended as an alternative regimen for infected animal bite-related wound, Oral suspension: 10 to 15 mg/kg orally twice a day, Tablets: 250 or 500 mg orally every 12 hours, Oral: For the treatment of pharyngitis/tonsillitis, otitis media, sinusitis, bronchitis, uncomplicated skin and skin structure infections, uncomplicated urinary tract infections, early Lyme disease, and impetigo, Postnatal age (PNA) less than 7 days: 50 mg/kg IV or IM every 12 hours, PNA at least 7 days: 50 mg/kg IV or IM every 8 hours, PNA up to 7 days: 50 mg/kg IV or IM every 12 hours, PNA greater than 7 days: 50 mg/kg IV or IM every 8 hours. Examples of drugs that can cause interactions with cefuroxime are listed below. Renal Excretion: Cefuroxime is excreted unchanged in the urine; in adults, approximately 50% of the administered dose is recovered in the urine within 12 hours. The identified pathogen and success + improvement ( Part I ) and success + improvement ( Part II -0.13. +0.103 ] duration of therapy interact with cefuroxime, oral contraceptives ( birth control pills may..., Legionella spp., and most strains of enterococci, e.g., Enterococcus (! Or medicine no longer needed longer contained or killed by antibiotics Streptococcus faecalis ), are resistant to and! Better suited for you than others in any of the patients in these studies Legionella spp., Acinetobactercalcoaceticus, spp.... A Mayo Clinic patient, this medicine is used alone or in combination with other broad-spectrum antibiotics, prolonged of... 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