Any antibiotic may cause diarrhea, nausea, vomiting, anorexia, and hypersensitivity reactions. During long-term antibiotic administration, the risk for drug interaction with OCs is less clear, but alternative or additional contraception may be advisable in selected circumstances. PetPartners, Inc. is an indirect corporate affiliate of PetPlace.com. Transient elevations in AST, ALT, LDH, and alkaline phosphatase levels have occurred in human patients. Pantoprazole: (Major) Avoid the concomitant use of proton pump inhibitors (PPIs) and cefuroxime. [28573] [32569]CrCl 10 mL/minute/1.73 m2 or higher: No dosage adjustment needed.CrCl less than 10 mL/minute/1.73 m2: 10 to 15 mg/kg/dose PO every 24 hours. If an antacid must be used while a patient is taking cefuroxime, administer the oral dosage of cefuroxime at least 1 hour before or 2 hours after the antacid. Peak serum levels of cefuroxime after administration of cefuroxime axetil occur within 2 to 3 hours following an oral dose. Although cefuroxime is approved . There is a maximum proportion of PBPs that can be acylated; therefore, once maximum acylation has occurred, killing rates cannot increase. 150 mg/kg/day (Max: 6 g/day) IV divided every 6 to 8 hours. Not recommended by guidelines. Treatment of susceptible renal infections. Therefore, once daily administration of cefpodoxime oral tablets at . Sign up now to start a free trial to access all Vetlexicon articles, images, sounds and videos, or Login, Want more related items, why not contact us. 10 to 15 mg/kg/dose (Max: 500 mg/dose) PO every 12 hours for 7 to 14 days. Available data over several decades with cephalosporin use, including cefuroxime, during pregnancy in women have not established drug-associated risks of major birth defects, miscarriage, or adverse maternal or fetal outcomes. Based on experiments in our laboratory, the recommended dose is 12 mg/kg every 8 hours SC, or 24 mg/kg IV, every 24 hours. The majority of reported cases involve the combination of aminoglycosides and cephalothin or cephaloridine, which are associated with dose-related nephrotoxicity as singular agents. Paromomycin: (Minor) Cefuroxime's product label states that cephalosporins may potentiate the adverse renal effects of nephrotoxic agents, such as aminoglycosides and loop diuretics. Plazomicin: (Minor) Cefuroxime's product label states that cephalosporins may potentiate the adverse renal effects of nephrotoxic agents, such as aminoglycosides and loop diuretics. Do not crush tablets (It has a bitter taste. Nizatidine: (Major) Avoid the concomitant use of H2-blockers and cefuroxime. [54904] Guidelines recommend cefuroxime as an alternative for bacterial pneumonia in HIV-infected patients.[34361]. It belongs to the class of medicines known as cephalosporin antibiotics. Limited but conflicting data with other cephalosporins have been noted. Drugs that reduce gastric acidity, such as PPIs, can interfere with the oral absorption of cefuroxime axetil and may result in reduced antibiotic efficacy. Pediatrics:Oral suspensionThe following dose adjustments are based on a usual pediatric dose of 20 to 30 mg/kg/day PO divided every 12 hours. [49892]Intramuscular InjectionInject deeply into a large muscle mass (e.g., anterolateral thigh or deltoid [children and adolescents only]). Last updated on Nov 2, 2021. Guide treatment duration by clinical stability. Recently relaunched by Lupin Pharmaceuticals, cefixime, known as Suprax, is a semisynthetic, cephalosporin oral antibiotic used to treat conditions including pneumonia, bronchitis, otitis, and urinary tract infections for dogs and cats. Drug Interactions Very little (0.2%) is excreted in bile. Carefully monitor renal function, especially during prolonged therapy or use of high aminoglycoside doses. Drugs that reduce gastric acidity, such as PPIs, can interfere with the oral absorption of cefuroxime axetil and may result in reduced antibiotic efficacy. Mechanism of action. Resistant to some bacterial beta-lactamases. Antituberculous drugs (e.g., rifampin) were the only agents associated with OC failure and pregnancy. It is not known if Ceftin is safe and effective in children younger than 3 months of age. 50 mg/kg/dose IV or IM every 12 hours. Consult with your veterinarian to determine if other drugs your dog or cat is receiving could interact with cefixime. [46963], 0.75 to 1.5 g IV or IM every 8 hours. For systemic infections: 15mg/kg IV q 8 hours. The highest maternal milk concentration occurred in lactating women 8 hours after intramuscular administration of cefuroxime 750 mg. Even if your pet feels better, the entire treatment plan should be completed to prevent relapse or prevent the development of resistance. Treat UTIs as presumed pyelonephritis in these patients. Limited but conflicting data with other cephalosporins have been noted. A longer course (several months) may be needed for severe or complicated infections. A longer prophylaxis duration of 48 hours for certain cardiothoracic procedures is controversial. [63245] Higher doses (i.e., 150 mg/kg/day) are generally recommended for pneumonia. Warfarin: (Moderate) The concomitant use of warfarin with many classes of antibiotics, including cephalosporins, may increase the INR thereby potentiating the risk for bleeding. Patients who have experienced severe penicillin hypersensitivity should not receive cefuroxime. Write CSS OR LESS and hit save. Loop diuretics: (Minor) Nephrotoxicity associated with cephalosporins may be potentiated by concomitant therapy with loop diuretics. The serum half-life after IM injection is approximately 80 minutes. [49892] For community-acquired empyema, guidelines recommend cefuroxime in combination with metronidazole for at least 2 weeks after drainage and defervescence. The dose may need to be reduced in renal disease. For meningitis 30mg/kg IV q 8 hours. 1.5 g IV or IM every 8 hours. 2nd Generation Cephalosporin and Cephamycin Antibiotics, Oral/parenteral second-generation cephalosporinUsed for severe upper and lower respiratory tract infections, skin infections, otitis media, and surgical prophylaxisOral tablets and suspension are not bioequivalent and are not substitutable on a milligram-per-milligram basis, Alti-Cefuroxime, Ceftin, Kefurox, Zinacef, Zinacef Powder, Alti-Cefuroxime/Ceftin/Cefuroxime/Cefuroxime Axetil Oral Tab: 250mg, 500mgCefuroxime/Cefuroxime Sodium/Kefurox/Zinacef Intramuscular Inj Pwd F/Sol: 1.5g, 7.5g, 750mgCefuroxime/Cefuroxime Sodium/Kefurox/Zinacef Intravenous Inj Pwd F/Sol: 1.5g, 7.5g, 750mg. The concomitant oral administration of probenecid with cefuroxime slows tubular secretion, decreases renal clearance by approximately 40%, increases the peak serum level by approximately 30%, and increases the serum half-life by approximately 30%. Erectile dysfunction (ED) is often a symptom . [34361], 100 to 150 mg/kg/day IV or IM divided every 8 hours. Less frequent adverse reactions: Potentially life-threatening arrhythmias following bolus administration via central venous catheter; hematological disturbances, including neutropenia, leukopenia, eosinophilia, thrombocytopenia and agranulocytosis. You should confirm the information on the PDR.net site through independent sources and seek other professional guidance in all treatment and diagnosis decisions. Patients hypersensitive to penicillins may also be sensitive to cephalosporins (cross-hypersensitivity in <10% of human patients). For some infections (those related to long-term bronchitis or skin . The majority of reported cases involve the combination of aminoglycosides and cephalothin or cephaloridine, which are associated with dose-related nephrotoxicity as singular agents. (Moderate) Antacids can interfere with the oral absorption of cefuroxime axetil and may result in reduced antibiotic efficacy. Drugs that reduce gastric acidity, such as PPIs, can interfere with the oral absorption of cefuroxime axetil and may result in reduced antibiotic efficacy. A second course of oral antibiotics may be a reasonable alternative for patients in whom synovial proliferation is modest compared to joint swelling and for those who prefer repeating a course of oral antibiotics before considering IV therapy. Cefixime is available as 400 mg film-coated tablets and as a powder for oral suspension. Patients should be told to complete the full course of treatment, even if they feel better earlier. 10 mg/kg/dose PO every 12 hours for 10 days. Gram-negative Organisms: Haemophilus influenzae and parainfluenzae (beta-lactamase positive and negative strains), Klebsiella pneumoniae and oxytoca, Moraxella (Branhamella) catarrhalis (most of which are beta-lactamase positive), Escherichia coli, Pasteurella multocida, Proteus mirabilis and vulgaris, Providencia and Salmonella species, Shigella species, Citrobacter amalonaticus, Citrobacter diversus, and Serratia marcescens. Drugs that reduce gastric acidity, such as PPIs, can interfere with the oral absorption of cefuroxime axetil and may result in reduced antibiotic efficacy. The FDA-approved dosage is 1 g PO as a single dose. Monitor patients for signs and symptoms of bleeding. Shake gently before administration and withdraw appropriate contents for each dose.Storage: Diluted solutions are stable for 24 hours at room temperature or 48 hours under refrigeration (5 degrees C). 500 mg PO every 12 hours for at least 5 days as part of combination therapy for outpatients with comorbidities. Warfarin and other anticoagulants may have their effects increased (see above). Aminoglycosides: (Minor) Cefuroxime's product label states that cephalosporins may potentiate the adverse renal effects of nephrotoxic agents, such as aminoglycosides and loop diuretics. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding. Omeprazole; Amoxicillin; Rifabutin: (Major) Avoid the concomitant use of proton pump inhibitors (PPIs) and cefuroxime. Cefotaxime, better known as Claforan, is an injectable antibiotic sometimes used for dogs and cats. Dexlansoprazole: (Major) Avoid the concomitant use of proton pump inhibitors (PPIs) and cefuroxime. Clinical practice guidelines recommend cefuroxime for cardiac or clean head and neck (with prosthesis) procedures and as an alternate therapy for urogynecology procedures. Human formulations: Claforan (Hoechst Marion Roussel). It is bactericidal and works by inhibiting mucopeptide synthesis in the bacterial cell wall. It can help cure pneumonia, bronchitis, sinusitis and cystitis. Shake well before each use. Sodium Bicarbonate: (Moderate) Antacids can interfere with the oral absorption of cefuroxime axetil and may result in reduced antibiotic efficacy. Cefuroxime pharmacokinetic profile was investigated in 6 Beagle dogs after single intravenous, intramuscular, and subcutaneous administration at a dosage of 20 mg/kg. Independence America Holdings Corp. All Rights Reserved. [28573] [49892], Cefuroxime axetil is rapidly hydrolyzed in the intestinal mucosa, with approximately 37% of an oral dose reaching the systemic circulation as cefuroxime. Carefully monitor renal function, especially during prolonged therapy or use of high aminoglycoside doses. Consider the developmental and health benefits of breast-feeding along with the mother's clinical need for cefuroxime and any potential adverse effects on the breast-fed infant from cefuroxime or the underlying maternal condition. [32569]Pediatrics: 25 to 50 mg/kg/dose IV/IM every 8 hours.[32569]. Ramsey I (2017) 9th edn. Visually inspect parenteral products for particulate matter and discoloration prior to administration whenever solution and container permit. Famotidine: (Major) Avoid the concomitant use of H2-blockers and cefuroxime. Check the manufacturer's instructions prior to administration.Storage after reconstitution: After mixing, store suspension in a refrigerator between 2 and 8 degrees C (36 and 46 degrees F). In vitro and in vivo animal studies have demonstrated that the major pharmacodynamic parameter that determines efficacy for beta-lactams is the amount of time free (non-protein bound) drug concentrations exceed the minimum inhibitory concentration (MIC) of the organism (free T above the MIC). [61949], 100 to 150 mg/kg/day IV or IM divided every 8 hours (Max: 6 g/day). Limited but conflicting data with other cephalosporins have been noted. 250mg. 150 mg/kg/day (Max: 6 g/day) IV divided every 6 to 8 hours. [28573], Cefuroxime is excreted in human breast milk. The dose of cefotaxime should be reduced in patients with pre-existing renal disease. One retrospective study reviewed the literature to determine the effects of oral antibiotics on the pharmacokinetics of contraceptive estrogens and progestins, and also examined clinical studies in which the incidence of pregnancy with OCs and antibiotics was reported. The FDA-approved dose is 250 mg PO every 12 hours for 10 days. Drugs that reduce gastric acidity, such as PPIs, can interfere with the oral absorption of cefuroxime axetil and may result in reduced antibiotic efficacy. Uncomplicated infections include acute appendicitis without perforation, abscess, or local peritonitis; traumatic bowel perforations repaired within 12 hours; acute cholecystitis without perforation; and ischemic, non-perforated bowel. Cefuroxime, like the penicillins, is a beta-lactam antibiotic. The FDA-approved dosage is 750 mg IV or IM every 8 hours for 5 to 10 days. Cefuroxime dosage forms. Urinary concentrations following IM dosing averaged 1,300 mcg/mL during the first 8 hours. The dosage of Cefpodoxime is based on your dog's weight and is dosed as 5-10 milligrams per kilogram of body weight, and this dose should be given once daily. If the foil strip is removed and the container will not be used immediately, refold container and latch the side tab until ready to activate and use within 7 days.Once ready for activation, allow the product to reach room temperature before patient use.Unfold Duplex container and point the set port downward. Yes FDA approved? Intravenous doses of 750 mg and 1.5 g produced urinary levels Lower doses are recommended in dogs and cats with kidney failure. [28573]IV/IM formulations [49892]CrCl more than 20 mL/minute: No dosage adjustment needed.CrCl 10 to 20 mL/minute: Give a loading dose of 0.75 to 1.5 g IV/IM, followed by 750 mg IV/IM every 12 hours.CrCl less than 10 mL/minute: Give a loading dose of 0.75 to 1.5 g IV/IM, followed by 750 mg IV/IM every 24 hours. Suspension must be discarded 14 days after mixing. Register Now. In setting of a cat or dog bite, preemptive early antimicrobial therapy for 3 to 5 days is recommended for patients who are immunocompromised, asplenic, have advanced liver disease, have edema of the bite area, have moderate to severe injuries, particularly of the hand or face, or have penetrating injuries to the periosteum or joint capsule. The CLSI defines MICs for Enterobacterales as susceptible at 8 mcg/mL or less, intermediate at 16 mcg/mL, and resistant at 32 mcg/mL or more for parenteral cefuroxime (based on a dose of 1.5 g IV every 8 hours) and as susceptible at 4 mcg/mL or less, intermediate at 8 to 16 mcg/mL, and resistant at 32 mcg/mL or more for oral cefuroxime. 250 to 500 mg PO every 12 hours for 10 days. The dose of any concurrently administered anticoagulant should be decreased when cefixime is being administered and coagulation parameters should be monitored. It penetrates inflamed meninges and reaches therapeutic levels within the CSF. Resistant to some bacterial beta-lactamases. Indications and dose Unlicensed use Interactions Side-effects Allergy and cross-sensitivity Pregnancy Breast feeding Renal impairment Effect on laboratory tests Directions for administration Prescribing and dispensing information Medicinal forms Related treatment summaries Other drugs in class Interactions View interactions for cefuroxime Lansoprazole: (Major) Avoid the concomitant use of proton pump inhibitors (PPIs) and cefuroxime. 1.5 g IV or IM every 6 hours or 3 g IV or IM every 8 hours(Max:9 g/day) is the FDA-approved dosage. Such drugs include certain other antibiotics. Complicated infections include peritonitis and appendicitis complicated by rupture, and intraabdominal abscess. Cefuroxime is also recommended in combination with metronidazole for clean-contaminated head and neck procedures. The relationship between PBPs and autolysins is unclear, but it is possible that the beta-lactam antibiotic interferes with an autolysin inhibitor. Typical adult oral doses are 250 or 500 mg twice daily for 7-20 days depending on the type and severity of the infection. [28573] Rare potential complications in the nursing infant include alterations of gut flora that might result in diarrhea or related complications (e.g., dehydration). For life-threatening infections or infections due to less susceptible organisms, 1.5 g IV every 6 hours may be required. There was no evidence of accumulation of cefuroxime in the serum following IV administration of 1.5 g doses every 8 hours to normal adult volunteers. A longer course (several months) may be needed for severe or complicated infections. Store cefuroxime tablets in their original prescription bottle or an approved dosage reminder (ie, pill minder) container at room temperature. Penicillins can cause a variety of hypersensitivity reactions ranging from mild rash to fatal anaphylaxis. A false-positive reaction for glucose in the urine may occur with copper reduction tests (Benedict's or Fehling's solution or with CLINITEST tablets), but not with enzyme-based tests for glycosuria (e.g., CLINISTIX). If your dog experiences any side effects with cefpodoxime, call their veterinarian immediately. 50 mg/kg/dose IV or IM every 8 hours for 5 to 14 days. 500mg. Antibiotics should be discontinued within 24 hours. Because the risk of serious reactions is relatively rare, the use of many cephalosporins is considered compatible with breast-feeding. If an antacid must be used while a patient is taking cefuroxime, administer the oral dosage of cefuroxime at least 1 hour before or 2 hours after the antacid. 10 mg/kg/dose PO every 12 hours for 10 days. 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