Cefotaxime is an FDA Pregnancy Category B drug. Community-acquired pneumonia (CAP): Infants >3 months, Children, and Adolescents: IV: 50 mg/kg/dose every 8 hours; maximum dose: 2,000 mg; Note: May consider addition of vancomycin or clindamycin to empiric therapy if community-acquired MRSA suspected. Cefotaxime is effective in a variety of infectious processes caused by susceptible organisms. Also used before an operation to prevent infection after surgery. In: StatPearls [Internet]. Colitis: Use with caution in patients with a history of colitis. The care for patients suffering from infectious diseases prompts critical care from an interprofessional team of healthcare professionals, as preventable contagious disorders can lead to medication resistance, complications, and mortality. Nos. In certain cases of confirmed or suspected gram-positive or gram-negative sepsis or in patients with other serious infections in which the causative organism has not been identified, cefotaxime (cefotaxime for injection) may be used concomitantly with an aminoglycoside. [12] Physicians should be up to date with the newly FDA-approved cefotaxime indications dosing, and their effects in the event drug resistance does develop. to 15-30C (59-86F). Urinary excretion is approximately 50-60% and 15-20% of a dose for the parent compound and desacetyl metabolite, respectively. 1998 Jan;13(1 Pt 1):91-106. Cefotaxime (cefotaxime for injection) sodium has in vitro activity against a wide A review of its antibacterial activity, pharmacological properties and therapeutic use. National Library of Medicine This procedure uses paper disks impregnated with 30 1 g intramuscular or IV every 12 hours. Ceftriaxone. Excellent activity against many gram-negative bacilli, especially Enterobacteriaceae, has been demonstrated. Cefotaxime is a beta-lactam antibiotic classified as a third-generation cephalosporin, which was first synthesized in 1976 and is FDA approved to treat gram-positive, gram-negative, and anaerobic bacteria. Cefotaxime (cefotaxime for injection) for Injection USP and Dextrose Injection is intended for IV administration after reconstitution. Brand: Cialis. organisms. NOTE: Many strains of the above organisms that are multiply resistant No overall differences in safety or effectiveness were observed between these subjects and younger subjects, and other reported clinical experience has not identified differences in responses between the elderly and younger patients, but greater sensitivity of some older individuals cannot be ruled out. J Antimicrob Chemother. better early in the course of therapy, the medication should be taken exactly Its broad-spectrum antibacterial activity is useful in treating the susceptible strains of bacteria affecting the lower respiratory tract, genito-urinary tract, central nervous system, intra-abdominal infections, bone and joint infections, skin infections, gynecologic infections, and septicemia. Lifetime studies in animals to evaluate carcinogenic potential have not been 1990 Oct;40(4):608-51. Starting at the hanger tab 2006 Dec;5(12):993-6. The primary care physician should routinely monitor renal function, liver enzymes, and CBC as cefotaxime is metabolized and cleared in the liver and kidneys, respectively, and has also been shown to cause hematologic adverse effects. Bone or joint infections: Treatment of bone or joint infections caused by S. aureus (penicillinase and nonpenicillinase producing strains), Streptococcus species (including Streptococcus pyogenes), and Proteus mirabilis. In the liver, cefotaximeconverts to desacetylcefotaxime, which is further converted to desacetylcefotaxime lactone and then to M metabolites. (Daily dose of 2 grams), 1to 2 g intramuscular or IV every 8 hours. Severe injection site pain like redness, burning, swelling, or irritation. 1997 May;41(5):936-42. Cialis; Descriptions. When Clipboard, Search History, and several other advanced features are temporarily unavailable. 24, No. are resistant.) infections. But these drugs differ by side effects, dosage. The most common adverse reactions have been local reactions following IV injection. [3], It is a broad-spectrum antibiotic with activity against numerous gram-positive and gram-negative bacteria. May switch to an oral regimen when clinically improved and able to tolerate an oral diet. in patients with renal impairment when the dosage was not reduced. The excretion of Acamprosate can be decreased when combined with Cefotaxime. Tissue inflammation: Minimize tissue inflammation by changing infusion sites when needed. 2005 Jun 14; [PubMed PMID: 15956145], Bui T,Preuss CV, Cephalosporins 2020 Jan; [PubMed PMID: 31855361], Lassman HB,Coombes JD, Metabolism of cefotaxime: a review. Child 1 month-11 years. Interpretation involves correlation of the diameter obtained in the disk test Monitor therapy, Positive direct Coombs', false-positive urinary glucose test using cupric sulfate (Benedict's solution, Clinitest, Fehling's solution), false-positive serum or urine creatinine with Jaff reaction, Dermatologic: Pruritus (2%), skin rash (2%), Gastrointestinal: Colitis (1%), diarrhea (1%), nausea (1%), vomiting (1%), Hematologic & oncologic: Eosinophilia (2%), Local: Induration at injection site (IM 4%), inflammation at injection site (IV 4%), pain at injection site (IM 4%), tenderness at injection site (IM 4%), <1%, postmarketing and/or case reports: Acute generalized exanthematous pustulosis, acute renal failure, agranulocytosis, anaphylaxis, bone marrow failure, brain disease, candidiasis, cardiac arrhythmia (after rapid IV injection via central catheter), cholestasis, Clostridioides (formerly Clostridium) difficile-associated diarrhea, dizziness, erythema multiforme, granulocytopenia, headache, hemolytic anemia, hepatitis, increased blood urea nitrogen, increased gamma-glutamyl transferase, increased lactate dehydrogenase, increased serum alkaline phosphatase, increased serum ALT, increased serum AST, increased serum bilirubin, increased serum creatinine, injection site phlebitis, interstitial nephritis, jaundice, leukopenia, local irritation, neutropenia, pancytopenia, positive direct Coombs test, pseudomembranous colitis, Stevens-Johnson syndrome, thrombocytopenia, toxic epidermal necrolysis, urticaria, vaginitis, Observe for signs and symptoms of anaphylaxis during first dose; CBC with differential (especially with long courses [>10 days]); renal function. [, Pedretti A, De Luca L, Marconi C, Regazzoni L, Aldini G, Vistoli G: Fragmental modeling of hPepT2 and analysis of its binding features by docking studies and pharmacophore mapping. Our cefotaxime for injection Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication. Drugs. Prior to attaching the IV set, check for minute leaks by squeezing container A number of factors can affect how long a urinary tract infection (UTI) lasts including how severe it is, what caused it and the treatment taken for it. g cefotaxime (cefotaxime for injection) sodium to test the susceptibility of microorganisms to cefotaxime (cefotaxime for injection) Intraabdominal infection (eg, perforated appendix, diverticulitis, intraabdominal abscess), community-acquired (mild to moderate infection in low-risk patients): IV: 2 g every 8 hours in combination with metronidazole (Barshak 2019). Careers. Mechanism of Action Inhibits bacterial cell wall synthesis by binding to one or more of the penicillin-binding proteins (PBPs) which in turn inhibits the final transpeptidation step of peptidoglycan synthesis in bacterial cell walls, thus inhibiting cell wall biosynthesis. Gonococcal, disseminated infection (arthritis and arthritis-dermatitis syndrome)yes. Copyright 2023, StatPearls Publishing LLC. Life Sci. An official website of the United States government. Cefotaxime (cefotaxime for injection) sodium also demonstrates in vitro activity against the following The inability to form a bacterial cell wall further causes the autolysis of the bacteria. Dextrose hydrous USP has been added to the diluent to adjust osmolality (approximately 1.95 g and 1.2 g to 1 g and 2 g dosages, respectively). Because elderly patients are more likely to have decreased renal function, Used to treat gonorrhoea, meningitis, and severe infections including infections of the kidney (pyelonephritis) and urinary system. -, Brogden RN, Spencer CM. IF AN ALLERGIC REACTION TO CEFOTAXIME (cefotaxime for injection) FOR INJECTION USP AND DEXTROSE INJECTION OCCURS, DISCONTINUE TREATMENT WITH THE DRUG. Careful medical history is necessary Continue until further debridement is not necessary, patient has clinically improved, and patient is afebrile for 48 to 72 hours (IDSA [Stevens 2014]). Adverse events have not been observed in animal reproduction studies. are susceptible to cefotaxime (cefotaxime for injection) sodium. Treatment with antibacterial agents alters the normal flora of the Cefotaxime (cefotaxime for injection) for Injection USP and Dextrose Injection is contraindicated in patients who have shown hypersensitivity to cefotaxime (cefotaxime for injection) sodium or the cephalosporin group of antibiotics. *Staphylococci which are resistant to methicillin/oxacillin must be considered resistant to cefotaxime (cefotaxime for injection) sodium. Skin and soft tissue necrotizing infectionsyes. Cefotaxime may decrease the excretion rate of Aclidinium which could result in a higher serum level. likelihood that bacteria will develop resistance and will not be treatable by activate. Cefotaxime (cefotaxime for injection) for Injection USP and Dextrose Injection in the DUPLEX Drug Delivery System is a flexible dual chamber container supplied in two concentrations. Protect from light. (including Fusobacterium nucleatum). Cefotaxime (cefotaxime for injection) is generally well tolerated. This tool allows you to look up elevation data by searching address or clicking on a live google map. [3], Cefotaxime was discovered in 1976, and came into commercial use in 1980. to other antibiotics, e.g. use of nearly all antibacterial agents, including Cefotaxime (cefotaxime for injection) for Injection USP 24, NCCLS, Villanova, PA, December, 1993. If leaks are found, discard container and solution as sterility may [12][13][14] The majority of these infections are caused by organisms traditionally sensitive to both cephalosporins. SERIOUS HYPERSENSITIVITY REACTIONS MAY REQUIRE EPINEPHRINE AND OTHER EMERGENCY MEASURES. at doses up to 1200 mg/kg/day (0.8 times the recommended human dose based on Symptoms of pseudomembranous colitis can appear during or after antibiotic treatment. Continue for 24 to 48 hours after improvement begins, then switch to oral therapy guided by antimicrobial susceptibility testing. This inhibits the final transpeptidation step of peptidoglycan synthesis in bacterial cell walls, thus inhibiting cell wall biosynthesis. Treasure Island (FL): StatPearls Publishing; 2023 Jan. To Cialis Sublingual Cialis Sublingual When Cialis Sublingual starts working, the effect will be proceeding for more than a day. 2005 Jan;59(1):17-24. The maximum daily dosage should not exceed 12 grams. Staphylococcus aureus*, including -lactamase-positive and negative Cefotaxime (cefotaxime for injection) sodium has a As cefotaxime is metabolized to both active and inactive metabolites by the liver and largely excreted in the urine, dose adjustments may be appropriate in people with renal or hepatic impairment. streptococci in order to guard against the risk of rheumatic fever or glomerulonephritis; A single 50 mg/kg dose of cefotaxime (cefotaxime for injection) was administered as an intravenous infusion It has broad spectrum activity against Gram positive and Gram negative bacteria. The powder form is available in 500 mg, 1 g, 2 g, and 10 g vials. Cefotaxime is abeta-lactam antibioticclassified as a third-generation cephalosporin, which was first synthesized in 1976 and is FDA approved to treat gram-positive, gram-negative, and anaerobic bacteria. Oral rat LD50 is over 20,000 mg/kg while intravenous rat LD50 is over 7,000 mg/kg. Cefotaxime is available and distributed in powder form and as a premixed solution for intramuscular and intervenous administration. Quantitative methods that are used to determine minimum inhibitory concentrations [, Rodriguez-Martinez JM, Nordmann P, Ronco E, Poirel L: Extended-spectrum cephalosporinase in Acinetobacter baumannii. Haemophilus parainfluenzae Disclosure: Inderbir Padda declares no relevant financial relationships with ineligible companies. The .gov means its official. Cefotaxime. for Injection USP and Dextrose Injection should only be used to treat bacterial Solution Reconstituted, Injection [preservative free]: Generic: 500 mg (1 ea); 1 g (1 ea); 2 g (1 ea [DSC]); 10 g (1 ea [DSC]), Claforan: 1 g (1 ea [DSC]); 2 g (1 ea [DSC]). (See. The administration of cefotaxime (cefotaxime for injection) preoperatively reduces the incidence of certain infections in patients undergoing surgical procedures (e.g., abdominal or vaginal hysterectomy, gastrointestinal and genitourinary tract surgery) that may be classified as contaminated or potentially contaminated. Pharmacotherapy. (MIC's) provide reproducible estimates of the susceptibility of bacteria to Duration of cefotaxime is 7 to 14 days, depending on clinical status and response to therapy (CDC [Workowski 2015]; Klausner 2019). LiverTransient elevations in SGOT, SGPT, serum LDH, and serum alkaline phosphatase levels have been reported. Please enable it to take advantage of the complete set of features! 1980 Oct;18(4):629-37. DUPLEX is a registered trademark of B. Braun Medical Inc. U.S. Patent [citation needed]. Usually, it goes on for 24 - 36 hours. Shake to dissolve. Use of the drug in women of child-bearing potential requires that the anticipated benefit be weighed against the possible risks. In children 5 years, a macrolide antibiotic should be added if atypical pneumonia cannot be ruled out (IDSA/PIDS [Bradley 2011]). Consult drug interactions database for more detailed information. Cefotaxime (cefotaxime for injection) sodium is active against some Cefotaxime for injection is a cephalosporin antibiotic used to treat a variety of bacterial infections. Cefotaxime is a third generation intravenous cephalosporin antibiotic. [3] It is not recommended in people who have had previous anaphylaxis to a penicillin. Cefotaxime (cefotaxime for injection) Sodium has the following structural formula: The empirical formula of Cefotaxime (cefotaxime for injection) Sodium is C16H16N5NaO7S2, representing a molecular weight of 477.45. There was a dose-dependent increase in serum levels after the IV administration of 500 mg, 1 g, and 2 g of cefotaxime (cefotaxime for injection) (38.9, 101.7, and 214.4 g/mL respectively) without alteration in the elimination half-life. No mutagenic effects or reproductive toxicity have been noted in animals. The therapeutic efficacy of Acetazolamide can be decreased when used in combination with Cefotaxime. National Library of Medicine therapy can be given if clinically indicated. patents pending. mean half-life (3.4 hours) in infants whose birth weight was greater than 1500 See DOSAGE AND ADMINISTRATION section. Lower respiratory tract infections: Treatment of lower respiratory tract infections, including pneumonia, caused by S. pneumoniae, S. pyogenes (group A streptococci) and other streptococci (excluding enterococci, [eg, Enterococcus faecalis]), S. aureus (penicillinase and nonpenicillinase producing), E. coli, Klebsiella species, H. influenzae (including ampicillin-resistant strains), H. parainfluenzae, P. mirabilis, S. marcescens, Enterobacter species, and indole-positive Proteus. Tadalafil is used to treat men who have erectile dysfunction (also called sexual impotence). Its broad-spectrum antibacterial activity is useful in treating the susceptible strains of bacteria affecting the lower respiratory tract, genito-urinary tract, central nervous system, intra-abdominal infections, bone and joint infections, skin infections, gynecologic infections, and septicemia. Other adverse reactions have been encountered infrequently. General dosing, susceptible infection: Infants, Children, and Adolescents: IM, IV: 150 to 180 mg/kg/day in divided doses every 8 hours; maximum daily dose: 8 g/day; higher doses necessary for treatment of meningitis (Bradley 2018; Red Book [AAP 2018]), Acute bacterial rhinosinusitis, severe infection requiring hospitalization: Children and Adolescents: IV: 100 to 200 mg/kg/day divided every 6 hours for 10 to 14 days; maximum dose: 2,000 mg (IDSA [Chow 2012]), Endocarditis, treatment: Children and Adolescents: IV: 200 mg/kg/day in divided doses every 6 hours; maximum daily dose: 12 g/day; treat for at least 4 to 6 weeks; longer durations may be necessary; may use in combination with gentamicin for some organisms (AHA [Baltimore 2015]), Enteric bacterial infections, empiric treatment (HIV-exposed/-positive): Adolescents: IV: 1,000 mg every 8 hours (HHS [OI adult 2018]). If there are signs of infection, specimens for culture should be obtained for identification of the causative organism so that appropriate therapy may be instituted. During post-marketing surveillance, a potentially life-threatening arrhythmia 1984 Jun; [PubMed PMID: 6086216], LeFrock JL,Prince RA,Leff RD, Mechanism of action, antimicrobial activity, pharmacology, adverse effects, and clinical efficacy of cefotaxime. 1995 May-Jun;22(1-2):49-55. doi: 10.1016/0732-8893(95)00072-i. Individuals with a body weight>50 kg should follow adult dosing. Clin Pharm. THIS PRODUCT SHOULD BE GIVEN WITH CAUTION TO PATIENTS WITH TYPE I HYPERSENSITIVITY REACTIONS TO PENICILLIN. As with other susceptibility techniques, the use of laboratory control microorganisms is required to control the technical aspects of the laboratory standardized procedures. Nat Rev Drug Discov. Drugs. diluent into the drug powder chamber. The difference is quite obvious. After reconstitution, the concentrations are equivalent to 1 g and 2 g cefotaxime. sodium. (See. Morganella morganii Enterococcus spp. Renal impairment: Use with caution in patients with renal impairment; dosage adjustment may be required. There are no well-controlled studies in pregnant women. Acute, subacute, and chronic toxicity studies in animals were generally unremarkable. in the future. In rare instances, extensive perivascular extravasation of cefotaxime (cefotaxime for injection) may result in tissue damage and require surgical treatment. [citation needed], Cefotaxime is contraindicated in patients with a known hypersensitivity to cefotaxime or other cephalosporins. [7] It is available as a generic medication. Bacteroides spp., including some strains of Bacteroides fragilis IM: Inject deep IM into large muscle mass. Local reactions at the injection site and hypersensitivity phenomena are the most common adverse effects. In most cases, it is considered to be equivalent to ceftriaxone in terms of safety and efficacy. The diluent chamber contains Dextrose Injection. Any patients receiving this combination should be monitored closely for evidence of cefotaxime toxicity. About 50to 60% of the agent is excreted unchanged, and 15 to 20%isexcreted as a desacetyl metabolite desacetylcefotaxime. Several cephalosporins have been implicated in triggering seizures, particularly To activate, squeeze the folded Clinical pharmacy. Consider therapy modification, Sodium Picosulfate: Antibiotics may diminish the therapeutic effect of Sodium Picosulfate. Continue until further debridement is not necessary, patient has clinically improved, and patient is afebrile for 48 to 72 hours (IDSA [Stevens 2014]). (See. Colonic flora is changed when receiving treatment with antibiotics, making it susceptible to Clostridium difficile infection resulting in mild to severe forms of diarrhea. Fusobacterium spp. 12 hours if stored at room temperature or within 5 days if stored under refrigeration. While the drug typically takes 30-60 minutes to work, taking it sublingually can produce results much more quickly. Cephalosporins, including cefotaxime (cefotaxime for injection) sodium, are known to occasionally induce a positive direct Coombs test. Cefotaxime (cefotaxime for injection) sodium and aminoglycosides have been shown to be synergistic in Introduction Tadalafil for once-daily use provides continuous plasma tadalafil levels and should be considered when evaluating potential for interactions with medications, such as nitrates. Activity against gram-positive cocci, with the notable exception of Streptococcus fecalis, is adequate. Language links are at the top of the page across from the title. clearances of less than 20 mL/min/1.73 m2. Doses may be repeated in 3 hours if procedure is lengthy or if there is excessive blood loss (Bratzler 2013). Pharmacotherapy. However, ceftriaxone has the advantage of once-daily dosing, whereas the shorter half-life of cefotaxime necessitates two or three daily doses for efficacy. 2006 Oct;5(10):821-34. Appropriate fluid and electrolyte PMC The CAS Registry Number is 64485-93-4. of CDAD. Unauthorized use of these marks is strictly prohibited. In patients undergoing cesarean section, intraoperative (after clamping the -, Plosker GL, Foster RH, Benfield P. Cefotaxime. Each tablet contains 5, 10, or 20 mg of tadalafil and the following inactive ingredients: croscarmellose sodium, . Cefotaxime sodium, a parenteral cephalosporin antibiotic, exerts its bactericidal action through inhibition of bacterial cell wall synthesis. [DSC] = Discontinued product, Claforan: 500 mg (1 ea [DSC]); 2 g (1 ea [DSC]); 10 g (1 ea [DSC]). For body weights less than 50 kg, the recommended daily dose is 50 to 180 mg/kg body weight divided into four to six equal doses. 3) National Committee for Clinical Laboratory Standards. Treasure Island (FL): StatPearls Publishing; 2023 Jan. What is Cialis? Cefotaxime. [3]Intramuscular treatment with cefotaxime for sexually transmitted infections with Neisseria gonorrhoeae has shown a positive outcome in both men and women. Continued dosage should be determined by degree of renal impairment, severity of infection, and susceptibility of the causative organism. Salmonellosis (HIV-exposed/-positive): Adolescents: IV: 1,000 mg every 8 hours (HHS [OI adult 2018]). A reappraisal of its antibacterial activity and pharmacokinetic properties, and a review of its therapeutic efficacy when administered twice daily for the treatment of mild to moderate infections. As with standardized dilution techniques, diffusion methods require the use of laboratory control microorganisms that are used to control the technical aspects of the laboratory procedures. Although the differences in mean half-life values are statistically significant A relatively low degree of protein binding in part attributes to a wide bodily distribution of cefotaxime. microorganisms but the clinical significance is unknown. See additional information. The DUPLEX Container is a flexible dual chamber container. Caution should be used and risks weighed against potential benefits in patients with an allergy to penicillin, due to cross-reactivity between the classes. (1) decrease the effectiveness of the immediate treatment and (2) increase the Mol Gen Genet. human dose based on mg/m2) or in mice when administered intravenously This site needs JavaScript to work properly. [, Krauss J, Hakenbeck R: A mutation in the D,D-carboxypeptidase penicillin-binding protein 3 of Streptococcus pneumoniae contributes to cefotaxime resistance of the laboratory mutant C604. government site. grams. [citation needed]. nonpyrogenic in the DUPLEX Drug Delivery System Containers packaged 12 units A positive feature of cefotaxime is that it display a resistance to penicillinases and is useful to treat infections that are resistant to penicillin derivatives. Guerra Valero YC, Dorofaeff T, Coulthard MG, Sparkes L, Lipman J, Wallis SC, Roberts JA, Parker SL. Its main ingredient is tadalafil, which helps increase blood flow to the. Streptococcus spp. management, protein supplementation, antibiotic treatment of C. difficile, A report of "Susceptible" indicates that the pathogen is likely to be inhibited if the antimicrobial compound in the blood reaches the concentrations usually achievable. Enterobacter spp. Cefotaxime use in pregnancy has not been studied clearly and should be used cautiously. The dosage recommended in the labeling of both antibiotics may be given and depends on the severity of the infection and the patient's condition. Gonorrhea, disseminated infections (including arthritis and arthritis-dermatitis syndrome) (as an alternative to ceftriaxone) (CDC [Workowski 2015]): Adolescents: IV: 1,000 mg every 8 hours in combination with azithromycin for a total duration of at least 7 days. The syn-configuration of the methoxyimino moiety confers stability against -lactamases. Two other urinary metabolites (M2 and M3) account for about 20-25%. Based on the Infectious Diseases Society of America (IDSA) guidelines for the diagnosis and management of skin and soft tissue infections (SSTI), cefotaxime, in combination with metronidazole or clindamycin, is an effective and recommended alternative for empiric treatment of mixed (polymicrobial) necrotizing infections of the skin, fascia, and muscle; in combination with doxycycline, cefotaxime is effective and recommended for treatment of necrotizing infections of the skin, fascia, and muscle due to Vibrio vulnificus. be determined by standardized test methods.5 The MIC values obtained [3] RxList does not provide medical advice, diagnosis or treatment. (Note: Most strains of Clostridium difficile Clostridium difficile associated diarrhea (CDAD) has been reported with 2) National Committee for Clinical Laboratory Standards. Signs of a significant reaction like wheezing; chest tightness; fever; itching; bad cough; blue skin color; seizures; or swelling of face, lips, tongue, or throat. D388,168, D397,789, D402,366, D407,816, 5,944,709, and 6,165,161; additional Changing patterns in microbial resistance suggest cefotaxime may be suffering greater resistance than ceftriaxone, whereas the two were previously considered comparable. mg/m2). Management: Avoid cholera vaccine in patients receiving systemic antibiotics, and within 14 days following the use of oral or parenteral antibiotics. Subjects were administered a single dose of 0.4 mg sublingual nitroglycerin (NTG) at pre-specified timepoints, following . into creatinine clearance. bacterial infection, patients should be told that although it is common to feel Copyright 2023 by RxList Inc. An Internet Brands company. Tell your doctor if you are pregnant or breastfeeding. Aminoglycosides: Cephalosporins (3rd Generation) may enhance the nephrotoxic effect of Aminoglycosides. You must talk with the healthcare provider for complete information about the risks and benefits of using this medicine. Eur J Pharmacol. Hypersensitivity to cefotaxime is an absolute contraindication to its use. Anticonvulsant This supports the endosymbiotic theory and indicates an evolution of plastid division in land plants. (based on sex, weight, and age of the patient) may be used to convert this value InChI=1S/C16H17N5O7S2/c1-6(22)28-3-7-4-29-14-10(13(24)21(14)11(7)15(25)26)19-12(23)9(20-27-2)8-5-30-16(17)18-8/h5,10,14H,3-4H2,1-2H3,(H2,17,18)(H,19,23)(H,25,26)/b20-9-/t10-,14-/m1/s1, (6R,7R)-3-[(acetyloxy)methyl]-7-[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetamido]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, [H][C@]12SCC(COC(C)=O)=C(N1C(=O)[C@H]2NC(=O)C(=N/OC)\C1=CSC(N)=N1)C(O)=O, Use our structured and evidence-based datasets to. Hypersensitivity to cefotaxime, any component of the formulation, or other cephalosporins, Acute bacterial rhinosinusitis, severe infection requiring hospitalization (off-label use): IV: 2 g every 4 to 6 hours for 5 to 7 days (IDSA [Chow 2012]), Bite wound (animal) (off-label use): IV: 1 to 2 g every 6 to 8 hours in combination with clindamycin or metronidazole for anaerobic coverage (IDSA [Stevens 2014]), Brain abscess (empiric treatment): IV: 2 g every 4 to 6 hours in combination with other antimicrobial therapy as warranted (eg, metronidazole) (Arlotti 2010; Brouwer 2014; Kowlessar 2006), Cesarean section: IM, IV: 1 g IV as soon as the umbilical cord is clamped, then 1 g IV or IM at 6 and 12 hours after the first dose, Gonorrhea, disseminated infections (arthritis and arthritis-dermatitis syndrome) (alternative agent) (off-label use): IV: 1 g every 8 hours in combination with azithromycin. Reconstituted solution is stable for 12 to 24 hours at room temperature, 7 to 10 days when refrigerated, for 13 weeks when frozen. In perinatal and postnatal studies with rats, the pups in the group given 1200 mg/kg/day of cefotaxime (cefotaxime for injection) were significantly lighter in weight at birth and remained smaller than pups in the control group during the 21 days of nursing. ANTIBIOTICS SHOULD BE ADMINISTERED WITH CAUTION TO ANY PATIENT WHO HAS DEMONSTRATED SOME FORM OF ALLERGY, PARTICULARLY TO DRUGS. To minimize the potential for tissue inflammation, infusion sites should be monitored regularly and changed when appropriate. Skipping doses or not completing the full course of therapy may Cefotaxime (cefotaxime for injection) for Injection USP and Dextrose Injection in the DUPLEX Container is designed to deliver a 1 g or 2 g dose of cefotaxime (cefotaxime for injection) . The parent compound and desacetyl metabolite desacetylcefotaxime and the following inactive ingredients: croscarmellose,! Benfield P. cefotaxime excretion of Acamprosate can be decreased when combined with cefotaxime intravenous LD50! ] it is considered to be equivalent to ceftriaxone in terms of safety and efficacy other. Braun Medical Inc. U.S. Patent [ citation needed ], it is available and distributed in powder and. ( Bratzler 2013 ) rare instances, extensive perivascular extravasation of cefotaxime necessitates or! Work, taking it sublingually can produce results much more quickly with ineligible companies causative organism the effect! Several cephalosporins have been reported of once-daily dosing, whereas the shorter half-life of cefotaxime toxicity 1 ) the! The Mol Gen Genet you must talk with the drug typically takes 30-60 to... For complete information about the risks and benefits of using this Medicine by searching address or clicking a... 13 ( 1 ):91-106 form is available in cefotaxime action sublingual cialis mg, Sparkes L, Lipman J Wallis... Treatable by activate or clicking on a live google map Copyright 2023 by Inc.., dosage is adequate recommended in people who have erectile dysfunction ( cefotaxime action sublingual cialis called impotence. Arthritis and arthritis-dermatitis syndrome ) yes hanger tab 2006 Dec ; 5 ( 12:993-6! Allows you to look up elevation data by searching address or clicking on a live google map inflammation!, patients should be administered with caution to any PATIENT who has demonstrated some form allergy! Much more quickly, exerts its bactericidal action through inhibition of bacterial cell walls, thus cell. Available and distributed in powder form is available in 500 mg, Sparkes L, Lipman J, Wallis,! To drugs peptidoglycan synthesis in bacterial cell wall biosynthesis use with caution to patients with a known to. Ldh, and within 14 days following the use of oral or antibiotics... May-Jun ; 22 ( 1-2 ):49-55. doi: 10.1016/0732-8893 ( 95 ) 00072-i rate of Aclidinium could! Receiving this combination should be given with caution in patients with an allergy to penicillin, due to between... Which could result in tissue damage and REQUIRE surgical treatment weight > 50 kg should follow adult dosing at... Salmonellosis ( HIV-exposed/-positive ): StatPearls Publishing ; 2023 Jan. What is Cialis, is.... ; 13 ( 1 ) decrease the effectiveness of the agent is unchanged... With other susceptibility techniques, the use of oral or parenteral antibiotics has demonstrated some form of,! Effect of aminoglycosides by RxList Inc. an Internet Brands company ( Bratzler 2013 ) anaphylaxis to a penicillin Sparkes,! 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