Do not give Sumatriptan Nasal Spray to other people, even if they have the same symptoms you have. Photo: Andreas Neumann. Seizures have been reported following administration of sumatriptan. Talk with your healthcare provider about your chance of having seizures while you take Sumatriptan Nasal Spray. Three of the most common are sumatriptan, zolmitriptan, and rizatriptan. Peripheral (Small) Arteries: In healthy volunteers (N = 18), a trial evaluating the effects of sumatriptan on peripheral (small vessel) arterial reactivity failed to detect a clinically significant increase in peripheral resistance. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. Most MAO inhibitors should also not be taken for two weeks before treatment with this medication. Your nose may feel wet inside and you may notice a slight taste after using the spray. Associated symptoms such as nausea, photophobia, and phonophobia were also assessed. The makers of these brands are not affiliated with and do not endorse Florida Pharmaceutical Products, LLC or its products. Corneal opacities were seen at the lowest dose tested, 2 mg/kg/day, and were present after 1 month of treatment. However, these side effects are like symptoms of a heart attack, which may include chest/jaw/left arm pain, shortness of breath, or unusual sweating. Napumpujte ho antioxidantmi a vitamnmi! Canada. Very bad headache or if headache is not better after the first dose. This Patient Information has been approved by the U.S. Food and Drug Administration. Corneal Opacities: Dogs receiving oral sumatriptan developed corneal opacities and defects in the corneal epithelium. Data from a prospective exposure registry and epidemiological studies of pregnant women have not detected an increased frequency of birth defects or a consistent pattern of birth defects among women exposed to sumatriptan compared with the general population ( see Data). Because these effects may be additive, use of ergotamine-containing or ergot-type medications (like dihydroergotamine or methysergide) and Sumatriptan Nasal Spray within 24 hours of each other is contraindicated. Sumatriptan Nasal Spray may cause serious side effects. 5mg; 20mg; Package. Do not take any MAO inhibitors (isocarboxazid, linezolid, metaxalone, methylene blue, moclobemide, phenelzine, procarbazine, rasagiline, safinamide, selegiline, tranylcypromine) during treatment with this medication. Oral treatment of pregnant rats with sumatriptan during the latter part of gestation and throughout lactation resulted in a decrease in pup survival. PA 1077/008/004 . Sumatriptan does not prevent migraine attacks or reduce the number of headaches you have. Sumatriptan bioavailability following intranasal administration is 17%, similar to that after oral administration (15%). Cambridge, Ontario. Elimination: The elimination half-life of sumatriptan administered as a nasal spray is approximately 2 hours, similar to the half-life seen after subcutaneous injection. . Last updated on Dec 3, 2022. Before you use Sumatriptan Nasal Spray, tell your healthcare provider about all of your medical conditions, including if you: Tell your healthcare provider about all the medicines you take, including prescription and nonprescription medicines, vitamins, and herbal supplements. Do not test or prime the spray before use. During pregnancy, this medication should be used only when clearly needed. Do not change your dose without first talking with your healthcare provider. The onset of symptoms usually occurs within minutes to hours of receiving a new or a greater dose of a serotonergic medication. Tell your doctor about the allergy and This is not a list of all drugs or health problems that interact with sumatriptan nasal spray. The pharmacokinetics of sumatriptan in patients with severe hepatic impairment has not been studied. Canada residents can call a provincial poison control center. Vhody smoothies zvisia od toho, o do nich dte. Such reactions can be life threatening or fatal. Safety and effectiveness in pediatric patients have not been established. Generic name: Sumatriptan Nasal Spray [soo-ma-TRIP-tan] The sample size in this study had 80% power to detect at least a 1.73- to 1.91-fold increase in the rate of major malformations. In all trials, doses of 10 and 20 mg were compared with placebo in the treatment of 1 to 3 migraine attacks. Limited examinations of the nose and throat did not reveal any clinically noticeable injury in these patients. Medically reviewed by Drugs.com. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. This Patient Information leaflet summarizes the most important information about Sumatriptan Nasal Spray. All rights reserved. Inactive ingredients: monobasic potassium phosphate NF, anhydrous dibasic sodium phosphate USP, sulfuric acid NF, sodium hydroxide NF, and water for injection USP. Sumatriptan nasal spray should be used with caution in patients with a history of epilepsy or conditions associated with a lowered seizure threshold. WARNING/CAUTION: Even though it may be rare, some people may have very bad and sometimes deadly side effects when taking a drug. not available . Because their vasospastic effects may be additive, co-administration of Sumatriptan Nasal Spray and other 5-HT 1 agonists (e.g., triptans) within 24 hours of each other is contraindicated. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. The dosage is based on your medical condition and response to treatment. Step 2. Sumatriptan Nasal Spray is not recommended for use in patients younger than 18 years of age. Generic name: Sumatriptan Nasal Spray [ soo-ma-TRIP-tan ] Brand names: Imitrex, Tosymra Drug class: Antimigraine agents Medically reviewed by Drugs.com. changes in color or sensation in your fingers and toes (Raynauds syndrome). Distribution: Protein binding, determined by equilibrium dialysis over the concentration range of 10 to 1,000 ng/mL, is low, approximately 14% to 21%. If you also take any ergotamine medication (such as dihydroergotamine) or other "triptan" drugs (such as zolmitriptan, rizatriptan), you will need to separate your sumatriptan dose from your dose of these other medications to lessen the chance of serious side effects. This product is for use in the nose only. Anaphylactic/anaphylactoid reactions have occurred in patients receiving sumatriptan. What Are Side Effects of Tosymra? How GoodRx . The total plasma clearance is approximately 1,200 mL/min. These are not all the possible side effects of Sumatriptan Nasal Spray. Check with your Cerebral hemorrhage, subarachnoid hemorrhage, and stroke have occurred in patients treated with 5-HT 1 agonists, and some have resulted in fatalities. A cardiovascular evaluation is recommended for geriatric patients who have other cardiovascular risk factors (e.g., diabetes, hypertension, smoking, obesity, strong family history of CAD) prior to receiving Sumatriptan Nasal Spray [see Warnings and Precautions (5.1)] . The incidence of adverse reactions in controlled clinical trials was not affected by gender, weight, or age of the patients; use of prophylactic medications; or presence of aura. In a trial of 14 healthy females, pretreatment with an MAO-A inhibitor decreased the clearance of subcutaneous sumatriptan, resulting in a 2-fold increase in the area under the sumatriptan plasma concentration-time curve (AUC), corresponding to a 40% increase in elimination halflife. a cold sweat; shortness of breath; a. Lab and/or medical tests (such as blood pressure) may be done while you are using this medication. The highest no-effect dose for this effect was 60 mg/kg/day. . Sumatriptan nasal spray is not used to prevent or decrease the number of migraine headaches you have. MAO inhibitors interaction studies have not been performed with intranasal sumatriptan. taken, how much, and when it happened. Discontinue Sumatriptan Nasal Spray if these disturbances occur. Consult your doctor for more details. taken any of the following medicines in the last 24 hours: an allergy to sumatriptan or any of the ingredients in Sumatriptan Nasal Spray. Check with your pharmacist. Signs of an allergic reaction, like rash; Signs of high blood pressure like very bad headache or dizziness, passing out, or change in eyesight. Graham Head, 66, who kidnapped and tried to rape two women, was caught after one victim remembered three digits of his car registration. Call your doctor or get medical Doing so will make you lose the dose. You can ask your healthcare provider or pharmacist for information about Sumatriptan Nasal Spray that is written for healthcare professionals. Administer 10 mg metered-spray dose into 1 nostril; 20 mg dose achieved by administering 10 mg in each nostril; Onzetra Xsail Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. If a patient has no response to the first migraine attack treated with Sumatriptan Nasal Spray, reconsider the diagnosis of migraine before Sumatriptan Nasal Spray is administered to treat any subsequent attacks. You could have more side effects. Keep all medical and lab appointments. Last updated on Nov 5, 2022. This is not a complete list of possible side effects. 6 Nasal sprays. A generic drug is an exact copy of the . Currently Viewing Generic View prices for the brand name using this dropdown. prednisone, diclofenac, celecoxib, sumatriptan, metoclopramide, verapamil, Botox, indomethacin, rizatriptan, Imitrex. Tell your doctor if you are pregnant, plan on getting pregnant, or are breast-feeding. How should I use Sumatriptan Nasal Spray? If you have any questions about sumatriptan nasal spray, please talk Do not take sumatriptan nasal spray by mouth. What are the ingredients in Sumatriptan Nasal Spray? GLAXOSMITHKLINE (IRELAND) LIMITED . Sumatriptan nasal spray is contraindicated in patients with a history of hypersensitivity reaction to sumatriptan. You will need to talk about the benefits and risks ( 1) Not indicated for the prophylactic therapy of migraine attacks. by Novocol Pharmaceutical of Canada, Inc. Taking more of sumatriptan nasal spray (a higher dose, more often) than your doctor told you to take may cause your headaches to become worse. (soo ma trip tan). The safety of treating an average of more than 4 headaches in a 30 day period has not been established. Discontinue Sumatriptan Nasal Spray if serotonin syndrome is suspected. Do not share your drugs with others and do not take anyone else's drugs. to you and the baby. Sumatriptan is a white to off-white powder that is very slightly soluble in water and in saline. Different brands of this medication have different storage needs. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. Before treating headaches in patients not previously diagnosed as migraineurs, and in migraineurs who present with atypical symptoms, exclude other potentially serious neurological conditions. What are the possible side effects of Sumatriptan Nasal Spray? Get medical help right away if you develop some of the following symptoms: fast heartbeat, hallucinations, loss of coordination, severe dizziness, severe nausea/vomiting/diarrhea, twitching muscles, unexplained fever, unusual agitation/restlessness. You may report side effects to Health Canada at 1-866-234-2345. There were insufficient data to assess the impact of race on efficacy. local irritation. The recommended adult dose of Sumatriptan Nasal Spray for the acute treatment of migraine is 5 mg, 10 mg, or 20 mg. Figure 2. cP<0.05 in comparison with 5 mg. Sumatriptan works by constricting (narrowing) the blood vessels in the head, stops transmission of pain signals to the brain, and blocks the release of chemicals that cause nausea and other migraine symptoms. $229.72 medication_outlined Availability Available See GoodRx coupons warning Are you looking for information on Onzetra Xsail (sumatriptan) nasal powder, sumatriptan (Imitrex) tablets, or sumatriptan (Imitrex, Imitrex Statdose) injection instead? Manufactured for Florida Pharmaceutical Products, LLC Sumatriptan binds with high affinity to human cloned 5-HT 1B/1D receptors. Description and Brand Names. had a stroke, transient ischemic attacks (TIAs), or problems with your blood circulation. In offspring of pregnant rats treated orally with sumatriptan during organogenesis, there was a decrease in pup survival. Consult your doctor before breast-feeding. Each 15 IMITREX Nasal Spray contains 5 or 20 mg of sumatriptan in a 100-L unit dose aqueous 16 buffered solution containing monobasic potassium phosphate NF, anhydrous dibasic sodium 17. Serotonin syndrome may occur with Sumatriptan Nasal Spray, particularly during co-administration with selective serotonin reuptake inhibitors (SSRIs), serotonin norepinephrine reuptake inhibitors (SNRIs), tricyclic antidepressants (TCAs), and MAO inhibitors [see Drug Interactions (7.4)] . Call your doctor right away if The consequences of extended and repeated use of Sumatriptan Nasal Spray on the nasal and/or respiratory mucosa have not been systematically evaluated in patients. He/she may also direct you to take your first dose of this medication in the office/clinic to monitor for serious side effects (such as chest pain). Loss of eyesight. Overuse of acute migraine drugs (e.g., ergotamine, triptans, opioids, or combination of these drugs for 10 or more days per month) may lead to exacerbation of headache (medication overuse headache). When administered by the intravenous route to pregnant rabbits, sumatriptan was embryolethal ( see Data). In all 5 trials utilizing the market formulation and recommended dosage regimen, the percentage of patients achieving headache response 2 hours after treatment was significantly greater among patients receiving Sumatriptan Nasal Spray at all doses (with one exception) compared with those who received placebo. Dihydroergotamine is not an ordinary pain reliever. Uses Before taking Warnings Side effects Overdose Dosage FAQ Uses of Sumatriptan Nasal Spray: It is used to treat migraine headaches. Seizures have happened in people taking Sumatriptan Nasal Spray who have never had seizures before. The 10 mg dose may be achieved by the administration of a single 5 mg dose in each nostril. Tell your healthcare provider about all the medicines you take, Especially tell your healthcare provider if. Sumatriptan nasal spray is contraindicated in patients with uncontrolled hypertension. In general, anaphylactic reactions to drugs are more likely to occur in individuals with a history of sensitivity to multiple allergens [see Contraindications (4) and Warnings and Precautions (5.10)] . In Canada - Call your doctor for medical advice about side effects. Know the medicines you take. Clinical trials of Sumatriptan Nasal Spray did not include sufficient numbers of patients aged 65 and older to determine whether they respond differently from younger patients. The tour begins on Aug. 3 in Sterling . Generic name: Sumatriptan Nasal Spray [ soo-ma-TRIP-tan ] Brand names: Imitrex, Tosymra Drug class: Antimigraine agents Medically reviewed by Drugs.com. The number of exposed pregnancy outcomes accumulated during the registry was insufficient to support definitive conclusions about overall malformation risk or for making comparisons of the frequencies of specific birth defects. Concomitant use with other Triptans or Ergot Medications: Inform patients that use of Sumatriptan Nasal Spray within 24 hours of another triptan or an ergot-type medication (including dihydroergotamine or methysergide) is contraindicated [see Contraindications (4) and Drug Interactions (7.1, 7.3)] . This includes if other forms of sumatriptan nasal spray were used for the first dose. The most common side effects of Sumatriptan Nasal Spray include: Tell your healthcare provider if you have any side effect that bothers you or that does not go away. It is not known if Sumatriptan Nasal Spray is safe and effective to treat cluster headaches. For all patients taking sumatriptan nasal spray: Use sumatriptan nasal spray as ordered by your doctor. Dosage form: nasal spray Alcohol or marijuana (cannabis) can make you more dizzy or drowsy. Talk with the doctor if you have questions about stomach and intestinal problems (gastrointestinal and colonic ischemic events). Sumatriptan nasal spray is contraindicated in patients with a history of stroke or TIA. The estimated probability of patients taking a second dose or other medication for migraine over the 24 hours following the initial dose of study treatment is summarized in Figure 2. Most of a radiolabeled dose of sumatriptan excreted in the urine is the major metabolite indole acetic acid (IAA) or the IAA glucuronide, both of which are inactive. Keep your head level and remove the nozzle from your nostril. Remove the Sumatriptan Nasal Spray unit from the aluminum pouch (see Figure A). Have your blood pressure checked as you have been told by your doctor. with your doctor, nurse, pharmacist, or other health care provider. Monitor blood pressure in patients treated with sumatriptan. Tools & Info. Racial Groups: The systemic clearance and C max of subcutaneous sumatriptan were similar in black (n = 34) and Caucasian (n = 38) healthy male subjects. This medication may raise your blood pressure. Generic name: sumatriptan Dosage form: Nasal Spray Company: Dr. Reddy's Laboratories, Inc. Sumatriptan belongs to a class of drugs known as triptans. How should this medicine be used? The occurrence of major birth defects (excluding fetal deaths and induced abortions without reported defects and all spontaneous pregnancy losses) during first-trimester exposure to sumatriptan was 4.2% (20/478 [95% CI: 2.6% to 6.5%]) and during any trimester of exposure was 4.2% (24/576 [95% CI: 2.7% to 6.2%]). See the cheapest pharmacy price and start saving on Sumatriptan today. The elimination halflife of sumatriptan is approximately 2 hours [see Clinical Pharmacology (12.3)] , and therefore monitoring of patients after overdose with Sumatriptan Nasal Spray should continue for at least 10 hours or while symptoms or signs persist. Procedure no. Check the product package for instructions on how to store your brand, or ask your pharmacist. The Estimated Probability of Patients Taking a Second Dose or Other Medication for Migraine Over the 24 Hours Following the Initial Dose of Study Treatment, Risk of Myocardial Ischemia and/or Infarction, Prinzmetals Angina, Other Vasospasm-Related Events, Arrhythmias, and Cerebrovascular Events, Concomitant use with other Triptans or Ergot Medications. This medicine is taken on an as needed basis. This medication comes in different brands with different strengths. Do not remove the unit until you are ready to use. Do not spray in your eyes. We comply with the HONcode standard for trustworthy health information. Insert the nozzle into your open nostril about inch. by Novocol Pharmaceutical of Canada, Inc.. 25 Wolseley Court, Product Name (in authorisation country) MRP/DCP Authorisation number . In a trial of 24 male volunteers, the bioavailability relative to subcutaneous injection was low, approximately 17%, primarily due to presystemic metabolism and partly due to incomplete absorption. In the U.S. general population, the estimated background risk of major birth defects and of miscarriage in clinically recognized pregnancies is 2% to 4% and 15% to 20%, respectively. Avoid spraying into your eyes. Last updated on Dec 3, 2022. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. Very bad and sometimes deadly heart problems like heart attack and a heartbeat that is not normal have rarely happened within a few hours This medicine is not meant to prevent or lower the number of migraine headaches you get. This Patient Information and Instructions for Use have been approved by the U.S. Food and Drug Administration. Life-threatening disturbances of cardiac rhythm, including ventricular tachycardia and ventricular fibrillation leading to death, have been reported within a few hours following the administration of 5-HT 1 agonists. Serious side effects of Imitrex Nasal Spray include: high blood pressure ( hypertension ), Sumatriptan nasal spray may cause coronary artery vasospasm (Prinzmetals angina), even in patients without a history of CAD. Additional smaller observational studies evaluating use of sumatriptan during pregnancy have not suggested an increased risk of teratogenicity. There are no data on the effects of sumatriptan on the breastfed infant or the effects of sumatriptan on milk production. In general, anaphylactic reactions to drugs are more likely to occur in individuals with a history of sensitivity to multiple allergens. If you notice other effects not listed above, contact your doctor or pharmacist. The highest no-effect dose was 50 mg/kg/day. . What should I avoid while using Sumatriptan Nasal Spray? Do not press the plunger yet. Data sources include IBM Watson Micromedex (updated 5 June 2023), Cerner Multum (updated 5 June 2023), ASHP (updated 10 Apr 2023) and others. It may harm them. Patients received doses as a single spray into 1 nostril. Or marijuana ( cannabis ) can make you lose the dose younger than 18 of! Effect was 60 mg/kg/day Court, product name ( in authorisation country ) authorisation! White to off-white powder that is very slightly soluble in water and saline. Your head level and remove the sumatriptan Nasal Spray by mouth after oral administration ( %... Doctor for medical advice, diagnosis or treatment the first dose problems with your provider. Of epilepsy or conditions associated with a history of hypersensitivity reaction to sumatriptan unit... 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