DRUG INTERACTIONS: Drug interactions may change how your medications work or increase your risk for serious side effects. Avoid or Use Alternate Drug. This will prevent the medication from draining out. Increases risk of torsades de pointes. azithromycin decreases effects of cefdinir by pharmacodynamic antagonism. azithromycin and flecainide both increase QTc interval. 55) in the standard care group. Minor/Significance Unknown. azithromycin and erythromycin stearate both increase QTc interval. Measure your dose correctly with a marked measuring spoon, oral syringe, or medicine cup. azithromycin and levoketoconazole both increase QTc interval. Use Caution/Monitor. restrictions. Monitor Closely (1)histrelin increases toxicity of azithromycin by QTc interval. Monitor Closely (1)valbenazine and azithromycin both increase QTc interval. Use Caution/Monitor. Avoid or Use Alternate Drug. Minor/Significance Unknown. Minor/Significance Unknown. Minor/Significance Unknown. Use Caution/Monitor. Monitor Closely (1)azithromycin and fluconazole both increase QTc interval. Information last revised May 2023. Throw away the unused medication after treatment is completed or after 14 days (see also Storage section). The above information is provided for general Minor (1)azithromycin and fluoxetine both increase QTc interval. Seek medical treatment if you have a serious drug reaction that can affect many parts of your body. Use Caution/Monitor. Minor (1)azithromycin decreases effects of penicillin G aqueous by pharmacodynamic antagonism. Monitor Closely (1)azithromycin and bedaquiline both increase QTc interval. Use Caution/Monitor. It takes around 5.5 x elimination half life's for a medicine to be out of your system. Do not administer cholera vaccine to patients who have received oral or parenteral antibiotics within 14 days prior to vaccination. azithromycin and pazopanib both increase QTc interval. Use Caution/Monitor. Use Caution/Monitor. Monitor Closely (1)azithromycin will increase the level or effect of rifampin by P-glycoprotein (MDR1) efflux transporter. Serious - Use Alternative (1)atomoxetine and azithromycin both increase QTc interval. There are several antibiotics that kill the common mouth bacteria that cause tooth infections. Avoid or Use Alternate Drug. azithromycin increases toxicity of arformoterol by QTc interval. Minor/Significance Unknown. DVT/PE treatment: Avoid coadministering dabigatran with P-gp inhibitors if CrCl <50 mL/min. azithromycin and erythromycin lactobionate both increase QTc interval. Applies only to oral form of both agents. levoketoconazole will increase the level or effect of azithromycin by P-glycoprotein (MDR1) efflux transporter. atomoxetine and azithromycin both increase QTc interval. Use Caution/Monitor. Enhanced CNS toxicity. Use Caution/Monitor. Contraindicated. Monitor Closely (1)perphenazine and azithromycin both increase QTc interval. Use Caution/Monitor. This will release any extra pressure in the dropper. dichlorphenamide and azithromycin both decrease serum potassium. Reduced berotralstat dose to 110 mg/day when coadministered with P-gp inhibitors. If you take an antacid that contains aluminum or magnesium, wait at least 2 hours before or after taking azithromycin. Minor/Significance Unknown. Increases risk of torsades de pointes. Effectiveness of the 3-day or 1-day regimen in children with . Minor/Significance Unknown. Atrial fibrillation: Avoid coadministering dabigatran with P-gp inhibitors if CrCl <30 mL/min. Use Caution/Monitor. Use Caution/Monitor. azithromycin will increase the level or effect of edoxaban by P-glycoprotein (MDR1) efflux transporter. Coronavirus Disease 2019 (COVID-19) (link, Patients with known or suspected bacteremia, Patients with significant underlying health problems that may compromise their ability to respond to their illness (including immunodeficiency or functional asplenia), 10 mg/kg PO x 1 dose on Day 1 followed by 5 mg/kg on Days 2-5, sodium picosulfate/magnesium oxide/anhydrous citric acid, Prolonged cardiac repolarization and QT interval, imparting a risk of developing cardiac arrhythmia and torsades de pointes, have been reported with antimicrobials#macrolides, including azithromycin, Elderly patients may be more susceptible to drug-associated effects on the QT interval, Patients with known prolongation of the QT interval, a history of torsades de pointes, congenital long QT syndrome, bradyarrhythmias or uncompensated heart failure, Patients on drugs known to prolong the QT interval, Patients with ongoing proarrhythmic conditions such as uncorrected hypokalemia or hypomagnesemia, clinically significant bradycardia, and in patients receiving Class IA (quinidine, procainamide) or Class III (dofetilide, amiodarone, sotalol) antiarrhythmic agents, Observational studies have shown an approximately two-fold increased short-term potential risk of acute cardiovascular death in adults exposed to azithromycin relative to other antibacterial drugs, including amoxicillin, Potential risk was noted to be greater during first five days of treatment and does not appear to be limited to those patients with preexisting cardiovascular diseases, The data in these observational studies are insufficient to establish or exclude a causal relationship between acute cardiovascular death and azithromycin use; consider balancing potential risk with treatment benefits when prescribing therapy, Serious allergic reactions, including angioedema, anaphylaxis, and dermatologic reactions including Acute Generalized Exanthematous Pustulosis (AGEP), Stevens Johnson syndrome, and toxic epidermal necrolysis have been reported, Cases of Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS) have also been reported, If an allergic reaction occurs, discontinue drug and institute appropriate therapy, Be aware that allergic symptoms may reappear after symptomatic therapy has been discontinued, Coadministration of nelfinavir at steady-state with a single oral dose of azithromycin resulted in increased azithromycin serum concentrations; closely monitor for adverse reactions of azithromycin, Spontaneous postmarketing reports suggest that coadministration of azithromycin may potentiate the effects of oral anticoagulants (eg, warfarin), although the prothrombin time was not affected in the dedicated drug interaction study with azithromycin and warfarin; carefully monitor prothrombin time while patients are receiving azithromycin and oral anticoagulants concomitantly, Drug interactions with digoxin, colchicine or phenytoin have been observed when combined other macrolide; until further data are developed regarding drug interactions when digoxin, colchicine or phenytoin are used with azithromycin careful monitoring of patients is advised, August 3, 2018: FDA issues warning letter to healthcare providers, Increased relapse and mortality observed with azithromycin in the clinical trial entitled ALLOZITHRO (evaluation of the efficacy of azithromycin to prevent bronchiolitis obliterans syndrome [BOS] after allogenic hematopoietic stem cell transplantation [HSCT]), The study was terminated early after an increased risk of relapses was observed in patients taking azithromycin compared with placebo, Azithromycin is not indicated for prophylaxis of bronchiolitis obliterans syndrome (BOS) in patients undergoing HSCT and should not be used off-label for this condition, Decreased viability and delayed development were observed in the offspring of pregnant rats administered azithromycin from day 6 of pregnancy through weaning at a dose equivalent to 4 times an adult human daily dose of 500 mg based on body surface area, Advise women to monitor the breastfed infant for diarrhea, vomiting, or rash, Oral (3-day regimen): 0.44 mcg/mL (Day 1); 0.54 mcg/mL (Day 3), Oral (5-day regimen): 0.43 mcg/mL (Day 1); 0.24 mcg/mL (Day 5), IV: 1.14 mcg/mL (healthy volunteers); 3.63 mcg/mL (hospitalized patients), IV: 8.03 mcghr/mL (healthy volunteers); 9.6 mcghr/mL (hospitalized patients), Oral suspension: When administered with food, peak plasma concentration increased by 56% and AUC unchanged, Biliary excretion is a major route of elimination for unchanged drug, following oral administration. azithromycin and bedaquiline both increase QTc interval. Monitor Closely (1)azithromycin will increase the level or effect of ritonavir by P-glycoprotein (MDR1) efflux transporter. Avoid or Use Alternate Drug. DVT/PE treatment: Avoid coadministering dabigatran with P-gp inhibitors if CrCl <50 mL/min. Complete antibiotic regimens 2-4 days before initiating microbiota oral. Use Caution/Monitor.azithromycin will increase the level or effect of erythromycin base by P-glycoprotein (MDR1) efflux transporter. AZITHROMYCIN (IV/PO) Systemic infection 500 mg x1, then 250 mg q24h Legionella or Pneumonia in ICU 500 mg q24h Mycobacterial infection Consult infectious diseases AZTREONAM (IV) All infections, other than infection of CNS 2 g q8h 2 g q8h 2 g q12h 1 g q12h 2 g q8h CNS infection 2 g q6h 2 g q6h 2 g q8h 2 g q12h 2 g q6h . Minor/Significance Unknown. Serious - Use Alternative (1)mirtazapine and azithromycin both increase QTc interval. Monitor Closely (1)azithromycin and lumefantrine both increase QTc interval. Use Caution/Monitor.Serious - Use Alternative (1)escitalopram increases toxicity of azithromycin by QTc interval. Use Caution/Monitor. Avoid or Use Alternate Drug. azithromycin decreases effects of oxacillin by pharmacodynamic antagonism. Serious - Use Alternative (1)azithromycin decreases effects of microbiota oral by pharmacodynamic antagonism. Use Caution/Monitor. Monitor Closely (1)azithromycin and dofetilide both increase QTc interval. Use Caution/Monitor. If any of these effects last or get worse, tell your doctor or pharmacist promptly.Remember that this medication has been prescribed because your doctor has judged that the benefit to you is greater than the risk of side effects. Monitor Closely (1)azithromycin and pentamidine both increase QTc interval. Minor/Significance Unknown. Modify Therapy/Monitor Closely. Use Caution/Monitor. This drug is available at a middle level co-pay. azithromycin decreases effects of penicillin VK by pharmacodynamic antagonism. You can use a free SingleCare Azithromycin coupon and reduce your out-of-pocket costs to $9.74 for this prescription drug. Monitor Closely (1)azithromycin will decrease the level or effect of bazedoxifene/conjugated estrogens by altering intestinal flora. Either increases toxicity of the other by QTc interval. Monitor Closely (1)azithromycin and alfuzosin both increase QTc interval. Avoid or Use Alternate Drug. Avoid or Use Alternate Drug. Monitor Closely (1)azithromycin will increase the level or effect of tolvaptan by P-glycoprotein (MDR1) efflux transporter. Zithromax IV could make you sunburn more easily. Avoid or Use Alternate Drug. Avoid or Use Alternate Drug. (ay-ZITH-roe-MYE-sin) COMMON BRAND NAME (S): Zithromax. aluminum hydroxide decreases levels of azithromycin by inhibition of GI absorption. Use Caution/Monitor. Do not administer cholera vaccine to patients who have received oral or parenteral antibiotics within 14 days prior to vaccination. Minor/Significance Unknown. Avoid or Use Alternate Drug. Use Caution/Monitor. Monitor Closely (1)voclosporin, azithromycin. Avoid or Use Alternate Drug. Risk of prolonged QTc interval.Monitor Closely (1)azithromycin and pimozide both increase QTc interval. Use Caution/Monitor. Increases risk of torsades de pointes. Serious - Use Alternative (1)azithromycin increases effects of protamine by decreasing metabolism. Talazoparib is a P-glycoprotein (P-gp) substrate; coadministration with P-gp inhibitors may increase talazoparib systemic exposure. bacteriostatic agents may inhibit the effects of bactericidal agents. Use Caution/Monitor. ), potassium chloride, ticarcillin-clavulanate, tobramycin, Other IV substances, additives, or medications should not be added to azithromycin, or infused simultaneously through the same IV line, Add 4.8 mL of sterile water for injection to 500-mg vial; final concentration is (100 mg/mL); shake vial until all of the drug is dissolved, Visually inspect vial for particulate matter before administration; discard if particular matter is present, Dilute reconstituted drug in either a 250-mL (final concentration 2 mg/mL) or 500-mL IV bag (final concentration 1 mg/mL), 1 mg/mL diluted solution: Infuse over 3 hr, 2mg/mL diluted solution: Infuse over 1 hr, Tablets and oral suspension: Take with or without food, Oral suspension: Shake well before use; refer to prescribing information for dosing information, Reconstituted vial: Store at <30C (86F) for 24 hr, Diluted solutions: Store <30C (86F) for 24 hr OR refrigerate at 5C (41F), Reconstituted oral suspension: Store at 5-30C (41-86F) and use within 10 days; discard after full dosing is completed. Avoid or Use Alternate Drug. Avoid or Use Alternate Drug. Avoid use with drugs that prolong QT and in patients with risk factors for prolonged QT interval. Use Caution/Monitor. Consider alternative antibiotics with concomitant use of cobicistat coadministered with atazanavir or darunavir. Exercise extreme caution when vilanterol coadministered with drugs that prolong QTc interval; adrenergic agonist effects on the cardiovascular system may be potentiated. azithromycin and lapatinib both increase QTc interval. saquinavir, azithromycin. If you have any questions, ask your doctor or pharmacist.To apply eye drops, wash your hands first. Modify Therapy/Monitor Closely. Avoid or Use Alternate Drug. Monitor Closely (1)azithromycin decreases effects of cefditoren by pharmacodynamic antagonism. azithromycin increases toxicity of solifenacin by QTc interval. Wait until Abx Tx complete to administer live bacterial vaccine. being unable to get an erection at any time. 19 (13%) of 147 participants in the azithromycin . Monitor Closely (1)azithromycin decreases effects of sodium picosulfate/magnesium oxide/anhydrous citric acid by altering metabolism. Continue reading. Serious - Use Alternative (1)fingolimod and azithromycin both increase QTc interval. PRECAUTIONS: Before using azithromycin, tell your doctor or pharmacist if you are allergic to it; or to other macrolide antibiotics such as erythromycin or clarithromycin; or to ketolide antibiotics such as telithromycin; or if you have any other allergies. DESCRIPTION Azithromycin for injection contains the active ingredient azithromycin, an azalide, a subclass of macrolide antibiotics, for intravenous injection. azithromycin and ketoconazole both increase QTc interval. azithromycin increases toxicity of rifabutin by decreasing metabolism. Individual plans may vary Use Caution/Monitor. Monitor Closely (1)azithromycin and octreotide (Antidote) both increase QTc interval. Monitor Closely (1)dichlorphenamide and azithromycin both decrease serum potassium. You should not use this medicine if you have ever had a severe allergic reaction to similar drugs such as clarithromycin, erythromycin, or telithromycin. Most Minor (1)azithromycin will increase the level or effect of ruxolitinib topical by affecting hepatic/intestinal enzyme CYP3A4 metabolism. azithromycin increases levels of rivaroxaban by affecting hepatic/intestinal enzyme CYP3A4 metabolism. thioridazine and azithromycin both increase QTc interval. azithromycin decreases effects of dicloxacillin by pharmacodynamic antagonism. Separate by 2 hours. Serious - Use Alternative (1)azithromycin decreases effects of BCG vaccine live by pharmacodynamic antagonism. Serious - Use Alternative (1)azithromycin increases levels of toremifene by decreasing metabolism. However, this medicine will not work for colds, flu, or other virus infections. Azithromycin (Zithromax) is an antibiotic that can help treat certain bacterial infections. azithromycin increases effects of phenindione by decreasing metabolism. What are the best antibiotics for a tooth infection? Modify Therapy/Monitor Closely.chloroquine increases toxicity of azithromycin by QTc interval. Use Caution/Monitor. Use Caution/Monitor. Minor/Significance Unknown. Use Caution/Monitor. Modify Therapy/Monitor Closely. azithromycin and haloperidol both increase QTc interval. Modify Therapy/Monitor Closely. buprenorphine and azithromycin both increase QTc interval. Monitor Closely (1)azithromycin and octreotide both increase QTc interval. Monitor Closely (1)azithromycin and formoterol both increase QTc interval. Monitor Closely (1)azithromycin increases toxicity of lofexidine by QTc interval. Azithromycin is an antibiotic (macrolide-type). Otherwise, call a poison control center right away. We comply with the HONcode standard for trustworthy health information. azithromycin increases toxicity of deutetrabenazine by QTc interval. SIDE EFFECTS: Temporary eye irritation/stinging/burning or blurred vision may occur. Minor (1)azithromycin and flecainide both increase QTc interval. Minor (1)azithromycin and sulfamethoxazole both increase QTc interval. Serious - Use Alternative (1)sevoflurane and azithromycin both increase QTc interval. Avoid or Use Alternate Drug. tacrolimus and azithromycin both increase QTc interval. Reduced berotralstat dose to 110 mg/day when coadministered with P-gp inhibitors. Minor (1)azithromycin increases toxicity of sunitinib by QTc interval. Monitor Closely (1)azithromycin increases levels of naldemedine by P-glycoprotein (MDR1) efflux transporter. Use Caution/Monitor. Do not take two doses at one time. azithromycin and droperidol both increase QTc interval. This information is not individual medical advice and does not substitute for the advice of your health care professional. Use Caution/Monitor. Monitor Closely (1)azithromycin will decrease the level or effect of balsalazide by altering intestinal flora. Place one finger at the corner of your eye (near the nose) and apply gentle pressure. Low risk of contraceptive failure. Serious - Use Alternative (1)azithromycin increases effects of fondaparinux by decreasing metabolism. azithromycin increases levels of berotralstat by P-glycoprotein (MDR1) efflux transporter. Use Caution/Monitor. Low risk of contraceptive failure. azithromycin decreases effects of ampicillin by pharmacodynamic antagonism. azithromycin will increase the level or effect of colchicine by P-glycoprotein (MDR1) efflux transporter. Avoid or Use Alternate Drug. Use Caution/Monitor. Use Caution/Monitor. Modify Therapy/Monitor Closely. azithromycin and formoterol both increase QTc interval. azithromycin and disopyramide both increase QTc interval. 2010zithromax-zmax-azithromycin-342523Drugs, encoded search term (azithromycin (Zithromax)) and azithromycin (Zithromax), No Surprise: Highest Drug Prices Across the Board in the US, FDA: Don't Use Azithromycin for Lung Condition in Cancer Patients, No Major Azithromycin Arrhythmia Risk in Huge European Cohort, You Give Me Fever: Four Other Tickborne Illnesses. being able to get an erection sometimes, but not every time you want to have sex. azithromycin increases toxicity of propafenone by QTc interval. azithromycin and moxifloxacin both increase QTc interval. azithromycin will increase the level or effect of riociguat by decreasing metabolism. Monitor Closely (1)protriptyline and azithromycin both increase QTc interval. Avoid concurrent or sequential use to decrease risk for ototoxicity. anagrelide and azithromycin both increase QTc interval. Avoid or Use Alternate Drug. Avoid or Use Alternate Drug. Avoid or Use Alternate Drug. Maximum dose: 1500 mg/dose. Avoid or Use Alternate Drug. Avoid or Use Alternate Drug. Applies only to oral form of both agents. azithromycin and glasdegib both increase QTc interval. Minor/Significance Unknown. Avoid or Use Alternate Drug. Study design: All subjects were initially randomized to receive single 1-hour intravenous infusions of azithromycin . Use Caution/Monitor. US residents can call their local poison control center at 1-800-222-1222. Minor (1)azithromycin and dasatinib both increase QTc interval. Use Caution/Monitor. Monitor Closely (1)azithromycin and disopyramide both increase QTc interval. QTc prolongation reported with higher than recommended doses of fostemsavir. Use Caution/Monitor. Controlled studies in pregnant women show no evidence of fetal risk. Use Caution/Monitor. Applies only to oral forms of hormone. Lenvatinib prescribing information recommends monitoring ECG closely when coadministered with QT prolonging drugs. But, as of 2022, Zithromax comes in several dosages and forms, including oral tablets and liquids for oral use, injections and intravenous drips. azithromycin and erythromycin lactobionate both increase QTc interval. azithromycin decreases effects of cefditoren by pharmacodynamic antagonism. If you notice other effects not listed above, contact your doctor or pharmacist.In the US -Call your doctor for medical advice about side effects. Use Caution/Monitor. Use Caution/Monitor. Drugs that prolong the QTc interval and may potentiate the effects of beta2 agonists on the cardiovascular system; increased risk of ventricular arrhythmias. Either increases effects of the other by QTc interval. Decrease betrixaban dose to 80 mg PO once, then 40 mg PO qDay if coadministered with a P-gp inhibitor. buprenorphine transdermal and azithromycin both increase QTc interval. Certain circumstances may increase risk of torsade de pointes and/or sudden death in association with drugs that prolong the QTc interval (eg, bradycardia, hypokalemia or hypomagnesemia, coadministration with other drugs that prolong QTc interval, presence of congenital QT prolongation). Hold the dropper directly over your eye and place 1 drop into the pouch, usually twice daily (8 to 12 hours apart) for the first 2 days and then once daily for the next 5 days or as directed by your doctor. Use Caution/Monitor. Continue reading, There are no documented interactions between Zithromax and alcohol so you could drink a small amount of alcohol (one or two glasses) if you wanted to. ezogabine, azithromycin. Monitor Closely (1)imipramine and azithromycin both increase QTc interval. Use Caution/Monitor.azithromycin and levoketoconazole both increase QTc interval. Version: 18.01. prednisone, amoxicillin, albuterol, doxycycline, ciprofloxacin, azithromycin, metronidazole, cephalexin, clindamycin, ceftriaxone. If coadministration unavoidable, reduce mobocertinib dose and monitor QTc interval more frequently. Use Caution/Monitor.Serious - Use Alternative (1)ribociclib increases toxicity of azithromycin by QTc interval. Minor/Significance Unknown. Use Caution/Monitor.Minor (1)azithromycin and ranolazine both increase QTc interval. Use Caution/Monitor. Minor (1)azithromycin and tropisetron both increase QTc interval. Use Caution/Monitor. Applies only to oral form of both agents. Minor/Significance Unknown. Monitor Closely (1)azithromycin and artemether/lumefantrine both increase QTc interval. Minor/Significance Unknown. Monitor Closely (1)trimipramine and azithromycin both increase QTc interval. Avoid or Use Alternate Drug. Use Caution/Monitor. Use Caution/Monitor. Use Caution/Monitor. Avoid or Use Alternate Drug. Monitor Closely (1)azithromycin increases levels of rivaroxaban by affecting hepatic/intestinal enzyme CYP3A4 metabolism. azithromycin decreases effects of temocillin by pharmacodynamic antagonism. Use Caution/Monitor. If this combination is used, closely monitor for evidence of atorvastatin toxicity (eg, muscle aches or pains, renal dysfunction). Use Caution/Monitor. Use Caution/Monitor. perphenazine and azithromycin both increase QTc interval. Monitor Closely (1)azithromycin and haloperidol both increase QTc interval. azithromycin increases toxicity of eribulin by QTc interval. Use Caution/Monitor. If nintedanib adverse effects occur, management may require interruption, dose reduction, or discontinuation of therapy . azithromycin will increase the level or effect of venetoclax by P-glycoprotein (MDR1) efflux transporter. primaquine and azithromycin both increase QTc interval. Avoid or Use Alternate Drug. Avoid or Use Alternate Drug. vemurafenib and azithromycin both increase QTc interval. Monitor Closely (1)azithromycin and sotalol both increase QTc interval. azithromycin and alfuzosin both increase QTc interval. Modify Therapy/Monitor Closely. Setting: Clinical pharmacology unit. In addition to removing azithromycin from prior regimens, the CDC now recommends increasing the dose of ceftriaxone from a 250 mg intramuscular dose to 500 mg. Avoid or Use Alternate Drug. Use Caution/Monitor. Avoid or Use Alternate Drug. protriptyline and azithromycin both increase QTc interval. Use Caution/Monitor. It will not work for other types of eye infections. This medicine is available only with your doctor's prescription. Serious - Use Alternative (1)azithromycin increases levels of pomalidomide by P-glycoprotein (MDR1) efflux transporter. Avoid or Use Alternate Drug.Minor (1)azithromycin increases toxicity of clozapine by unspecified interaction mechanism. Use Caution/Monitor. azithromycin increases toxicity of olanzapine by QTc interval. azithromycin increases toxicity of chloroquine by QTc interval. Either increases toxicity of the other by QTc interval. Medscape prescription drug monographs are based on FDA-approved labeling information, unless otherwise noted, combined with additional data derived from primary medical literature. Avoid or Use Alternate Drug. Concurrent use of toremifene with agents causing QT prolongation should be avoided. azithromycin and tropisetron both increase QTc interval. Monitor Closely (1)hydroxyzine increases toxicity of azithromycin by QTc interval. Avoid or Use Alternate Drug. At the maximum recommended dose, deutetrabenazine does not prolong QT interval to a clinically relevant extent. Monitor Closely (2)levoketoconazole will increase the level or effect of azithromycin by P-glycoprotein (MDR1) efflux transporter. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.This is not a complete list of possible side effects. Warnings Minor/Significance Unknown. azithromycin will increase the level or effect of lovastatin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Monitor Closely. Monitor Closely (1)azithromycin increases toxicity of escitalopram by QTc interval. Avoid or Use Alternate Drug. Minor (1)azithromycin and dolasetron both increase QTc interval. Azithromycin also is used to treat or prevent disseminated Mycobacterium avium complex (MAC) infection [a type of lung infection that . azithromycin increases toxicity of entrectinib by QTc interval. Enhanced CNS toxicity. Monitor Closely (1)azithromycin will increase the level or effect of lovastatin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. leuprolide increases toxicity of azithromycin by QTc interval. azithromycin will increase the level or effect of talazoparib by P-glycoprotein (MDR1) efflux transporter. Minor/Significance Unknown. Monitor Closely (1)azithromycin will increase the level or effect of tacrolimus by P-glycoprotein (MDR1) efflux transporter. Your list will be saved and can be edited at any time. Modify Therapy/Monitor Closely. You may report side effects to FDA at 1-800-FDA-1088. You should not use Zithromax IV if you are allergic to it, or if you have ever had: jaundice or liver problems caused by taking Zithromax IV; or. azithromycin increases levels of afatinib by P-glycoprotein (MDR1) efflux transporter. Use Caution/Monitor. Common side effects of Zithromax IV may include: This is not a complete list of side effects and others may occur. Modify Therapy/Monitor Closely. Serious - Use Alternative (1)azithromycin will increase the level or effect of riociguat by decreasing metabolism. Use Caution/Monitor. Risk of prolonged QTc interval. lofepramine and azithromycin both increase QTc interval. Use Caution/Monitor. Indicated for treatment of acute bacterial exacerbations of chronic bronchitis due to Haemophilus influenzae, Moraxella catarrhalis, or Streptococcus pneumoniae 500 mg PO qDay for 3 days OR. Serious - Use Alternative (1)azithromycin increases toxicity of vilanterol/fluticasone furoate inhaled by QTc interval. Serious - Use Alternative (1)buprenorphine subdermal implant and azithromycin both increase QTc interval. Modify Therapy/Monitor Closely. azithromycin and octreotide (Antidote) both increase QTc interval. ZITHROMAX 500 mg tablets are supplied as pink modified capsular shaped, engraved, film-coated tablets containing azithromycin dihydrate equivalent to 500 mg of azithromycin. Serious - Use Alternative (1)arsenic trioxide and azithromycin both increase QTc interval. azithromycin increases levels of rifaximin by P-glycoprotein (MDR1) efflux transporter. Serious - Use Alternative (1)cobicistat, azithromycin. Low risk of contraceptive failure. Serious - Use Alternative (1)anagrelide and azithromycin both increase QTc interval. Wait until Abx Tx complete to administer live bacterial vaccine. Minor (1)azithromycin increases toxicity of pimavanserin by QTc interval. This drug is available at the lowest co-pay. Minor/Significance Unknown. Modify Therapy/Monitor Closely. Do not drive, use machinery, or do any activity that requires clear vision until you are sure you can perform such activities safely.During pregnancy, this medication should be used only when clearly needed. Applies only to oral forms of hormone. goserelin increases toxicity of azithromycin by QTc interval. Monitor Closely (1)osilodrostat and azithromycin both increase QTc interval. 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