When is azathioprine used? Avoid or Use Alternate Drug. Risk of neutropenia. Comment: Pretomanid regimen associated with hepatotoxicity. Use Caution/Monitor. Last updated on Jan 27, 2023. Serious - Use Alternative (1)azathioprine decreases effects of anthrax vaccine by pharmacodynamic antagonism. Azathioprine 50 MG Tablet acts as an immuno-suppressant drug, which is used to treat ulcerative colitis, rheumatoid arthritis, Crohn's disease, and in kidney transplants to prevent the rejection of a new kidney. trastuzumab deruxtecan, azathioprine. Either increases effects of the other by immunosuppressive effects; risk of infection. Caution should be taken in patients on concomitant immunosuppressants or with impaired immune systems because of increased risk for serious infections. azathioprine decreases effects of diphtheria & tetanus toxoids/acellular pertussis/poliovirus, inactivated vaccine by pharmacodynamic antagonism. Contraindicated. 25mg 50mg 75mg 100mg. Avoid or Use Alternate Drug. Contraindicated. NOTES: Do not share this medication with others.Lab and/or medical tests (such as complete blood count, liver/kidney function) should be done while you are taking this medication. Do not use medications containing mercaptopurine while using azathioprine. Monitor Closely (1)azathioprine decreases effects of zoster vaccine recombinant by pharmacodynamic antagonism. Monitor Closely (1)azathioprine, hydroxyurea. Risk of neutropenia. Serious - Use Alternative (1)azathioprine decreases effects of rabies vaccine by pharmacodynamic antagonism. azathioprine decreases effects of pneumococcal vaccine heptavalent by pharmacodynamic antagonism. Mechanism: pharmacodynamic synergism. Avoid or Use Alternate Drug. Use Caution/Monitor. Monitor Closely (1)azathioprine decreases effects of dengue vaccine by immunosuppressive effects; risk of infection. Get medical help right away if you have any of these side effects: clumsiness, loss of coordination/balance, weakness, sudden change in your thinking (such as confusion, difficulty concentrating, memory loss), difficulty talking/walking, seizure, vision changes.A very serious allergic reaction to this drug is rare. Contraindicated. captopril, azathioprine. azathioprine decreases effects of measles, mumps, rubella and varicella vaccine, live by pharmacodynamic antagonism. Always ask your health care professional for complete information about this product and your specific health needs. Contraindicated (1)azathioprine, upadacitinib. Contraindicated. azathioprine decreases effects of pneumococcal vaccine polyvalent by pharmacodynamic antagonism. Effect of interaction is not clear, use caution. Take this medication with food to reduce stomach upset.The dosage is based on your medical condition, weight, and response to treatment. Coadministration of ocrelizumab with immunosuppessants is expected to increase the risk of immunosuppression. Serious - Use Alternative (1)azathioprine and tongkat ali both increase immunosuppressive effects; risk of infection. azathioprine decreases effects of travelers diarrhea and cholera vaccine inactivated by pharmacodynamic antagonism. Tablet Powder for solution for injection Drug action For azathioprine Azathioprine is metabolised to mercaptopurine. Keep all medical and lab appointments. Either increases toxicity of the other by immunosuppressive effects; risk of infection. antithymocyte globulin equine and azathioprine both increase immunosuppressive effects; risk of infection. This will help to stop any feelings of queasiness or nausea. Immunosuppressive therapies, including irradiation, antimetabolites, alkylating agents, cytotoxic drugs, and corticosteroids (used in greater than physiologic doses), may reduce the immune responses to vaccines. Avoid or Use Alternate Drug. Share cases and questions with Physicians on Medscape consult. Immunosuppressants may interfere with development of active immunity. Please confirm that you would like to log out of Medscape. Mechanism: pharmacodynamic synergism. azathioprine decreases effects of hepatitis a/typhoid vaccine by pharmacodynamic antagonism. Contraindicated. Immunosuppressants also increase risk of infection with concomitant live vaccines. Avoid or Use Alternate Drug. Serious - Use Alternative (1)azathioprine, pretomanid. Stay away from anyone who has an infection that may easily spread (such as chickenpox, COVID-19, measles, flu). Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. Increased risk of myelosuppression. When switching from drugs with prolonged immune effects, consider the half-life and mode of action of these drugs in order to avoid unintended additive immunosuppressive effects. Monitor Closely (1)azathioprine, denosumab. Use caution when switching patients from long-acting therapies with immune effects. Consult your pharmacist or local waste disposal company. Minor/Significance Unknown. Comments: Initial dose: 1 mg/kg (50 to 100 mg) orally or IV per day given in 1 to 2 divided doses Contraindicated. Avoid or Use Alternate Drug. IMPORTANT: HOW TO USE THIS INFORMATION: This is a summary and does NOT have all possible information about this product. azathioprine decreases effects of influenza virus vaccine quadrivalent, intranasal by pharmacodynamic antagonism. Avoid or Use Alternate Drug. Use Caution/Monitor. Avoid or Use Alternate Drug. azathioprine decreases effects of typhoid vaccine live by pharmacodynamic antagonism. Avoid contact with people who have recently received live vaccines (such as flu vaccine inhaled through the nose).To lower the chance of getting cut, bruised, or injured, use caution with sharp objects like razors and nail cutters, and avoid activities such as contact sports.Since this drug can be absorbed through the skin and lungs and may harm an unborn baby, women who are pregnant or who may become pregnant should not handle this medication or breathe the dust from the tablets.Tell your doctor if you are pregnant or plan to become pregnant. Monitor Closely (1)azathioprine decreases effects of meningococcal group B vaccine by pharmacodynamic antagonism. Serious - Use Alternative (1)antithymocyte globulin rabbit and azathioprine both increase immunosuppressive effects; risk of infection. Neutropenia or febrile neutropenia incidence were increased when trastuzumab was coadministered with myelosuppressive chemotherapy. restrictions. azathioprine decreases effects of hepatitis b vaccine by pharmacodynamic antagonism. azathioprine decreases effects of rabies vaccine by pharmacodynamic antagonism. Contraindicated. Comments: Studies: Contraindicated. Monitor Closely (1)quinapril, azathioprine. HOW TO USE: Take this medication by mouth as directed by your doctor, usually once or twice daily. Avoid or Use Alternate Drug. Monitor Closely (1)azathioprine and isavuconazonium sulfate both decrease immunosuppressive effects; risk of infection. Immunosuppressants also increase risk of infection with concomitant live vaccines. Contraindicated. Avoid alcohol and hepatotoxic agents, including herbal supplements and drugs other than bedaquiline and linezolid. Contraindicated. 35. mesalamine increases toxicity of azathioprine by Mechanism: unspecified interaction mechanism. Contraindicated. Immunosuppressants also increase risk of infection with concomitant live vaccines. Greater than 6 years: 2.5 to 3.5 mg/kg per day in patients with normal levels of thiopurine methyltransferase. Pexidartinib can cause hepatotoxicity. Mechanism: pharmacodynamic synergism. Avoid or Use Alternate Drug. Mechanism: pharmacodynamic synergism. Risk of neutropenia. If it is near the time of the next dose, skip the missed dose. Monitor Closely (1)enalapril, azathioprine. Patients vaccinated within a 14-day period before starting or during immunosuppressive therapy should be revaccinated =3 months after therapy is discontinued if immune competence has been restored. Contraindicated. Avoid or Use Alternate Drug. This usually comes out to 50 mg to 150 mg per day. Patients with MG may have to stay on this medication indefinitely-- it is a long-term treatment. Immunosuppressants also increase risk of infection with concomitant live vaccines. Mechanism: pharmacodynamic synergism. Use Caution/Monitor. Immunosuppressive therapies, including irradiation, antimetabolites, alkylating agents, cytotoxic drugs and corticosteroids (used in greater than physiologic doses), may reduce the immune response to cholera vaccine. azathioprine decreases effects of tetanus toxoid adsorbed or fluid by pharmacodynamic antagonism. azathioprine and everolimus both increase immunosuppressive effects; risk of infection. Serious - Use Alternative (1)azathioprine decreases effects of influenza virus vaccine trivalent, adjuvanted by pharmacodynamic antagonism. Introduction How does azathioprine work? Serious - Use Alternative (1)azathioprine and tacrolimus both increase immunosuppressive effects; risk of infection. Avoid or Use Alternate Drug. Because of extensive Contraindicated. Erectile dysfunction (ED) is often a symptom . Use Caution/Monitor. Use Caution/Monitor. Immunosuppressive drugs may reduce the immune response to influenza vaccine. alefacept and azathioprine both increase immunosuppressive effects; risk of infection. Immunosuppressants also increase risk of infection with concomitant live vaccines. azathioprine decreases effects of phenindione by unknown mechanism. In this condition, the body's defense system (immune system) attacks healthy joints. Contraindicated. Therapeutic response occurs after several weeks of therapy, usually 6 to 8 weeks. Initial dose: 2 mg/kg per day in combination with prednisolone 0.6 to 0.8 mg/kg per day, with prednisolone reduced to 0.1 mg/kg within 2 to 3 months Use Caution/Monitor. Avoid or Use Alternate Drug. azathioprine decreases effects of dengue vaccine by immunosuppressive effects; risk of infection. Risk of neutropenia. Immunosuppressive drugs may reduce the immune response to influenza vaccine. Patients vaccinated within a 14-day period before starting or during immunosuppressive therapy should be revaccinated =3 months after therapy is discontinued if immune competence has been restored. Use Caution/Monitor. Immunosuppressants also increase risk of infection with concomitant live vaccines. quinapril, azathioprine. Either increases effects of the other by immunosuppressive effects; risk of infection. Use Caution/Monitor. Use Caution/Monitor. Avoid or Use Alternate Drug. Avoid or Use Alternate Drug. Use Caution/Monitor. Serious - Use Alternative (1)azathioprine decreases effects of hepatitis A vaccine inactivated by pharmacodynamic antagonism. Use Caution/Monitor. Serious - Use Alternative (1)azathioprine decreases effects of influenza virus vaccine trivalent by pharmacodynamic antagonism. Do not increase your dose or use this drug more often or for longer than prescribed. Immunosuppressants also increase risk of infection with concomitant live vaccines. azathioprine decreases effects of heparin by unknown mechanism. Minor/Significance Unknown. Monitor Closely (1)mipomersen, azathioprine. Each scored tablet contains 50 mg azathioprine and the inactive ingredients lactose, magnesium stearate, potato starch, povidone, and stearic acid. Crush one-hundred-twenty 50 mg tablets in a mortar and reduce to a fine powder. Use Caution/Monitor. See WARNINGS. Avoid or Use Alternate Drug. This will be a single-dose, open-label, randomised, two-period crossover study with orally administered 1 x 5mL (50 mg) of Jayempi Oral Suspension 10mg/mL versus oral azathioprine tablet 50mg (Imurek, Aspen Pharma Trading Limited, Dublin, Ireland) on two separate occasions conducted under fasting conditions in healthy male and female subjects at a single study centre. Contraindicated. Risk of neutropenia. Use Caution/Monitor. Lupus Nephritis: ozanimod, azathioprine. Use Caution/Monitor. Avoid or Use Alternate Drug. Immunosuppressive drugs may reduce the immune response to influenza vaccine. Coadministration with ifosfamide may increase the risk of immunosuppression and myelosuppression. Contraindicated. Use Caution/Monitor. being unable to get an erection at any time. Serious - Use Alternative (1)azathioprine decreases effects of adenovirus types 4 and 7 live, oral by pharmacodynamic antagonism. Consult your doctor if any of these side effects persist or worsen. Monitor Closely (1)azathioprine decreases effects of argatroban by unknown mechanism. Monitor Closely (1)trastuzumab, azathioprine. Immunosuppressants also increase risk of infection with concomitant live vaccines. Either increases toxicity of the other by pharmacodynamic synergism. trandolapril, azathioprine. Add 40 mL of the vehicle (1:1 mixture of Ora-Sweet and Ora-Plus . Contraindicated. azathioprine decreases effects of dalteparin by unknown mechanism. Do not take azathioprine during pregnancy and breastfeeding. Monitor Closely (1)ublituximab and azathioprine both increase immunosuppressive effects; risk of infection. Study (n=55) Immunosuppressive therapies may reduce the effectiveness of zoster vaccine recombinant. Use Caution/Monitor. Mechanism: pharmacodynamic synergism. It occurs due to the production of pathogenic autoantibodies that bind to components of the neuromuscular junction, the most common being the acetylcholinesterase receptor (AChR). Serious - Use Alternative (1)azathioprine, idecabtagene vicleucel. Contraindicated. Do not double the dose to catch up. mipomersen, azathioprine. lisinopril, azathioprine. Avoid or Use Alternate Drug. belatacept and azathioprine both increase immunosuppressive effects; risk of infection. Use Caution/Monitor. Risk of neutropenia. Pexidartinib can cause hepatotoxicity. Serious - Use Alternative (1)azathioprine decreases effects of diphtheria & tetanus toxoids/acellular pertussis/poliovirus, inactivated vaccine by pharmacodynamic antagonism. Monitor Closely (1)azathioprine decreases effects of antithrombin alfa by unknown mechanism. azathioprine decreases effects of cholera vaccine by immunosuppressive effects; risk of infection. Take your next dose at the regular time. Contraindicated. Serious - Use Alternative (1)azathioprine decreases effects of human papillomavirus vaccine, quadrivalent by pharmacodynamic antagonism. Avoid tanning booths and sunlamps. azathioprine decreases effects of rabies vaccine chick embryo cell derived by pharmacodynamic antagonism. This website also contains material copyrighted by 3rd parties. Written by Cerner Multum. Immunosuppressants also increase risk of infection with concomitant live vaccines. It is usually given as a single daily dose on the day of, and in some cases 1 to 3 days before, transplantation. Monitor Closely (1)azathioprine decreases effects of phenindione by unknown mechanism. Contraindicated. Avoid or Use Alternate Drug. Monitor Closely (1)ponesimod and azathioprine both increase immunosuppressive effects; risk of infection. Use Caution/Monitor. Use Caution/Monitor. This information is not individual medical advice and does not substitute for the advice of your health care professional. Serious - Use Alternative (1)azathioprine and hydroxychloroquine sulfate both increase immunosuppressive effects; risk of infection. Comment: Pretomanid regimen associated with hepatotoxicity. Dosage for Azasan The dose of Azasan required to prevent rejection and minimize toxicity varies. moexipril, azathioprine. When switching from drugs with prolonged immune effects, consider the half-life and mode of action of these drugs to avoid unintended additive immunosuppressive effects. oxaliplatin and azathioprine both increase immunosuppressive effects; risk of infection. Important warnings Other warnings Increased infection. Avoid or Use Alternate Drug. Capsule 50 mg 75 mg 100 mg Powder for injection 100 mg/vial Dosage Considerations - Should be Given as Follows: Kidney Transplantation Prevention of transplant rejection 3-5 mg/kg/day intravenously/orally initially on day of transplant or 3 days before transplant (rare) Maintenance: 1-3 mg/kg/day intravenously/orally Rheumatoid Arthritis Applies to the following strengths: 50 mg; 100 mg; 75 mg Usual Adult Dose for: Renal Transplant Rheumatoid Arthritis Crohn's Disease - Acute Crohn's Disease - Maintenance Chronic Inflammatory Demyelinating Polyradiculoneuropathy Atopic Dermatitis azathioprine decreases effects of diphtheria & tetanus toxoids/ acellular pertussis vaccine by pharmacodynamic antagonism. Use Caution/Monitor. The oral LD 50 s for single doses of azathioprine tablets in mice and rats are 2500 mg/kg and 400 mg/kg, respectively. Contraindicated. Immunosuppressive drugs may reduce the immune response to influenza vaccine. Your list will be saved and can be edited at any time. Serious - Use Alternative (1)azathioprine decreases effects of hepatitis a/typhoid vaccine by pharmacodynamic antagonism. Serious - Use Alternative (1)azathioprine decreases effects of tetanus toxoid adsorbed or fluid by pharmacodynamic antagonism. Either increases toxicity of the other by pharmacodynamic synergism. Either increases effects of the other by immunosuppressive effects; risk of infection. . Use Caution/Monitor. Use Caution/Monitor. azathioprine and tacrolimus both increase immunosuppressive effects; risk of infection. commonly, these are "non-preferred" brand drugs or specialty ramipril, azathioprine. Avoid or Use Alternate Drug. Avoid coadministration of pexidartinib with other products know to cause hepatoxicity. Serious - Use Alternative (1)azathioprine decreases effects of measles (rubeola) vaccine by pharmacodynamic antagonism. Contraindicated. What are the side effects of azathioprine? Serious - Use Alternative (1)alefacept and azathioprine both increase immunosuppressive effects; risk of infection. azathioprine decreases effects of meningococcal group B vaccine by pharmacodynamic antagonism. Ask your doctor for details.Azathioprine can make you more likely to get infections or may make current infections worse. Serious - Use Alternative (1)azathioprine decreases effects of human papillomavirus vaccine, nonavalent by pharmacodynamic antagonism. IV: Doses should generally be infused over 30 to 60 minutes; it may be administered over 5 minutes and, for the daily dose, over 8 hours, IV: Once reconstituted, the solution for injection should be used within 24 hours, TPMT testing may be required in patients with abnormal CBC results that do not respond to dose reduction, Treatment cessation may be required for severe hematologic or other toxicity, Appropriate handling procedures for immunosuppressive agents according to local guidelines should be considered, Hematologic: CBC, including platelet count, weekly for the first month, twice a month for the second and third months, then once a month or more often if necessary, Immunologic: Signs and symptoms of infection, Minimize exposure to sunlight and UV light by wearing protective clothing and using a sunscreen with a high protection factor, Report any unusual bleeding or bruising, or signs and symptoms of infection. azathioprine, brexucabtagene autoleucel. 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