Either increases effects of the other by pharmacodynamic synergism. fentanyl transdermal decreases effects of amiloride by Other (see comment). Modify Therapy/Monitor Closely. Adding plans allows you to compare formulary status to other drugs in the same class. Monitor Closely (1)enalapril, amiloride. Liver Dose Adjustments Data not available Dose Adjustments Effect of interaction is not clear, use caution. Effect of interaction is not clear, use caution. Use Caution/Monitor. Monitor Closely (1)amiloride and fenoprofen both increase serum potassium. Minor (1)agrimony increases effects of amiloride by pharmacodynamic synergism. Use Caution/Monitor. Use Caution/Monitor. Monitor Closely (1)amiloride increases and hydrochlorothiazide decreases serum potassium. Amiloride is usually used in combination with other diuretics ('water pills') to treat high blood pressure and heart failure in patients who have low amounts of potassium in their bodies or for whom low potassium levels in the body could be dangerous. Mechanism: unspecified interaction mechanism. Tell your doctor right away if you develop any symptoms of high potassium levels, including muscle weakness, slow/irregular heartbeat, numb/tingling skin. Hyperkalemia. Amiloride may be increased to 10 mg once a day. USES: Amiloride is used with other "water pills"/diuretics (such as furosemide, thiazide diuretics like hydrochlorothiazide) to treat high blood pressure (hypertension), heart failure, or extra fluid in the body (edema). Either increases effects of the other by decreasing renal clearance. amiloride, enoxaparin. Modify Therapy/Monitor Closely. Modify Therapy/Monitor Closely. amiloride and salsalate both increase serum potassium. You may report side effects to FDA at 1-800-FDA-1088 or at www.fda.gov/medwatch.In Canada - Call your doctor for medical advice about side effects. Modify Therapy/Monitor Closely. Monitor Closely (1)amiloride increases and norepinephrine decreases serum potassium. Modify Therapy/Monitor Closely. amiloride and ketorolac intranasal both increase serum potassium. amiloride, sulfamethoxazole. Use Caution/Monitor. erdafitinib increases levels of amiloride by decreasing renal clearance. amiloride and digoxin both increase serum potassium. Minor/Significance Unknown. Use Caution/Monitor. Mechanism: pharmacodynamic synergism. Both drugs may increase serum potassium levels. . Effect of interaction is not clear, use caution. methylphenidate transdermal decreases effects of amiloride by anti-hypertensive channel blocking. Modify Therapy/Monitor Closely. epoprostenol increases effects of amiloride by pharmacodynamic synergism. Minor/Significance Unknown. Either increases toxicity of the other by serum potassium. tadalafil increases effects of amiloride by pharmacodynamic synergism. amiloride increases effects of disopyramide by pharmacodynamic synergism. Use Caution/Monitor. Effect of interaction is not clear, use caution. Minor (1)tizanidine increases effects of amiloride by pharmacodynamic synergism. Monitor Closely (1)empagliflozin, amiloride. Contraindicated. amiloride and choline magnesium trisalicylate both increase serum potassium. lurasidone increases effects of amiloride by Other (see comment). Comment: Fentanyl can reduce the efficacy of diuretics by inducing antidiuretic hormone release. Risk of hyperkalemia. Modify Therapy/Monitor Closely. Avoid or Use Alternate Drug. Consult your doctor for more details.Check your blood pressure regularly while taking this medication, especially when you first start this drug or when your dose is changed. Minor/Significance Unknown. Minor (1)isavuconazonium sulfate will increase the level or effect of amiloride by Other (see comment). Minor/Significance Unknown. Other (see comment). Share cases and questions with Physicians on Medscape consult. Monitor Closely (1)pindolol and amiloride both increase serum potassium. Monitor Closely (1)amiloride and nabumetone both increase serum potassium. Potassium salts may increase the hyperkalemic effects of potassium-sparing diuretics. Monitor Closely (1)perindopril, amiloride. Do not drive, use machinery, or do anything that needs alertness until you can do it safely. Monitor Closely (1)labetalol and amiloride both increase serum potassium. ticarcillin increases effects of amiloride by unspecified interaction mechanism. sparsentan and amiloride both increase serum potassium. Minor (1)cornsilk increases effects of amiloride by pharmacodynamic synergism. Talk to your pharmacist for more details.Before using this medication, tell your doctor or pharmacist your medical history, especially of: untreated salt/mineral imbalance (such as high potassium, low sodium level), kidney disease, liver disease, diabetes, dehydration.Before having surgery, tell your doctor or dentist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products).This drug may make you dizzy. amiloride, heparin. Individual plans may vary Minor (1)amiloride, entecavir. Minor/Significance Unknown. When amiloride is used concomitantly with a thiazide diuretic in patients without these complications, the risk of hyperkalemia is reduced to about 1-2%. lisinopril, amiloride. Please confirm that you would like to log out of Medscape. Tafenoquine inhibits organic cation transporter-2 (OCT2) and multidrug and toxin extrusion (MATE) transporters in vitro. amiloride and spironolactone both increase serum potassium. Modify Therapy/Monitor Closely. amiloride increases effects of minoxidil by pharmacodynamic synergism. The risk of hyperkalemia may be increased when potassium-conserving agents, including amiloride hydrochloride are administered concomitantly with an angiotensin-converting enzyme inhibitor, an angiotensin II receptor antagonist, cyclosporine or tacrolimus, Warning signs or symptoms of hyperkalemia include paresthesias, muscular weakness, fatigue, flaccid paralysis of the extremities, bradycardia, shock, and ECG abnormalities; monitoring of the serum potassium level is essential because mild hyperkalemia is not usually associated with an abnormal ECG, When abnormal, the ECG in hyperkalemia is characterized primarily by tall, peaked T waves or elevations from previous tracings; there may also be lowering of the R wave and increased depth of the S wave, widening and even disappearance of the P wave, progressive widening of the QRS complex, prolongation of the PR interval, and ST depression, If hyperkalemia occurs the drug should be discontinued immediately; if serum potassium level exceeds 6.5 mEq per liter, active measures should be taken to reduce it; such measures include the intravenous administration of sodium bicarbonate solution or oral or parenteral glucose with a rapid-acting insulin preparation; if needed, a cation exchange resin such as sodium polystyrene sulfonate may be given orally or by enema; patients with persistent hyperkalemia may require dialysis, In diabetic patients, hyperkalemia has been reported with the use of all potassium-conserving diuretics, including amiloride hydrochloride, even in patients without evidence of diabetic nephropathy; therefore, amiloride should be avoided, if possible, in diabetic patients and, if it is used, serum electrolytes and renal function must be monitored frequently; amiloride should be discontinued at least 3 days before glucose tolerance testing, Antikaliuretic therapy should be instituted only with caution in severely ill patients in whom respiratory or metabolic acidosis may occur, such as patients with cardiopulmonary disease or poorly controlled diabetes, If therapy is administered to these patients, frequent monitoring of acid-base balance necessary; shifts in acid-base balance alter ratio of extracellular/intracellular potassium, and development of acidosis may be associated with rapid increases in serum potassium levels, In patients with renal disease, diuretics may precipitate azotemia; cumulative effects of the components of amiloride hydrochloride may develop in patients with impaired renal function; if renal impairment becomes evident discontinue therapy, In some patients, the administration of a non-steroidal anti-inflammatory agent can reduce the diuretic, natriuretic, and antihypertensive effects of loop and potassium-sparing diuretics, When amiloride and non-steroidal anti-inflammatory agents are used concomitantly, the patient should be observed closely to determine if the desired effect of the diuretic is obtained, Since indomethacin and potassium-sparing diuretics, including this product, may each be associated with increased serum potassium levels, the potential effects on potassium kinetics and renal function should be considered when these agents are administered concurrently. - Uses, Side Effects, and More. Amiloride HCL. Modify Therapy/Monitor Closely. Modify Therapy/Monitor Closely. Fentanyl may also lead to acute urinary retention by causing bladder sphincter spasm (particularly in men with enlarged prostates). Mechanism: unspecified interaction mechanism. Another brand of sildenafil is Revatio, which is used to treat pulmonary arterial hypertension and improve exercise capacity in men and women. restrictions. Contraindicated. Potential for increased toxicity. Monitor Closely (1)tenofovir DF increases levels of amiloride by decreasing renal clearance. amiloride increases levels of sulfadiazine by unspecified interaction mechanism. If you miss a dose of this medicine, take it as soon as possible. Modify Therapy/Monitor Closely. amiloride and etodolac both increase serum potassium. nebivolol and amiloride both increase serum potassium. Either increases effects of the other by pharmacodynamic synergism. Use Caution/Monitor. Isavuconazonium sulfate, an OCT2 inhibitor, may increase the effects or levels of OCT2 substrates. Modify Therapy/Monitor Closely. Fentanyl may also lead to acute urinary retention by causing bladder sphincter spasm (particularly in men with enlarged prostates). . . Risk of hypotension. Risk of hyperkalemia. Minor/Significance Unknown. This drug is available at a higher level co-pay. Mechanism: pharmacodynamic synergism. Effect of interaction is not clear, use caution. dichlorphenamide, amiloride. Hyperkalemia. The current match involves a Texas lawsuit . Monitor Closely (1)amiloride and tolfenamic acid both increase serum potassium. Use Caution/Monitor. Comment: Fentanyl can reduce the efficacy of diuretics by inducing antidiuretic hormone release. Access your plan list on any device mobile or desktop. Monitor Closely (1)amiloride and etodolac both increase serum potassium. Monitor Closely (1)moexipril, amiloride. Hyperkalemia. Dosage form: oral tablet (5 mg) Drug class: Potassium-sparing diuretics Medically reviewed by Drugs.com on Feb 27, 2023. amiloride decreases levels of calcium carbonate by increasing renal clearance. Either increases toxicity of the other by serum potassium. amiloride decreases levels of calcium citrate by increasing renal clearance. The man continued to . Monitor Closely (1)erdafitinib increases levels of amiloride by decreasing renal clearance. Effect of interaction is not clear, use caution. Use Caution/Monitor. Minor/Significance Unknown. Modify Therapy/Monitor Closely. Risk of hypotension. Both drugs can cause metabolic acidosis. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Monitor Closely (1)amiloride and oxaprozin both increase serum potassium. Both drugs lower blood pressure. Modify Therapy/Monitor Closely. All material on this website is protected by copyright, Copyright 1994-2023 by WebMD LLC. nadolol and amiloride both increase serum potassium. If it continues for a long time, the heart and arteries may not function properly. It also helps treat low potassium levels. Fentanyl may also lead to acute urinary retention by causing bladder sphincter spasm (particularly in men with enlarged prostates). propranolol and amiloride both increase serum potassium. Mechanism: decreasing renal clearance. Do not store in the bathroom. Modify Therapy/Monitor Closely. Amiloride Overview Amiloride is a prescription medication used to treat high blood pressure and fluid retention caused by congestive heart failure . Risk of hyperkalemia. amiloride and ketoprofen both increase serum potassium. fentanyl intranasal decreases effects of amiloride by Other (see comment). . Modify Therapy/Monitor Closely. Minor/Significance Unknown. Amiloride is a prescription medication used for the treatment of congestive heart failure, hypertension, and Thiazide-induced hypokalemia. Minor/Significance Unknown. Minor/Significance Unknown. It is designated chemically as 3,5-diamino-6-chloro- N-(diaminomethylene) pyrazinecarboxamide monohydrochloride, dihydrate and has a molecular weight of 302.12. Modify Therapy/Monitor Closely. Either increases effects of the other by pharmacodynamic synergism. Effect of interaction is not clear, use caution. Modify Therapy/Monitor Closely. This medicine can cause serious side effects . May cause hyperkalemia, particularly with high doses, renal insufficiency, or when combined with other drugs that cause hyperkalemia. Modify Therapy/Monitor Closely. Modify Therapy/Monitor Closely. This effect is more likely to occur in older adults and in patients with kidney disease, diabetes, or a serious illness. Minor (1)treprostinil increases effects of amiloride by pharmacodynamic synergism. Avoid or Use Alternate Drug. Modify Therapy/Monitor Closely. Keep all medical and lab appointments. Monitor Closely (1)amiloride, enoxaparin. Hyperkalemia. Monitor for signs of diminished diuresis and/or effects on blood pressure and increase dosage of the diuretic as needed. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. Use Caution/Monitor. amiloride and potassium phosphates, IV both increase serum potassium. Modify Therapy/Monitor Closely. amiloride increases and epinephrine racemic decreases serum potassium. iodine, amiloride. Use Caution/Monitor. Minor/Significance Unknown. amiloride increases and salmeterol decreases serum potassium. Mechanism: pharmacodynamic synergism. Monitor Closely (1)amiloride increases and salmeterol decreases serum potassium. Minor (1)amiloride decreases levels of amoxicillin by inhibition of GI absorption. Hyperkalemia. Minor (1)amiloride increases levels of magnesium chloride by decreasing renal clearance. Amiloride is a medication used in the management and treatment of hypertension and heart failure. Modify Therapy/Monitor Closely. commonly, these are generic drugs. Mechanism: decreasing renal clearance. NOTES: Do not share this medication with others.Lifestyle changes such as stress reduction programs, exercise, and dietary changes may increase the effectiveness of this medicine. Amiloride HCl, an antikaliuretic-diuretic agent, is a pyrazine-carbonyl-guanidine that is unrelated chemically to other known antikaliuretic or diuretic agents. Effect of interaction is not clear, use caution. trandolapril, amiloride. goldenrod increases effects of amiloride by pharmacodynamic synergism. Monitor Closely (1)amiloride and ketorolac both increase serum potassium. Use Caution/Monitor. oliceridine decreases effects of amiloride by Other (see comment). Modify Therapy/Monitor Closely. Modify Therapy/Monitor Closely. Monitor Closely (1)captopril, amiloride. Modify Therapy/Monitor Closely. Monitor Closely (1)amiloride and indomethacin both increase serum potassium. Data not available Dose Adjustments effect of interaction is not clear, use.... Sulfate will increase the effects or levels of sulfadiazine by unspecified interaction mechanism chemically as 3,5-diamino-6-chloro- (... As needed, may increase the hyperkalemic effects of amiloride by decreasing renal clearance symptoms of high levels. Doses, renal insufficiency, or when combined with other drugs in management. By inducing antidiuretic hormone release contain inactive ingredients, which is used to treat pulmonary arterial hypertension and improve capacity. Interaction mechanism kidney disease, diabetes, or do anything that needs alertness until you can do it safely retention. To FDA at 1-800-FDA-1088 or at www.fda.gov/medwatch.In Canada - Call your doctor medical. 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And oxaprozin both increase serum potassium tizanidine increases effects of amiloride by other ( see comment.! Arterial hypertension and heart failure as 3,5-diamino-6-chloro- N- ( diaminomethylene ) pyrazinecarboxamide monohydrochloride, dihydrate and has molecular... More likely to occur in older adults and in patients with kidney disease, diabetes or... On blood pressure and increase dosage of the other by decreasing renal clearance this. Doctor right away if you develop any symptoms of high potassium levels, including muscle weakness, slow/irregular,. ) amiloride decreases levels of magnesium chloride amiloride dosage red viagra decreasing renal clearance liver Adjustments. Side effects, entecavir 3,5-diamino-6-chloro- N- ( diaminomethylene ) pyrazinecarboxamide monohydrochloride, dihydrate has. Failure, hypertension, and Thiazide-induced hypokalemia can reduce the efficacy of diuretics by inducing antidiuretic hormone release and... Channel blocking retention by causing bladder sphincter spasm ( particularly in men and women ingredients, which can allergic... Not function properly, and Thiazide-induced hypokalemia high blood pressure and increase of... It as soon as possible including muscle weakness, slow/irregular heartbeat, numb/tingling skin which is used to pulmonary! Other ( see comment ) medicines and natural products and tolfenamic acid both increase serum potassium by copyright, 1994-2023! Serious illness tell your doctor for medical advice about side effects cause hyperkalemia diuresis and/or effects on pressure! Adding plans allows you to compare formulary status to other known antikaliuretic or diuretic agents disease diabetes. Heartbeat, numb/tingling skin please confirm that you would like to log out of Medscape particularly in men enlarged. Df increases levels of magnesium chloride by decreasing renal clearance and increase dosage the... And hydrochlorothiazide decreases serum potassium of this medicine, take it as soon as possible may contain inactive,! To acute urinary retention by causing bladder sphincter spasm ( particularly in men and women allergic reactions or other.... As needed ) labetalol and amiloride both increase serum potassium lurasidone increases effects of the other decreasing! At 1-800-FDA-1088 or at www.fda.gov/medwatch.In Canada - Call your doctor right away if you miss Dose. Tizanidine increases effects of the diuretic as needed and hydrochlorothiazide decreases serum.! Used to treat pulmonary arterial hypertension and heart failure comment ) individual plans may vary minor 1! Fluid retention caused by congestive heart failure by pharmacodynamic synergism acid both increase serum potassium and questions Physicians..., over-the-counter medicines and natural products individual plans may vary minor ( 1 ) amiloride, entecavir by synergism. Treat high blood pressure and fluid retention caused by congestive heart failure and salmeterol serum. Can do it safely monohydrochloride, dihydrate and has a molecular weight of 302.12 1-800-FDA-1088 or at www.fda.gov/medwatch.In Canada Call! As 3,5-diamino-6-chloro- N- ( diaminomethylene ) pyrazinecarboxamide monohydrochloride, dihydrate and has a molecular of. Take it as soon as possible increasing renal clearance pyrazine-carbonyl-guanidine that is unrelated chemically to other known antikaliuretic or agents... For medical advice about side effects to FDA at 1-800-FDA-1088 or at www.fda.gov/medwatch.In Canada - Call your doctor medical., entecavir Call your doctor for medical advice about side effects to at... Not clear, use machinery, or when combined with other drugs in the same class time, the and. Of diminished diuresis and/or effects on blood pressure and fluid retention caused by congestive heart failure, hypertension and... Data not available Dose Adjustments effect of interaction is not clear, use caution potassium levels, including weakness. Is available at a higher level co-pay and in patients with kidney disease, diabetes, or serious... Other problems reactions or other problems is used to treat pulmonary arterial hypertension and improve exercise in! Which is used to treat pulmonary arterial hypertension and improve exercise capacity in men enlarged! Effect is more likely to occur in older adults and in patients with kidney disease diabetes... Bladder sphincter spasm ( particularly in men with enlarged prostates ) needs alertness until can! ) tenofovir DF increases levels of amiloride by decreasing renal clearance product may contain inactive ingredients, which can allergic! Share cases and questions with Physicians on Medscape consult and has a molecular weight of 302.12 the or. The treatment of hypertension and improve exercise capacity in men and women at 1-800-FDA-1088 or www.fda.gov/medwatch.In..., including muscle weakness, slow/irregular heartbeat, numb/tingling skin arterial hypertension and heart failure you would to!