Use Caution/Monitor.serdexmethylphenidate/dexmethylphenidate and pseudoephedrine both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Monitor Closely (2)arformoterol and pseudoephedrine both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor. Either increases toxicity of the other by Other (see comment). Use Caution/Monitor.ibuprofen and piroxicam both increase serum potassium. Ergot derivatives may enhance the vasoconstricting effect of pseudoephedrine and eventually significantly increasing blood pressure. Minor/Significance Unknown. Ibuprofen / pseudoephedrine systemic 200 mg / 30 mg (083), Motrin IB Sinus, Sine-Aid IB, Dayquil Pressure and Pain Caplet, Motrin Cold and Flu, Motrin Childrens Cold, Motrin Sinus Headache, Dimetapp Childrens Cold and Fever, Children's Ibuprofen Cold Relief. Monitor Closely (1)nefazodone, ibuprofen. Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed. Increased risk of upper GI bleeding. timolol and ibuprofen both increase serum potassium. Use Caution/Monitor. Increased risk of upper GI bleeding. isoproterenol and pseudoephedrine both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. bromocriptine, pseudoephedrine. Minor/Significance Unknown. Use Caution/Monitor. NSAIDs may diminish the antihypertensive effect of ACE inhibitors. Monitor Closely (1)fish oil triglycerides will increase the level or effect of ibuprofen by anticoagulation. ibuprofen will increase the level or effect of terbinafine by affecting hepatic enzyme CYP2C9/10 metabolism. Minor/Significance Unknown. Use Caution/Monitor. Use Caution/Monitor. Either increases toxicity of the other by pharmacodynamic synergism. Avoid or Use Alternate Drug. Minor/Significance Unknown. Use Caution/Monitor.ibuprofen decreases effects of propranolol by pharmacodynamic antagonism. Use Caution/Monitor. meclofenamate and ibuprofen both increase anticoagulation. Ibuprofen and pseudoephedrine is a combination medicine used to treat stuffy nose, sinus congestion, cough, and pain or fever caused by the common cold or flu. Modify Therapy/Monitor Closely. ibuprofen and forskolin both increase anticoagulation. Coadministration may result in a significant decrease in renal function. Avoid or Use Alternate Drug. ibuprofen will increase the level or effect of chlorpropamide by acidic (anionic) drug competition for renal tubular clearance. Either increases toxicity of the other by Other (see comment). Either increases toxicity of the other by pharmacodynamic synergism. Avoid or Use Alternate Drug. Use Caution/Monitor. SSRIs inhib. Avoid or Use Alternate Drug. Modify Therapy/Monitor Closely. Long term (>1 wk) NSAID use. Other (see comment). duloxetine, ibuprofen. Avoid or Use Alternate Drug. Comment: Increased risk of CNS stimulation and seizures with high doses of fluoroquinolones. Either increases toxicity of the other by pharmacodynamic synergism. Monitor Closely (1)ibuprofen, deflazacort. serotonin uptake by platelets.Serious - Use Alternative (1)milnacipran increases effects of pseudoephedrine by sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Each drug may increase the photosensitizing effect of the other. spironolactone and ibuprofen both increase serum potassium. Use Caution/Monitor. the smallest effective dose should be used. Monitor Closely (1)defibrotide increases effects of ibuprofen by P-glycoprotein (MDR1) efflux transporter. Risk of cardiac arrhythmia or sudden death, more likely w/thioridazine than other phenothiazines. ibuprofen increases and cyclopenthiazide decreases serum potassium. Monitor Closely (2)ibuprofen decreases effects of penbutolol by pharmacodynamic antagonism. Use Caution/Monitor. Monitor Closely (2)ibuprofen decreases effects of silodosin by pharmacodynamic antagonism. But you'll have to purchase it from behind the pharmacy counter because of the pseudoephedrine. Monitor Closely (2)ibuprofen and choline magnesium trisalicylate both increase anticoagulation. Use Caution/Monitor. ibuprofen and mefenamic acid both increase serum potassium. irbesartan and ibuprofen both increase serum potassium. Ibuprofen can increase your risk of fatal heart attack or stroke, even if you don't have any risk factors. lofepramine, pseudoephedrine. Monitor Closely (1)dabigatran and ibuprofen both increase anticoagulation. Ergot derivatives may enhance the vasoconstricting effect of pseudoephedrine and eventually significantly increasing blood pressure. ergoloid mesylates increases effects of pseudoephedrine by pharmacodynamic synergism. Effect of interaction is not clear, use caution. ibuprofen and ketorolac both increase anticoagulation. . ibuprofen and potassium chloride both increase serum potassium. hydralazine, pseudoephedrine. NSAIDs decrease prostaglandin synthesis. Either increases toxicity of the other by Other (see comment). Use Caution/Monitor. Coadministration may result in a significant decrease in renal function. Use Caution/Monitor. Coadministration may result in a significant decrease in renal function. Monitor Closely (1)sodium sulfate/?magnesium sulfate/potassium chloride increases toxicity of ibuprofen by Other (see comment). Toxicity may result from coadministration of tenofovir DF with other drugs that are also primarily excreted by glomerular filtration and/or active tubular secretion including high-dose or multiple-dose NSAIDs; alternatives to NSAIDs should be considered. Avoid or Use Alternate Drug. Monitor Closely (2)ibuprofen decreases effects of sotalol by pharmacodynamic antagonism. Avoid or Use Alternate Drug. Use Caution/Monitor. Minor (1)ibuprofen increases levels of vancomycin by decreasing renal clearance. Monitor Closely (1)dextroamphetamine and pseudoephedrine both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor. increases risk of bleeding. Either increases toxicity of the other by Other (see comment). Avoid or Use Alternate Drug. pharmacodynamic antagonism. Monitor Closely (1)ibuprofen decreases effects of phenoxybenzamine by pharmacodynamic antagonism. milnacipran increases effects of pseudoephedrine by sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor. ibuprofen will increase the level or effect of probenecid by acidic (anionic) drug competition for renal tubular clearance. Use Caution/Monitor.fenoprofen and ibuprofen both increase serum potassium. ibuprofen decreases effects of hydralazine by pharmacodynamic antagonism. Minor (1)creatine, ibuprofen. Use Caution/Monitor. Use Caution/Monitor. Monitor Closely (1)ibuprofen increases and carbenoxolone decreases serum potassium. Interaction more likely in certain predisposed pts. desvenlafaxine increases effects of pseudoephedrine by sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Monitor Closely (1)phenylephrine and pseudoephedrine both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Ergot derivatives may enhance the vasoconstricting effect of pseudoephedrine and eventually significantly increasing blood pressure. Modify Therapy/Monitor Closely. Effect of interaction is not clear, use caution. Monitor Closely (2)fluoxetine will increase the level or effect of ibuprofen by affecting hepatic enzyme CYP2C9/10 metabolism. Use Caution/Monitor. Use Caution/Monitor. Monitor Closely (1)phendimetrazine and pseudoephedrine both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Use Caution/Monitor. Use Caution/Monitor. Other (see comment). Modify Therapy/Monitor Closely. Use Caution/Monitor.Minor (1)ibuprofen decreases effects of furosemide by pharmacodynamic antagonism. Use Caution/Monitor. Use Caution/Monitor. only. Either increases toxicity of the other by Other (see comment). Modify Therapy/Monitor Closely. Minor/Significance Unknown. Use Caution/Monitor. Contraindicated. Either increases toxicity of the other by Other (see comment). Serious - Use Alternative (1)ibuprofen and apixaban both increase anticoagulation. Either increases toxicity of the other by Other (see comment). butalbital will decrease the level or effect of ibuprofen by affecting hepatic enzyme CYP2C9/10 metabolism. ibuprofen increases and methyclothiazide decreases serum potassium. Ergot derivatives may enhance the vasoconstricting effect of pseudoephedrine and eventually significantly increasing blood pressure. Avoid or Use Alternate Drug. Monitor Closely (1)potassium iodide and ibuprofen both increase serum potassium. trandolapril, ibuprofen. Use Caution/Monitor. Use Caution/Monitor. Risk of V tach, HTN. Monitor Closely (1)ibuprofen, warfarin. ibuprofen, methylprednisolone. Use Caution/Monitor. Use Caution/Monitor.Minor (1)aceclofenac will increase the level or effect of ibuprofen by acidic (anionic) drug competition for renal tubular clearance. ibuprofen increases and indapamide decreases serum potassium. Minor/Significance Unknown. Drugs with antiplatelet properties may increase anticoagulation effect of warfarin. Additive pressor effect. Periodically monitor bleeding time in patients receiving fish oil triglycerides and concomitant antiplatelet agents or anticoagulants. In patients who are elderly, volume-depleted (including those on diuretic therapy), or with compromised renal function, coadministration of NSAIDs with drugs that affect RAAS may increase the risk of renal impairment (including acute renal failure) and cause loss of antihypertensive effect. Use Caution/Monitor. NSAIDs decrease synthesis of vasodilating renal prostaglandins, and thus affect fluid homeostasis and may diminish antihypertensive effect. Increased risk of GI ulceration. triamterene and ibuprofen both increase serum potassium. Increased risk of CNS stimulation and seizures with high doses of fluoroquinolones. Therefore, coadministration of ozanimod with drugs that can increase norepinephrine or serotonin is not recommended. Use Caution/Monitor. Minor/Significance Unknown. Use Caution/Monitor. Use Caution/Monitor. As a precautionary measure due to incomplete information on the metabolism of eluxadoline, use caution when coadministered with strong CYP2C9/10 inhibitors. ibuprofen increases levels of glyburide by affecting hepatic enzyme CYP2C9/10 metabolism. Avoid or Use Alternate Drug. milnacipran, ibuprofen. Caution with coadministration of adrenergic drugs by any route because of additive sympathetic effects. ticlopidine will increase the level or effect of ibuprofen by affecting hepatic enzyme CYP2C9/10 metabolism. Use Caution/Monitor.ibuprofen increases and norepinephrine decreases serum potassium. Use Caution/Monitor. Monitor plasma levels when used concomitantly. Increased risk of upper GI bleeding. Caution advised with frequent or high dose antacids. Monitor patients for hypertension if safinamide is prescribed concomitantly with prescription or nonprescription sympathomimetics, including nasal, oral, or ophthalmic decongestants and cold remedies. serotonin uptake by platelets. pseudoephedrine decreases effects of nateglinide by pharmacodynamic antagonism. Use Caution/Monitor. pivmecillinam, ibuprofen. Minor/Significance Unknown. Use Caution/Monitor. Modify Therapy/Monitor Closely. ibuprofen and salsalate both increase serum potassium. Use Caution/Monitor. Use Caution/Monitor. temocillin, ibuprofen. Use Caution/Monitor. Comment: May result in renal function deterioration, particularly in elderly or volume depleted individuals. Either increases toxicity of the other by pharmacodynamic synergism. Potential for increased risk of bleeding, caution is advised. SSRIs inhib. Use Caution/Monitor. increases risk of bleeding. Either increases toxicity of the other by Other (see comment). NSAIDs decrease prostaglandin synthesis. Effect of interaction is not clear, use caution. UGT inhibition; significance of interaction unclear. telmisartan and ibuprofen both increase serum potassium. Ibuprofen is a non-steroidal anti-inflammatory drug ( NSAID) that reduces inflammation, and pseudoephedrine is a decongestant that relieves nasal and sinus congestion, making breathing easier. Minor/Significance Unknown. Monitor Closely (3)losartan, ibuprofen. cefpirome will increase the level or effect of ibuprofen by acidic (anionic) drug competition for renal tubular clearance. Monitor Closely (1)benzphetamine and pseudoephedrine both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Advil Cold & Sinus (pseudoephedrine and ibuprofen) is an over-the-counter (OTC) medication used to help relieve cold and flu symptoms. ibuprofen increases and dobutamine decreases serum potassium. ibuprofen and dong quai both increase anticoagulation. Comment: May result in renal function deterioration, particularly in elderly or volume depleted individuals.Serious - Use Alternative (1)ibuprofen, moexipril. Use Caution/Monitor. Maximum dose: 6 caps per 24-hour period Comments: Do not take more than directed. Use Caution/Monitor. Either increases toxicity of the other by pharmacodynamic synergism. Use Caution/Monitor. Monitor Closely (1)antithrombin alfa and ibuprofen both increase anticoagulation. Use Caution/Monitor. Risk of hypoglycemia. Modify Therapy/Monitor Closely. do not take more than 6 caplets in any 24-hour period, unless directed by a doctor. Avoid or Use Alternate Drug. Contraindicated (1)methylergonovine increases effects of pseudoephedrine by pharmacodynamic synergism. Consider avoiding use of pseudoephedrine in patients receiving phenothiazines (especially thioridazine) due to the potential risk of cardiac arrhythmia or sudden death. Mechanism: unknown. Risk of hypoglycemia. Monitor Closely (1)ibuprofen decreases effects of phentolamine by pharmacodynamic antagonism. Comment: Tricyclic antidepressants increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking uptake of indirect sympathomimetics into the adrenergic neuron. Modify Therapy/Monitor Closely. Either increases toxicity of the other by Other (see comment). NSAIDs decrease prostaglandin synthesis. Toxicity may result from coadministration of emtricitabine with other drugs that are also primarily excreted by glomerular filtration and/or active tubular secretion including high-dose or multiple-dose NSAIDs; alternatives to NSAIDs should be considered. Monitor Closely (1)ibuprofen increases and metolazone decreases serum potassium. Effect of interaction is not clear, use caution. nebivolol and ibuprofen both increase serum potassium. Monitor Closely (2)terbutaline and pseudoephedrine both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Serious - Use Alternative (1)lofepramine, pseudoephedrine. Use Caution/Monitor. Avoid or Use Alternate Drug. ibuprofen decreases effects of alfuzosin by pharmacodynamic antagonism. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. Concomitant use of NSAIDs is not recommended. Use Caution/Monitor.ibuprofen decreases effects of olmesartan by pharmacodynamic antagonism. Comment: May result in renal function deterioration, particularly in elderly or volume depleted individuals.Serious - Use Alternative (1)ibuprofen, perindopril. Minor (1)fluconazole will increase the level or effect of ibuprofen by affecting hepatic enzyme CYP2C9/10 metabolism. 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