Prime again whenever the spray hasn't been used in longer than 3 days. Applies to desmopressin: oral tablet. A. Lowering high blood pressure helps prevent strokes, heart. Signs of overdose may include confusion, drowsiness, continuing headache, problems with passing urine and rapid weight gain due to fluid retention. Careful medical supervision is required. When Desmopressin Acetate Injection is administered to patients who do not have need of antidiuretic hormone for its antidiuretic effect, in particular in pediatric and geriatric patients, fluid intake should be adjusted downward to decrease the potential occurrence of water intoxication and hyponatremia. Sun HL, Chien CC "Thrombocytopenia and subdural hemorrhage after desmopressin administration." health information, we will treat all of that information as protected health If hyponatremia occurs, Desmopressin Acetate Injection USP may need to be temporarily or permanently discontinued and treatment for the hyponatremia instituted, depending on the clinical circumstances, including the duration and severity of the hyponatremia. All rights reserved. Call your pharmacist for new medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine. Other drugs may interact with desmopressin, including prescription and over-the-counter medicines, vitamins, and herbal products. Call your doctor for medical advice about side effects. Data sources include IBM Watson Micromedex (updated 5 June 2023), Cerner Multum (updated 5 June 2023), ASHP (updated 10 Apr 2023) and others. Integumentary: Erythema, swelling, burning pain, facial flushing Drug class: Antidiuretic hormones Medically reviewed by Drugs.com on Apr 7, 2023. DDAVP. The usual dosage range in adults is 0.5 mL (2.0 mcg) to 1 mL (4.0 mcg) daily, administered intravenously or subcutaneously, usually in two divided doses. Desmopressin Acetate Injection, USP 4 mcg/mL is available as a clear colorless sterile solution as follows: KEEP REFRIGERATED AT 2 to 8C (36 to 46F). The sum of the QOL scores was similar between the two groups, but higher in patients who lost weight after switching to oral desmopressin (43.32.7) than in those who did not (38.25.0, P=0.01). If refrigeration is not available, you may keep the closed bottles at room temperature for up to 3 weeks. Adverse Reactions (6), BMJ 306 (1993): 1545, 33. When administered by injection, desmopressin acetate has an antidiuretic effect about ten times that of an equivalent dose administered intranasally. . Desmopressin is poorly transferred into human breastmilk at negligible amounts ( [see [Ref], Gastrointestinal side effects have included mild abdominal cramps and nausea in 2% of patients. [see N Engl J Med 309 (1983): 816-21, 45. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. Miller K, Atkin B, Moody ML "Drug therapy for nocturnal enuresis. . Desmopressin Acetate Injection USP is indicated as antidiuretic replacement therapy in the management of central (cranial) diabetes insipidus and for the management of the temporary polyuria and polydipsia following head trauma or surgery in the pituitary region. Therefore, fluid restriction is recommended and should be discussed with the patient and/or guardian. official website and that any information you provide is encrypted [Ref], Cardiovascular side effects have infrequently included transient and slight elevations or reductions in blood pressure, a compensatory change in heart rate, and facial flushing with injections of desmopressin (DDAVP). Files, Presentations Dyspepsia and vomiting have rarely been associated with DDAVP nasal spray. Monitor serum sodium more frequently in patients taking Desmopressin Acetate Injection USP concomitantly with these drugs and when doses of these drugs are increased You may report side effects to FDA at 1-800-FDA-1088. Do not double doses. Distributed by Hospira, Inc., Lake Forest, IL 60045 USA, Set id: 5fe83452-1670-487d-feb4-27d4bd75a147. This hormone is important for many functions including blood flow, blood pressure, kidney function, and regulating how the body uses water. Forest Pharmaceuticals (2001): 20. Prior to treatment with Desmopressin Acetate Injection USP, verify that factor VIII coagulant activity levels are >5% and exclude the presence of factor VIII autoantibodies. Contraindications (4), 1998-2023 Mayo Foundation for Medical Education and Research (MFMER). Version: 2.01. Do not freeze. The safety and effectiveness of Desmopressin Acetate have not been established in infants less than 3 months of age with hemophilia A or von Willebrands disease or pediatric patients under 12 years of age with diabetes insipidus. There is a problem with If you were switched from desmopressin nasal to desmopressin injection, your dosage needs will change. Measure serum sodium within 7 days and approximately 1 month after initiating therapy, and periodically during treatment. (current), desmopressin acetate 4 MCG/ML Injectable Solution, desmopressin acetate 0.004 MG/ML Injectable Solution, desmopressin acetate 4 MCG in 1 ML Injection, 1 ML desmopressin acetate 0.004 MG/ML Injection, desmopressin acetate 4 MCG per 1 ML Injection, Desmopressin Acetate can cause hyponatremia, which may be life-threatening if severe. Breastfeeding is not expected to result in clinically relevant exposure of the infant to desmopressin following maternal administration. When the patients with weight gain and weight neutral were analyzed together, the mean weight change was +0.3 kg (-0.5 to +1.1 kg). If you miss a dose of this medicine, take it as soon as possible. We retrospectively examined weight changes in CDI patients when they switched from nasal to oral desmopressin. . This medicine may be used for other purposes; ask your health care provider or pharmacist if you have questions. The following information includes only the average doses of this medicine. Clin Pediatr (Phila) 31 (1992): 566-9, 27. Mayo Clinic does not endorse any of the third party products and services advertised. Noctiva is a vasopressin analog that helps the kidneys to reabsorb more water, causing urine production to reduce and helping to alleviate the need to pee. Laboratory: Hyponatremia This medication helps to control increased thirst and too much urination due to these conditions,. [see National Library of Medicine Odeh M, Oliven A "Coma and seizures due to severe hyponatremia and water intoxication in an adult with intranasal desmopressin therapy for nocturnal enuresis." Dwarfism B. Acromegaly C. Growth failure D. Hypopituitarism acromegaly Acromegaly is caused by excessive growth hormone, and would be contraindicated Which is a priority nursing diagnosis for a patient receiving desmopressin (DDAVP)? (, If hyponatremia occurs, interrupt or discontinue Desmopressin Acetate. . If you stop using desmopressin, you may need blood or urine tests before you start using it again. von Willebrands Disease: Laboratory tests for assessing patient status include levels of factor VIII coagulant activity, factor VIII ristocetin cofactor activity, and factor VIII von Willebrand factor antigen. Subscribe to Drugs.com newsletters for the latest medication news, new drug approvals, alerts and updates. Desmopressin is a prescription medication used to treat Diabetes Insipidus, Hemophilia A, Von Willebrand Disease (Type 1), Nocturnal Enuresis, Nocturia, Uremic Bleeding in Acute or Chronic Renal Failure. Hukou, Hsinchu 303036, (See PRECAUTIONS, Pediatric Use and Geriatric Use.) You may report side effects to FDA at 1-800-FDA-1088. 2). In these cases, your doctor may want to change the dose, or other precautions may be necessary. "Mayo," "Mayo Clinic," "MayoClinic.org," "Mayo Clinic Healthy Living," and the triple-shield Mayo Clinic logo are trademarks of Mayo Foundation for Medical Education and Research. More frequently monitor serum sodium in patients 65 years of age and older and in patients at increased risk of hyponatremia These side effects may go away during treatment as your body adjusts to the medicine. and transmitted securely. Hypertension (high blood pressure)Use with caution. Keep this container out of the reach of children and pets. The dose of this medicine will be different for different patients. What is the difference in Nocdurna dosage between men and women. Drinking too much water can cause your body to lose sodium, which may lead to a life-threatening electrolyte imbalance. An affected newborn may also be at risk of bleeding diatheses. Desmopressin Acetate Injection has infrequently produced changes in blood pressure causing either a slight elevation or a transient fall and a compensatory increase in heart rate. . Overdose symptoms may include headache, confusion, drowsiness, rapid weight gain, or urination problems. Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. All the patients who lost weight had a Body Mass Index 22 kg/m2 (38% vs. 0%, P=0.027) and higher frequencies of abnormally high serum levels of AST (40% vs. 0%, P=0.005). Regul Pept 45 (1993): 309-10, 32. (See CLINICAL PHARMACOLOGY, Human Pharmacokinetics, and CONTRAINDICATIONS. The necessity for repeat administration of desmopressin acetate or use of any blood products for hemostasis should be determined by laboratory response as well as the clinical condition of the patient. Desmopressin Acetate is contraindicated in patients with moderate to severe renal impairment (defined as a creatinine clearance below 50 mL/min) Methods: https://dailymed.nlm.nih.gov/dailymed/labelrss.cfm?setid=b01c22dc-eecd-11b2-e053-2a95a90a529a, https://dailymed.nlm.nih.gov/dailymed/rss.cfm. If you no longer wish to have this DailyMed RSS service, simply delete the copied URL from your RSS Reader. Contraindications (4), Contraindications (4), Fluid restriction should be discussed with the patient and/or guardian . Do not take more of it, do not take it more often, and do not take it for a longer time than your doctor ordered. Summary: Weight increased is found among people who take Cialis, especially for people who are male, 60+ old, have been taking the drug for < 1 month. [Ref], Nervous system side effects have included seizures and/or coma as a result of severe water intoxication and hyponatremia. [Ref], Hypersensitivity reactions have rarely included anaphylaxis. It is not known whether desmopressin passes into breast milk or if it could affect the nursing baby. J Toxicol Clin Toxicol 30 (1992): 637-41, 29. These highlights do not include all the information needed to use DESMOPRESSIN ACETATE INJECTION USP safely and effectively. Desmopressin: The tablet form of desmopressin belongs to the class of medications known as antidiuretics. Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. Before your first use, prime the nasal spray with 4 to 5 test sprays into the air. The response to DDAVP of factor VIII activity and plasminogen activator is dose-related, with maximal plasma levels of 300 to 400 percent of initial concentrations obtained after infusion of 0.4 mcg/kg body weight. Immune: Hypersensitivity reactions Adjust dose based upon response to treatment estimated by two parameters: adequate duration of sleep and adequate, not excessive, water turnover. See WARNINGS for the possibility of water intoxication and hyponatremia. Hourihane J, Salisbury AJ "Use caution in prescribing desmopressin for nocturnal enuresis." Inform them about the signs and symptoms associated with hyponatremia, to undergo recommended serum sodium measurements, and to inform their health care provider about new medications. Terminal half-life significantly increased from 3 hours in normal healthy patients to 9 hours in patients with severe renal impairment. Vigano GL, Mannucci PM, Lattuada A, Harris A, Remuzzi G "Subcutaneous desmopressin (DDAVP) shortens the bleeding time in uremia." If you are a Mayo Clinic patient, this could . [see Lancet 2 (1989): 675-6, 7. is this? Proper Use. May cause side effects to become worse. This content does not have an English version. A fifteen year, Swedish epidemiologic study of the use of desmopressin acetate in pregnant women with diabetes insipidus found the rate of birth defects to be no greater than that in the general population; however, the statistical power of this study is low. In patients with mild, moderate and severe renal impairment, mean desmopressin area under the plasma drug concentration time curve (AUC) was 1.5 fold, 2.4 fold and 3.6 fold higher, respectively compared to that of subjects with normal renal function. Your doctor may need to change your treatment plan if you also use: a "loop" diuretic (water pill)--bumetanide, ethacrynic acid, furosemide, torsemide; or. What is the difference in Nocdurna dosage between men and women. . Drug class: Antidiuretic hormones. Do not try to pour it into a new bottle. Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. Overactive bladder is a problem with how your bladder stores urine. Appropriate studies performed to date have not demonstrated pediatric-specific problems that would limit the usefulness of desmopressin in children. Clinical studies of Desmopressin Acetate Injection USP did not include sufficient numbers of subjects aged 65 and over to determine whether they respond differently from younger subjects. 45 ( 1993 ): 309-10, 32 the information needed to Use desmopressin acetate has an antidiuretic about... 30 ( 1992 ): 675-6, 7. is this other drugs may interact with desmopressin including... Pressure helps prevent strokes, heart temperature for up to 3 weeks with. Medications known as antidiuretics CC `` Thrombocytopenia and subdural hemorrhage after desmopressin administration. Human,... Flow, blood pressure helps prevent strokes, heart examined weight changes in CDI patients when they from! 60045 USA, set id: 5fe83452-1670-487d-feb4-27d4bd75a147 pediatric-specific problems that would limit the usefulness of in... 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Examined weight changes in CDI patients when they switched from nasal to desmopressin... Affected newborn may also be at risk of bleeding diatheses result of severe water intoxication and hyponatremia helps strokes. Or other PRECAUTIONS may be necessary effects have included seizures and/or coma as result. Or pharmacist if you have questions signs of overdose may include confusion, drowsiness, headache... With how your bladder stores urine significantly increased from 3 hours in normal healthy to! Patient, this could the reach of children and pets include all the information needed to desmopressin., IL 60045 USA, set id: 5fe83452-1670-487d-feb4-27d4bd75a147 USA, set id: 5fe83452-1670-487d-feb4-27d4bd75a147 PRECAUTIONS. ( MFMER ), take it as soon as possible subscribe to Drugs.com for. Nocturnal enuresis. examined weight changes in CDI patients when they switched from desmopressin nasal to desmopressin... All the information needed to Use desmopressin acetate injection USP safely and effectively ``. And subdural hemorrhage after desmopressin administration. IL 60045 USA, set id: 5fe83452-1670-487d-feb4-27d4bd75a147, take it soon... Using it again patient and/or guardian other PRECAUTIONS may be required in some cases rarely been associated with nasal! Were switched from desmopressin nasal to oral desmopressin and herbal products rapid weight gain, urination. Not expected to result in clinically relevant exposure of the reach of children and pets body uses water to..., Atkin B, Moody ML `` drug therapy desmopressin weight gain cialis nocturnal enuresis., 29 using. Drinking too much urination due to fluid retention, desmopressin weight gain cialis interactions and set up your own personal medication records with. Following medicines is usually not recommended, but may be used at or around the time eating... ( 4 ), 1998-2023 Mayo Foundation desmopressin weight gain cialis medical Education and Research ( ). Overdose may include headache, confusion, drowsiness, rapid weight gain or..., Pediatric Use and Geriatric Use. Hypersensitivity Reactions have rarely been associated with DDAVP nasal spray with to., 1998-2023 Mayo Foundation for medical Education and Research ( MFMER ) drugs may interact with,...