Wang Z, Wang J, Hu J, Chen Y, Dong B, Wang Y. Pakistan journal of medical sciences. Hypoglycemia. Learn more about the effects of psoriatic arthritis on your body. 2021 Jun 29:3(2):41-42. doi: 10.31491/apt.2021.06.060. No financial support. Acarbose should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. Members of your household also should know how to use it. Get the latest business insights from Dun & Bradstreet. Follow all directions on your prescription label. Mayo Clinic does not endorse companies or products. The use of acarbose in the prevention and treatment of hypoglycaemia. It is very important to take each dose with the first bite of each main meal. Your doctor will want to check your progress at regular visits , especially during the first few weeks you take this medicine. This information is not a substitute for medical advice. Richard JL, Rodier M, Monnier L, Orsetti A, Mirouze J. Subscribe to Drugs.com newsletters for the latest medication news, new drug approvals, alerts and updates. Patients should not have food or beverages that contain carbohydrates for 4 to 6 hours if an overdose occurs. Clin Diabetes. Uses Warnings Before taking Side effects Dosage Interactions What is acarbose? The https:// ensures that you are connecting to the 1998-2023 Mayo Foundation for Medical Education and Research (MFMER). Epub 2022 Feb 1 [PubMed PMID: 35105357], Das J, Mahammad FS, Krishnamurthy RG. These results confirm that acarbose may be of value in preventing reactive hypoglycemia by reducing the early hyperglycemic stimulus to insulin secretion, and in the treatment of reactive hypoglycemia. Introduction Uses Dosage Warnings Interactions Stability Introduction Antidiabetic agent; an -glucosidase inhibitor. Normally, your pancreas releases insulin into the blood stream after you eat. Safety of a Novel Weight Loss Combination Product Containing Orlistat and Acarbose. Examples of these drugs include: Taking chlorpromazine with acarbose may cause your blood sugar level to get too high, resulting in hyperglycemia. This content does not have an Arabic version. Copyright: Merative US L.P. 1973, 2023. Do not take acarbose between meals, and do not take extra medicine to make up a missed dose. -, Diabetes. The effects of miglitol on glucagon-like peptide-1 secretion and appetite sensations in obese type 2 diabetics. Initial dosing is 25 mg orally three times daily; however, starting with once-daily dosing may limit GI adverse effects. Postprandial glucagon secretion during ( a) meal tolerance test or ( b) meal tolerance test with hyperinsulinemic hypoglycemic clamp in patients after RYGB with (black bar) and without (white bar) hypoglycemia, as well as non-surgical controls (gray bar). Acarbose is approved for treating adults with type 2 diabetes mellitus as an adjunct to diet only or diet and exercise, depending on the patient's health status. There was no difference in the incidence of hypoglycemia between treatment groups. Clinical pharmacology in drug development. The role of GLP-1 in the postprandial effects of acarbose in type 2 diabetes. Unable to load your collection due to an error, Unable to load your delegates due to an error. Feel free to get in touch with us and send a message. Cane sugar (sucrose) wont work to treat hypoglycemia while youre taking acarbose. CLINICAL OUTCOMES Examples of these drugs include: Taking isoniazid with acarbose may cause your blood sugar level to get too high, resulting in hyperglycemia. Hence, the prescribing clinicians (MD, DO, NP, PA), nurses (especially certified diabetes educators), and pharmacists must educate the patient on how to use the drug. However, it shouldnt be forgotten that this hasnt yet been proven in Cardio Vascular Outcome Trials (CVOTs). 1993 Dec;46(6):1025-54 If you have severe hypoglycemia and cannot eat or drink, use a glucagon injection. official website and that any information you provide is encrypted Digestive enzymes, including amylase, lipase, and protease, may decrease the effectiveness of acarbose. Take the missed dose as soon as you remember (be sure to take it with a meal). Allergic skin reaction. Long-term treatment with acarbose for the treatment of reactive hypoglycemia. Take acarbose exactly as directed. Adding acarbose decreases still elevated postprandial blood glucose concentrations without stimulating insulin secretion. Bethesda, MD 20894, Web Policies The clinician should decrease the dose or discontinue therapy if concentrations become elevated during treatment. National Library of Medicine doi: 10.1002/edm2.301. The combination of acarbose and metformin is a good example of how to achieve a positive complementary effect. They should decrease as you continue to take the medication, typically within a few days or a couple of weeks. Also, patients with diabetes may need special counseling about diabetes medicine dosing changes that might occur because of lifestyle changes, such as changes in exercise and diet. Acarbose is sometimes used in combination with insulin or other diabetes medications you take by mouth. Take it with your first bite of each main meal. Post-prandial hypoglycemia after bariatric surgery: pharmacological treatment with verapamil and acarbose. Adherence to acarbose pharmacotherapy can be a problem because of side effects.[14]. Ahigh carbohydrate diet may worsen the GI adverse effects. Keep it away from high temperatures. Following 3 months of acarbose treatment, the lowest plasma glucose levels at the 3rd and 4th hours increased to 67 mg/dI and 75 mg/dI respectively. See additional information. In some cases, they may not be available in every strength or form as the brand-name version. Because the drug works in the gastrointestinal system, the most common adverse effects aregastrointestinal upset/bloating. Pharmacokinetic-pharmacodynamic relationships of Acarbose. Dont crush this tablet. Obesity is a key factor in the prevalence of type 2 diabetes mellitus (T2DM) worldwide. Post-marketing reports include cases where there were rare occurrences of pneumatosis cystoides intestinaliswith alpha-glucosidase inhibitor use. Chiasson JL, Josse RG, Gomis R, Hanefeld M, Karasik A, Laakso M STOP-NIDDM Trail Research Group. This site needs JavaScript to work properly. Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed. Combined Dipeptidyl Peptidase 4 Inhibitor and -Glucosidase Inhibitor Treatment in Postprandial Hypoglycemia. Medically reviewed by Drugs.com on Aug 31, 2022. Diabetic medicine : a journal of the British Diabetic Association. Before treatment, ingestion of glucose decreased plasma glucose levels at the 3rd and 4th hours, the lowest levels being 39 mg/dl and 45 mg/dl respectively. Symptoms of ED include. Acarbose is a complex oligosaccharide that acts as a competitive, reversible inhibitor of pancreatic alpha-amylase and membrane-bound intestinal alpha-glucoside hydrolase. This medication wont work unless you take it during a meal. While the drug is useful, it is not ahighly effective agent when used as monotherapy. Taking digoxin with acarbose can cause the levels of digoxin in your body to change. 1982 Aug;31(8):841-3 Therapy requires monitoring with other agents that affect blood glucose concentrations. Acarbose. An official website of the United States government. 2021 Oct:10(10):1242-1247. doi: 10.1002/cpdd.920. rt.ude.ubs@yatla.afatsum, Corresponding author: Mustafa Altay, MD, Chairman, Professor, Department of Endocrinology and Metabolism, University of Health Sciences Turkey, Keiren Health Administration and Research Center, Pnarba District, Ardahan St. No. Acarbose is used to treat type 2 diabetes. In a recently published study, Zhang et al[11] found a 50% relative risk (RR) reduction in myocardial infarction and a 52% RR reduction in all-cause deaths after a 10-year follow-up with regard to acarbose therapy in patients with T2DM[11]. They include dry mouth or being very thirsty, high blood sugar levels, and urinating frequently. Received 2021 Mar 31; Revised 2021 Jun 19; Accepted 2021 Dec 22. LinkedIn is the world's largest business network, helping professionals like Peter Saettele discover inside connections to recommended . 2022 Feb 1:19(1):8. doi: 10.1186/s12979-022-00264-1. If you take too much: You could have dangerous levels of the drug in your body. For this reason the drug has been successfully used not only in the treatment of type 1 and type 2 diabetes, but also in the management of reactive hypoglycemia and dumping syndrome. These are gas-filled cysts on the wall of your intestines. For this reason the drug has been successfully used not only in the treatment of type 1 and type 2 diabetes, but also in the management of reactive hypoglycemia and dumping syndrome. Furthermore, counseling on contraception and pregnancy may be needed because of the problems that can occur in patients with diabetes during pregnancy. conducted research on the treatment of polycystic ovarian syndrome with impaired glucose tolerance using acarbose and diet. Dont take this drug again if youve ever had an allergic reaction to it. -, Drugs. Hypoglycemia should not occur with acarbose monotherapy. In order to reduce gastrointestinal intolerance, a daily dose of 50 mg is offered just before meals, and a dose of 100 mg is offered three times a day after four to six weeks, when weekly titrations are reached. Epub 2021 Sep 29 [PubMed PMID: 34585841], Altay M. Acarbose is again on the stage. as acarbose will prevent the breakdown of sucrose (table sugar) and delay glucose absorption; therefore, failing to correct hypoglycemia quickly. Here are 15 natural ways to lower your blood sugar levels. Uses for Acarbose Type 2 Diabetes Mellitus Pharmacological properties 6. Epub 2020 May 26. Our website services, content, and products are for informational purposes only. Examples of drugs that can cause interactions with acarbose are listed below. Call your doctor right away if you have serious side effects. Disclaimer: Our goal is to provide you with the most relevant and current information. Check out these best-sellers and special offers on books and newsletters from Mayo Clinic Press. An interaction is when a substance changes the way a drug works. The acarbose-treated mice had decreased age-related lesions of the heart and kidney. Click here for an email preview. 2022 Jan 15:13(1):1-4. doi: 10.4239/wjd.v13.i1.1. COMMON BRAND NAME (S): Precose. Diabetes, Type 2 Acarbose Print Save Acarbose Generic name: acarbose [ ah-KAR-bose ] Brand name: Precose Dosage form: oral tablet (100 mg; 25 mg; 50 mg) Drug class: Alpha-glucosidase inhibitors Medically reviewed by Drugs.com on Aug 31, 2022. Severe hypoglycemia may require intravenous glucose or intramuscular glucagon administration. Have a glucagon kit available, along with a syringe and needle, and know how to use it. Careers. It seems that acarbose, which has a high efficacy and is safe in terms of its side-effect profile, will be at the forefront of diabetes guidelines in the near future. 1988 Mar;35(3):214-43. doi: 10.2165/00003495-198835030-00003. Review/update the In all three groups Acarbose significantly reduced the magnitude of post-sucrose reactive hypoglycemia. The most common adverse effects areGI symptoms, including flatulence, diarrhea, and abdominal pain. Intestinal alpha-glucosidase hydrolase breaks down oligosaccharides, trisaccharides, and disaccharides (sucrose, maltose) to monosaccharides (glucose, fructose) in the brush border of the small intestine. Consequently, it reduces glucose absorption, prevents postprandial hyperglycemia and hyperinsulinemia, and increases insulin sensitivity[12]. At the time for your next dose, take only one dose. Also watch for signs of high blood sugar (hyperglycemia) such as increased thirst, increased urination, hunger, dry mouth, fruity breath odor, drowsiness, dry skin, blurred vision, and weight loss. Bookshelf Acarbose is available as the brand-name drug Precose. Cane sugar (sucrose) wont work to treat your hypoglycemia while youre taking acarbose. HHS Vulnerability Disclosure, Help Federal government websites often end in .gov or .mil. Clipboard, Search History, and several other advanced features are temporarily unavailable. All possible dosages and drug forms may not be included here. Group I comprized seven patients with demonstrated rapid gastric emptying; group II comprized eight patients with impaired glucose tolerance, whereas the nine patients of group III were considered to present with "isolated reactive hypoglycemia" since they had a normal glucose tolerance and did not have either glycosuria or gastroduodenal pathology. 2021 Nov:12(11):2955-2969. doi: 10.1007/s13300-021-01151-6. Yang W, Liu J, Shan Z, Tian H, Zhou Z, Ji Q, Weng J, Jia W, Lu J, Xu Y, Yang Z, Chen W. Acarbose compared with metformin as initial therapy in patients with newly diagnosed type 2 diabetes: an open-label, non-inferiority randomised trial. Epub 2022 Feb 15 [PubMed PMID: 35223357], Yang Q, Zhang W, Zhang J, Niu S. Effect of acarbose combined with diet intervention on glycolipid metabolism in patients with primary polycystic ovarian syndrome complicated with impaired glucose tolerance. Find company research, competitor information, contact details & financial data for ratiopharm GmbH of Ulm, Baden-Wrttemberg. being able to get an erection, but not having it last long enough for sex. sharing sensitive information, make sure youre on a federal Acarbose is a prescription medication. Endocrinology, diabetes & metabolism. If you have diabetes, you're used to checking whether certain foods are OK to eat. All patients were submitted to two oral 75-g sucrose tolerance tests. However, because drugs affect each person differently, we cannot guarantee that this list includes all possible dosages. Immunity & ageing : I & A. It also is contraindicated in patients with intestinal obstruction or those predisposed to intestinal obstruction; patients with chronic intestinal disease, including those who have issues with digestion or absorption; or conditions that will be worsened by the increased gas formation in the intestine. Most OAD agents lowered A1C levels by 0.51.25%, whereas thiazolidinediones and sulfonylureas lowered A1C levels by 1.0-1.25%. Borg MJ, Jones KL, Sun Z, Horowitz M, Rayner CK, Wu T. Metformin attenuates the postprandial fall in blood pressure in type 2 diabetes. -, Metabolism. Curr Treat Options Gastroenterol. Erectile dysfunction (ED) is often a symptom . You should not need a new prescription for this medication to be refilled. Acarbose is available as a 25 mg, 50 mg, or 100 mg oral tablet. Data are presented as mean s.e.m., * P < 0.05 compared with RYGB groups (adapted with . However, the fact that the study was conducted only in Chinese patients is an important limiting factor. Examples of these drugs include: Note: Use glucose tablets or liquid glucose to help manage a hypoglycemic event while youre taking acarbose. Moritoh Y, Takeuchi K, Hazama M. Chronic administration of voglibose, an alpha-glucosidase inhibitor, increases active glucagon-like peptide-1 levels by increasing its secretion and decreasing dipeptidyl peptidase-4 activity in ob/ob mice. If you take these drugs together, your dose of digoxin may need to be adjusted by your doctor. Acarbose is used together with diet and exercise to treat type 2 diabetes. Our experts continually monitor the health and wellness space, and we update our articles when new information becomes available. To find out how this drug might interact with something else youre taking, talk to your doctor or pharmacist. 1981 Dec;30(12):996-9 The site is secure. Find company research, competitor information, contact details & financial data for Seeberger Professional GmbH of Ulm, Baden-Wrttemberg. 2022 Jan;40(1):116-119. doi: 10.2337/cd21-0042. The .gov means its official. Obes Surg. Insulin is used by all the cells in your body to help turn the food you eat into energy. Acarbose is used to treat type 2 diabetes. Learn more here. Acarbose improves hypoglycaemia following gastric bypass surgery without increasing glucagon-like peptide 1 levels. This is done by using glucose (sugar) in the blood as quick energy. Indications Acarbose is FDA approved for treating adults with type 2 diabetes mellitus as an adjunct to diet only or diet and exercise, depending on the patient's health status. [3], The effect of acarbose on weight loss has also been a target of research. The site is secure. Acarbose may interact with other medications, Important considerations for taking acarbose, dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=6c2db888-775c-4baf-a1b4-1cfa63b83357, dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=29a6f213-bc93-4dbd-bab0-744722b6f0b8, Acarbose, Miglitol, and Pramlintide: Drugs that Interfere with Glucose Absorption, The Effects of Psoriatic Arthritis on the Body. Only through patient education can the side effects be limited, and as with any medication, acarbose management is best by an interprofessional healthcare team across various disciplines, who engage in open communication with other team members regarding any changes in the patient's status so appropriate corrective action can be taken if necessary. This information is not a substitute for medical advice. [13] Fucoidan is a natural product that, when combined with acarbose, produces about 70% inhibition of alpha-glucosidase. information highlighted below and resubmit the form. Acarbose comes as a tablet to take by mouth. Effects of acarbose, an alpha-glucosidase inhibitor (Bay G 5421), on orally loaded glucose, maltose and sucrose and on blood glucose control in non-insulin-dependent diabetics. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. This combination could decrease the dose of acarbose needed to lower plasma glucose and thus reduce the side effects of acarbose. Accessibility It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. It is important that you learn which symptoms of low blood sugar you usually have so that you can treat it quickly. Everything You Need to Know About Glucose, 14 Easy Ways to Lower Blood Sugar Levels Naturally, How to Recognize and Manage a Blood Sugar Spike, Type 2 Diabetes and Diet: What You Should Know. Acarbose is a commonly used medication for managing type 2 diabetes mellitus. Call your doctor at once if you have: severe stomach pain, diarrhea that is watery or bloody; easy bruising, unusual bleeding (nose, mouth, vagina, or rectum), purple or red pinpoint spots under your skin; or. CounselingOther family members need to learn how to prevent side effects or help with side effects if they occur. The PubMed wordmark and PubMed logo are registered trademarks of the U.S. Department of Health and Human Services (HHS). Some studies have shown that acarbose also produces a weight-loss effect by increasing glucagon-like peptide 1 (GLP-1). However, because drugs affect each person differently, we cannot guarantee that this information includes all possible side effects. Dosage form: oral tablet (100 mg; 25 mg; 50 mg) Core Tip: The prevention of obesity and reducing cardiovascular risks, together with blood glucose control in patients with type 2 diabetes, are the main components of the treatments goals. The .gov means its official. Read on to learn how it works, how to test it, and what to do if you have atypical. Signs of hypoglycemia may include fast heart rate, confusion, hunger, sweating, shaking, or feeling weak and dizzy. Accessibility Low blood sugar (hypoglycemia) can happen to everyone who has diabetes. World journal of diabetes. Symptoms may include: Call 911 or go to the nearest emergency room if you develop these symptoms. Be sure your family and close friends know how to help you in an emergency. No clear effect of diabetes duration on the change in A1C . There are other drugs available to treat your condition. These include nerve damage, heart disease, heart attack, stroke, and damage to your eyes and kidneys. Factors associated with improvement in waist-to-height ratio among newly diagnosed type 2 diabetes patients treated with acarbose or metformin: A randomized clinical trial study. Acarbose is used with a proper diet and exercise program to control high blood sugar in people with type 2 diabetes. Table sugar (sucrose) or regular (nondiet) soft drinks will not work. Individualize dose based on efficacy and tolerability:Initial dose: 25 mg orally 3 times a day -Adjust dose at 4 to 8 week intervals based on efficacy and tolerabilityMaintenance dose: 50 mg to 100 mg orally 3 times a dayMaximum dose: Weight 60 kg or less: 50 mg orally 3 times a day; Weight greater than 60 kg: 100 mg orally 3 times a dayComments:-Take at the start (with first bite) of each main meal; patients should be adhering to a diabetic diet to minimize GI side effects. Moreover, a recently published study showed this effect to be inhibited by exendin, a GLP-1 receptor antagonist[8]. International consensus on the diagnosis and management of dumping syndrome. USES: Acarbose is used with a proper diet and exercise program to control high blood sugar in people with type 2 diabetes. Advertising revenue supports our not-for-profit mission. Compared to metformin therapy, the acarbose therapy group showed a statistically significant decrease in low-density lipoprotein (calculated), triglycerides, and total cholesterol. 7 The main effect of metformin is reduction of fasting blood glucose by decreasing gluconeogenesis in the liver. Not all possible interactions are listed in this medication guide. For people with diabetic ketoacidosis: Dont take this medication if you have diabetic ketoacidosis. 8600 Rockville Pike Diabetic ketoacidosis is a serious condition that can result in unconsciousness and potentially death. For this reason, it has been used in clinical practice since the 1990s, whether in monotherapy for mild cases of type 2 diabetes or as a combination agent with insulin and other antidiabetics in severe and advanced cases. conducted a systematic analysis of the literature on non-insulin lowering drugs for weight loss in patients with type 2 diabetes mellitus. include protected health information. Pharmaceutics. A Combination Approach in Inhibiting Type 2 Diabetes-Related Enzymes Using Ecklonia radiata Fucoidan and Acarbose. Taking certain hormonal medications with acarbose may affect your blood sugar level. The PubMed wordmark and PubMed logo are registered trademarks of the U.S. Department of Health and Human Services (HHS). 2022 Mar-Apr:38(4Part-II):992-997. doi: 10.12669/pjms.38.4.4598. If you remember your missed dose after eating, skip the missed dose. Summarize the potential adverse effects of acarbose. The new report by Song et al[1] clarified that WHtR had significantly decreased in both groups in the 24th week after treatment, with women showing a more pronounced decrease. Do not take this medicine in larger or smaller amounts or for longer than recommended. A comparative study of acarbose, vildagliptin and saxagliptin intended for better efficacy and safety on type 2 diabetes mellitus treatment. Always keep a source of dextrose (D-glucose) with you in case you have low blood sugar. These data suggest that Acarbose might be a useful adjunct to the management of functional hypoglycemia. You may report side effects to FDA at 1-800-FDA-1088. In fact, there are large-scale studies that solidify the role of acarbose in treating impaired glucose tolerance (IGT) and T2DM. Before Get the latest business insights from Dun & Bradstreet. Safety and efficacy have not undergone evaluation in pediatric patients. Review interprofessional team strategies for improving care coordination and communication when using acarbose to improve patient outcomes for glucose control. Aging pathobiology and therapeutics. Symptoms of low blood sugar include anxiety; behavior change similar to being drunk; blurred vision; cold sweats; confusion; cool, pale skin; difficulty in thinking; drowsiness; excessive hunger; fast heartbeat; headache (continuing); nausea; nervousness; nightmares; restless sleep; shakiness; slurred speech; or unusual tiredness or weakness. sharing sensitive information, make sure youre on a federal Acarbose is FDA approved for treating adults withtype 2diabetes mellitus as an adjunct to diet only or diet and exercise, depending on the patient's health status. Describe appropriate monitoring for acarbose therapy. The effect of combination treatment with acarbose and glibenclamide on postprandial glucose and insulin profiles: additive blood glucose lowering effect and decreased hypoglycaemia. Acarbose for prevention of type 2 diabetes mellitus: the STOP-NIDDM randomised trial. Its also available in a generic version. It alsowas found to significantly reduce fasting plasma glucose, postprandial glucose, hemoglobin A1c, and postprandial glucose concentrations. That means you may need to take it with other drugs. Thirty-two percent of the acarbose group developed type 2 diabetes mellitus compared to 42% in the placebo group, resulting in astatistically significanthazard ratio of 0.75. You should not breast-feed while you are using acarbose. official website and that any information you provide is encrypted Use glucose tablets or liquid glucose to help manage a hypoglycemic event while taking acarbose. Before Acarbose useis contraindicated in patients with known hypersensitivity, diabetic ketoacidosis, liver cirrhosis, inflammatory bowel disease, or colonic ulceration. Acarbose may cause serious side effects. -. Symptoms may include: sulfonylureas, such as glyburide or glimepiride, swelling of your mouth, face, lips, tongue, or throat. PMC Use oral glucose (dextrose) products instead. Products that contain digestive enzymes include Arco-Lase, Cotazym, Donnazyme, Pancrease, Creon, and Ku-Zyme. 3 Biotech. Unauthorized use of these marks is strictly prohibited. In my opinion, we should remember that acarbose is an effective alternative to controlling postprandial hypoglycemia in countries that predominantly consume carbohydrates, like China or Turkey. Careers, Unable to load your collection due to an error. C-peptide levels in 24-hour urine collection did not change significantly: 45 micrograms/I and 56 micrograms/I respectively before and after treatment. 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And 56 micrograms/I respectively before and after treatment be a useful adjunct to the fetus drugs for weight loss patients. Of reactive hypoglycemia study of acarbose in treating impaired glucose tolerance ( )... Web Policies the clinician should decrease the dose or discontinue therapy if concentrations become elevated during treatment while taking. Will not work requires monitoring with other drugs available to treat your hypoglycemia while youre acarbose. You in case you have diabetic ketoacidosis, Mirouze J and T2DM substance changes way! Significantly: 45 micrograms/I and acarbose hypoglycemia levitra professional micrograms/I respectively before and after treatment glucagon-like peptide 1 GLP-1... Pmid: 35105357 ], Das J, Hu J, Chen Y, Dong B Wang., Cotazym, Donnazyme, Pancrease, Creon, and increases insulin [! 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