Monitor Closely (1)rucaparib will increase the level or effect of vincristine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Monitor Closely (1)nicardipine will increase the level or effect of vincristine by P-glycoprotein (MDR1) efflux transporter. Avoid or Use Alternate Drug. being able to get an erection, but not having it last long enough for sex. Minor/Significance Unknown. Minor/Significance Unknown. Monitor Closely (2)cyclosporine will increase the level or effect of vincristine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Either increases levels of the other by plasma protein binding competition. Minor/Significance Unknown. Most WebHow to Take Vincristine. Minor/Significance Unknown. Monitor Closely (1)siponimod and vincristine both increase immunosuppressive effects; risk of infection. Use Caution/Monitor. Minor (1)cyclophosphamide will increase the level or effect of vincristine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. amiodarone will increase the level or effect of vincristine by P-glycoprotein (MDR1) efflux transporter. Modify Therapy/Monitor Closely. Istradefylline 40 mg/day increased peak levels and AUC of P-gp substrates in clinical trials. Reduce P-gp substrate dose if needed.Serious - Use Alternative (2)vincristine will increase the level or effect of lonafarnib by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Avoid or Use Alternate Drug. fosphenytoin will decrease the level or effect of vincristine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Minor/Significance Unknown. The dose should be calculated on an individual basis and should not be increased beyond the level which produces therapeutic benefit. Monitor serum potassium during initiation and dosage adjustment of either finererone or weak CYP3A4 inhibitors. Use Caution/Monitor.Minor (1)phenobarbital will decrease the level or effect of vincristine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor. Rare Black, tarry stools blood in urine or stools cough or hoarseness fever or chills pinpoint red spots on skin unusual bleeding or bruising Check with your doctor as soon as possible if any of the following side effects occur while taking vincristine: More common Blurred or double vision constipation difficulty in walking drooping eyelids Serious - Use Alternative (1)idelalisib will increase the level or effect of vincristine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Live-attenuated vaccines should be avoided for at least 3mo after cessation of immunosuppressive therapy. Use Caution/Monitor. Minor (1)miconazole vaginal will increase the level or effect of vincristine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Minor/Significance Unknown. CLINICAL PHARMACOLOGY Use Caution/Monitor. Use Caution/Monitor.Minor (1)ritonavir will increase the level or effect of vincristine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Monitor Closely. being able to get an erection sometimes, but not every time you want to have sex. vincristine will increase the level or effect of ruxolitinib topical by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Consider increasing CYP3A substrate dose if needed. Use Caution/Monitor. Vincristine sulfate is for intravenous administration only. If generic versions of this product have been approved by the FDA, there may be generic equivalents available. Takeaway Levitra (vardenafil) is a brand name medication used to treat symptoms of erectile dysfunction (ED), a condition which affects millions of people worldwide. Use Caution/Monitor. WebMarqibo dose delay or reduction, as well as supportive care measures for . saquinavir will increase the level or effect of vincristine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Minor (1)amobarbital will decrease the level or effect of vincristine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Tecovirimat is a weak CYP3A4 inducer. Minor/Significance Unknown. vincristine will increase the level or effect of lonafarnib by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Monitor Closely (1)lapatinib will increase the level or effect of vincristine by P-glycoprotein (MDR1) efflux transporter. Minor (1)butabarbital will decrease the level or effect of vincristine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. nitazoxanide, vincristine. Minor (1)conivaptan will increase the level or effect of vincristine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Serious - Use Alternative (1)vincristine decreases effects of adenovirus types 4 and 7 live, oral by pharmacodynamic antagonism. Use Caution/Monitor. WebFind patient medical information for vincristine intravenous on WebMD including its uses, side effects and safety, interactions, pictures, warnings and user ratings. simvastatin will increase the level or effect of vincristine by P-glycoprotein (MDR1) efflux transporter. Live-attenuated vaccines should be avoided for at least 3mo after cessation of immunosuppressive therapy. Monitor Closely (2)levoketoconazole will increase the level or effect of vincristine by P-glycoprotein (MDR1) efflux transporter. Minor/Significance Unknown. Minor/Significance Unknown. tipranavir will increase the level or effect of vincristine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. vincristine decreases levels of phenytoin by increasing metabolism. Monitor Closely (1)nitazoxanide, vincristine. Minor (1)metronidazole will increase the level or effect of vincristine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Side Effects. Monitor Closely (1)vincristine, ospemifene. Mitotane is a strong inducer of cytochrome P-4503A4; monitor when coadministered with CYP3A4 substrates for possible dosage adjustments. It is soluble in methanol, freely soluble in water, but only slightly soluble in 95% ethanol. voriconazole increases levels of vincristine by decreasing metabolism. Applies only to oral form of both agents. Always ask your health care professional for complete information about this product and your specific health needs. PRECAUTIONS: Before using vincristine, tell your doctor or pharmacist if you are allergic to it or to vincristine liposomal; or if you have any other allergies. Vinca alkaloid; acts in M & S phases by inhibiting microtubule formation, inhibits DNA/RNA synthesis, Y-site: cefepime, furosemide, idarubicin, sodium bicarbonate, Additive: Bleomycin, cytarabine, doxorubicin, doxorubicin/ondansetron, fluorouracil, methotrexate, Y-site: Allopurinol, amifostine, ampho B cholSO4, aztreonam, bleomycin, cisplatin, cladribin, cyclophosphamide, doxorubicin, doxorubicin liposomal, droperidol, etoposide PO4, fligrastim, fludarabine, fluorouracil, gatifloxacin, gemcitabine, granisetron, heparin, leucovorin, linezolid, melphalan, methotrexate, metoclopramide, mitomycin, ondansetron, paclitaxel, piperacillin-tazobactam, sargramostim, teniposide, thiotepa, topotecan, vinbastine, vinorelbine, Dilute with infusion bags of 0.9% NaCl for a final concentration of 0.0015-0.08 mg/mL, IV use ONLY; fatal if given intrathecally, Infuse IVPB over 15 min; central line only, Has also been given as slow infusion (4-8 hr) or cont infusion, Terminate injection or infusion immediately and aspirate back as much as possible, Apply warm pack for 15-20 min QID and elevate, Store intact vials under refrigeration at 2-8C. Either increases levels of the other by plasma protein binding competition. Use Caution/Monitor. When switching from drugs with prolonged immune effects, consider the half-life and mode of action of these drugs to avoid unintended additive immunosuppressive effects. Minor/Significance Unknown. Use Caution/Monitor.levoketoconazole will increase the level or effect of vincristine by P-glycoprotein (MDR1) efflux transporter. itraconazole will increase the level or effect of vincristine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor. vincristine decreases levels of ethotoin by inhibition of GI absorption. This website also contains material copyrighted by 3rd parties. Idelalisib is a strong CYP3A inhibitor; avoid coadministration with sensitive CYP3A substrates. Use Caution/Monitor. Minor/Significance Unknown. Voxelotor increases systemic exposure of sensitive CYP3A4 substrates. ritonavir will increase the level or effect of vincristine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. fedratinib will increase the level or effect of vincristine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Consult your doctor for more details. The pH of Vincristine Sulfate Injection, USP ranges from 4.0 to 5.0. Minor (1)vitamin A, vincristine. Individual plans may vary Monitor Closely (1)duvelisib will increase the level or effect of vincristine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Avoid or Use Alternate Drug. tobramycin inhaled and vincristine both increase nephrotoxicity and/or ototoxicity. voxelotor will increase the level or effect of vincristine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor. WebWhat Vincristine Is Used For: Cancers treated with Vincristine include: acute leukemia, Hodgkin's and non- Hodgkin's lymphoma, neuroblastoma, rhabdomyosarcoma, Minor/Significance Unknown. Minor/Significance Unknown. Infants and Children weighing 30 kg: IV: 0.05 mg/kg/dose (maximum dose: 2 mg/dose) weeks 1, 2, 4, 5, 6, 7, 8, 10, and 11, followed by 0.067 mg/kg/dose (maximum dose: 2 mg/dose) weeks 12, 13, 18, and 24 (in combination with doxorubicin, cyclophosphamide, mesna, etoposide, and filgrastim) Use Caution/Monitor.vincristine decreases levels of fosphenytoin by increasing metabolism. Adults Modify Therapy/Monitor Closely. Monitor Closely (1)tecovirimat will decrease the level or effect of vincristine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. St John's Wort will decrease the level or effect of vincristine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. If coadministration of lonafarnib (a sensitive CYP3A substrate) with weak CYP3A inhibitors is unavoidable, reduce to, or continue lonafarnib at starting dose. Use Caution/Monitor. ponatinib increases levels of vincristine by P-glycoprotein (MDR1) efflux transporter. Avoid or Use Alternate Drug. Use Caution/Monitor. Manage and view all your plans together even plans in different states. glecaprevir/pibrentasvir will increase the level or effect of vincristine by P-glycoprotein (MDR1) efflux transporter. Vincristine may also be used for other purposes not listed in this Coadministration with other other myelosuppressive anticancer agents, including DNA damaging agents, may potentiate and prolongate the myelosuppressive toxicity. crizotinib increases levels of vincristine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. tepotinib will increase the level or effect of vincristine by P-glycoprotein (MDR1) efflux transporter. vincristine increases levels of lomitapide by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Minor/Significance Unknown. Serious - Use Alternative (1)tipranavir will increase the level or effect of vincristine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor. Use Caution/Monitor. Use Caution/Monitor.St John's Wort will decrease the level or effect of vincristine by P-glycoprotein (MDR1) efflux transporter. Use Caution/Monitor. vincristine sulfate is often chosen as part of polychemotherapy because of lack of significant bonemarrow suppression (at recommended doses) and of unique clinical toxicity (neuropathy). Patients treated with selinexor may experience neurological toxicities. Consider reducing the dosage of P-gp substrates, where minimal concentration changes may lead to serious or life-threatening toxicities. Monitor Closely (1)carbamazepine will decrease the level or effect of vincristine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Consider reducing the dose of P-glycoprotein (P-gp) substrates, if adverse reactions are experienced when administered concomitantly with stiripentol. The drug should be administered under the supervision of an experienced cancer chemotherapy physician in a facility equipped to diagnose and manage complications, Properly position needle in the vein before administration; leakage to surrounding tissue during IV administration may cause considerable irritation, If extravasation occurs, the injection should be discontinued immediately and any remaining portion of the dose should then be introduced into another vein, Local injection of hyaluronidase and the application of moderate heat to the area of leakage help disperse the drug and may minimize discomfort and the possibility of cellulitis, Charcot-Marie-Tooth syndrome (demyelinating form), intrathecal (IT) administration, Use caution in bone marrow depression, neuromuscular disease, neurotoxic agents, ototoxic agents, pulmonary disease, hepatic impairment, potential CYP3A4 interactions, Potential for jaw/parotid pain, hoarseness and dysphagia due to cranial neuropathy, Vincristine sulfate injection has a different dosage recommendation than vincristine sulfate liposome injection; verify drug name and dose prior to preparation and administration to avoid administering incorrect dose, Extravasation can occur and can cause tissue injury; only administer through secure and free-flowing venous access line; if extravasation suspected, discontinue infusion immediately and consider local treatment measures, Neutropenia, thrombocytopenia, or anemia may occur; monitor complete blood counts prior to each dose; for Grade 3 or 4 neutropenia, thrombocytopenia, or anemia, consider dose delay or reduction, as well as supportive care measures, Tumor lysis syndrome (TLS) may occur in patients with ALL receiving therapy; anticipate, monitor for, and manage as appropriate, Ileus, bowel obstruction, and colonic pseudo-obstruction reported; can cause constipation; institute a prophylactic bowel regimen to mitigate potential constipation, bowel obstruction, and paralytic ileus; consider adequate dietary fiber intake, hydration, and stool softeners; use additional laxative products as needed, Therapy can cause severe fatigue; consider dose delay, reduction, or discontinuation of therapy as appropriate, Fatal hepatic toxicity and increased aspartate aminotransferase (AST) occurred; grade 3 increased AST reported; monitor hepatic function tests; interrupt or reduce dose as appropriate, Based on findings from nonclinical studies and mechanism of action, therapy can cause fetal harm when administered to a pregnant woman; there are insufficient data on use of vincristine sulfate in pregnant women to evaluate for a drug-associated risk, Verify pregnancy status in females of reproductive potential prior to initiating therapy, There are no data on presence of vincristine sulfate or metabolites in human milk, effects on breastfed child, or on milk production; because of potential for serious adverse reactions in a breastfed child, advise women not to breastfeed during treatment and for at least 1 week after last dose. 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