Cases of aggravation of symptoms of dementia (e.g. The efficacy of Blerone XL has not been demonstrated in children (see section 5.1). Uses. This product may contain inactive ingredients, which can cause allergic reactions or other problems. The effect of tolterodine was evaluated in patients, examined with urodynamic assessment at baseline and, depending on the urodynamic result, they were allocated to a urodynamic positive (motor urgency) or a urodynamic negative (sensory urgency) group. Pred vedenm motorovch vozidiel alebo pouvanm strojov by pacienti mali pozna svoju reakciu na liek. 2008 Nov;102(9):1128-32. doi: 10.1111/j.1464-410X.2008.07907.x. Consequently, tolterodine is not recommended during pregnancy. Trenaman SC, Bowles SK, Andrew MK, Goralski K. Pharmacol Res Perspect. For the full list of excipients, see section 6.1. Epub 2005 Nov 28. ketoconazole and itraconazole) and antiproteases is not recommended due to increased serum concentrations of tolterodine in poor CYP2D6 metabolisers with (subsequent) risk of overdosage (see section 4.4). Continue typing to refine. If you have any questions, ask your doctor or pharmacist. The excretion of radioactivity after administration of [14C]-tolterodine is about 77% in urine and 17% in faeces. National Library of Medicine How should this medicine be used? Treat symptoms as follows: - Severe central anticholinergic effects (e.g. Bethesda, MD 20894, Web Policies Treat symptoms as follows: - Severe central anticholinergic effects (e.g. If someone has overdosed and has serious symptoms such as passing out or trouble breathing, call 911. Modifiers of Response to Treatment With Fesoterodine for Urgency-Predominant Urinary Incontinence in a Randomized Controlled Trial. The changes in QT intervals did not significantly differ between placebo and treatment groups. - Concomitant administration of medicinal products known to prolong QT-interval including Class IA (e.g. This helps with bladder spasms, the urge to urinate, and control over your urination. 2013 Dec 6;6:1-16. doi: 10.2147/RRU.S40034. 1999 Oct;33(10):1073-82. doi: 10.1345/aph.18427. If you need to take more trips to the toilet than normal, this is called urinary frequency. FOIA alie osobitn upozornenia s uveden v SPC (as 4.4). Res Rep Urol. Do not share this medication with others. The apparent half-life for tolterodine given as the capsule is about 6 hours in extensive and about 10 hours in poor metabolisers (devoid of CYP2D6). Naa spolonos ako prevdzkovate tejto strnky neme poskytova poradenstvo a konzultcie otzok k zdravotnm problmom. In the US, Tolterodine (tolterodine systemic) is a member of the drug class urinary antispasmodics and is used to treat Urinary Frequency and Urinary Incontinence. WebMD does not provide medical advice, diagnosis or treatment. 362/2011 Z.z. Two paediatric phase 3 randomised, placebo-controlled, double-blind 12 week studies were conducted using tolterodine extended release capsules. The clinical relevance of these findings is unknown. It is soluble in methanol, slightly soluble in ethanol, and practically insoluble in toluene. The primary metabolic route is mediated by the polymorphic enzyme CYP2D6 and leads to the formation of the 5-hydroxymethyl metabolite. Generic Detrol Availability Last updated on Apr 13, 2023. Healthcare professionals are asked to report any suspected adverse reactions via the Yellow Card Scheme at: www.mhra.gov.uk/yellowcard or search for MHRA Yellow Card in the Google Play or Apple App Store. The exposure of the active moiety per mg dose is similar in adults and adolescents. Epub 2008 Jul 21. ketoconazole and itraconazole) and antiproteases is not recommended due to increased serum concentrations of tolterodine in poor CYP2D6 metabolisers with (subsequent) risk of overdose (see section 4.4). The role of sex, age and genetic polymorphisms of CYP enzymes on the pharmacokinetics of anticholinergic drugs. Wang L, Chiang C, Liang H, Wu H, Feng W, Quinney SK, Li J, Li L. Biomed Res Int. Five metabolites were structurally identified in urine. To help you remember, use it at the same times each day. The .gov means its official. Excipients with known effect: lactose monohydrate 65.41-68.99 mg. For the full list of excipients, see section 6.1. If it is near the time of the next dose, skip the missed dose. Bethesda, MD 20894, Web Policies Ask your pharmacist which type of laxative is right for you. Clipboard, Search History, and several other advanced features are temporarily unavailable. Popis Cialis 20 mg tbl flm 1x2 ks: Liek obsahuje lieivo tadalafil, ktor patr do skupiny ltok nazvanch inhibtory fosfodiesterzy typu 5. The most severe adverse events observed were accommodation disturbances and micturition difficulties. Drug interaction studies have shown no interactions with warfarin or combined oral contraceptives (ethinyl estradiol/levonorgestrel). Tolterodine - Brand names: Blerone, Detrol, Detrusitol, Inconex, Mariosea, Neditol, Preblacon, Santizor On this page About tolterodine Key facts Who can and cannot take tolterodine How and when to take tolterodine Side effects How to cope with side effects of tolterodine Pregnancy and breastfeeding Cautions with other medicines The carboxylated metabolite and the corresponding dealkylated metabolite account for about 51% and 29% of the urinary recovery, respectively. The exposure of the active moiety per mg dose is similar in adults and adolescents. Do not start, stop, or change the dosage of any medicines without your doctor's approval. Takeaway Medications, including anticholinergics and drugs that relax your bladder, may help treat an overactive bladder. We comply with the HONcode standard for trustworthy health information. Liek nie je uren na pouitie uien. Oki T, Maruyama S, Takagi Y, Yamamura HI, Yamada S. Eur J Pharmacol. Generic Name (S): tolterodine View Free Coupon Uses This medication is used to treat an overactive bladder. A total of 710 paediatric patients (486 on tolterodine and 224 on placebo) aged 5-10 years with urinary frequency and urge urinary incontinence were studied. Not known (cannot be estimated from the available data), Confusion, hallucinations, disorientation, Dry eyes, abnormal vision (including abnormal accommodation), Palpitations, cardiac failure, arrhythmia, Dyspepsia, constipation, abdominal pain, flatulence, diarrhoea, General disorders and administration site conditions. No significant difference between the two groups was observed in either study with regard to change from baseline in total number of incontinence episodes/week (see section 4.8). A subset (about 7%) of the population is devoid of CYP2D6 activity. The mean exposure of the active moiety per mg dose is approximately two-fold higher in children between 5-10 years than in adults (see sections 4.2 and 5.1). Tolterodine is a competitive, specific muscarinic receptor antagonist with a selectivity for the urinary bladder over salivary glands in vivo. Subscribe to Drugs.com newsletters for the latest medication news, new drug approvals, alerts and updates. hallucinations, severe excitation): treat with physostigmine. Light blue opaque-light blue opaque size 1 hard gelatin capsules containing four white, round, biconvex coated tablets. Ask your doctor or pharmacist for more details. In extensive metabolisers this metabolite contributes significantly to the therapeutic effect (see section 5.2). HHS Vulnerability Disclosure, Help Stav registrcie: D - Registrcia bez obmedzenia platnosti, poda 50 zk. Studies in animals have shown reproductive toxicity (see section 5.3). QT prolongation can rarely cause serious (rarely fatal) fast/irregular heartbeat and other symptoms (such as severe dizziness, fainting) that need medical attention right away. Tolterodine should be avoided during lactation. Tolterodine comes as a tablet and an extended-release (long-acting) capsule to take by mouth. Tolterodine is in a class of medications called antimuscarinics. The potential risk for humans is unknown. Je nm to to, no otzky zdravotnho charakteru vm me kvalifikovane zodpoveda len v lekr alebo lekrnik. 2005 May;27(5):511-30. doi: 10.1016/j.clinthera.2005.05.008. Vetky produkty patriace do skupiny HLG04BE08, Stav registrcie: D - Registrcia bez obmedzenia platnosti, poda 50 zk. A clinical study has indicated that tolterodine is not a metabolic inhibitor of CYP2D6, 2C19, 2C9, 3A4 or 1A2. The effect of prokinetics like metoclopramide and cisapride may be decreased by tolterodine. Dry mouth, dry eyes, headache, constipation, stomach upset/pain, dizziness, drowsiness, tiredness, or blurred vision may occur. The effect of the treatment can be expected within 4 weeks. Absolute change and percentage change relative to baseline. The plasma levels of other metabolites were markedly (up to 12-fold) increased in these patients. A cardboard box containing the appropriate number of blisters of transparent PVC/PE/PVDC Aluminium foil and an instruction leaflet. Pri erektilnej dysfunkcii sa m liek ui aspo 30 mint pred plnovanou pohlavnou aktivitou. Singh-Franco D, Machado C, Tuteja S, Zapantis A. Clin Ther. The changes in QT intervals did not significantly differ between placebo and treatment groups. About 2-fold higher exposure of unbound tolterodine and the 5-hydroxymethyl metabolite is found in subjects with liver cirrhosis (see sections 4.2 and 4.4). Drug interactions may change how your medications work or increase your risk for serious side effects. It is not intended as a substitute for the expertise and judgement of your physician, pharmacist or other healthcare professional. This survey is being conducted by the WebMD marketing sciences department. The mean exposure of the active moiety per mg dose is approximately two-fold higher in children between 5-10 years than in adults (see sections 4.2 and 5.1). Cialis (tadalafil) is a prescription medication used to treat erectile dysfunction (ED). The volume of distribution of tolterodine is 113 L. Tolterodine is extensively metabolised by the liver following oral dosing. b) zk. Due to the pharmacological effect of tolterodine it may cause mild to moderate antimuscarinic effects, like dryness of the mouth, dyspepsia and dry eyes. The pharmacokinetics is linear in the therapeutic dose range. If you notice other effects not listed above, contact your doctor or pharmacist. Would you like email updates of new search results? The effect of the treatment can be expected within 4 weeks. Tolterodine prolonged-release capsules give a slower absorption of tolterodine than the immediate-release tablets do. Start typing to retrieve search suggestions. Tolterodine may cause a condition that affects the heart rhythm (QT prolongation). 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