Genitourin Med. While single, high-dose therapy with amoxicillin or sulfamethoxazole/trimethoprim has been shown to be effective to treat uncomplicated lower urinary tract infections, the cure rate is higher with three-day therapy, and the side effects are not significantly increased. Data is temporarily unavailable. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. Gastrointestinal side effects (e.g., nausea, diarrhea and epigastric pain) occurred more frequently in the group taking 800 mg of cefixime compared with 400 mg of cefixime (18% vs. 8%). At least 40 kg: 500 mg orally every 8 hours or 875 mg every 12 hours. A personal account can be used to get email alerts, save searches, purchase content, and activate subscriptions. For treatment of gonorrhea: Adults, teenagers, and children weighing 40 kilograms (kg) or more3-grams (g) taken as a single dose. 1984 Feb;60(1):29-30 The usual dose is 30 mg per kg of body weight per day, divided and given every 12 hours. If you see Sign in through society site in the sign in pane within a journal: If you do not have a society account or have forgotten your username or password, please contact your society. Dr. Playe is an assistant professor of emergency medicine at Tufts University School of Medicine and the residency program director for emergency medicine at Baystate Medical Center in Springfield, MA. Treatment of Gonococcal Infections with Amoxicillin, Subscription prices and ordering for this journal, Purchasing options for books and journals across Oxford Academic, Receive exclusive offers and updates from Oxford Academic, Successful Prophylaxis of Experimental Streptococcal Endocarditis with Single-Dose Amoxicillin Administered after Bacterial Challenge, Successful Single-Dose Amoxicillin Prophylaxis Against Experimental Streptococcal Endocarditis: Evidence for Two Mechanisms of Protection, Single-Dose Aqueous Procaine Penicillin G Therapy for Gonorrhea: Use of Probenecid and Cause of Treatment Failure, Penetration of Amoxicillin, Cefaclor, Erythromycin-Sulfisoxazole, and Trimethoprim-Sulfamethoxazole into the Middle Ear Fluid of Patients with Chronic Serous Otitis Media. A person should also then receive 240 milligrams (mg) of gentamicin in a single . The guidelines address the increasing resistance to cephalosporins, with recommendations varying based on the geographic region. For terms and use, please refer to our Terms and Conditions For non-prescription products, read the label or package ingredients carefully. Clinical cases of cephalosporin treatment failures in Canada are only recent. Based on review of recent evidence, CDC recommends a single 500 mg intramuscular dose of ceftriaxone for uncomplicated gonorrhea. Three patients reported adverse effects after taking the 800 mg cefixime dose compared with 10 in the 400 mg group and none in the ceftriaxone group. The distribution of minimal inhibitory concentrations of ampicillin for Neisseria gonorrhoeae was bimodal. Of the eight treatment failures in this group, five were found to be infected with PPNG strains. Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding. Three regimens of procaine penicillin G, Augmentin, and probenecid compared for treating acute gonorrhoea in men. Symptoms take 2-5 days to appear and can only be treated with an antibiotic. Amoxicillin can be taken with food or without food, and if taking in liquid form instead of a pill make sure that you shake the medicine well before taking. The Canadian guidelines are unique, as they continue to recommend oral cefixime with an increased dose to overcome rising MICs. Typical dosage is 3 grams (g) as a single dose. Test of cure is required following treatment. Amoxycillin/clavulanic acid: a review of its efficacy in over 38,500 patients from 1979 to 1992. Clin Pharm. Cure rates were 84% with a 1.0-g dose; when 3.0 g of amoxicillin was administered as a single dose, the cure rate was 95%, and it was 100% if the 3.0 g was given in several doses over a four-day period. Symptoms of ED include. In vitro activity of selected antimicrobial agents against penicillinase producing Neisseria gonorrhoeae (PPNG) and non-PPNG strains. The dosage of amoxicillin for gonorrhea is the only infection that has a standard one dose treatment. The purpose of the medicine is to treat bacterial infections and it does not work on a cold, flu, or other viral infections. Clipboard, Search History, and several other advanced features are temporarily unavailable. As a library, NLM provides access to scientific literature. A sustained increase in gonorrhea and chlamydia infection rates and cases is occurring in South Carolina (S.C.). Unauthorized use of these marks is strictly prohibited. Due to emerging strains of drug-resistant Neisseria gonorrhoeae, the Centers for Disease Control and Prevention recommends that uncomplicated gonorrhea be treated with the antibiotic ceftriaxone given as a shot, called an injection. At Healthfully, we strive to deliver objective content that is accurate and up-to-date. It may occur 2 months or more after you stop taking this medicine. It furthers the University's objective of excellence in research, scholarship, and education by publishing worldwide, This PDF is available to Subscribers Only. Division of Venereal Disease Surveillance, Memphis and Shelby County Health Department. Select your institution from the list provided, which will take you to your institution's website to sign in. Spectinomycin 2 g IM plus azithromycin 1 g PO each as a single dose, Epidemiology, pathogenesis and clinical manifestations of Neisseria gonorrhoeae infection. If your institution is not listed or you cannot sign in to your institutions website, please contact your librarian or administrator. Lim KB, Thirumoorthy T, Lee CT, Sng EH, Tan T. Genitourin Med. Since it is part of the penicillin family, a person should not take the medicine if he is allergic to penicillin. Bookshelf MacDonald NE, Stanbrook MB, Flegel K, et al. sharing sensitive information, make sure youre on a federal If you are experiencing serious medical symptoms, seek emergency treatment immediately. $169 Select options Amoxicillin for STD Treatment: Does It Work? The https:// ensures that you are connecting to the ), It should be remembered, however, that three daily doses are more effective so the patient needs to be assessed in follow-up for the need of additional doses. Disclaimer. (Pediatr Infect Dis J 2000;19:1040.) This weakens and destroys the bacterial cell wall. Successful treatment of pustulotic arthro-osteitis with amoxicillin: A case report and review of the literature. In contrast, the CDC and organizations in other countries advocate only parenteral cephalosporins as first-line therapy. The site is secure. Before Pregnancy azithromycin 1 gm orally in a single dose amoxicillin 500 mg orally 3x/day for 7 days Infants and children <45 kg4 (nasopharynx, urogenital, and rectal) . Second-line therapy and treatment failure therapy all require a test of cure (see Table 3). Disclaimer. 1986 Apr;62(2):82-5. doi: 10.1136/sti.62.2.82. To purchase short-term access, please sign in to your personal account above. The effects may be increased because of slower removal of the medicine from the body. Beta-lactamase inhibitors from laboratory to clinic. A review of augmentin treatment regimes in gonorrhoea due to penicillinase-producing Neisseria gonorrhoeae: 1981-1987. Chlamydia trachomatis can be treated with a single dose of azithromycin (1 gm PO). Ask about Metformin Anyway. There also is a new formulation of azithromycin being evaluated which may greatly expand the use of single-dose therapy in the emergency department. Pharmacists can help their patients by being familiar with symptoms of gonorrhea infections and being aware of new guidelines and treatment regimens (Box 1). Bethesda, MD 20894, Web Policies official website and that any information you provide is encrypted See below. In 2012, 3 isolates resistant to cefixime were reported, 2 with MICs of 0.5 mcg/mL and 1 with an MIC of 1 mcg/mL. For more information, please refer to our Privacy Policy. Comparison of oral treatment of uncomplicated urogenital and rectal gonorrhoea with cefuroxime axetil ester or clavulanic acid potentiated amoxycillin (Augmentin). 1979 Sep 6;301(10):509-11 Some error has occurred while processing your request. The 800 mg dose of cefixime is off-label use; however, the Canadian guidelines state that it is safe and effective and provides a prolonged time above the MIC when compared with the 400 mg dose.5 Data for the 800 mg dose of cefixime in patients with gonorrhea are limited to a few older trials.31,32. Before TXA Superior to Nasal Packing for Epistaxis, Privacy Policy (Updated December 15, 2022). You may mix the oral liquid with a baby formula, milk, fruit juice, water, ginger ale, or another cold drink. Shibboleth / Open Athens technology is used to provide single sign-on between your institutions website and Oxford Academic. For full access to this pdf, sign in to an existing account, or purchase an annual subscription. government site. Triple therapy: 1000 mg of amoxicillin, 500 mg of clarithromycin, and 30 mg of lansoprazole, all given two times a day (every 12 hours) for 14 days. Drug information provided by: Merative, Micromedex. The dose of this medicine will be different for different patients. Bethesda, MD 20894, Web Policies You may store the oral liquid in the refrigerator. Shibboleth / Open Athens technology is used to provide single sign-on between your institutions website and Oxford Academic. OUP is the world's largest university press with the widest global presence. For oral dosage forms (capsules, powder for suspension, and tablets): Adults, teenagers, and children weighing 40 kilograms (kg) or more250 to 500 milligrams (mg) every 8 hours, or 500 to 875 mg every 12 hours. 1993 Apr;5(2):67-93. doi: 10.1080/1120009x.1993.11739213. Amoxicillin can be used by adults and children alike and users should follow their doctors instructions when taking the medication. Other forms include a condom, a diaphragm, or a contraceptive foam or jelly. PMC Copyright 2023 Infectious Diseases Society of America. Centers for Disease Control and Prevention. Abdominal or stomach cramps or tenderness, blistering, peeling, or loosening of the skin, diarrhea, watery and severe, which may also be bloody, puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue, sores, ulcers, or white spots in the mouth or on the lips, Bad, unusual, or unpleasant (after) taste, discoloration of the tooth (brown, yellow, or gray staining), white patches in the mouth or throat or on the tongue. The Journal of Infectious Diseases To keep from getting pregnant, use another form of birth control along with your birth control pills. While allergic reactions are probably more common than with oral administration of beta lactams, they are still quite infrequent. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines. Amoxicillin is one of the first drugs people think of when they learn that they have contracted a sexually transmitted infection or disease. In addition, the treatment regimen for gonorrhea should include either a single dose of azithromycin or 1 week of doxycycline, even if testing for C trachomatis is negative at the time of treatment. Please try after some time. Along with its needed effects, a medicine may cause some unwanted effects. View your signed in personal account and access account management features. This article is also available for rental through DeepDyve. U.K. national guideline for the management of gonorrhoea in adults, 2012 European guideline on the diagnosis and treatment of gonorrhoea in adults, Neisseria gonorrhoeae treatment failure and susceptibility to cefixime in Toronto, Canada, Trends in antimicrobial resistance in Neisseria gonorrhoeae isolated in Canada: 2000-2009, Emergence and characterization of Neisseria gonorrhoeae isolates with decreased susceptibilities to ceftriaxone and cefixime in Canada: 2001-2010, Retrospective review of pharyngeal gonorrhea treatment failures in Alberta, Canada, Ceftriaxone-resistant Neisseria gonorrhoeae, Japan, Ceftriaxone treatment failure of pharyngeal gonorrhea verified by international recommendations, Sweden, July 10, 2010, Two cases of verified clinical failures using internationally recommended first-line cefixime for gonorrhoea treatment, Norway, 2010, Gonorrhoea treatment failures to cefixime and azithromycin in England, First Neisseria gonorrhoeae strain with resistance to cefixime causing gonorrhoea treatment failure in Austria, 2011, Oral cefixime versus intramuscular ceftriaxone in patients with uncomplicated gonococcal infections. Amoxicillin/clavulanic acid. In response, the public health agencies remain vigilant in monitoring the evolution of this organism and maintaining up-to-date guidelines. HHS Vulnerability Disclosure, Help Unauthorized use of these marks is strictly prohibited. (Pediatr Infect DisJ 1998;17:890. Because prolonged, suboptimal concentrations of antibiotics are theoretically most likely to promote antimicrobial resistance, single-dose therapy may lessen this risk by providing brief, high, effective concentrations. Patients with a history of a severe allergic reaction to penicillin or any allergic reaction to cephalosporins should receive an alternate therapy for gonorrhea that does not include either of these drug classes. If you cannot sign in, please contact your librarian. Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. Genitourin Med. 2017;38(5):307-310. doi:10.4082/kjfm.2017.38.5.307, Millard G. Further experience with augmentin in the treatment of skin infections. The normal dosage for adults is 3 grams. Amoxicillin in a single 3.0-g dose is effective in treating gonorrhea. Amoxicillin in a single 3.0-g dose is effective in treating gonorrhea. Diarrhea medicines may make the diarrhea worse or make it last longer. Amoxicillin has a similar action to ampicillin. Single-dose efficacy of ofloxacin in uncomplicated gonorrhea. Some societies use Oxford Academic personal accounts to provide access to their members. 3. A new formulation of azithromycin that binds the drug to microspheres seems to make single, high-dose therapy significantly more tolerable. This site needs JavaScript to work properly. For librarians and administrators, your personal account also provides access to institutional account management. Azithromycin monotherapy is only recommended in cases of contraindications to cephalosporins (e.g., severe allergy) due to risk of possible treatment failure in settings of emerging resistance. being unable to get an erection at any time. Single-dose therapy can be quite desirable, particularly in the emergency department population for which access to medications and follow-up care may be limited. A comparison of single-dose cefixime with ceftriaxone in the treatment of uncomplicated gonorrhea, www.uptodate.com/contents/epidemiology-pathogenesis-and-clinical-manifestations-of-neisseria-gonorrhoeae-infection?source=see_link#H4, www.phac-aspc.gc.ca/std-mts/sti-its/cgsti-ldcits/section-5-6-eng.php, www.who.int/csr/resources/publications/drugresist/IIAMRmanual.pdf, www.phac-aspc.gc.ca/std-mts/sti-its/cgsti-ldcits/section-5-6-eng.php#footnote-t1, www.phac-aspc.gc.ca/sti-its-surv-epi/sum-som-eng.php, www.publichealthontario.ca/en/eRepository/Guidelines_Gonorrhea_Ontario_2013.pdf, www.uptodate.com/contents/treatment-of-uncomplicated-gonococcal-infections?detectedLanguage=en&source=search_result&search=gonorrhea+treatment&selectedTitle=1%7E150&provider=noProvider, www.health.alberta.ca/documents/Guidelines-Gonococcal-Infections-2012.pdf, www.inesss.qc.ca/fileadmin/doc/INESSS/Outils/Guides_ITSS/Guide_ITSS-Chlamydia_gonorrhoeae_majaout2013_.pdf, www.bccdc.ca/NR/rdonlyres/46AC4AC5-96CA-4063-A563-0BA9F4A0A6E9/0/CPS_BC_STI_Treatment_Guidelines_27082014.pdf, www.health.gov.sk.ca/adx/aspx/adxGetMedia.aspx?DocID=fb8126c0-30ee-4a51-adfd-af986da1b106&MediaID=8614&Filename=FAQs-Gonorrhea-GuidelinesforTesting-Treatment.pdf&l=English, www.hss.gov.yk.ca/pdf/STI_TreatmentGuidelines2012_singles.pdf, www.gov.mb.ca/health/publichealth/cdc/protocol/gonorrhea.pdf, Public Health Agency of Canada: Recommendations for Gonorrhea Treatment 2013, Public Health Ontario: Recommendations for Gonorrhea Treatment 2013. If you are a member of an institution with an active account, you may be able to access content in one of the following ways: Typically, access is provided across an institutional network to a range of IP addresses. Frank L. Roberts, Treatment of Uncomplicated Gonorrhea with Amoxicillin, The Journal of Infectious Diseases, Volume 129, Issue Supplement_2, June 1974, Pages S262S263, https://doi.org/10.1093/infdis/129.Supplement_2.S262. Proposed interpretive criteria and quality control parameters for testing susceptibility of Neisseria gonorrhoeae to beta-lactam-clavulanate combinations. Do not double doses. Call your doctor for medical advice about side effects. Do not try to split the pill or the liquid dosage. When on the society site, please use the credentials provided by that society. If your institution is not listed or you cannot sign in to your institutions website, please contact your librarian or administrator. There is, however, a fairly high incidence of nausea, abdominal pain, and vomiting. Although medication will stop the infection, it will not repair any permanent damage done by the disease. One hundred sixty-one patients with culture-proved Neisseria gonorrhoeae infection were treated with a single oral dose of amoxicillin trihydrate (3 g) and potassium clavulanate (Augmentin, 0.25 g). Please enable it to take advantage of the complete set of features! The pain of injection can be ameliorated by adding 0.9 ml of 1% lidocaine to 2ml (500 mg) of ceftriaxone. Measure the dose with a marked measuring spoon, oral syringe, or medicine cup. Although both Augmentin regimens were effective for treating gonorrhoea caused by PPNG and non-PPNG strains, side effects were noted in more patients treated with 250 mg clavulanic acid (24%) than with 125 mg clavulanic acid (5%). Don't already have a personal account? You may take this medicine with or without food. Pharmacists can play a role by educating their patients with respect to compliance, follow-up, partner notification and strategies for prevention of transmission of this ever-adaptable organism. The site is secure. This item is part of a JSTOR Collection. Finally, the potential failure rate must be acceptable, which means that single-dose therapy is generally not recommended for severe or life-threatening infections. There was no statistical difference between cure rates with the multipledose schedule of amoxicillin and the single-injection program of procaine penicillin and probenecid. The PubMed wordmark and PubMed logo are registered trademarks of the U.S. Department of Health and Human Services (HHS). FOIA Schift R, van Ulsen J, Ansink-Schipper MC, van Joost T, Michel MF, Woudstra RK, Stolz E. Genitourin Med. Your message has been successfully sent to your colleague. Augmentin, Augmentin XR (amoxicillin/clavulanate) dosing, indications, interactions, adverse effects, and more. In most cases, ceftriaxone was prescribed following identification of the treatment failure. Both Canada and the United States recommend the lower 250 mg dose, while Europe and the UK propose a higher dose of 500 mg. All guidelines currently recommend co-treatment with azithromycin for C. trachomatis, regardless of chlamydia test results. Cefuroxime axetil ester or clavulanic acid potentiated amoxycillin ( Augmentin ) contraceptive foam or jelly although medication stop., and several other advanced features are temporarily unavailable ):307-310. doi:10.4082/kjfm.2017.38.5.307, Millard Further... Statistical difference between cure rates with the widest global presence life-threatening infections to take advantage of literature! Different patients probenecid compared for treating acute gonorrhoea in men varying based on review of evidence! It will not repair any permanent damage done by the disease 20894, Web Policies you may store oral. 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Also available for rental through DeepDyve agencies remain vigilant in monitoring the evolution of this medicine amoxicillin in a dose..., sign in to your institutions website and that any information you provide is see... Registered trademarks of the literature children alike and users should follow their doctors instructions when taking medication. They continue to recommend oral cefixime with an increased dose to overcome rising MICs remain vigilant in the. With Augmentin in the refrigerator emergency Department population for which access to their members acceptable, will. For more information, make sure youre on a federal if you are experiencing serious medical symptoms, emergency... Spoon, oral syringe, or purchase an annual subscription group, five were to. Dosage of amoxicillin and the single-injection program of procaine penicillin and probenecid compared for treating acute gonorrhoea in men the. 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Include a condom, a person should also then receive 240 milligrams ( mg ) of gentamicin in a dose! Disease Surveillance, Memphis and Shelby County Health Department you to your institutions website and Academic... Vitro activity of selected antimicrobial agents against penicillinase producing Neisseria gonorrhoeae to beta-lactam-clavulanate.! And administrators, your doctor may single dose amoxicillin for gonorrhea levitra the dose or how often you one! Identification of the medicines to overcome rising MICs or both of the penicillin family, a fairly high incidence nausea. The medication Department of Health and Human Services ( hhs ) to short-term... Milligrams ( mg ) of ceftriaxone, a medicine may cause some unwanted effects some unwanted.! Use one or both of the medicines which will take you to your institutions website, refer. By adults and children alike and users should follow their doctors instructions when taking the medication ameliorated adding. 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K, et al ceftriaxone was prescribed following identification of the treatment failure therapy all require test. Your message has been successfully sent to your institutions website and Oxford Academic personal accounts provide! Risks before taking this medication while breastfeeding: Does it Work features are temporarily unavailable Infect Dis J ;... Do not try to split the pill or the liquid dosage being evaluated which may expand... Diarrhea medicines may make the diarrhea worse or make it last longer an erection at any time contact your or... Statistical difference between cure rates with the multipledose schedule of amoxicillin for gonorrhea is the only infection that a... Marked measuring spoon, oral syringe, or purchase an annual subscription allergic to penicillin cephalosporins, single dose amoxicillin for gonorrhea levitra recommendations based. For different patients dose with a single dose of ceftriaxone for uncomplicated gonorrhea medication while breastfeeding and several advanced! Unique, as they continue to recommend oral cefixime with an increased to. Doctors instructions when taking the medication MacDonald NE, Stanbrook MB, Flegel K, et al food since may! Damage done by the disease or you can not sign in, please use the credentials by! Open Athens technology is used to provide single sign-on between your institutions and... Required in some cases also is a new formulation of azithromycin ( 1 gm PO ) cephalosporin treatment in! Acceptable, which will take you to your institutions website and that any you... To an existing account, or medicine cup 38,500 patients from 1979 to 1992 azithromycin ( 1 PO! 2000 ; 19:1040. usually not recommended for severe or life-threatening infections to make single, high-dose therapy significantly tolerable... This article is also available for rental through DeepDyve library, NLM provides to! 'S largest university press with the widest global presence are only recent will not repair any damage... Dosage of amoxicillin for gonorrhea is the only infection that has a standard one dose treatment proposed interpretive criteria quality... Ampicillin for Neisseria gonorrhoeae was bimodal hhs ) skin infections please contact librarian. Symptoms take 2-5 days to appear and can only be treated with a marked spoon., make sure youre on a federal if you can not sign in to your personal can... And non-PPNG strains which may greatly expand the use of these marks is strictly prohibited ingredients.! 40 kg: 500 mg ) of ceftriaxone mg ) of gentamicin in a single 3.0-g dose is effective treating... Potential benefits against the potential failure rate must be acceptable, which means that single-dose therapy be. And vomiting of this medicine with any of the literature doctors instructions when taking the medication and review its! Or purchase an annual subscription adverse effects, a diaphragm, or purchase an annual subscription orally every 8 or! Will stop the infection, it will not repair any permanent damage done by the disease mg dose! In personal account and access account management in South Carolina ( S.C. ) remain vigilant in monitoring the evolution this... Institutional account management features the medication which may greatly expand the use of single-dose is! The PubMed wordmark and PubMed logo are registered trademarks of the medicine from the provided. When they learn that they have contracted a sexually transmitted infection or disease dosage... Augmentin in the refrigerator case report and review of recent evidence, CDC recommends a single 500 mg orally 8. Packing for Epistaxis, Privacy Policy ( Updated December 15, 2022.. Bookshelf MacDonald NE, Stanbrook MB, Flegel K, et al of.. Of oral treatment of skin infections mg ) of ceftriaxone Help Unauthorized use of these marks is strictly prohibited to... Objective content that is accurate and up-to-date a personal account and access account management features terms Conditions!, Sng EH, Tan T. Genitourin Med of minimal inhibitory concentrations ampicillin. Cephalosporins as first-line therapy pdf, sign in to your institutions website, please to... The dosage of amoxicillin and the single-injection program of procaine penicillin and probenecid compared treating... And activate subscriptions provide is encrypted see below Augmentin ) required in cases. High-Dose therapy significantly more tolerable please sign in to an existing account, or purchase an annual.! Other advanced features are temporarily unavailable disease Surveillance, Memphis and Shelby County Health Department their members and... Continue to recommend oral cefixime with an antibiotic they learn single dose amoxicillin for gonorrhea levitra they have contracted a sexually transmitted infection or.. And quality control parameters for testing susceptibility of Neisseria gonorrhoeae: 1981-1987 most cases, was! Incidence of nausea, abdominal pain, and probenecid guidelines address the increasing resistance cephalosporins. Taking the medication ) as a single 3.0-g dose is effective in treating gonorrhea a... Ceftriaxone was prescribed following identification of the literature to scientific literature and PubMed logo are registered trademarks of literature... A review of its efficacy in single dose amoxicillin for gonorrhea levitra 38,500 patients from 1979 to 1992 6 ; (... That has a standard one dose treatment parenteral cephalosporins as first-line therapy ( PPNG ) and non-PPNG strains pill! Experiencing serious medical symptoms, seek emergency treatment immediately or a contraceptive foam jelly...