Simethicone is a medication that causes gas bubbles to coalesce, facilitating expulsion desflurane and loperamide both increase QTc interval. Applies only to oral form of both agents. Last updated on May 25, 2023. Use Caution/Monitor. Avoid or Use Alternate Drug. 2-12 years: 40 mg/dose; do not exceed 480 mg/day. All H 2-receptor antagonists are equipotent when used in equivalent doses. lonafarnib will increase the level or effect of loperamide by P-glycoprotein (MDR1) efflux transporter. Use Caution/Monitor. Serious - Use Alternative (1)buprenorphine and loperamide both increase QTc interval. Use Caution/Monitor. itraconazole and loperamide both increase QTc interval. If use with an acid-reducing agent cannot be avoided, administer infigratinib 2 hr before and after administration of a locally-acting antacid. Avoid or Use Alternate Drug. 27.3 to 43.2 kg: Loperamide 2 mg-simethicone 125 mg orally once after the first loose stool, followed by loperamide 1 mg-simethicone 62.5 mg orally once after each subsequent loose stool. Avoid or Use Alternate Drug. If you need to go to A&E, do not drive yourself. Monitor for reduced therapeutic effect. Children 12 years and Adolescents: 40 to 125 mg 4 times daily as needed after meals and at bedtime; with some formulations, may administer a single 250 mg dose if needed; maximum daily dose: 500 mg/24 hours nilotinib will increase the level or effect of loperamide by P-glycoprotein (MDR1) efflux transporter. For patients taking the chewable tablet form of this medicine: For patients taking the oral liquid form of this medicine: Avoid foods that seem to increase gas. aripiprazole and loperamide both increase QTc interval. Coadministration with other CNS depressants, such as skeletal muscle relaxants, may cause respiratory depression, hypotension, profound sedation, coma, and/or death. Monitor for hypotension, respiratory depression, and profound sedation. Maximum dose: Calcium carbonate 4500 mg-simethicone 480 mg (6 tablets)/day. If your child takes this drug on a regular basis, give a missed dose as soon as you think about it. It does NOT include all information about conditions, treatments, medications, side effects, or risks that may apply to a specific patient. Data sources include IBM Watson Micromedex (updated 5 June 2023), Cerner Multum (updated 5 June 2023), ASHP (updated 10 Apr 2023) and others. This website also contains material copyrighted by 3rd parties. Use Caution/Monitor. You may report side effects to FDA at 1-800-FDA-1088 or at www.fda.gov/medwatch.In Canada - Call your doctor for medical advice about side effects. Monitor therapeutic drug concentrations, as indicated, or consider reducing the dosage of the P-gp substrate and titrate to clinical effect. Monitor Closely (1)lithium and loperamide both increase QTc interval. arformoterol and loperamide both increase QTc interval. Use Caution/Monitor. Dosage recommendation may vary among countries and individual products (refer to specific product guideline). Maximum daily dose: 480 mg/24 hours. buprenorphine, long-acting injection and loperamide both increase QTc interval. Avoid or Use Alternate Drug. Use Caution/Monitor. We do not suggest simethicone for the treatment of infantile colic. Tell the doctor and pharmacist about all of your childs drugs (prescription or OTC, natural products, vitamins) and health problems. Overview simethicone surfactant Interaction Characteristics: urine alkalinizer Avoid/Use Alternative dextroamphetamine lisdexamfetamine Monitor/Modify Tx levothyroxine lithium Caution Advised amantadine aspirin Use Caution/Monitor. Dosage Forms & Strengths tablet 80mg 125mg capsule 125mg 180mg tablet, chewable 80mg 125mg liquid, oral 20mg/0.3mL oral suspension 20mg/0.3mL 40mg/0.6mL strip, orally disintegrating 40mg 62.5mg Gas. Keep all drugs out of the reach of children and pets. Monitor Closely (1)phenobarbital will decrease the level or effect of loperamide by P-glycoprotein (MDR1) efflux transporter. Monitor Closely (1)lomitapide increases levels of loperamide by P-glycoprotein (MDR1) efflux transporter. Use Caution/Monitor. Modify Therapy/Monitor Closely. Monitor Closely (1)lovastatin will increase the level or effect of loperamide by P-glycoprotein (MDR1) efflux transporter. Monitor Closely (1)gemifloxacin and loperamide both increase QTc interval. tacrolimus and loperamide both increase QTc interval. There is no specific information comparing use of simethicone in the elderly with use in other age groups. Avoid or Use Alternate Drug. Monitor for hypotension, respiratory depression, and profound sedation. artemether and loperamide both increase QTc interval. Tell your healthcare professional if you are taking any other prescription or nonprescription (over-the-counter [OTC]) medicine. You must check to make sure that it is safe to give this drug with all of your childs other drugs and health problems. The manufacturer may have changed the ingredients. Symptoms of ED include. Discontinue loperamide immediately if constipation occurs. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. Serious - Use Alternative (1)bedaquiline and loperamide both increase QTc interval. Adults and teenagersUsual dose is 40 to 125 mg four times a day, after meals and at bedtime or the dose may be 150 mg three times a day, after meals. Use the dosing syringe provided, or use a medicine dose-measuring device (not a kitchen spoon). Do not take more of this product than recommended for your age.If you are using the chewable tablets, chew each tablet well and swallow.If your condition lasts or gets worse, or if you think you may have a serious medical problem, get medical help right away. Avoid or Use Alternate Drug. Brand Names: US Monitor or titrate P-gp substrate dose if coadministered. Increases risk for constipation related serious adverse reactions. For oral dosage forms (capsules or tablets): Adults and teenagersUsual dose is 60 to 125 milligrams (mg) four times a day, after meals and at bedtime. Coadministration of metoclopramide intranasal with drugs that impair GI motility may decrease systemic absorption of metoclopramide. Avoid or Use Alternate Drug. Use Caution/Monitor. erdafitinib will increase the level or effect of loperamide by P-glycoprotein (MDR1) efflux transporter. Chew the tablets before swallowing. being unable to get an erection at any time. Modify Therapy/Monitor Closely. Serious - Use Alternative (1)fentanyl transdermal, loperamide. Use Caution/Monitor. Certain circumstances may increase risk of torsade de pointes and/or sudden death in association with drugs that prolong the QTc interval (eg, bradycardia, hypokalemia or hypomagnesemia, coadministration with other drugs that prolong QTc interval, presence of congenital QT prolongation). Monitor Closely (1)vemurafenib increases levels of loperamide by P-glycoprotein (MDR1) efflux transporter. Monitor Closely (1)sunitinib and loperamide both increase QTc interval. Avoid or Use Alternate Drug. dolasetron and loperamide both increase QTc interval. Measure liquid medicine carefully. The dose should not be more than 500 mg in twenty-four hours. Use of any information is solely at the user's own risk. cyclosporine will increase the level or effect of loperamide by P-glycoprotein (MDR1) efflux transporter. Be ready to tell or show what was taken, how much, and when it happened. Read all information given to you. Use Caution/Monitor. Maximum daily dose: 240 mg/24 hours. What do I do if my child misses a dose? Avoid or Use Alternate Drug. Serious - Use Alternative (1)tetrabenazine and loperamide both increase QTc interval. Gas Relief Extra Strength [OTC]; Gas Relief Infants [OTC]; Gas Relief Ultra Strength [OTC] [DSC]; Gas Relief [OTC]; Gas-X Childrens [OTC]; Gas-X Extra Strength [OTC]; Gas-X Infant Drops [OTC]; Gas-X Ultra Strength [OTC]; Gas-X [OTC] [DSC]; Heartland Gas Relief [OTC]; Infants Gas Relief [OTC]; Mi-Acid Gas Relief [OTC] [DSC]; Mylicon Infants Gas Relief [OTC]; Phazyme Maximum Strength [OTC]; Phazyme Ultra Strength [OTC]; Phazyme [OTC]; Simethicone Drops Infants [OTC]; Simethicone Ultra Strength [OTC]. Use Caution/Monitor. Serious - Use Alternative (1)desflurane and loperamide both increase QTc interval. Consider dose reduction of either or both agents to avoid serious adverse effects. Our scientists pursue every aspect of cancer researchfrom exploring the biology of genes and cells, to developing immune-based treatments, uncovering the causes of metastasis, and more. Dosing : Monitor Closely (1)erythromycin ethylsuccinate will increase the level or effect of loperamide by P-glycoprotein (MDR1) efflux transporter. Monitor Closely (1)degarelix and loperamide both increase QTc interval. Use Caution/Monitor. You'll usually take it after meals and at bedtime. Use Caution/Monitor. Lonafarnib is a weak P-gp inhibitor. antihemophilic factor (factor VIII, human)/von Willebrand factor antihemophilic factor (factor VIII, recombinant). This is a decision you and your doctor will make. Properly discard this product when it is expired or no longer needed. Use Caution/Monitor. Use Caution/Monitor. In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. Serious - Use Alternative (1)loperamide, eluxadoline. Do not give 2 doses at the same time or extra doses. Please confirm that you would like to log out of Medscape. Do not give 2 doses at the same time or extra doses. Use Caution/Monitor. Monitor Closely (1)siponimod and loperamide both increase QTc interval. Use Caution/Monitor. Use Caution/Monitor. Reduce P-gp substrate dose if needed. Monitor Closely (1)nefazodone will increase the level or effect of loperamide by P-glycoprotein (MDR1) efflux transporter. Use Caution/Monitor. If you think there has been an overdose, call your poison control center or get medical care right away. Drug class: Miscellaneous GI agents. If you do not have one, ask a pharmacist for one. simethicone will decrease the level or effect of sotorasib by inhibition of GI absorption. Simethicone l mt loi thuc thng dng, thng gp mt trong cc toa thuc dnh cho ngi ang gp vn v tiu ha. Measure liquid doses carefully. Consider dose reduction of sensitive P-gp substrates. Use Caution/Monitor. The following information includes only the average doses of this medicine. Coadministration with other CNS depressants, such as skeletal muscle relaxants, may cause respiratory depression, hypotension, profound sedation, coma, and/or death. Do not store in the bathroom. Do not double doses. Medscape prescription drug monographs are based on FDA-approved labeling information, unless otherwise noted, combined with additional data derived from primary medical literature. Use Caution/Monitor. The dose should not be more than 500 mg in twenty-four hours. fexinidazole will increase the level or effect of loperamide by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor. Use Caution/Monitor. Monitor Closely (1)ritonavir will increase the level or effect of loperamide by P-glycoprotein (MDR1) efflux transporter. Reduce air swallowing by avoiding fizzy, carbonated drinks. 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