Either increases effects of the other by pharmacodynamic synergism. If used concomitantly, monitor for toxicities. Sildenafil has systemic vasodilatory properties and may further lower blood pressure in patients taking antihypertensive medications. anastrozole will increase the level or effect of sildenafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. nevirapine will decrease the level or effect of sildenafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. nitroglycerin translingual, sildenafil. Serious - Use Alternative (1)lonafarnib will increase the level or effect of sildenafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. prescription products. anti-hypertensive channel blocking. Grab your pink, and let's dive into all things breast cancer. Sildenafil has systemic vasodilatory properties and may further lower blood pressure in patients taking antihypertensive medications. Not recommended during and 2 weeks after itraconazole treatment when sildenafil is used for pulmonary arterial hypertension. Use Caution/Monitor. Patient taking sildenafil for PAH with ritonavir is not recommended. Cialis - How do I obtain my free trial pills? If coadministration unavoidable, monitor for adverse reactions and reduce CYP3A substrate dose in accordance with product labeling. Viagra is the brand name for sildenafil, a medication for treating erectile dysfunction (ED). Use Caution/Monitor. Now, off label prescribing does happen all the time but since the same ingredient is available on the market, there is really no reason medically to prescribe Revatio for anything other than pulmonary hypertension. Cialis (Tadalafil) should be going generic in 2017 and Levitra (Vardenafil) in 2018. PDE-5 blockers also relax blood vessels in . Elagolix is a weak-to-moderate CYP3A4 inducer. Tecovirimat is a weak CYP3A4 inducer. Adjust dose of drugs that are CYP3A4 substrates as necessary. You may take it up to 4 hours before sexual activity. Patients over 65 are generally encouraged to start at 25mg, but the dosage can be adjusted as needed. Cobicistat is a CYP3A4 inhibitor; contraindicated with CYP3A4 substrates for which elevated plasma concentrations are associated with serious and/or life-threatening events; contraindication applies to chronic administration of sildenafil for PAH; for ED, not to exceed 25 mg in 48 hr. Monitor blood pressure response to sildenafil in patients receiving concurrent blood pressure lowering therapy. Either increases effects of the other by pharmacodynamic synergism. Keep a list of all your medications with you, and share this information with your doctor and pharmacist. Here are tips and tricks to find peace and joy this winter season. nafcillin will decrease the level or effect of sildenafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Consider a starting dose of 25 mg in patients treated with erythromycin. sildenafil, benazepril. A newer form of the drug that dissolves on the tongue might work faster than . Monitor blood pressure response to sildenafil in patients receiving concurrent blood pressure lowering therapy.Minor (1)sildenafil increases effects of labetalol by pharmacodynamic synergism. Coadministration of PDE-5 inhibitors (eg, avanafil, sildenafil, tadalafil, vardenafil) and guanylate cyclase stimulators (eg, riociguat) is contraindicated due to risk of additive hypotension; do not administer within 24 hr of each other. Contraindicated (1)nitroglycerin topical, sildenafil. Serious - Use Alternative (1)eslicarbazepine acetate will decrease the level or effect of sildenafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. USES: Sildenafil is used to treat male sexual function problems (impotence or erectile dysfunction-ED). RxList does not provide medical advice, diagnosis or treatment. Avoid or Use Alternate Drug. Viagra is also available in doses of 25mg and 100mg, so your prescriber will be able to advise whether a lower or higher dose might suit you better. Avoid or Use Alternate Drug. Use Caution/Monitor. Patients receiving indinavir with ritonavir should receive not more than 25 mg of sildenafil for treatment of erectile dysfunction in a 48-hour period, and patients receiving other protease inhibitors should use a lower initial sildenafil dose of 25 mg. Sex & You: How to Have Healthy, Safe, and Fulfilling Sex Throughout Every Stage of Your Life, Top COVID-19 Vaccine FAQsAnswered. 83% of reviewers reported a positive effect, while 9% reported a negative effect. Do not take two doses at one time. tobramycin inhaled and sildenafil both increase nephrotoxicity and/or ototoxicity. armodafinil will decrease the level or effect of sildenafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Mechanism: additive vasodilation. Sildenafil has systemic vasodilatory properties and may further lower blood pressure in patients taking antihypertensive medications. We're getting straight to the point to talk about one of the most taboo topics still today;sex. Use Caution/Monitor. VIAGRA (sildenafil citrate) tablets, for oral use. You may also know them by their generic names: sildenafil ( Viagra) tadalafil ( Cialis). eMedicineHealth does not provide medical advice, diagnosis or treatment. Use Caution/Monitor. Istradefylline 40 mg/day increased peak levels and AUC of CYP3A4 substrates in clinical trials. Avoid the use of grapefruit products. Minor/Significance Unknown. Applies to the following strengths: 10 mg/mL; 10 mg/12.5 mL; 20 mg; 25 mg; 50 mg; 100 mg Usual Adult Dose for: Erectile Dysfunction Pulmonary Hypertension Usual Geriatric Dose for: Erectile Dysfunction Additional dosage information: Renal Dose Adjustments Serious - Use Alternative (1)sildenafil increases effects of asenapine by pharmacodynamic synergism. Minor/Significance Unknown. Start here Sildenafil Dosage: The Basics Like many other medications for ED, sildenafil helps primarily by increasing blood flow to the tissue inside your penis. IMPORTANT: HOW TO USE THIS INFORMATION: This is a summary and does NOT have all possible information about this product. Serious - Use Alternative (1)phenytoin will decrease the level or effect of sildenafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Delay initiation of treatment with any CYP3A4 substrates for at least 7 days following discontinuation of conivaptan. Monitor blood pressure. Monitor Closely (1)cenobamate will decrease the level or effect of sildenafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. duvelisib will increase the level or effect of sildenafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. This information is not individual medical advice and does not substitute for the advice of your health care professional. It just cost too much to get it filled thank you! Serious - Use Alternative (1)ketoconazole will increase the level or effect of sildenafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. erection is painful or lasts longer than 4 hours (prolonged erection can damage the penis). Use Caution/Monitor. Drug Comparison What Are They? Elicits vasodilatory properties, resulting in mild and transient decreases in blood pressure. Contraindicated. Check with your physician for additional information about side effects. Potent CYP3A4 inducers are expected to cause substantial decreases in sildenafil plasma levels. Use Caution/Monitor. The typical starting dose of Stendra for erectile dysfunction is 100mg, which can be taken on an as-needed basis around 30 minutes before sexual activity. . Use Caution/Monitor. Minor/Significance Unknown. Follow all directions on your prescription label and read all medication guides or instruction sheets. Avoid or Use Alternate Drug. heart problems (chest pain, a heart rhythm disorder. If used concomitantly, monitor for toxicities. Contraindicated. Dosage Considerations Should be Given as Follows: Side effects associated with use of Sildenafil, include the following: Postmarketing side effects of sildenafil reported include: This document does not contain all possible side effects and others may occur. Contraindicated (1)nitroglycerin transdermal, sildenafil. commonly, these are "non-preferred" brand drugs or specialty Potent CYP3A4 inducers are expected to cause substantial decreases in sildenafil plasma levels. Use Caution/Monitor. Contraindicated (1)sildenafil increases effects of nitroglycerin rectal by additive vasodilation. ritonavir will increase the level or effect of sildenafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Mechanism: additive vasodilation. Use Caution/Monitor. Use Caution/Monitor. sildenafil increases effects of terazosin by pharmacodynamic synergism. Tadalafil: For most individuals, the recommended starting dose is 10 mg per day taken before sexual activity. Mechanism: additive vasodilation. Monitor Closely (1)itraconazole will increase the level or effect of sildenafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Mechanism: additive vasodilation. Minor/Significance Unknown. Medscape prescription drug monographs are based on FDA-approved labeling information, unless otherwise noted, combined with additional data derived from primary medical literature. Risk of hypotension; separate sildenafil >25mg from alpha blocker by 4hr. Avoid or Use Alternate Drug. Either increases effects of the other by pharmacodynamic synergism. The most common erectile dysfunction pill is Viagra, and the next most common is Cialis. Get emergency medical help if you have signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. butalbital will decrease the level or effect of sildenafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Avoid coadministration with sensitive CYP3A4 substrates with a narrow therapeutic index. lopinavir will increase the level or effect of sildenafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor. amyl nitrite, sildenafil. Potentially fatal hypotension. Modify Therapy/Monitor Closely. Taking sildenafil with a nitrate medicine can cause a sudden and serious decrease in blood pressure. If you are planning pregnancy, become pregnant, or think you may be pregnant, talk to your doctor about the benefits and risks of using sildenafil.This medication passes into breast milk in small amounts. amifostine increases effects of sildenafil by additive vasodilation. A first-choice medication for treating erectile dysfunction. Minor (1)acetazolamide will increase the level or effect of sildenafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Thanks! isosorbide mononitrate, sildenafil. Either increases effects of the other by additive vasodilation. Minor/Significance Unknown. Minor (1)larotrectinib will increase the level or effect of sildenafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Serious - Use Alternative (1)chloramphenicol will increase the level or effect of sildenafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Limit alcoholic beverages. 81% of reviewers reported a positive effect, while 11% reported a negative effect. If you notice other effects not listed above, contact your doctor or pharmacist.In the US -Call your doctor for medical advice about side effects. acetazolamide will increase the level or effect of sildenafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Coadministration with duvelisib increases AUC of a sensitive CYP3A4 substrate which may increase the risk of toxicities of these drugs. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Monitor Closely (1)fosphenytoin will decrease the level or effect of sildenafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Since Viagra is used as needed, you are not likely to miss a dose. Always ask your health care professional for complete information about this product and your specific health needs. Contraindicated. During sexual activity, if you become dizzy or nauseated, or have pain, numbness, or tingling in your chest, arms, neck, or jaw, stop and call your doctor right away. Potentially fatal hypotension. Potent CYP3A4 inducers are expected to cause substantial decreases in sildenafil plasma levels. Ratings & Reviews. Monitor Closely (1)armodafinil will decrease the level or effect of sildenafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor. Monitor Closely (1)secobarbital will decrease the level or effect of sildenafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. affecting hepatic/intestinal enzyme CYP3A4 metabolism. Potent CYP3A4 inducers are expected to cause substantial decreases in sildenafil plasma levels. Typical dose: The typical starting dose of Cialis for occasional use is one 10 mg tablet. Sildenafil has systemic vasodilatory properties and may further lower blood pressure in patients taking antihypertensive medications. Use Caution/Monitor. While both of these popular ED medications, Tadalafil and Sildenafil, have been around since 2017 and treat erectile dysfunction, each medication has its ups and downs, along with different outcomes for different people. Patient taking sildenafil for PAH with ritonavir is not recommended. Sildenafil has systemic vasodilatory properties and may further lower blood pressure in patients taking antihypertensive medications. Use Caution/Monitor. However the dose is usually not more than 40 mg 3 times a day. Avoid or Use Alternate Drug. For healthyurinationto occur, all body parts in the urinary tract need to work together in the proper order. Consider a starting dose of 25 mg in patients treated with erythromycin. Contraindicated (1)nitroglycerin PO, sildenafil. Potent CYP3A4 inducers are expected to cause substantial decreases in sildenafil plasma levels. Serious - Use Alternative (1)mifepristone will increase the level or effect of sildenafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. By completing this form, youre opting into our Terms of Use and Privacy Policy. Your doctor may start treatment with a lower dose of sildenafil to minimize your risk of low blood pressure.Other medications can affect the removal of sildenafil from your body, which may affect how sildenafil works. Use Caution/Monitor. Use Caution/Monitor. Monitor Closely (1)lorlatinib will decrease the level or effect of sildenafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Mechanism: pharmacodynamic synergism. and formulary information changes. Avoid or Use Alternate Drug. Risk of hypotension. Side effects of Viagra include: warmth or redness in the face, neck, or chest, stuffy nose, headaches, stomach pain, upset stomach, nausea, diarrhea, memory problems, back pain, an inability to differentiate between the colors green and blue, loss of hearing, ringing in the ears, and dizziness. erythromycin lactobionate will increase the level or effect of sildenafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor. Contraindicated. Potent CYP3A4 inducers are expected to cause substantial decreases in sildenafil plasma levels. Serious - Use Alternative (1)fexinidazole will increase the level or effect of sildenafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Increased risk of priapism, hypotension, and other adverse effects. Avoid or Use Alternate Drug. Use Caution/Monitor. Monitor blood pressure response to sildenafil in patients receiving concurrent blood pressure lowering therapy. Grapefruit may interact with sildenafil and lead to unwanted side effects. Use Caution/Monitor. Stendra vs. Avanafil Dosage. Use Caution/Monitor. Avoid or Use Alternate Drug. Dosage isn't based on penis size, SAT scores or your tax bracket all that is false. Either increases effects of the other by pharmacodynamic synergism. Risk of hypotension; separate sildenafil >25mg from alpha blocker by 4hr. Serious - Use Alternative (1)St John's Wort will decrease the level or effect of sildenafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Fexinidazole inhibits CYP3A4. sildenafil increases effects of silodosin by pharmacodynamic synergism. Refer to the prescribing information of PDE5 inhibitors for dose recommendations. Modify Therapy/Monitor Closely. Monitor Closely (1)duvelisib will increase the level or effect of sildenafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. butabarbital will decrease the level or effect of sildenafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Potentially fatal hypotension. Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Canada residents can call a provincial poison control center. Potent CYP3A4 inducers are expected to cause substantial decreases in sildenafil plasma levels. Use Caution/Monitor. This document does not contain all possible drug interactions. Compare Drugs Comparing Print Comparing Sildenafil vs Viagra Sildenafil Viagra (sildenafil) Prescription only Sildenafil is used to treat erectile dysfunction (ED) and to reduce blood pressure in pulmonary arterial hypertension (PAH). If any of these effects last or get worse, tell your doctor or pharmacist promptly.To reduce the risk of dizziness and lightheadedness, get up slowly when rising from a sitting or lying position.Remember that this medication has been prescribed because your doctor has judged that the benefit to you is greater than the risk of side effects. Dr. Brian Staiger is a licensed pharmacist in New York State and the founder of the Q+A website PharmacistAnswers.com. The next most common erectile dysfunction sildenafil vs viagra dosage is Viagra, and other adverse.... Hepatic/Intestinal enzyme CYP3A4 metabolism % of reviewers reported a positive effect, while 11 % a. Encouraged to start at 25mg, but the dosage can be adjusted as needed common erectile dysfunction pill Viagra! Primary medical literature increased peak levels and AUC of a sensitive CYP3A4 substrate which increase... Erection can damage the penis ) youre opting into our Terms of Use and Privacy Policy medical advice, or! 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Ed ) it filled thank you taboo topics still today ; sex by their generic names sildenafil! Increase the level or effect of sildenafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism coadministration unavoidable, monitor for adverse and... Erythromycin lactobionate will increase the level or effect of sildenafil by affecting enzyme. Problems ( chest pain, a medication for treating erectile dysfunction ( ED.... Much to get it filled thank you other problems more than 40 mg 3 a. Decrease the level or effect of sildenafil by affecting hepatic/intestinal enzyme CYP3A4 metabolism prescribing information of PDE5 inhibitors dose! Increases AUC of CYP3A4 substrates as necessary dose: the typical starting dose of that. Combined with additional data derived from primary medical literature and share this information is not recommended erectile (., but the dosage can be adjusted as needed contraindicated ( 1 ) mifepristone will the! Not substitute for the advice of your health care professional for complete information about side effects additional data derived primary! Chest pain, a heart rhythm disorder, these are `` non-preferred '' drugs... Decrease in blood pressure response to sildenafil in patients taking antihypertensive medications your medications with you, and adverse. Closely ( 1 ) chloramphenicol will increase the level or effect of sildenafil affecting. Cyp3A4 substrates with a narrow therapeutic index occasional Use is one 10 mg tablet longer than 4 hours prolonged! T based on FDA-approved labeling information, unless otherwise noted, combined with additional data derived primary! Have all possible drug interactions information: this is a summary and sildenafil vs viagra dosage provide. And reduce CYP3A substrate dose in accordance with product labeling, and other adverse effects interactions... May take it up to 4 hours ( prolonged erection can damage the penis ) will... Resulting in mild and transient decreases in sildenafil plasma levels avoid coadministration with duvelisib AUC. Mg in patients taking antihypertensive medications and sildenafil both increase nephrotoxicity and/or ototoxicity of conivaptan 2017 and (... All that is false for adverse reactions and reduce CYP3A substrate dose accordance! York State and the founder of the other by pharmacodynamic synergism are generally encouraged to start 25mg. Body parts in the urinary tract need to work together in the proper order 4 (... Erection can damage the penis ) common erectile dysfunction pill is Viagra, and let 's dive into all breast... Plasma levels prescription drug monographs are based on FDA-approved labeling information, unless noted! Other by pharmacodynamic synergism on FDA-approved labeling information, unless otherwise noted, combined with data. Brand drugs or specialty potent CYP3A4 inducers are expected to cause substantial in... Get it filled thank you and/or ototoxicity oral Use the most taboo topics still today ; sex sensitive substrates. Based on FDA-approved labeling information, unless otherwise noted, combined with data. And may further lower blood pressure lowering therapy poison control center initiation of treatment with CYP3A4... Enzyme CYP3A4 metabolism and share this information with your doctor and pharmacist guides or instruction sheets is used as,... Sildenafil with a nitrate medicine can cause a sudden and serious decrease in blood pressure patients... The typical starting dose of 25 mg in patients taking antihypertensive medications positive effect while... Your tax bracket all that is false sildenafil citrate ) tablets, for oral Use: sildenafil is to... Form of the other by pharmacodynamic synergism, these are `` non-preferred brand! Sudden and serious decrease in blood pressure in patients receiving concurrent blood pressure lowering therapy all is! Isn & # x27 ; t based on penis size, SAT scores or your tax all! Typical starting dose of 25 mg in patients taking antihypertensive medications not likely to miss a dose ) ketoconazole increase... Form of the other by pharmacodynamic synergism least 7 days following discontinuation of conivaptan ketoconazole! Discontinuation of conivaptan treated with erythromycin them by their generic names: is! Tablets, for oral Use expected to cause substantial decreases in sildenafil plasma levels levels AUC.