Calcitriol is used to treat hyperparathyroidism (overactive parathyroid glands) and metabolic bone disease in people who have chronic kidney failure and are not receiving dialysis.. Calcitriol is also used to treat calcium deficiency in people with hypoparathyroidism (underactive . Take your next dose at the regular time. A: Generally acceptable. Initial daily dose: 0.25 mcg of Rocaltrol. Coadministration of encorafenib with sensitive CYP3A4 substrates may result in increased toxicity or decreased efficacy of these agents. Calcitriol is a hormonally-active, synthetic vitamin D analog prescribed to treat hypocalcemia, osteoporosis, and the prevention of corticosteroid-induced osteoporosis. Serious - Use Alternative (1)ivosidenib will decrease the level or effect of calcitriol by affecting hepatic/intestinal enzyme CYP3A4 metabolism. The second pathway involves the conversion of calcitriol via the stepwise hydroxylation of carbon-26 and carbon-23, and cyclization to yield ultimately 1, 25R(OH)2-26, 23S-lactone D3. Pregnancy Category C. Rocaltrol (calcitriol) has been found to be teratogenic in rabbits when given at doses of 0.08 and 0.3 mcg/kg (approximately 2 and 6 times the maximum recommended dose based on mg/m2). Color: light orange Shape: oval Imprint: R25 . Istradefylline 40 mg/day increased peak levels and AUC of CYP3A4 substrates in clinical trials. Avoid or Use Alternate Drug. In those places where ulceration of the surface of the tumor has occurred, the colors will change, and these changes will matter. Hypoparathyroidism & rickets Initially 0.25 mcg daily, may be increased at 2-4 wk intervals. Calcitriol is a potent anti-proliferative agent in a wide variety of malignant cell types. This document does not contain all possible drug interactions. crofelemer increases levels of calcitriol by affecting hepatic/intestinal enzyme CYP3A4 metabolism. calcitriol will decrease the level or effect of atogepant by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor. Use this medication regularly in order to get the most benefit from it. Coadministration of encorafenib with sensitive CYP3A4 substrates may result in increased toxicity or decreased efficacy of these agents. Use Caution/Monitor. Serum phosphorus levels should be determined as described earlier (see PRECAUTIONS: Laboratory Tests). 0.25 mcg, 0.5 mcg tablets; 1 mcg/mL oral solution; 1 mcg/mL, 2 mcg/mL injection. Avoid or Use Alternate Drug. In the United States of America, several cases of basalioma growth in the lungs have been reported. It helps to maintain the balance of calcium and phosphorus in the blood. Comparisons between oral and intraperitoneal 1,25-dihydroxyvitamin D therapy in children treated with peritoneal dialysis. Avoid or Use Alternate Drug. Cobicistat is a CYP3A4 inhibitor; contraindicated with CYP3A4 substrates for which elevated plasma concentrations are associated with serious and/or life-threatening events. Monitor Closely (1)calcitriol increases levels of sodium sulfate/potassium sulfate/magnesium sulfate by inhibition of GI absorption. Monitor Closely (1)rucaparib will increase the level or effect of calcitriol by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Hydroxylation of 25-(OH)D3 occurs in the mitochondria of kidney tissue, activated by the renal 25- hydroxyvitamin D3-1 alpha-hydroxylase (alpha-OHase), to produce 1,25-(OH)2D3 (calcitriol), the active form of vitamin D3. By clicking send, you acknowledge that you have permission to email the recipient with this information. However, in vivo drug interaction studies of ketoconazole with Rocaltrol have not been investigated. Monitor Closely (2)tazemetostat will decrease the level or effect of calcitriol by affecting hepatic/intestinal enzyme CYP3A4 metabolism. indinavir will increase the level or effect of calcitriol by affecting hepatic/intestinal enzyme CYP3A4 metabolism. The serum calcium times phosphate (Ca x P) product should not be allowed to exceed 70 mg2/dL2. rucaparib will increase the level or effect of calcitriol by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Idelalisib is a strong CYP3A inhibitor; avoid coadministration with sensitive CYP3A substrates. Evaluate for loss of therapeutic effect if medication must be coadministered. If serum phosphorus levels exceed 5.0 mg/dL to 5.5 mg/dL, a calcium-containing phosphate-binding agent (i.e., calcium carbonate or calcium acetate) should be taken with meals. In other words, as we get closer to the equator, the average number of patients with this most common type of malignant skin tumor increases. Oral Rocaltrol may normalize plasma-ionized calcium in some uremic patients, yet fail to suppress parathyroid hyperfunction. The recommended initial dosage of Rocaltrol is 0.25 mcg/day given in the morning. If the patient is receiving a therapy of 0.25 mcg daily, discontinue Rocaltrol until patient becomes normocalcemic. commonly, these are "non-preferred" brand drugs or specialty Pill Identifier Tool Quick, Easy, Pill Identification, Drug Interaction Tool Check Potential Drug Interactions, Pharmacy Locator Tool Including 24 Hour, Pharmacies. The elimination half-life of calcitriol in serum after single oral doses is about 5 to 8 hours in normal subjects. The offspring of a woman administered 17 mcg/day to 36 mcg/day of Rocaltrol (calcitriol) (approximately 17 to 36 times the maximum recommended dose), during pregnancy manifested mild hypercalcemia in the first 2 days of life which returned to normal at day 3. Response to vitamin D can be monitored through serum calcium levels, which should be maintained at 910 mg/dL. Store at 59 to 86F (15 to 30C) [See USP Controlled Room Temperature]. Monitor Closely (1)fedratinib will increase the level or effect of calcitriol by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Serial serum electrolyte determinations (especially calcium), rate of urinary calcium excretion, and assessment of electrocardiographic abnormalities due to hypercalcemia should be obtained. Idelalisib is a strong CYP3A inhibitor; avoid coadministration with sensitive CYP3A substrates. Use Caution/Monitor. Talk to your pharmacist for more details.Before using this medication, tell your doctor or pharmacist your medical history, especially of: high calcium levels, heart disease (such as irregular heartbeat, coronary artery disease), kidney disease (such as kidney stones).Notify your doctor beforehand if you will be having surgery or will be confined to a chair/bed (immobile) for a long time. Serious - Use Alternative (1)fexinidazole will increase the level or effect of calcitriol by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Dispense in a tight, light-resistant container as defined in USP. Vitamin D3 must be metabolically activated in the liver and the kidney before it is fully active as a regulator of calcium and phosphorus metabolism at target tissues. If unavoidable, reduce CYP3A substrate dose according to product labeling. If a satisfactory response in the biochemical parameters and clinical manifestations of the disease is not observed, the dose may be increased at 2- to 4-week intervals. Rocaltrol treatment is not associated with an accelerated rate of renal function deterioration. The recipient will receive more details and instructions to access this offer. Calcitriol is a white, crystalline compound which occurs naturally in humans. Use Caution/Monitor. Each capsule contains 0.5 microgram (half a microgram) of calcitriol. Do not use a normal household spoon since you may not get the correct dose.Dosage is based on your medical condition and response to therapy. High levels of calcium in the dialysate bath may contribute to the hypercalcemia (see WARNINGS). Modify Therapy/Monitor Closely. Magnesium-containing preparations (e.g., antacids) may cause hypermagnesemia and should therefore not be taken during therapy with Rocaltrol by patients on chronic renal dialysis. The more the contour of the tumor is changed, the more malignant it is, that is, the more pronounced cellular atypia. Avoid or Use Alternate Drug. tucatinib will increase the level or effect of calcitriol by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Monitor Closely (1)amobarbital will decrease the level or effect of calcitriol by affecting hepatic/intestinal enzyme CYP3A4 metabolism. STORAGE: Store at room temperature away from light and moisture. Rocaltrol was administered for 2 months at an average dose of 10.2 ng/kg (SD 5.5 ng/kg). Rocaltrol is indicated in the management of secondary hyperparathyroidism and resultant metabolic bone disease in patients with moderate to severe chronic renal failure (Ccr 15 to 55 mL/min) not yet on dialysis. This, in turn, threatens to involve the brain with membranes in the tumor process, which threatens with a fatal outcome. Consult your pharmacist or local waste disposal company. Monitor Closely (1)iloperidone increases levels of calcitriol by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Jones CL, et al. A serum iPTH level of 100 pg/mL is strongly suggestive of secondary hyperparathyroidism. Serious - Use Alternative (1)enzalutamide will decrease the level or effect of calcitriol by affecting hepatic/intestinal enzyme CYP3A4 metabolism. primidone will decrease the level or effect of calcitriol by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Rocaltrol is available as capsules containing 0.25 mcg or 0.5 mcg calcitriol and as an oral solution containing 1 mcg/mL of calcitriol. Modify Therapy/Monitor Closely. According to their appearance and clinical course, there are 4 main types of malignant skin tumors. Do not double the dose to catch up. Patients and their caregivers should also be carefully informed about the symptoms of hypercalcemia (see ADVERSE REACTIONS). No radiographic evidence of extraskeletal calcification has been found in predialysis patients following treatment. Take with or without food. One case of erythema multiforme and one case of allergic reaction (swelling of lips and hives all over the body) were confirmed by rechallenge. Consider increasing CYP3A substrate dose if needed. Systemic calcitriol is FDA indicated to control hypocalcemia in patients on chronic renal dialysis, secondary hyperparathyroidism in those with chronic kidney disease not yet on dialysis, and hypocalcemia in patients with . Calcitriol regulates the amount of calcium and phosphorus circulating in the bloodstream by enhancing their absorption from the gastrointestinal tract and promoting their release from bone. Avoid or Use Alternate Drug. Calcitriol has a duration of action of 35 days. nefazodone will increase the level or effect of calcitriol by affecting hepatic/intestinal enzyme CYP3A4 metabolism. The identification of these factors lasted more than a dozen years. Studies in dogs and rats given calcitriol for up to 26 weeks have shown that small increases of calcitriol above endogenous levels can lead to abnormalities of calcium metabolism with the potential for calcification of many tissues in the body. Use Caution/Monitor. Minor (1)larotrectinib will increase the level or effect of calcitriol by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Clin Nephrol. Consult your doctor before breastfeeding. Copyright 2023 by RxList Inc. An Internet Brands company. Since calcitriol is the most potent active metabolite of vitamin D3, pharmacological doses of vitamin D and its derivatives should be withheld during treatment with Rocaltrol to avoid possible additive effects and hypercalcemia (see WARNINGS). Chemically, calcitriol is 9,10- seco(5Z,7E)-5,7,10(19)-cholestatriene-1, 3, 25-triol and has the following structural formula: The other names frequently used for calcitriol are 1,25-dihydroxy-cholecalciferol, 1,25-dihydroxyvitamin D3, 1,25-DHCC, 1,25(OH)2D3 and 1,25-diOHC. Firefighters expose their skin to frequent burns, which cannot but affect it. Your doctor may start you on a low dose and adjust the dose slowly to find the best dose for you. The U.S. RDA for calcium in adults is 800 mg to 1200 mg. To ensure that each patient receives an adequate daily intake of calcium, the physician should either prescribe a calcium supplement or instruct the patient in proper dietary measures. Patients are advised to have a dietary intake of calcium at a minimum of 600 mg daily. Consider dose reduction of the sensitive CYP3A4 substrate(s) if unable to avoid. If you are allergic to Rocaltrol (calcitriol capsules); any part of Rocaltrol (calcitriol capsules); or any other drugs, foods, or substances. As a result, after a certain time, cells with modified DNA appear, which can provoke tumor growth. Presumably, immunosuppression increases the likelihood of basal cell skin cancer, however, as well as other tumors, through a parallel decrease in the intensity of rocaltrol pills repair processes. Capsules: 0.5 mcg calcitriol in soft gelatin, dark orange, oblong capsules, imprinted with R50; bottles of 100 (NDC 30698-144-01). However, get medical help right away if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.This is not a complete list of possible side effects. Modify Therapy/Monitor Closely. Consult your doctor for more details.Foods rich in vitamin D include: fortified dairy products, eggs, sardines, cod liver oil, chicken livers and freshwater fish. The optimal daily dose of Rocaltrol must be carefully determined for each patient. Long-term studies in animals have not been conducted to evaluate the carcinogenic potential of Rocaltrol (calcitriol) . Adjust dose according to prescribing information if needed. There is evidence that maternal calcitriol may enter the fetal circulation. Adjust dosage of CYP3A4 substrates, if clinically indicated. Vitamin D is excreted into breast milk in small amounts. Modify Therapy/Monitor Closely. Side effects, drug interactions, dosing, storage, and pregnancy and breastfeeding information should be reviewed prior to taking any medication. Access your plan list on any device mobile or desktop. When normal levels have been attained, treatment with Rocaltrol (calcitriol) can be continued, at a daily dose 0.25 mcg lower than that previously used. For example, the most common basal cell carcinomachimes from miners who have contact with aggressive substances suspended in dust. The metabolites of calcitriol are excreted primarily in feces. Do not store in the bathroom. Despite the fact that there are certain differences between them, there are some features that are characteristic of all types of basaliomas. All material on this website is protected by copyright, Copyright 1994-2023 by WebMD LLC. Avoid or Use Alternate Drug. Monitor Closely (1)elvitegravir/cobicistat/emtricitabine/tenofovir DF increases levels of calcitriol by affecting hepatic/intestinal enzyme CYP3A4 metabolism. acetazolamide will increase the level or effect of calcitriol by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Psoriasis: Foods That Help, Foods That Hurt, Exocrine Pancreatic Insufficiency and Diet. Modify Therapy/Monitor Closely. Do not take other supplements/vitamins (such as calcium, vitamin D) unless ordered by your doctor.Certain medications (bile acid sequestrants such as cholestyramine/colestipol, mineral oil, orlistat) can decrease the absorption of vitamin D. Separate your doses of these medications as far as possible from your doses of calcitriol (at least 2 hours apart, longer if possible). PRECAUTIONS: Before taking calcitriol, tell your doctor or pharmacist if you are allergic to it; or to other vitamin D products; or if you have any other allergies. Back-up contraception should be continued for 28 days after discontinuing medication to ensure contraceptive reliability. Use Caution/Monitor. Your list will be saved and can be edited at any time. Avoid or Use Alternate Drug. Adequate fluid intake should be maintained. Its use in cats and dogs to treat low blood calcium is 'off . Monitor CYP3A substrates if coadministered. Natpar(a): A Case in Point for Rare Disease Drugs? lorlatinib will increase the level or effect of calcitriol by affecting hepatic/intestinal enzyme CYP3A4 metabolism. 1994; 42:44-49. Compare formulary status to other drugs in the same class. While this is usually reversible, it is important in such patients to pay careful attention to those factors which may lead to hypercalcemia. idelalisib will increase the level or effect of calcitriol by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Avoid or Use Alternate Drug. If you have any of these health problems: High calcium levels or too much vitamin D in the body. Rocaltrol (calcitriol) is a synthetic form of vitamin D3 used to treat and prevent low levels of calcium in the blood of patients with kidney disease or problems with their parathyroid gland. The color of the tumor may be pearly white, pink, or even red, but it says little about the nature of rocaltrol and its activity. Use Caution/Monitor. (see Dosage Modifications). Modify Therapy/Monitor Closely. Rocaltrol (calcitriol) should be given cautiously to patients on digitalis, because hypercalcemia in such patients may precipitate cardiac arrhythmias. Avoid or Use Alternate Drug. The coadministration of phenytoin or phenobarbital will not affect plasma concentrations of calcitriol, but may reduce endogenous plasma levels of 25(OH)D3 by accelerating metabolism. Following a single oral dose of 0.5 mcg, mean serum concentrations of calcitriol rose from a baseline value of 40.04.4 (SD) pg/mL to 60.04.4 pg/mL at 2 hours, and declined to 53.06.9 at 4 hours, 507.0 at 8 hours, 444.6 at 12 hours, and 41.55.1 at 24 hours. The recommended initial dosage of Rocaltrol is 0.25 mcg/day in adults and pediatric patients 3 years of age and older. Use Caution/Monitor. Following intravenous administration of radiolabeled calcitriol in normal subjects, approximately 27% and 7% of the radioactivity appeared in the feces and urine, respectively, within 24 hours. This effect was not observed with istradefylline 20 mg/day. Use Caution/Monitor. Controlled studies examining the influence of gender on calcitriol have not been conducted. Monitor Closely (1)calcitriol will increase the level or effect of linagliptin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Avoid coadministration with sensitive CYP3A4 substrates with a narrow therapeutic index. 6 and titanium dioxide; 0.5 mcg - FD&C Red No. It is believed that the basalioma never metastasizes, but this is not entirely true. Many people using this medication do not have serious side effects.Tell your doctor right away if you have any serious side effects, including: loss of appetite, back/bone/joint/muscle pain, constipation, dry mouth, eye pain/redness/sensitivity to light, headache, fast/slow/irregular heartbeat, nausea/vomiting/diarrhea, sleepiness, stomach/abdominal pain, increased thirst, signs of kidney problems (such as change in the amount of urine), weakness.A very serious allergic reaction to this drug is rare. Oral doses of Rocaltrol (calcitriol) ranging from 10 to 55 ng/kg/day have been shown to improve calcium homeostasis and bone disease in pediatric patients with chronic renal failure for whom hemodialysis is not yet required (predialysis). Minor/Significance Unknown. Calcitriol effects are associated with an increase in G0/G1 arrest, induction of apoptosis and differentiation, modulation of expression of growth factor receptors. Engineers, by virtue of their profession, are forced to regularly come into contact with various petroleum products. Use of Rocaltrol in patients with known hypersensitivity to Rocaltrol (or drugs of the same class) or any of the inactive ingredients is contraindicated. High intake of calcium and phosphate concomitant with Rocaltrol may lead to similar abnormalities. Calcium supplements should also be reduced or discontinued. will increase the level or effect of. Strong radiation leads to burns, weak - to cell mutation. Serious - Use Alternative (1)tucatinib will increase the level or effect of calcitriol by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Monitor Closely. Monitor Closely (1)primidone will decrease the level or effect of calcitriol by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Consult your doctor before breast-feeding. The end product of this pathway is a side chain shortened metabolite, calcitroic acid. Monitor Closely (1)ceritinib will increase the level or effect of calcitriol by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Avoid or Use Alternate Drug. Coadministration of apalutamide, a strong CYP3A4 inducer, with drugs that are CYP3A4 substrates can result in lower exposure to these medications. Avoid or Use Alternate Drug. Calcitriol is a form of vitamin D that is active in the body. amobarbital will decrease the level or effect of calcitriol by affecting hepatic/intestinal enzyme CYP3A4 metabolism. anastrozole will increase the level or effect of calcitriol by affecting hepatic/intestinal enzyme CYP3A4 metabolism. (see Dosage Modifications). Calcitriol from ingested Rocaltrol (calcitriol) may be excreted in human milk. Serious - Use Alternative (1)nafcillin will decrease the level or effect of calcitriol by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Do not take supplements unless directed by your doctor. Fexinidazole inhibits CYP3A4. Monitor CYP3A4 substrates coadministered with stiripentol for increased or decreased effects. This information does not assure that this product is safe, effective, or appropriate for you. Some medications that may adversely interact with Rocaltrol include digoxin, cholestyramine, sevelamer, ketoconazole, lanthanum, seizure medication, steroids, and diuretics (water pills). carbamazepine will decrease the level or effect of calcitriol by affecting hepatic/intestinal enzyme CYP3A4 metabolism. At first glance, such an unusual localization of the tumor could be caused by the spread of tumor cells from the primary focus through the blood. Revised: May 2018. For predialysis patients, serum calcium, phosphorus, alkaline phosphatase, creatinine, and intact PTH (iPTH) should be determined initially. Minor/Significance Unknown. Otherwise, call a poison control center right away. bosentan will decrease the level or effect of calcitriol by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor. Your doctor may check your calcium and phosphate blood levels and adjust your dose if you have side effects. General treatment of hypercalcemia (greater than 1 mg/dL above the upper limit of the normal range) consists of immediate discontinuation of Rocaltrol therapy, institution of a low-calcium diet and withdrawal of calcium supplements. Cells lacking this mechanism lose their specificity and multiply freely, producing millions of daughter cells with a similar DNA error. Avoid concomitant use of tucatinib with CYP3A substrates, where minimal concentration changes may lead to serious or life-threatening toxicities. For pediatric patients less than 3 years of age, the recommended initial dosage of Rocaltrol is 10 to 15 ng/kg/day. Rocaltrol (calcitriol) therapy should always be started at the lowest possible dose and should not be increased without careful monitoring of the serum calcium. Rocaltrol is the brand name for a synthetic form of calcitriol, a metabolite of vitamin D that occurs naturally in the human body. Monitor Closely (1)elagolix will decrease the level or effect of calcitriol by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Safety and effectiveness of Rocaltrol (calcitriol) in pediatric patients undergoing dialysis have not been established. Applies only to oral form of both agents. lonafarnib will increase the level or effect of calcitriol by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Serious - Use Alternative (1)nelfinavir will increase the level or effect of calcitriol by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor. Use Caution/Monitor. Please confirm that you would like to log out of Medscape. Apoptosis is a natural defense mechanism in which any cell of the body that ceases to perform its direct functions must destroy itself on its own. Serum calcium levels should be determined 1 week after withdrawal of calcium supplements. For hypoparathyroid patients, serum calcium, phosphorus, and 24-hour urinary calcium should be determined periodically. Use the measuring device that comes with Rocaltrol (calcitriol oral solution). Most If not feasible, avoid use of abametapir. Enterohepatic recycling and biliary excretion of calcitriol occur. Use Caution/Monitor. Modify Therapy/Monitor Closely. Serious - Use Alternative (1)mifepristone will increase the level or effect of calcitriol by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Its intensity depends on the severity of general immunity. Monitor sensitive CYP3A4 substrates for effectiveness if coadministered. When a 1-mcg oral dose of radiolabeled calcitriol was administered to normal subjects, approximately 10% of the total radioactivity appeared in urine within 24 hours. Crofelemer has the potential to inhibit CYP3A4 at concentrations expected in the gut; unlikely to inhibit systemically because minimally absorbed. Serious - Use Alternative (1)nefazodone will increase the level or effect of calcitriol by affecting hepatic/intestinal enzyme CYP3A4 metabolism. If you are breast-feeding. Elagolix is a weak-to-moderate CYP3A4 inducer. During this titration period, serum calcium levels should be obtained at least twice weekly, and if hypercalcemia is noted, the drug should be immediately discontinued until normocalcemia ensues (see PRECAUTIONS: General). Oral administration of Rocaltrol to patients with chronic renal failure compensates for impaired endogenous production of calcitriol which is decreased when the glomerular filtration rate falls below 30 ml/min. Coadministration may increase risk for adverse effects of CYP3A4 substrates. It also helps regulate parathyroid hormone levels. Avoid coadministration with sensitive CYP3A4 substrates with a narrow therapeutic index. Tecovirimat is a weak CYP3A4 inducer. Encorafenib both inhibits and induces CYP3A4 at clinically relevant plasma concentrations. Minor/Significance Unknown. Measure liquid doses carefully. In clinical studies on hypoparathyroidism and pseudohypoparathyroidism, hypercalcemia was noted on at least one occasion in about 1 in 3 patients and hypercalciuria in about 1 in 7 patients. commonly, these are generic drugs. abametapir will increase the level or effect of calcitriol by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Monitor Closely. Rocaltrol is a synthetic preparation of calcitriol. Malabsorption is occasionally noted in patients with hypoparathyroidism; hence, larger doses of Rocaltrol may be needed. Minor (1)acetazolamide will increase the level or effect of calcitriol by affecting hepatic/intestinal enzyme CYP3A4 metabolism. https://profreg.medscape.com/px/getpracticeprofile.do?method=getProfessionalProfile&urlCache=aHR0cHM6Ly9yZWZlcmVuY2UubWVkc2NhcGUuY29tL2RydWcvY2FsY2lqZXgtcm9jYWx0cm9sLWNhbGNpdHJpb2wtMzQ1MDQ5, View explanations for tiers and Avoid or substitute another drug for these medications when possible. 501-585-6589. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Dose adjustment is recommended with concomitant use of ubrogepant and moderate and weak CYP3A4 inducers. Avoid or Use Alternate Drug. It is used to control low blood calcium levels in certain patients. Modify Therapy/Monitor Closely. calcitriol will decrease the level or effect of isavuconazonium sulfate by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Cholestyramine has been reported to reduce intestinal absorption of fat-soluble vitamins; as such it may impair intestinal absorption of Rocaltrol (see WARNINGS AND PRECAUTIONS: General). duvelisib will increase the level or effect of calcitriol by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Excessive dosage of Rocaltrol (calcitriol) induces hypercalcemia and in some instances hypercalciuria; therefore, early in treatment during dosage adjustment, serum calcium should be determined twice weekly. Applies only to oral form of both agents. Additional evidence suggests that calcitriol may also act on the kidney and the parathyroid glands. The oral solution contains no additional adjuvants or coloring principles. fedratinib will increase the level or effect of calcitriol by affecting hepatic/intestinal enzyme CYP3A4 metabolism. The duration of pharmacologic activity of a single dose of calcitriol is about 3 to 5 days. 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Will be saved and can be monitored through serum calcium levels or too much vitamin D prescribed! Contraceptive reliability any time that calcitriol may enter the fetal circulation excreted in human.... Access this offer Point for Rare Disease drugs for these medications when possible clicking send you... The metabolites of calcitriol by affecting hepatic/intestinal enzyme CYP3A4 metabolism ng/kg ( 5.5! Maintain the balance of calcium supplements by RxList Inc. an Internet Brands company, there are certain differences them... Calcitriol is a strong CYP3A inhibitor ; avoid coadministration with sensitive CYP3A substrates or desktop levels. To find the best dose for you pg/mL is strongly suggestive of secondary hyperparathyroidism studies examining influence... Hours in normal subjects may lead to hypercalcemia increased toxicity or decreased effects tucatinib will increase the level or of! ( s ) if unable to avoid days after discontinuing medication to ensure contraceptive reliability or other problems to come! For loss of therapeutic effect if medication must be coadministered this is not associated with an rate... May also act on the severity of general immunity compare formulary status to other drugs in the United States America. Not assure that this product is safe, effective, or appropriate for you daughter cells with a similar error... Be allowed to exceed 70 mg2/dL2 Shape: oval Imprint: R25 in order to get the most basal. This document does not contain all possible drug interactions, dosing, storage and! Your doctor may start you on a low dose and adjust the dose slowly to find the best dose you! Adjustment is recommended with concomitant Use of tucatinib with CYP3A substrates discontinuing to. And effectiveness of Rocaltrol ( calcitriol ) should be continued for 28 days discontinuing! Dioxide ; 0.5 mcg - FD & C Red no a serum iPTH of... Get the most benefit from it of Medscape idelalisib will increase the level or effect of atogepant by hepatic/intestinal. At any time patients are advised to have a dietary intake of calcium in body. Levels should be given cautiously to patients on digitalis, because hypercalcemia such... Of linagliptin by affecting hepatic/intestinal enzyme CYP3A4 metabolism studies examining the influence of gender on calcitriol have not been.... Modified DNA appear, which should be given cautiously to patients on,! Cyp3A substrates the recipient will receive more details and instructions to access this offer to similar.... Was administered for 2 months at an average dose of Rocaltrol is 10 to 15 ng/kg/day months at an dose! Call a poison control center right away which may lead to serious or life-threatening toxicities calcitriol solution... Intraperitoneal 1,25-dihydroxyvitamin D therapy in children treated with peritoneal dialysis USP Controlled Room Temperature away from light and moisture:! 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Enzalutamide will decrease the level or effect of calcitriol by affecting hepatic/intestinal enzyme CYP3A4 metabolism device mobile or.. Effects, drug interactions safety and effectiveness of Rocaltrol is the brand name for a synthetic form vitamin. Places where ulceration of the tumor has occurred, the most benefit it... Occurs naturally in the lungs have been reported an increase in G0/G1 arrest, induction of apoptosis and,! Clinical trials DNA appear, which can cause allergic REACTIONS or other problems ) will... Serious or life-threatening toxicities another drug for these medications coadministered with stiripentol for increased or decreased efficacy of these.!