All rights reserved. Portions of this document last updated: May 01, 2023, Original article: https://www.mayoclinic.org/drugs-supplements/prochlorperazine-oral-route/side-effects/drg-20406263. Prochlorperazine can temporarily lower the number of white blood cells in your blood, increasing the chance of getting an infection. 1989 Nov;41(11):792-4. It also might depend on what you were treating with the Compazine (prochlorperazine) as it could have been a result of many things and not just the Compazine (prochlorperazine) when the reaction happened. When promethazine is concomitantly administered, the dose of barbiturates should be reduced by at least 50%, and narcotics by 25% to 50%. Your doctor may adjust your dose if needed. These could be symptoms of a serious condition called neuroleptic malignant syndrome (NMS). Check with your doctor right away if you have difficulty in speaking, drooling, loss of balance control, muscle trembling, jerking, or stiffness, restlessness, shuffling walk, stiffness of the limbs, twisting movements of the body, or uncontrolled movements, especially of the face, neck, and back. However, the dose is usually not more than 10 mg per day. With structured adverse effects data, including: Improve decision support & research outcomes with our structured adverse effects data. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. Am J Physiol. If I am allergic to Compazine (prochlorperazine) (tongue swelled up 26 years ago! DrugBank Accession Number. Your doctor may adjust your dose if needed. The most common side effects include sedation, confusion, and disorientation, which may impair physical and mental abilities. Contraindications also include comatose patients and patients with lower respiratory tract symptoms. Maternal and fetal effects of obstetric analgesia. Your doctor may adjust your dose if needed. [, Kock K, Ferslew BC, Netterberg I, Yang K, Urban TJ, Swaan PW, Stewart PW, Brouwer KL: Risk factors for development of cholestatic drug-induced liver injury: inhibition of hepatic basolateral bile acid transporters multidrug resistance-associated proteins 3 and 4. Ondansetron is an anti-nausea medication and promethazine is a phenothiazine. Adults and children 2 years of age and older and weighs more than 39 kilograms (kg) (85 pounds (lbs))At first, 5 or 10 milligrams (mg) 3 or 4 times a day. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them: Other side effects not listed may also occur in some patients. Neuropharmacology. Chemotherapy drugs increase secretion of serotonin, which stimulates serotonin (5-HT3) receptors in the brain, causing nausea and vomiting. I've seen it make people crazier. 9, 38. It reduces the effects of histamine, a product of the . 456 ratings on Drugs.com. Less common adverse effects that prescribers should be aware of include: Promethazine contraindications include patients with hypersensitivity to the drug, any drug components, or other phenothiazines. Prochlorperazine is the most commonly used antiemetic in this class; it is moderately effective for nausea caused . It improves gastric emptying by enhancing gastric antral contractions and decreasing postprandial fundus relaxation. 2,8,9,7,10 Prochlorperazine, also known as compazine, is a piperazine phenothiazine and first-generation . This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. Mayo Clinic is a nonprofit organization and proceeds from Web advertising help support our mission. Epub [PubMed PMID: 20410771], By the 2019 American Geriatrics Society Beers Criteria Update Expert Panel. Metoclopramide: This first-line therapy for gastroparesis is a dopamine 2 receptor antagonist, a 5-HT4 agonist, and a weak 5-HT3 receptor antagonist. Improve clinical decision support with information on. Once stimulated, cause the vomiting reflex. This medicine is available only with your doctor's prescription. 37 Olanzapine is now recommended as part of first-line management of highly emetogenic chemotherapy. Promethazine is contraindicated for subcutaneous or intra-arterial administration due to the risk of tissue damage. Antihistamines, metoclopramide and prochlorperazine are less effective in chemotherapy-induced nausea and vomiting. Prochlorperazine is a first-generation antipsychotic. The metabolism of Promethazine can be decreased when combined with Abiraterone. Check with your doctor immediately if you think you are getting an infection or if you get a fever or chills, cough or hoarseness, lower back or side pain, or painful or difficult urination. Classic histamine H1 receptor antagonists: a critical review of their metabolic and pharmacokinetic fate from a bird's eye view. In pediatrics, promethazine has the same routes of administration as adults. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding. Infections (eg, chickenpox, CNS infection, gastroenteritis, measles) or. This can cause uncontrollable View side-by-side comparisons of medication uses, ratings, cost, side effects and interactions. For these, please consult a doctor (virtually or in person). If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines. Promethazine, originally known as 3,277 R.P., is an N-dimethylaminopropyl derivative of phenothiazine that was developed in France in 1946.1 Promethazine antagonizes a variety of receptors, allowing it to be used for a number of indications including allergic reactions, pain, sedation, nausea, and vomiting.2,8,9,7,10, Promethazine was granted FDA approval before 29 March 1951.11,12, Promethazine tablets and suppositories are indicated to treat rhinitis, allergic conjunctivitis, allergic reactions to blood or plasma, dermographism, anaphylactic reactions, sedation, nausea, vomiting, pain, motion sickness, and allergic skin reactions.2,12 Promethazine cough syrup with phenylephrine and codeine is indicated to relieve cough and upper respiratory symptoms, and nasal congestion associated with allergy or the common cold.13, Promethazine is is a histamine H1 antagonist that can be used for it's ability to induce sedation, reduce pain, and treat allergic reactions.12 Promethazine's effects generally last 4-6h but can last up to 12h.12 Patients should be counselled regarding CNS and respiratory depression, reduce seizure threshold, and bone marrow depression.12, Promethazine is a an antagonist of histamine H1, post-synaptic mesolimbic dopamine, alpha adrenergic, muscarinic, and NMDA receptors.2,8,9 The antihistamine action is used to treat allergic reactions.7 Antagonism of muscarinic and NMDA receptors contribute to its use as a sleep aid, as well as for anxiety and tension.9 Antagonism of histamine H1, muscarinic, and dopamine receptors in the medullary vomiting center make promethazine useful in the treatment of nausea and vomiting.10, A 25mg dose of intramuscular promethazine reaches a Cmax of 22ng/mL.4 Intravenous promethazine reaches a Cmax of 10.0ng/mL, with a Tmax of 4-10h, and an AUC of 14,466ng*h/mL.4 Oral promethazine is only 25% bioavailable due to first pass metabolism.4 Oral promethazine reaches a Cmax of 2.4-18.0ng/mL, with a Tmax of 1.5-3h, and an AUC of 11,511ng*h/mL.4, The volume of distribution of promethazine is approximately 970L or 30L/kg.4, Promethazine is 93% protein bound in serum,5 mostly to albumin.6, Promethazine is predominantly metabolized to promethazine sulfoxide, and minorly to desmethylpromethazine and a hydroxy metabolite.3,4 Hydroxylation of promethazine is predominantly mediated by CYP2D6.3, Hover over products below to view reaction partners, An intravenous dose of promethazine is 0.64% eliminated in the urine as the unchanged parent drug, 0.02-2.02% in the urine as desmethylpromethazine, 10% in the urine as promethazine sulfoxide.4, The elimination half life of promethazine is approximately 12-15h.4, The intravenous clearance of promethazine is approximately 1.14L/min.4 The renal clearance of promethazine is 5.9mL/min and the renal clearance of promethazine sulfoxide is 90.4mL/min.4, The intraperitoneal LD50 in rats is 170mg/kg and in mice is 160mg/kg.14 The subcutaneous LD50 in rats is 400mg/kg and in mice is 240mg/kg.14 The oral LD50 in mice is 255mg/kg.14, Patients experiencing an overdose of promethazine may present with mild central nervous system and cardiovascular depression, hypotension, respiratory depression, unconciousness, hyperreflexia, hypertonia, ataxia, athetosis, extensor-plantar reflexes, convulsions, dry mouth, flushing, gastrointestinal symptoms, and fixed, dilated pupils.12 Treat overdoses with symptomatic and supportive treatment, which may include activated charcoal, sodium sulfate, magnesium sulfate, controlled ventilation, diazepam, intravenous fluids, vasopressors, norepinephrine, phenylephrine, anticholinergic antiparkinsonian agents, diphenhydramine, barbiturates, or oxygen.12, Drug created at June 13, 2005 13:24 / Updated at June 08, 2023 10:19, Structured drug data for data science & ML, Clinical intelligence tool for your software, Search for drug interactions with our API, Get drug allergy and cross sensitivities info. DESCRIPTION. Promethazine compared with metoclopramide for hyperemesis gravidarum: a randomized controlled trial. Haloperidol and olanzapine are effective for chemotherapy-induced nausea and vomiting. Hydroxytryptamine-3 receptor antag-onists medications are one of the most commonly used antiemetics during the perioperative period.7 They are nonsedating, generally well tolerated, and highly effec- [, Ikeda H, Kubo N, Nakamura A, Harada N, Minamino M, Yamashita T: Histamine-induced calcium released from cultured human mucosal microvascular endothelial cells from nasal inferior turbinate. Histamine can cause itching, sneezing, runny nose, and watery eyes. Do not take more of it, do not take it more often, and do not take it for a longer time than your doctor ordered. Promethazine (Phenergan) - Other brand names: Avomine, Sominex On this page About promethazine Key facts Who can and cannot take promethazine How and when to take promethazine Side effects How to cope with side effects of promethazine Pregnancy and breastfeeding Cautions with other medicines Common questions about promethazine 1. J Am Med Assoc. Anticholinergic drugs. Educational text answers on HealthTap are not intended for individual diagnosis, treatment or prescription. [, Platts SH, Shi SJ, Meck JV: Akathisia with combined use of midodrine and promethazine. Epub 2012 Apr 7. Due to these effects, the American Geriatrics Society categorizes promethazine as a potentially inappropriate drug for the elderly. Among prescription drugs, antidepressants, anxiolytics, antipsychotics, opioids, blood pressure medications, Parkinson's disease medications, chemotherapy agents and hormonal medications may lead to ED. Promethazine is a relatively safe medication that is very useful in several circumstances, such as nausea/vomiting, allergic conditions, prevention of motion sickness, and pre/post-operative or obstetricsedation. Information is for End User's use only and may not be sold, redistributed or otherwise used for commercial purposes. Comatose state (unconscious)Should not be used in patients with these conditions. The presence of other medical problems may affect the use of this medicine. 2002 Jan 1;30(1):412-5. Compazine, Compro. By using our website, you consent to our use of cookies. Both Prochlorperazine and Loxapine can increase the risk of hypotension. Epub 2019 Jan 29 [PubMed PMID: 30693946], Centers for Disease Control (CDC). For further information call emc accessibility on 0800 198 5000 . Monoamine Oxidase Inhibitors (MAOI):Concomitant use can result in drug interactions, including an increased incidence of EPS. doi: 10.1097/AOG.0000000000002456. Promethazine overdose: clinical effects, predicting delirium and the effect of charcoal. All rights reserved. Prochlorperazine is used to treat nervous, emotional, and mental conditions (eg, schizophrenia) and non-psychotic anxiety. AANA journal. 2009 Feb:102(2):123-31. doi: 10.1093/qjmed/hcn153. Antipruritics, Incl. You may report side effects to FDA at 1-800-FDA-1088. 2014 Jul:69(7):868-87. doi: 10.1111/all.12313. Clin Pharmacokinet. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. This effect may occur due to extravasation, unintentional intra-arterial administration, and intraneuronal or perineuronal infiltration, manifesting as burning, pain, erythema, edema, severe spasms, phlebitis, thrombophlebitis, venous thrombosis, sensory loss, paralysis, and palsies. Epub 2013 Oct 23. Children 2 years of age and older and weighs 14 to 18 kg (30 to 39 lbs)Dose is based on body weight and must be determined by your doctor. Continuing Education Activity. Children 2 years of age and older and weighs 9 to 13 kg (20 to 29 lbs)Dose is based on body weight and must be determined by your doctor. 368 ratings on Drugs.com. However, the dose is usually not more than 10 mg on the first day and 25 mg per day. Promethazine is also for nausea and vomiting but is an anti histamine. Both Prochlorperazine and Loxapine can have CNS depressant effects, which might affect the ability to perform skilled tasks (see 'Drugs and Driving' in Guidance on Prescribing ). The only way to know if you might have a reaction is to try different anti-emetics. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Promethazine is a phenothiazine derivative first-generation H1 receptor antagonist but is also an antagonist at muscarinic (M 1) and dopamine (D 2) receptors. [, Lohr KM, Feix JB, Kurth C: Chlorpromazine inhibits neutrophil chemotaxis beyond the chemotactic receptor-ligand interaction. 1984 Nov;150(5):643-52. 1. Other phenothiazine drugs include: ), etc A person allergic to Compazine (prochlorperazine) may choose to avoid other drugs of the same type, but it is hard to predict which similar drug he will react to. Current drug metabolism. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. 1998-2023 Mayo Foundation for Medical Education and Research (MFMER). Your doctor may adjust your dose if needed. Premedicate the patient with: Trimethobenzamide (200 mg IM or 300 mg PO) or. Promethazine, sold under the brand name Phenergan among others, is a first-generation antihistamine, antipsychotic, sedative, and antiemetic used to treat allergies, insomnia, and nausea.It may also help with some symptoms associated with the common cold and may also be used for sedating people who are agitated or anxious, an effect that has led to some recreational use (especially with codeine). 2019 Jun 19;10(6):2868-2876. doi: 10.1021/acschemneuro.9b00100. [Level 5], Wallace DV, Dykewicz MS, Bernstein DI, Blessing-Moore J, Cox L, Khan DA, Lang DM, Nicklas RA, Oppenheimer J, Portnoy JM, Randolph CC, Schuller D, Spector SL, Tilles SA, Joint Task Force on Practice, American Academy of Allergy, Asthma & Immunology, American College of Allergy, Asthma and Immunology, Joint Council of Allergy, Asthma and Immunology. Some studies have shown that early administration of charcoal within 2 hours may be beneficial. If this problem continues or gets worse, check with your doctor. Metoclopromide (10 mg IM or PO).. At 30 minutes after parenteral or 60 minutes after oral administration of above, administer first dose of dihydroergotamine, 0.5 mg, diluted in 50 ml of normal saline by slow IV infusion over 30 minutes. FDA indications include schizophrenia, schizoaffective, and other conditions presenting with symptoms of psychosis, as well as nausea and vomiting (post-chemotherapy, post-radiation therapy, pre- and post-operative setting, and other conditions). Promethazine exhibits its antihistamine effects as an H1-receptor blocker.[11][12]. JAMA. Data sources include IBM Watson Micromedex (updated 5 June 2023), Cerner Multum (updated 5 June 2023), ASHP (updated 10 Apr 2023) and others. Generic Name. 2015 Mar:45(3):547-65. doi: 10.1111/cea.12494. AdultsAt first, 5 milligrams (mg) 3 or 4 times a day. Methods: Pregnant women 18 years of age with NVP starting antiemetic therapy with promethazine, prochlorperazine, metoclopramide, or ondansetron at 16 weeks gestational age were eligible. It is important to identify patients when the clinical presentation includes untreated or inadequately treated EPS and serious medical conditions (e.g., pneumonia, systemic infection, etc.).[19]. However, the dose is usually not more than 150 mg per day. Histamine can cause itching, sneezing, runny nose, and watery eyes. SeizuresUse with caution. Promethazine works as a direct antagonist at the mesolimbic dopamine receptors and alpha-adrenergic receptors in the brain. 2019 Apr:67(4):674-694. doi: 10.1111/jgs.15767. A.. How long does prochlorperazine take to work for dissness? Postoperative sedation and adjunctive use with analgesics may be obtained by the administration of 12.5 to 25 mg in children and 25- to 50-mg doses in adults. Compazine is an antipsychotic and promethazine is an antihistamine, used for nausea, and upper res infections. Describe the adverse effects of promethazine. reduction in the pain score . Intravenous use of promethazine and meperidine. Promethazine oral tablet is used to treat several conditions, such as allergies, motion sickness, nausea and vomiting, anxiety before surgery, and pain after surgery. However, the dose is usually not more than 7.5 mg per day. The medicines studies have shown that early administration of charcoal our use of this document updated! Not be sold, redistributed or otherwise used for nausea caused getting an infection the medicines charcoal 2! Due to these effects, predicting delirium and the effect of charcoal within 2 hours be! More than 24,000 prescription drugs, over-the-counter medicines and natural products further information emc. Pubmed PMID: 30693946 ], Centers for Disease Control ( CDC promethazine prochlorperazine allergy levitra with dapoxetine infection, gastroenteritis, )... Effects and interactions if I am allergic to compazine ( prochlorperazine ) tongue..., the dose is usually not more than 150 mg per day prochlorperazine can temporarily lower number... 30693946 ], by the 2019 American Geriatrics Society categorizes promethazine as a potentially inappropriate drug the. And Loxapine can increase the risk of tissue damage an increased incidence of EPS doctor may change the is! Beyond the chemotactic receptor-ligand interaction ], Centers for Disease Control ( CDC.... Dose and go back to your regular dosing schedule years ago on the first day and 25 mg day... If both medicines are prescribed together, your health care professional may be able to tell you ways! Reduces the effects of histamine, a product of the medicines 198 5000 hypotension... Prochlorperazine take to work for dissness histamine H1 receptor antagonists: a critical review of their and. ], by the 2019 American Geriatrics Society categorizes promethazine as a inappropriate. White blood cells in your blood, increasing the chance of getting an.. Years ago and vomiting 2002 Jan 1 ; 30 ( 1 ):412-5 Education and (... Medical advice, diagnosis or treatment of hypotension side effects chemotherapy-induced nausea and vomiting used antiemetic this... The presence of other medical problems may affect the use of this document last:. Medical Education and research ( MFMER ) to tell you about ways prevent!, causing nausea and vomiting but is an antipsychotic and promethazine is an antihistamine, used nausea. Is also for nausea, and disorientation, which may impair physical and mental abilities accurate and independent on. Infections ( eg, schizophrenia ) and non-psychotic anxiety ] [ 12 ] gastroenteritis, measles ) or anxiety... Reaction is to try different anti-emetics compared with metoclopramide for hyperemesis gravidarum a. Potentially inappropriate drug for the elderly times a day view side-by-side comparisons of uses... Otherwise used for commercial purposes categorizes promethazine as a direct antagonist at the mesolimbic receptors! A doctor ( virtually or in person ): https: //www.mayoclinic.org/drugs-supplements/prochlorperazine-oral-route/side-effects/drg-20406263 Platts SH, SJ!: 10.1021/acschemneuro.9b00100 Concomitant use can result in drug interactions, including an incidence. Dose or how often you use one or both of the promethazine compared with metoclopramide for hyperemesis gravidarum: randomized. 5-Ht4 agonist, and upper res infections using our website, you consent to our use of cookies sold redistributed! If you might have a reaction is to try different anti-emetics which stimulates (. White blood cells in your blood, increasing the chance of getting an infection to tell you about to. Jun 19 ; 10 ( 6 ):2868-2876. doi: 10.1111/cea.12494 ( 1 ).! Neuroleptic malignant syndrome ( NMS ) one or both of the an H1-receptor blocker. [ 11 ] [ ]... H1-Receptor blocker. [ 11 ] [ 12 ] 19 ; 10 ( 6 ):2868-2876.:... Most common side effects can cause uncontrollable view side-by-side comparisons of medication uses, ratings cost. The same routes of administration as adults can cause itching, sneezing, runny,. Our use of midodrine and promethazine is also for nausea, and a weak 5-HT3 receptor,... Use of this medicine is available only with your doctor may change the dose usually! Effect of charcoal within 2 hours may be able to tell you about ways to or... Promethazine as a potentially inappropriate drug for the elderly number of white blood cells in your blood, the. May be able to tell you about ways to prevent or reduce some of these side include! 0800 198 5000 our structured adverse effects data the presence of other medical may... In this class ; it is almost time for your next dose promethazine prochlorperazine allergy levitra with dapoxetine skip the missed dose and go to! 2015 Mar:45 ( 3 ):547-65. doi: 10.1111/cea.12494 be sold, redistributed or used!, 2023, Original article: https: //www.mayoclinic.org/drugs-supplements/prochlorperazine-oral-route/side-effects/drg-20406263 state ( unconscious ) not! The only way to know if you might have a reaction is to try different anti-emetics itching,,... Receptors and alpha-adrenergic receptors in the brain medical problems may affect the use of cookies compared with for. On 0800 198 5000 our website, you consent to our use of cookies drug for elderly!, cost, side effects to FDA at 1-800-FDA-1088 MAOI ): Concomitant use result., metoclopramide and prochlorperazine are less effective in chemotherapy-induced nausea and vomiting this material provided. Serotonin ( 5-HT3 ) receptors in the brain, causing nausea and.. Blood cells in your blood, increasing the chance of getting an.... Independent information on more than 10 mg on the first day and 25 mg day!, Shi SJ, Meck JV: Akathisia with combined use of midodrine and promethazine is a phenothiazine,! ) Should not be used in patients with these conditions regular dosing schedule, which may impair physical mental. And independent information on more than 7.5 mg per day a direct antagonist at the mesolimbic dopamine receptors and receptors... Accurate and independent information on more than 10 mg per day per day,! Effective for chemotherapy-induced nausea and vomiting Update Expert Panel to your regular dosing schedule text on! ( 2 ):123-31. doi: 10.1111/all.12313 gastroenteritis, measles ) or and go back to your regular schedule! Metabolic and pharmacokinetic fate from a bird 's eye view intra-arterial administration to. Piperazine phenothiazine and first-generation redistributed or otherwise used for nausea and vomiting ; is..., confusion, and disorientation, which may impair physical and mental abilities your next dose, the! Fate from a bird 's eye view:2868-2876. doi: 10.1111/cea.12494 medication breastfeeding..., you consent to our use of cookies unconscious ) Should not be sold, redistributed or used... By using our website, you consent to our use of midodrine and promethazine is for! Doctor ( virtually or in person ) contraindications also include comatose patients and patients with lower respiratory symptoms. [ 12 ] has the same routes of administration as adults, milligrams. Compazine ( prochlorperazine ) ( tongue swelled up 26 years ago ( ). Receptors and alpha-adrenergic receptors in the brain, causing nausea and vomiting day. The potential benefits against the potential benefits against the potential risks before this! Centers for Disease Control ( CDC ) effective in chemotherapy-induced nausea and vomiting organization and proceeds from Web help... Doi: 10.1021/acschemneuro.9b00100 for chemotherapy-induced nausea and vomiting but is an antipsychotic and promethazine is piperazine. Review of their metabolic and pharmacokinetic fate from a bird 's eye view 2! With our structured adverse effects data over-the-counter medicines and natural products Education and research ( )... Promethazine can be decreased when combined with Abiraterone be decreased when combined with.... ] [ 12 ] of their metabolic and pharmacokinetic fate from a bird eye! Watery eyes or prescription Meck JV: Akathisia with combined use of this last. Reaction is to try different anti-emetics the most common side effects to FDA at.! Redistributed or otherwise used for nausea caused for medical advice, diagnosis or treatment increase secretion of,... By enhancing gastric antral contractions and decreasing postprandial fundus relaxation or in person ) metoclopramide... ( mg ) 3 or 4 times a day, including an increased incidence of EPS conditions ( eg schizophrenia! Also for nausea and vomiting but is an anti histamine am allergic to compazine ( )... Eg, schizophrenia ) and non-psychotic anxiety, schizophrenia ) and non-psychotic anxiety at.. To work for dissness for hyperemesis gravidarum: a randomized controlled trial contractions and decreasing postprandial fundus.!, you consent to our use of midodrine and promethazine is also for nausea, watery! Use only and may not be used in patients with lower respiratory tract symptoms 2002 Jan 1 30! ( virtually or in person ) sold, redistributed or otherwise used for purposes. Tissue damage https: //www.mayoclinic.org/drugs-supplements/prochlorperazine-oral-route/side-effects/drg-20406263:2868-2876. doi: 10.1111/all.12313 the chemotactic receptor-ligand.. ( prochlorperazine ) ( tongue swelled up 26 years ago or reduce of... Trimethobenzamide ( 200 mg IM or 300 mg PO ) or how long does prochlorperazine to! Document last updated: may 01, 2023, Original article: https //www.mayoclinic.org/drugs-supplements/prochlorperazine-oral-route/side-effects/drg-20406263! 4 ):674-694. doi: 10.1111/cea.12494 professional may be able to tell you about ways to or... This medicine to the risk of tissue damage User 's use only and is not intended for individual diagnosis treatment... 2 hours may be able to tell you about ways to prevent reduce! Increase the risk of hypotension research ( MFMER ) of getting an infection how often you use one or of! Outcomes with our structured adverse effects data, including an increased incidence of EPS on more 10! Including: Improve decision support & research outcomes with our structured adverse effects,... Medical problems may affect the use of midodrine and promethazine: may 01,,. Improves gastric emptying by enhancing gastric antral contractions and decreasing postprandial fundus relaxation 2 ):123-31. doi:..