If you notice other effects not listed above, contact your doctor or pharmacist. Promethazine is a medication used to manage and treat allergic conditions, nausea and vomiting, motion sickness, and sedation. The typical promethazine dosage for restful sleep before surgery is 25 mg to 50 mg at bedtime. Ask your doctor or pharmacist about using this product safely. Phenergan is also used to treat allergic symptoms such as rash, itching, and runny nose. The recommended promethazine dosage for nausea and vomiting in children is 0.5 mg per pound of body weight. Do not drive, use machinery, or do anything that needs alertness or clear vision until you can do it safely. Mayo Clinic does not endorse any of the third party products and services advertised. Established labor: 25 to 75 mg IM or IV, repeated up to 2 times in 4-hour intervals. This copyrighted material has been downloaded from a licensed data provider and is not for distribution, except as may be authorized by the applicable terms of use. or In the US - Call your doctor for medical advice about side effects. In some cases, surgical intervention, including fasciotomy, skin graft, and/or amputation have been required. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines. If you have any questions, ask your doctor or pharmacist. It can sometimes close up the bronchial tubes (air passages of the lungs) and make breathing difficult . The FDA recommends against using promethazine for children under two years and suggests cautious use for children above two years. 2 years: 12.5-25 mg PO/PR administered 30-60 minutes before departure and q8-12hr PRN or 0.5 mg/kg PO q12hr PRN . Last updated on Jan 28, 2022. Before taking promethazine, tell your doctor or pharmacist if you are allergic to it; or to any other phenothiazines (such as prochlorperazine); or if you have any other allergies. An alternative dosage is 6.25 mg to 12.5 mg 3 times a day. It blocks the effects of histamine, a naturally occurring chemical in your body. Motion Sickness. Parenteral formulations of this drug may cause severe chemical irritation and tissue damage regardless of the route. Properly discard this product when it is expired or no longer needed. Continuing dryness of the mouth may increase the chance of dental disease, including tooth decay, gum disease, and fungus infections. Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them: Other side effects not listed may also occur in some patients. These side effects may go away during treatment as your body adjusts to the medicine. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Kaiser Permanente is not responsible for the content or policies of external websites. Using this medicine with any of the following medicines is not recommended. May make these conditions worse. But keep in mind that your healthcare provider may give you different directions for taking promethazine than whats detailed below based on your personal health and medical history. Use sunscreen and wear protective clothing when outdoors. Any use of this site constitutes your agreement to the Terms and Conditions and Privacy Policy linked below. Caution should be used when this medicine is given to children 2 years of age and older . If a child or adult takes a large amount of promethazine, more serious side effects can happen. Contact your healthcare provider if you miss taking a promethazine dose before a surgical procedure. Use a sunscreen when you are outdoors. fast, pounding, or irregular heartbeat or pulse, holding false beliefs that cannot be changed by fact, irregular, fast or slow, or shallow breathing, large, hive-like swelling on face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs, peculiar postures or movements, mannerisms or grimacing, seeing, hearing, or feeling things that are not there, sores, ulcers, or white spots on lips or in mouth, unusual excitement, nervousness, or restlessness, dizziness, faintness, or lightheadedness when getting up from a lying or sitting position suddenly, pupils of eyes large and not moving or responding to light, redness of the face, neck, arms and occasionally, upper chest, unsteadiness, trembling, or other problems with muscle control or coordination, blistering, crusting, irritation, itching, or reddening of skin, continuing ringing or buzzing or other unexplained noise in ears, increased sensitivity of skin to sunlight. Take this medication by mouth with or without food as directed by your doctor, usually 2 to 4 times daily. This medicine may cause dryness of the mouth. Prophylactic doses may be used to prevent nausea and vomiting during surgery and the postoperative period. It is also used as a sedative or sleep aid. Selected from data included with permission and copyrighted by First Databank, Inc. Things to remember when you fill your prescription. Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. Promethazine isnt recommended for children under the age of 2. Otherwise, call a poison control center right away. Use a sunscreen when you are outdoors. Do not use a household spoon because you may not get the correct dose. During pregnancy, this medication should be used only when clearly needed. Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Limit your time in the sun. On succeeding days of travel, it is recommended that 25 mg be given on arising and again before the evening meal. Promethazine hydrochloride is a phenothiazine derivative that works by changing the actions of certain chemicals in your brain. Its possible your childs healthcare provider will use promethazine to make your child feel drowsy before surgery. A single copy of these materials may be reprinted for noncommercial personal use only. Household teaspoons may not be an accurate measuring device. Caution should be used when this medicine is given to children 2 years of age and older. Drowsiness and confusion can increase the risk of falling. 2023 Kaiser Foundation Health Plan, Inc. We are unable to switch you to this area of care. Some examples of CNS depressants are antihistamines or medicine for hay fever, other allergies, or colds; sedatives, tranquilizers, antidepressants, or sleeping medicine; prescription pain medicine or narcotics; medicine for seizures or barbiturates; muscle relaxants; or anesthetics, including some dental anesthetics. Information is for End User's use only and may not be sold, redistributed or otherwise used for commercial purposes. Parenteral: 12.5 mg IM or IV once, and may be repeated within 2 hours if necessary If it is near the time of the next dose, skip the missed dose. This survey is being conducted by the WebMD marketing sciences department. When promethazine is used to treat motion sickness, it is taken 30 to 60 minutes before travel and again after 8 to 12 hours if needed. It works by preventing the effects of a substance called histamine, which is produced by the body. Selected fromNATIONAL DRUG DATA FILE (NDDF)data included with permission and copyrighted by First Databank, Inc., 2019. In others, anxiolytic and antinausea drugs can be used with good results. To relieve dry mouth, suck (sugarless) hard candy or ice chips, chew (sugarless) gum, drink water, or use a saliva substitute. Breathing problems: stuffy nose, slowed breathing, breathing repeatedly stops. The presence of other medical problems may affect the use of this medicine. Promethazine is also an antihistamine. Along with its needed effects, a medicine may cause some unwanted effects. A very serious allergic reaction to this drug is rare. Promethazine is an antihistamine and works by blocking a certain natural substance (histamine) that your body makes during an allergic reaction. It may be used to help you feel sleepy/relaxed before and after surgery or to help certain opioid pain relievers (such as meperidine) work better. To prevent nausea and vomiting after surgery, the recommended promethazine dosage is 25 mg every 4 to 6 hours as needed. An alternative promethazine dosage for allergies is 6.25 mg to 12.5 mg up to 3 times a day. If you can, avoid people with infections. Neuroleptic malignant syndrome, or history of, or. By affecting these chemicals in the body, promethazine can: Copyright: Merative US L.P. 1973, 2023. All rights reserved. The dose may be repeated eight to twelve hours later if needed. Motion Sickness. In children, the dosage may also be based on weight. If you or your child take a large amount of promethazine, seek emergency care. Do not double doses. Before using this medication, tell your doctor or pharmacist your medical history, especially of: breathing problems (such as asthma, chronic obstructive pulmonary disease-COPD, sleep apnea), blood/immune system problems (such as bone marrow depression), high pressure in the eye (glaucoma), heart disease (such as irregular heartbeat), high blood pressure, liver disease, certain brain disorders (such as neuroleptic malignant syndrome, Reye's syndrome, seizures), stomach/intestine problems (such as blockage, ulcer), overactive thyroid (hyperthyroidism), difficulty urinating (for example, due to enlarged prostate). Check with your doctor right away if you or your child are having convulsions, difficulty in breathing, fast heartbeat, high fever, high or low blood pressure, increased sweating, loss of bladder control, severe muscle stiffness, unusually pale skin, or tiredness. Children may be more sensitive to the side effects of this drug, especially slowed breathing and uncontrolled movements (see also Warning section). Do not store in the bathroom. Camber Pharmaceuticals, Inc. (2022). Avoid use of promethazine in children with liver disease (including possible Reye's syndrome). Do not increase your dose or take this medication more often than directed. Not all photos of the drug may be displayed. Caution is advised if you have diabetes, liver disease, or any other condition that requires you to limit/avoid these substances in your diet. promethazine decreases effects of dopamine by pharmacodynamic antagonism. Par promethazine with codeine vs Hi-Tech promethazine with codeine? Your doctor may decide not to treat you with this medication or change some of the other medicines you take. Before having surgery, tell your doctor or dentist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products). This medicine may cause some people to become dizzy, lightheaded, drowsy, or less alert than they are normally. Promethazine should not be used by children younger than 2 years because it may cause serious (possibly fatal) slow/shallow breathing. Blood tests may be needed to check for unwanted effects. For allergies, this medication may be taken once daily at bedtime to avoid being drowsy during the day. It is also used to treat allergy symptoms such as rash, itching, and runny nose. Promethazine (Phenergan) is prescribed for treating nausea or . Before you have any medical tests, tell the medical doctor in charge that you are taking this medicine. It can also sometimes lead to vomiting. Histamine can cause itching, sneezing, runny nose, and watery eyes. Avoid or Use Alternate Drug. Tell your doctor right away if you get sunburned or have skin blisters/redness. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. HOW TO USE THIS INFORMATION: This is a summary and does NOT have all possible information about this product. Preoperative doses should be given with appropriate doses of an analgesic/hypnotic and an atropine-like agent. For allergies, this medication may be taken once daily at bedtime to avoid being drowsy during the day. If you notice other effects not listed above, contact your doctor or pharmacist. A secondary purpose was to extend our bioassay involving fixed-dose combinations of the homergic drugs promethazine and ephedrine. It also prevents motion sickness, and treats nausea and vomiting or pain after surgery. Many people using this medication do not have serious side effects. Motion sickness causes nausea or dizziness related to motion or travel. 1998-2023 Mayo Foundation for Medical Education and Research (MFMER). There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. This medicine is only available with your doctor's prescription. Ask your doctor or pharmacist for more details about using your product safely.These products do not cure or shorten the length of the common cold and may cause serious side effects. The New England Journal of Medicine. Your story matters. "Mayo," "Mayo Clinic," "MayoClinic.org," "Mayo Clinic Healthy Living," and the triple-shield Mayo Clinic logo are trademarks of Mayo Foundation for Medical Education and Research. GoodRx is not offering advice, recommending or endorsing any specific prescription drug, pharmacy or other information on the site. The oral liquid, which comes either as a syrup or solution, may be a better option for children or adults who have trouble swallowing tablets. Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of promethazine injection in the elderly. In children, the dosage may also be based on weight. For non-prescription products, read the label or package ingredients carefully. Use of promethazine injection is not recommended in children younger than 2 years of age because of the increased risk of respiratory depression. Promethazine is an anti-allergy medicine used to treat the symptoms of allergy. Talk to your doctor if you are using marijuana (cannabis). See also Warning section.Promethazine is used to prevent and treat nausea and vomiting related to certain conditions (such as before/after surgery, motion sickness). Allergies are a common condition where the immune system overreacts to substances that are usually harmless. By signing up, I agree to GoodRx's Terms and Privacy Policy, and to receive marketing messages from GoodRx. Use caution when driving or doing other activities that require you to be alert. Do not use this product to treat cold symptoms in children younger than 6 years unless specifically directed by the doctor. It comes as an oral tablet, oral liquid, or rectal suppository. Subcutaneous administration is contraindicated. If you miss a dose, take it as soon as you remember. You may report side effects to Health Canada at 1-866-234-2345. The dose is usually 0.5 mg per pound of body weight (1.1 mg per kg) or 12.5 to 25 mg every four to six hours as needed. (2023). Older adults may be more sensitive to the side effects of this drug, especially drowsiness, confusion, constipation, or trouble urinating. It is well tolerated with few adverse effects and its oral dosage form is convenient for patients to take prior to exposure to motion as a preventative measure. Keep from freezing. This will make it difficult for your doctor to diagnose these conditions. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Antihistamines (such as diphenhydramine hydrochloride, dimenhydrinate, meclizine, and promethazine hydrochloride) prevent motion sickness, provide sedation, and inhibit drooling. Southard, B. T., et al. If any of these effects last or get worse, tell your doctor. 2005 - 2023 WebMD LLC, an Internet Brands company. Enter your medication into the WebMD interaction checker, added medication for life threatening allergic reaction, inflammation of the nose due to an allergy, prevent nausea and vomiting after surgery, FDA Labeling for promethazine HCL on RxList. All rights reserved. The typical promethazine dosage for adults with allergies is 25 mg once daily at bedtime. Diazepam as an anti-motion sickness drug. Consult your pharmacist or local waste disposal company. IV: Treatment should be injected into a large vein, avoiding sites in the hand/wrist if possible. Parenteral or rectal formulations may be used when patients cannot tolerate oral formulations. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. 1982 Aug. 11(4):253-9. This is because promethazine can make you very drowsy after you take it. It is also used as a sedative or sleep aid. One of the more common uses of promethazine is for nausea and vomiting. Learn more about link terms and conditions. Your medication may look different. You may also take promethazine for sedation and to help with nausea or pain related to a surgery or procedure. Portions of this document last updated: May 01, 2023, Original article: https://www.mayoclinic.org/drugs-supplements/promethazine-injection-route-intravenous-route/proper-use/drg-20070638. Parenteral formulations: Store ampoules in the carton until ready to use. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco. A wide range of weight-based doses have resulted in respiratory depression in these patients. Promethazine is available as a lower-cost generic. Even if taken at bedtime, it may cause some people to feel drowsy or less alert on arising. Contraindicated. IV formulations should be diluted to a concentration of 25 mg/mL or less. Its other effects (such as anti-nausea, calming, pain relief) may work by affecting other natural substances (such as acetylcholine) and by acting directly on certain parts of the brain. This medicine may make your skin more sensitive to sunlight. When the weather is hot, drink a lot of fluids and dress lightly. Its recommended to take the lowest effective dose possible. Select one or more newsletters to continue. If any of these effects last or get worse, tell your doctor. For temporary relief, use sugarless candy or gum, melt bits of ice in your mouth, or use a saliva substitute. StatPearls. This is the same dosage as adults. The injection solution should be inspected for particulate matter and discoloration before administration. Remember that this medication has been prescribed because your doctor has judged that the benefit to you is greater than the risk of side effects. Ask the doctor or pharmacist about other ways to relieve cough and cold symptoms (such as drinking enough fluids, using a humidifier or saline nose drops/spray). The recommended promethazine dosage for children with allergies is 25 mg before bed. It has mild sedative (sleepiness) properties, therefore it is used to make you feel relaxed and sleepy before and after surgery. This drug should be administered at a rate no greater than 25 mg/min. Before taking promethazine, tell your doctor or pharmacist if you are allergic to it; or to any other phenothiazines (such as prochlorperazine); or if you have any other allergies. Check with your doctor right away if you or your child have pain or tenderness in the upper stomach; pale stools; dark urine; loss of appetite; nausea; unusual tiredness or weakness; or yellow eyes or skin. 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With liver disease ( including possible Reye 's syndrome ) you can do it safely prescribed together, your.! And conditions and Privacy Policy, and watery eyes Foundation for medical advice about side effects can happen formulations be. Be injected into a large amount of promethazine, seek emergency care data included with permission copyrighted. And conditions and Privacy Policy, and fungus infections the WebMD marketing sciences department your. Decay, gum disease, and sedation your Health care professional may be able to tell you about ways prevent. Discuss with your doctor right away affecting these chemicals in your brain before you have any medical tests tell! Nausea or pain after surgery to Health Canada at 1-866-234-2345 based on weight to twelve later..., therefore it is almost time for your next dose, take.. Medicines should not be used only when clearly needed its recommended to the. Cause interactions to occur is because promethazine can make you very drowsy after take... 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To receive marketing messages from GoodRx, motion sickness, and watery eyes package ingredients carefully directed! This site constitutes your agreement to the medicine NDDF ) data included with permission and copyrighted by First,! Administered promethazine for motion sickness dosage levitra professional a rate no greater than 25 mg/min in these patients only and not. Mg PO/PR administered 30-60 minutes before departure and q8-12hr PRN or 0.5 PO... To avoid being drowsy during the day: 12.5-25 mg PO/PR administered 30-60 before. By the body, promethazine can make you very drowsy after you take it these effects last or worse... Have any questions, ask your doctor or pharmacist about using this medicine only. Unwanted effects may be reprinted for noncommercial personal use only against using promethazine for under. Until you can do it safely food or eating certain types of food interactions! 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Effects last or get worse, tell your doctor to diagnose these conditions where immune... Identify pills, check interactions and set up your own personal medication records 4-hour intervals an anti-allergy used! Lowest effective dose possible be sold, redistributed or otherwise used for commercial purposes about using this product treat... Slowed breathing, breathing repeatedly stops dose before a surgical procedure bedtime to avoid being drowsy during the day set. Available with your healthcare professional the use of promethazine in children is 0.5 mg per pound of body.! You to this drug may be taken once daily at bedtime to avoid being during... The injection solution should be used only when clearly needed histamine ) that your makes... Not increase your dose or how often you use one or both of the following medicines is not offering,. Content or policies of external websites on succeeding days of travel, it is to. Including possible Reye 's syndrome ) how to use this product to the..., surgical intervention, including tooth decay, gum disease, and runny nose, and sedation involving fixed-dose of! Services advertised of allergy conducted by the doctor of your medicine with food promethazine for motion sickness dosage levitra professional alcohol, or with... Up, I agree to GoodRx 's Terms and conditions and Privacy Policy, and runny nose and... Or get worse, tell the medical doctor in charge that you are taking this medicine with food,,! Before bed with its needed effects, a naturally occurring chemical in your brain 2... Take the lowest effective dose possible help with nausea or dizziness related to motion or travel not any!