data of pharmaceutical manufacturers, it does not validate or verify the Inhibitors of dipeptidyl peptidate-4 (DPP-4) are essentially weight neutral and include alogliptin, sitagliptin, saxagliptin and linagliptin. Nebivolol is a beta-blocker. The increased use of pharmaceuticals in the past decade may, in part, contribute to the increasing rates of overweight and obesity globally. However, inconsistencies exist when defining the weight effects of medication. Virk S, Schwartz TL, Jindal S, Nihalani N, Jones N. Psychiatric medication induced obesity: an aetiologic review. DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. Information may be obtained if you have access to ToxBase the primary clinical toxicology database of the National Poisons Information Service. Leren P, Foss PO, Nordvik B, Fossbakk B. Aliskiren reduces sympathetic nerve activity and blood pressure in chronic kidney disease patients. Applies to prazosin: oral capsules. The information stored on FDB Multilex is not exhaustive. National Library of Medicine Rosenstock J, Hassman DR, Madder RD, et al. There are several clinical guidelines that categorize medications as those that promote weight loss, weight gain or have weight neutral effects. Pieber TR, Famulla S, Eilbracht J, et al. Viagra (sildenafil) is a prescription drug that's used to treat erectile dysfunction (ED). Furthermore, when switching from a diuretic . Portions of this document last updated: March 01, 2023. All medicines can have side effects. Canagliflozin compared with sitagliptin for patients with type 2 diabetes who do not have adequate glycemic control with metformin plus sulfonylurea: a 52-week randomized trial. Comparison of rilmenidine and lisinopril on ambulatory blood pressure and plasma lipid and glucose levels in hypertensive women with metabolic syndrome. Once the decision has been made to change medications, clinicians should be cognizant to switch only one medication at a time, so that the effects on weight and medical efficacy can be appropriately evaluated.190 A protocol highlighting clear instructions should be created for the patient to minimize the potential of withdrawal symptoms. that the information they have is current. Prazosin is used to treat hypertension ( high blood pressure ). professionals will retain FULL and SOLE responsibility for deciding Kinon BJ, Basson BR, Gilmore JA, Tollefson GD. that all information is provided from FDB Multilex on the basis that the Side effects include: The https:// ensures that you are connecting to the Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum. de Luis DA, Conde R, Gonzlez-Sagrado M, et al. Sgaard J, Lane R, Latimer P, et al. Lastly, recently, some reviews have been published which examine the weight effect of medication.4,5 However, similar to clinical guidelines, they are either devoid of or only provide estimates for some of the medications discussed. Psychopathologies are tightly linked with weight changes.69 Patients with mental health disorders are two to three times more likely to develop obesity than the general population.10 A review examining psychiatric medication effect on weight suggests that over the course of treatment, ~70% of patients will experience some weight gain.6 A list of commonly used antipsychotics and their weight effects can be found in Table 1. cannot advise as to particular cases. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Coniff RF, Shapiro JA, Seaton TB, Bray GA. Multicenter, placebo-controlled trial comparing acarbose (BAY g 5421) with placebo, tolbutamide, and tolbutamide-plus-acarbose in non-insulin-dependent diabetes mellitus. Treatment-emergent weight changes associated with antihypertensives. Pratley RE, Kipnes MS, Fleck PR, Wilson C, Mekki Q. Efficacy and safety of the dipeptidyl peptidase-4 inhibitor alogliptin in patients with type 2 diabetes inadequately controlled by glyburide monotherapy. O 0. Less common side effects of Minipress include vomiting, diarrhea, constipation, fluid retention ( edema ), dizziness on standing, shortness of breath, fainting, motion sickness, depression, nervousness, rash, Drugs commonly associated with weight change: a systematic review and meta-analysis. Clozapine, diabetes mellitus, weight gain, and lipid abnormalities: a five-year naturalistic study. Effects of telmisartan vs olmesartan on metabolic parameters, insulin resistance and adipocytokines in hypertensive obese patients. The top prescription drugs of 2011 in the United States: antipsychotics and antidepressants once again lead CNS therapeutics. When switching to a more weight-favorable medication, non-weight-related side effects must also be taken into consideration. Combined treatment of severe essential hypertension with the new angiotensin converting enzyme inhibitor ramipril. Berken GH, Weinstein DO, Stern WC. Mcquade RD, Stock E, Marcus R, et al. A 12-week study comparing moclobemide and sertraline in the treatment of outpatients with atypical depression. Prolonged administration of chlorpromazine (thorazine) hydrochloride: clinical and laboratory survey of fifty patients. Effects of enalapril, a new angiotensin-converting enzyme inhibitor, in a controlled trial in heart failure. Malone M. Medications associated with weight gain. This is because (and all healthcare Guelfi JD, Ansseau M, Timmerman L, Krsgaard S, Mirtazapine-Venlafaxine Study Group Mirtazapine versus venlafaxine in hospitalized severely depressed patients with melancholic features. How it works Prazosin may be used to reduce high blood pressure. A prolonged erection (priapism) can damage the penis. Initiate therapy at the lowest dose, as the elderly are more susceptible to hypotension. Associations between changes in glucagon-like peptide-1 and bodyweight reduction in patients receiving acarbose or metformin treatment. and maintenance do not know the particular circumstances, condition or Comparative efficacy of preprandial or postprandial Humalog Mix75/25 versus glyburide in patients 60 to 80 years of age with type 2 diabetes mellitus. and maintenance do not know the particular circumstances, condition or Many are due to the drug's effects on the nervous system such as dizziness, drowsiness, and fatigue, its most common side effects. Minipress (prazosin)." As studies differ in treatment duration, dose, concomitant medications and intervention type, changes in weight observed in clinical practice may be different from the results presented here. While FDB Multilex use reputable sources of information, such as published Drent ML, van der Veen EA. Douketis JD, Macie C, Thabane L, Williamson DF. Examples include low blood pressure and . Yang W, Chen L, Ji Q, et al. http://creativecommons.org/licenses/by-nc/3.0/, https://www.cdc.gov/nchs/fastats/drug-use-therapeutic.htm, https://www.accessdata.fda.gov/drug-satfda_docs/label/2008/020357s031,021202s016lbl.pdf, http://www.novonordisk.ca/content/dam/Canada/AFFILIATE/www-novonordisk-ca/OurProducts/PDF/Saxenda_PM_English.pdf, Bupropion (norepinephrinedopamine reuptake inhibitor), Mirtazapine (noradrenergic and specific serotonergic). Lipase inhibition: a novel concept in the treatment of obesity. However, thiazolidinediones are associated with the most weight gain of antihyperglycemics, second only to insulin. Lastly, trazodone (1.2 to +0.9 kg50,52) may have the most favorable weight profiles of all TCAs as a few studies have observed small amounts of weight loss with its use. Domecq JP, Prutsky G, Leppin A, et al. Dapagliflozin maintains glycaemic control while reducing weight and body fat mass over 2 years in patients with type 2 diabetes mellitus inadequately controlled on metformin. Notes: +=>1 kg. Common side effects of Minipress include dizziness, headache, drowsiness, lack of energy, weakness, palpitations, and nausea. It is important to note that patients who are given sulfonylureas as a first-line treatment regimen may experience greater weight gain. Richardson DW, Freund J, Gear AS, Mauck HP, Preston LW. You may need a dose adjustment or your blood pressure checked more often if you take both medications. The effect of enalapril and timolol on blood lipids: a randomized multicenter hypertension study in general practice in Norway. van der Zijl NJ, Sern EH, Goossens GH, et al. With medical big data and proven AI algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. As population demographics have shifted dramatically in the last 30 years, findings of studies examined may be dated and may not be generalizable to the population today. Burnet J. This is because (and all healthcare Alternative treatment options for patients with type 2 diabetes include thiazolidinediones. Comparative efficacy and tolerability of 15 antipsychotic drugs in schizophrenia: a multiple-treatments meta-analysis. Effect of naltrexone plus bupropion on weight loss in overweight and obese adults (COR-I): a multicentre, randomised, double-blind, placebo-controlled, Phase 3 trial. This content does not have an English version. First Databank UK Ltd is proud of the extensive editorial and quality control Prazosin should only be used in pregnancy when the benefits outweigh the potential risk. 8600 Rockville Pike Impact of empagliflozin added on to basal insulin in type 2 diabetes inadequately controlled on basal insulin: a 78-week randomized, double-blind, placebo-controlled trial. Stenlf K, Cefalu WT, Kim KA, et al. A long-term study of the influence of indapamide on the exchangeable potassium and sodium pools in hypertensive patients. Lithium is commonly prescribed for the treatment of bipolar disorder and has been associated with lesser, yet relevant weight gain (1.19.9 kg30,33). Weight gain. 1. Further, while not all of the classes of medication examined in this review have weight-favorable alternatives, there exist many other tools to mitigate weight gain associated with medication use, such as changes in dosing, medication delivery or the use of adjunctive therapies. More pronounced gains of 3.689 and 4.2 kg80 have been reported in patients prescribed glyburide and gliclazide as the first-line diabetes treatment, respectively. Dietary supplementation with fish oil in ulcerative colitis. Make your tax-deductible gift and be a part of the cutting-edge research and care that's changing medicine. Summary Commonly reported side effects of prazosin include: dizziness. Cirillo M, Marcarelli F, Mele AA, Romano M, Lombardi C, Bilancio G. Parallel-group 8-week study on chlorthalidone effects in hypertensives with low kidney function. Dosage should be adjusted according to the patient's clinical response. Conversely, the two most commonly used calcium channel blockers, amlodipine (0.7 to +0.8 kg170,172) and diltiazem (0.1 to +1.2 kg173,175), are relatively weight neutral with <1.5 kg weight changes on average. Drent ML, van der Veen EA lipase inhibition: a multiple-treatments meta-analysis, Goossens GH, et al in... 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