[13], O. gratissimum repels the thrips Thrips tabaci, and so is a useful insect repellent in other crops. 2 Ed. Nearly 4,000 species worldwide belong to the Lamiaceae family, and there are approximately 200 species of the genus Ocimum. Lin Y., Shi R., Wang X., Shen H.M. Luteolin, a flavonoid with potential for cancer prevention and therapy. Mohammed, A., Tanko, Y., Okasha, M. A., et al. Antinociceptive properties of the essential oil of Ocimum gratissimum L. (Labiatae) in mice. Matasyoh, L. G., Matasyoh, J. C., Wachira, F. N., et al. Pl. Torres R.G., Casanova L., Carvalho J., Marcondes M.C., Costa S.S., Sola-Penna M., Zancan P. Ocimum basilicum but not Ocimum gratissimum present cytotoxic effects on human breast cancer cell line MCF-7, inducing apoptosis and triggering mTOR/Akt/p70S6K pathway. Annual Review of Phytopathology, 40, 221249. This is only a brief summary of general information about this product. Li Y., Wen J.M., Du C.J., Hu S.M., Chen J.X., Zhang S.G., Zhang N., Gao F., Li S.J., Mao X.W., Miyamoto H., Ding K.F. Machado K., Islam M.T., Ali E.S., Rouf R., Uddin S.J., Dev S., Shilpi J.A., Shill M.C., Reza H.M., Das A.K., Shaw S., Mubarak M.S., Mishra S.K., Melo-Cavalcante A. Ajitkumar, D., & Seeni, S. (1998). It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this product. Joseph I.E., Jaja I.F., Boyi A.H., Olugbenga O.M. Antinociceptive activity and redox profile of the monoterpenes (+)-camphene, p-cymene, and geranyl acetate in experimental models. Bombay: Popular Prakashan Pvt Ltd. Nakamura, C. V., Nakamura, T. U., Bando, E., et al. Attenuated brain oxidative stress, damage and neurological deficits, Neuroprotective effect on cerebral ischemia, Hydrogen peroxide-induced toxicity in human HepG2 cells. Sahoo, Y., Pattnaik, S. K., & Chand, P. K. (1997). Lin C., Chao P., Shen C., Shu J., Yen S., Huang C., Liu J. Fakae, B. antihypertension, anti-inflammatory, and anti-cancer. Chemical composition and antimicrobial activity of essential oil of thyme (Thymus vulgaris) from eastern Morocco. Chang, S. S., Matijasevic, O. Evidence-Based Complementary and Alternative Medicine. Background The ethanolic extract of the leaves of Ocimium gratisimum L. (Lamiaceae), used in traditional medicine for the treatment of several ailments such as urinary tract, wound, skin and gastrointestinal infections, was evaluated for its antibacterial properties against four clinical bacteria isolates namely: Escherichia coli, Proteus mirabilis, Staphylococcus aureus and Pseudomonas . It also decreased caspase 3 and PARP expressions, and CDK4and p-ERK1/2 expressions. Nangia-Makker P, Raz T, Tait L, Shekhar MP, Li H, Balan V, Makker H, Fridman R, Maddipati K, Raz A. 2019. WHO Global Report on Traditional and Complementary Medicine 2019. Liapi C., Anifandis G., Chinou I., Kourounakis A.P., Theodosopoulos S., Galanopoulou P. Antinociceptive properties of 1,8-Cineole and beta-pinene, from the essential oil of Eucalyptus camaldulensis leaves, in rodents. (2001). 484489). Plant, 33, 293296. (1983). In vivo antimalarial activity of essential oils from Cymbopogon citratus and Ocimum gratissimum on mice infected with Plasmodium berghei. Bhat, S. R., Chandel, K. P. S., & Malik, S. K. (1995). Micropropagation of Hemidesmus indicus (L.) through axillary bud culture. Phytotherapy Research, 13, 427429. Abdulrahman, F. (1992). (2010). Acomprehensive review of the antibacterial, antifungal and antiviral potential of essential oils and their chemical constituents against drug-resistant microbial pathogens. They also offered 50% protection of treated mice against seizure-induced mortality. Phytotherapy Research, 12, 288290. (Tshilanda 2015) In human hepatocellular carcinoma cell lines, an aqueous O. gratissimum extract increased tumor apoptosis in a dose-dependent manner, with little to no effect on noncancerous Chang liver cells. Ocimum gratissimum, also called basil clove, African basil, is an Ocimum species from Africa, South Asia, and South America [].It is a species of tropical plants popularly referred to as "scent leaf," as Nigerians love to call it. Antioxidant, anti-inflammatory and anticarcinogenic activity. (Sumitha 2016), Avoid use. New Delhi: Malhotra Publishing House. (1990). Duman, A. D., Telci, I., Dayisoylu, K. S., et al. Mahapatra S.K., Roy S. Phytopharmacological approach of free radical scavenging and anti-oxidative potential of eugenol and Ocimum gratissimum Linn. In vitro clonal propagation of Holy BasilOcimum sanctum L. plant tissue culture and biotechnology (Vol. Portland: Timber Press. The UK is the first country to allow OTC access to Sanofi's tadalafil-based erectile dysfunction drug Cialis following a successful switch. Bioscience Discovery, 3, 2024. The effects of ethanolic plant extracts of Ocimum gratissimum L. and Carica papaya L. on in vitro inhibition of the mycelia growth of the isolates were determined. Sowing requirement: Small round brown seeds. It is a valuable medicinal plant which has numbers of. Shinde, A. N., Malpatha, N., & Fulzele, D. P. (2009). Mahapatra S.K., Chakraborty S.P., Roy S. Immunomodulatory role of Ocimum gratissimum and ascorbic acid against nicotine-induced murine peritoneal macrophages in vitro. PubMed (Huang 2020), In a study in rats, O. gratissimum essential oil demonstrated endothelium-dependent, vasorelaxant effects and decreased perfusion pressure in isolated mesenteric vascular beds. Janick, J. Shaw M., Wu J., Wang M. Antihypertensive effects of. Anyone you share the following link with will be able to read this content: Sorry, a shareable link is not currently available for this article. Global promotion of herbal medicine: Indias opportunity. Hypersensitivity to any components of the plant species should be considered a contraindication. 10, pp. Rabelo, M., Souza, E. P., Soares, P. M. G., et al. (2000). Google Scholar. It has elliptic-lanceolate leaves that taper at both ends, and long, pale, white to pinkish flower spikes. Among these, drought stress is one of the most impacting factors which alter seriously the plant physiology, finally leading to the decline of the crop productivity. The isolates were identified as Aspergillus . Salehi B., Mishra A.P., Shukla I., Sharifi-Rad M., del Mar Contreras M., Segura-Carretero A., Fathi H., Nasrabadi N.N., Kobarfard F., Sharifi-Rad J. Thymol, thyme, and other plant sources: health and potential uses. Decrease in the function of -aminobutyric acid coupled chloride channel produced by repeated administration of pentylenetetrazole in rats. CAS Decreased Interleukin-(IL)-6 and tumor necrosis factor (TNF)-, myeloperoxidase, nitric oxide, cyclooxygenase-2 and malondialdehyde in the colon, Repairs colonic mucosa injury via anti-inflammatory and anti-oxidant activity, 50 and 100 mg/kg of phenolic-enriched ethylacetate fraction of, Reduced exudate volume, leucocyte count, nitrite, TNF-a, and myeloperoxidase activity. Corda, M. G., Giorgi, O., Longoni, B., et al. Meta-analysis reports suggested that green tea (GT) consumption is associated with mild to moderate effects on major global killers. (2009). Aqueous and methanolic extracts have demonstrated reversible and time-dependent inhibition of CYP2B6. Joshi, R. K. (2013). Ameliorative effect of aqueous leaf extract of Solanum aethiopicum on phenylhydrazine-induced anaemia and toxicity in rats. Aqueous leaf extract of Ocimum gratissimum potentiates activities of plasma and hepatic antioxidant enzymes in rats. Information regarding safety and efficacy in pregnancy and lactation is lacking. International Journal of Food and Safety, 5, 1519. To enhance the health promoting potential of GT, one of the strategies is to combine it with traditionally used medicinal plants (Ocimum gratissimum, Cymbopogon citratus, Cymbopogon flexuosus, and Hibiscus rosa-sinensis). 1990. (2004). Natural products from higher plants and plant cell culture. Recknagel, R. O. Balyan, S. S., & Pushpagandan, P. (1988). Journal of Hygiene, Epidemiology, Microbiology, and Immunology, 36, 303309. Biochemical Systematics and Ecology, 29, 287204. Antioxidant properties and chemical constituents of ethanolic extract and its fractions of. It is a herbaceous plant that belongs to family Lamiaceae. (1995). Namdeo, A. G., Jadhav, T. S., Rai, P. K., et al. 2023 Springer Nature Switzerland AG. Preparation, characterization and therapeutic properties of gum Arabic-stabilized gallic acid nanoparticles. It is important to fully inform your doctor about the herbal, vitamins, mineral or any other supplements you are taking before any kind of surgery or medical procedure. Pant B. Phytotherapy Research, 1148, 630634. Antibacterial activity of Ocimum gratissimum L. essential oil. Data Documentation. Chandrappa, S. M., Harsha, R., Dinesha, R., et al. Chemical variation of essential oil constituents of Ocimum gratissimum L. from Benin, and impact on antimicrobial properties and toxicity against Artemiasalina leach. This perennial and odoriferous plant is now found in all continents and possesses generally acknowledged medicinal properties. (2005). Dode, L. B., Bobrowski, V. L., Braga, E. J. This plant has immense therapeutic uses. Comparative effects of methanol and oil extracts of Ocimum gratissimum on testicular morphology and epididymal sperm reserve of adult male albino rats (Wistar strain), Joshi R.K. Chemical composition, in vitro antimicrobial and antioxidant activities of the essential oils of. Chiu, C. C., Huang, C. Y., Chen, T. Y., et al. (Ejike 2013), Similar to other members of the Ocimum genus, O. gratissimum contains an essential oil, alkaloids, glycosides, tannins, and other chemical constituents. Okoli C.O., Ezike A.C., Agwagah O.C., Akah P.A. Natural antioxidant from rosemary and sage. Its leaves are ovate or ovate-lanceolate, measure up to 10 5 cm, and sub-acuminate to acuminate at the apex, with dots on both sides. Biotechnology for the production of plant natural products. (2012). Mulabagal, V., & Tsay, H. S. (2004). Tsai S.-F., Lee S.-S. Neolignans as xanthine oxidase inhibitors from Hyptis rhomboides. Lee MJ, Chen HM, Tzang BS (2011) Ocimum gratissimum aqueous extract protects H9c2 myocardiac cells from H2O2-induced cell apoptosis through akt signaling. Screening of some medical plants for anti-salmonella activity. Nigerian Quarterly Journal of Hospital Medicine, 19, 106109. Alexandria: ASHS Press. Paula-Freire L.I., Andersen M.L., Molska G.R., Khn D.O., Carlini E.L. B., Campbell, A. M., Barrett, J., et al. 4.12.1.12 Ocimum gratissimum (Lamiaceae): Clove basil. Essential oils plants (Vol. Chemopreventive effect of Ocimum sanctum on DMBA induced hamster buccal pouch carcinogenesis. The pharmacological potential of rutin. Khosroushahi, A. Y., Valizadeh, M., Ghasempour, A., et al. Nevadensin is a naturally occurring selective inhibitor of human carboxylesterase 1. WHO . (2006). We comply with the HONcode standard for trustworthy health information. Akinyemi, K. O., Mendie, U. E., Smith, S. T., et al. Bhat, K. G. (2003). Antibacterial properties of the Vietnamese cajeput oil and ocimum oil in combination with antibacterial agents. Attenuated anemia, thrombocytopenia, and leucocytosis, 200 and 400 mg/kg/day of aqueous leaf extract of, Acetic acid-induced colitis in male Wistar rats, Decreased the activities of MPO, SOD, NO and increased GSH levels in colitis rats Decreased diarrhea score and ulcer score to normal, Anti-inflammatory and anti-oxidative properties. Ocimum gratissimum, also known as clove basil, African basil,[1] and in Hawaii as wild basil,[2] is a species of basil. (1993). 19, pp. Lopez, P., Sanchez, K., Batlle, R., et al. Anthelmintic activity of essential oil of Ocimum gratissimum Linn. Flora of Udupi (1st ed.). 627657). Caragay, A. Journal of Applied Sciences and Environmental Management, 12, 3339. This information is not specific medical advice and does not replace information you receive from your health care provider. Zhong, J. J. Venuprasad M.P., Kandikattu H.K., Razack S., Khanum F. Phytochemical analysis of Ocimum gratissimum by LC-ESI MS/MS and its antioxidant and anxiolytic effects South Afr. The Journal of Experimental Biology, 40, 65773. 239240). Patnaik, J., & Debata, B. K. (1996). (2010). Shokoufeh Hassani, in Reference Module in Biomedical Sciences, 2023 Uses The extract decreased the cell viability of HCC SK-Hep 1 and HA22T cells. and eugenol against Haemonchus contortus. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. Philippe, S., Souabou, F., & Guy, A. Plant Cell, Tissue and Organ Culture, 28, 229230. Plant Signaling & Behavior, 6, 17201731. Comparison of antioxidant activity of insulin, Ocimum gratissimum L., and Vernonia amygdalina L. in type 1 diabetic rat model. 177122). Tohidi B., Rahimmalek M., Arzani A., Trindade H. Sequencing and variation of terpene synthase gene (TPS2) as the major gene in biosynthesis of thymol in different Thymus species. Aziba, P. I., Bass, D., & Elegbe, Y. (1999). Roitman, C., Roitman, I., & Azevedo, H. P. (1972). Inhibition of glutathione-S-transferases (GSTs) from parasitic nematodes by extracts from traditional Nigerian medicinal plants. The effect of honey and surfactant type on the antibacterial properties of the leaf essential oil of, Ouyang X., Wei L., Pan Y., Shiwen Huang S., Hengshan Wang H., Gregorio B., Begonia G.B., Stephen I.N., Ekunwe S.I.N. ), Advances in new crops (pp. Influence of abiotic stress signals on secondary metabolites in plants. 4 UNI | 4.95 per 1UNI. Dubey, N. K., Tiwari, T. N., Mandin, D., et al. Growth of an insect Trypanosomatid at 37C in a defined medium. (Ernst 2002), None well documented. Guest lecture presented at the National scientific conference organized by the Nigerian Society of Pharmacognosy (NSP) at Zaria, Nigeria, pp. African Journal of Biotechnology, 6, 760765. PubMed Lahlou S., Interaminense L., Leal-Cardoso J.H., Morais S.M., Duarte G.P. Antifungal properties of Ocimum gratissimum essential oil (ethyl cinnamatechemotype). Tatsadjieu, N. L., Etoa, F. X., Mbofung, C. M. F., et al. Anticonvulsant and anxiolytic evaluation of leaf extracts of Ocimum gratissimum, a culinary herb. Effect of aqueous leaves extract of Ocimum gratissimum on hematological parameters in rats. Tropicultura, 26(2), 7883. In Vitro Cellular and Developmental Biology. Chemical composition, in vitro antimicrobial and antioxidant activities of the essential oils of Ocimum gratissimum, O. Sanctum and their major constituents. (1992). The plant is about 12 feet long, and its leaves have cloves-like flavor that leads to its use in vegetables seasoning. Sulistiarini, D., Oyen, L. P. A., & Nguyen, X. D. (1999). (Ofem 2012b), O. gratissimum extracts have been used in topical preparations as a mosquito repellent. In vitro rapid clonal propagation of Ocimum basilicum L. Plant Tissue Culture, 12, 2735. The chemotaxonomic significance of two bioactive caffeic acid esters, nepetoidins A and B, in the Lamiaceae. The present study has been carried out to identify the chemical constituents present in the leaves, stems and seeds of Ocimum gratissimum plant using Gas Chromatography Mass Spectroscopy along with its functional group analysis using Fourier Transform Infrared Spectrophotometer. (2003). Evaluation of the antinociceptive activity of Ocimum gratissimum L. (Lamiaceae) essential oil and its isolated active principles in mice. Effects of exogenous metallothionein on acute cadmium toxicity in rats. Google Scholar. Preliminary phytochemistry and antibacterial activity of ethanolic extract of Ocimum gratissimum. Pessoa L.M., Morais S.M., Bevilaqua C.M., Luciano J.H. Brazilian Archives of Biology and Technology, 49, 867871. Seeds seem to need strong sunlight to germinate, although germination has been achieved even during an average UK summer.[6]. EJEAF Che, 4, 10861093. This product may adversely interact with certain health and medical conditions, other prescription and over-the-counter drugs, foods, or other dietary supplements. Rufino A.T., Ribeiro M., Sousa C., Judas F., Salgueiro L., Cavaleiro C., Mendes A.F. Antioxidant, anti-inflammatory, antimicrobial, anticancer, cardioprotective, neuroprotective, antidiabetic, anti-osteoporotic, estrogenic/antiestrogenic, anxiolytic, analgesic and antiallergic activities. Journal of Ethnopharmacology, 105, 161166. (Obianime 2011, Ofem 2012a), The essential oil was reportedly nontoxic in mice, with a high acute median lethal dose of 11,622.67 mcL/kg. B., Heish, O. Basil. (2012). (WHO 2002), Equivocal findings regarding toxic effects of orally administered O. gratissimum on hematological parameters (eg, red blood cell count, hemoglobin, platelet and neutrophil counts) have been reported in animal studies; the effects on human blood are unknown. The aqueous extract of Ocimum gratissimum leaves ameliorates acetic acid-induced colitis via improving antioxidant status and hematological parameters in male Wistar rats. Despite the known biological activities and ethnomedicinal applications, comparative evaluation of the effects of. An in vitro study described inhibitory activity of African basil extracted by various methods (ie, aqueous, ethanolic, methanolic) on CYP2B6 as well as on rifampicin metabolism. Onajobi, F. D. (1986). (2002). Sofowora A., Ogunbodede E., Onayade A. Novel target genes responsive to apoptotic activity by Ocimum gratissimum in human osteosarcoma cells. (Dang 2020, Mai 2020), Limited reports in rodents suggest glucose-lowering effects of O. gratissimum extracts, indicating a propensity of O. gratissimum to reverse impairment of nutrient digestion and absorption in diabetes mellitus. Antioxidant, anti-inflammatory, anticancer, cardioprotective, hepatoprotective, gastroprotective, nephroprotective, antimicrobial, and immune-modulatory activity. Data sources include IBM Watson Micromedex (updated 5 June 2023), Cerner Multum (updated 5 June 2023), ASHP (updated 10 Apr 2023) and others. Ezekwesili, C. N., Obiora, K. A., & Ugwu, O. P. (2004). (1977). Karthikeyan, K., Ravichandran, P., & Govindasamy, S. (1999). The Journal of Protozoology, 19, 346349. Plant Cell Reports, 15, 473497. Talabi J.Y., Makanjuola S.A. Proximate, phytochemical, and. 19 Citations Metrics Abstract Ocimum is one of the most revered medicinally useful plants which have various species. Chitwood, D. J. Acta Biologica Cracoviensia Series Botanica, 52(2), 5058. It is a herbaceous plant that belongs to family Lamiaceae. (Ejike 2013), In rats with induced gastric ulcers, an aqueous leaf extract of O. gratissimum decreased gastric acid secretion and ulceration. (1983) An acidic xylan from the capsular polysaccharide complex of Ocimum gratissimum seeds. Scientific Name(s): Ocimum gratissimum L.Common Name(s): African basil, Clove basil, East Indian basil, Nchanwu leaf, Russian basil, Shrubby basil, Tree basil, Wild basil (Hawaii). Sofowora E.A. Sowing season: Spring, but as perennial spring to autumn. Plant, 46(4), 348353. Brazilian Journal of Medical and Biological Research, 36, 521524. Phytochemical constituent and antioxidant activity of extract from the leaves of O. gratissimum. Afr. Ocimum gratissimum, common name tulsi, is considered as a sacred plant and worshiped in India. PubMed Journal of Ethnopharmacology, 18, 311. Global Journal of Pharmaceutical, 5, 191200. Mycoses, 36, 333336. Recognized synonyms for African basil include Ocimum suave and Ocimum viride Willd. [14], Pharmacology of extracts and essential oils, Influence of light, temperature and gibberellic acid on the germination of, Chemical composition, antibacterial activity in vitro and brine-shrimp toxicity of the essential oil from inflorescences of, Nutritional and antimicrobial properties of, Food preservative potential of essential oils and fractions from, Last edited on 17 February 2023, at 15:49, Kew World Checklist of Selected Plant Families, "The medicinal values of scent leaf (Ocimum gratissimum)", Celso Vataru Nakamura, Tania Ueda-Nakamura, Erika Bando, Abraho Fernandes Negro Melo, Dogenes Aparcio Garcia Cortez, Benedito Prado Dias Filho, "Antibacterial Activity of, International Journal of Food Microbiology, "Semiochemicals for Thrips and Their Use in Pest Management", https://en.wikipedia.org/w/index.php?title=Ocimum_gratissimum&oldid=1139930900, This page was last edited on 17 February 2023, at 15:49. (2005). GCMS of microwave-assisted hydrodistillation extracted essential oils from, Antioxidant activity and superoxide radical inhibition, hypolipidemic action, Antiviral, inhibitory, anticoagulant, antitumor, antimicrobial, antimalarial, antioxidant, anti-inflammatory, anti-leishmania, and analgesic effects, Anti-inflammatory activity, management of dermatophytosis, Anti-inflammatory and anti-catabolic effects, Anti-inflammatory, antioxidant, antinociceptive, anticancer, antidiabetic, antihyperalgesic, antiviral, and gastroprotective effects, relief of heartburn and gastroesophageal reflux, Mucolytic and spasmolytic action on the respiratory tract, anti-inflammatory and anti-oxidant, antinociceptive activity, Anticonvulsant activity, antifungal activity, antitumor activity, Antimicrobial and insect-repellent properties, anti-inflammatory activity, antihyperlipidemic, antidepressant, neuroprotective and anticancer properties. 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Natural products, Giorgi, O., Longoni ocimum gratissimum cialis professional B., et al by repeated administration of in! H. P. ( 2004 ) in type 1 diabetic rat model revered medicinally plants! Germination has been achieved even during an average UK summer. [ 6 ] ( vulgaris!