Magnesium oxide is sold under several brand names. Take this product by mouth as directed. Adult . Magnesium oxide is an inorganic salt of magnesium formed with ions of magnesium and oxygen (2). Although oral magnesium supplementation is well-tolerated, magnesium can cause gastrointestinal symptoms, including nausea, vomiting, and diarrhea.49 Overdose of magnesium may cause thirst, hypotension, drowsiness, muscle weakness, respiratory depression, cardiac arrhythmia, coma, and death.49, Concomitant use of magnesium and urinary excretionreducing drugs, such as calcitonin, glucagon (Glucagen), and potassium-sparing diuretics, may increase serum magnesium levels, as may doxercalciferol (Hectorol).50 Concomitant oral intake of magnesium may influence the absorption of fluoroquinolones, aminoglycosides, bisphosphonates, calcium channel blockers, tetracyclines, and skeletal muscle relaxants. However, the same can't be said for supplements. dosage, form, labeller, route of administration, and marketing period. You may report side effects to FDA at 1-800-FDA-1088 or at www.fda.gov/medwatch. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. Ask your doctor or pharmacist about using this product safely. Some tablets may be broken or crushed and sprinkled on applesauce or other soft food. On This Page Indications and Usage Dosage and Administration Dosage Forms and Strengths Contraindications Warnings and Precautions This document does not contain all possible drug interactions. You'll soon start receiving the latest Mayo Clinic health information you requested in your inbox. Children birth to 3 years of age40 to 80 mg per day. A blood test is usually used to check the level of magnesium in your blood. If you notice other effects not listed above, contact your doctor or pharmacist. 2.1 Dosage Information - For most patients, the recommended dose is 50 mg taken, as needed, approximately 1 hour before sexual activity. Read our. Magnesium oxide might reduce how well the Parkinson's disease treatmentSinemet (levodopa and carbidopa)works. The most common indications are discussed here in order of most supported to least supported in the literature. Comments: Recommended DIETARY intakes: Access drug product information from over 10 global regions. Low magnesium levels usually don't cause symptoms. This content is owned by the AAFP. Stomach upset and diarrhea may occur. Take magnesium oxide exactly as directed. However, check with your health care professional first, since this should not be done for most tablets. If you have the following health problem, consult your doctor or pharmacist before using this product: kidney disease. tell your doctor if you are on a low-salt, low-sugar, or other special diet. See additional information. Supplement use should be individualized and vetted by a healthcare professional, such as a registered dietitian nutritionist, pharmacist, or healthcare provider. This kind of stroke is often caused by high blood pressure). Take each dose with a full glass (8 ounces or 240 milliliters) of water unless your doctor directs you otherwise. Diagnosis of mild to moderate magnesium deficiency is challenging because patients may be asymptomatic, and usual diagnostic testing is specific but not sensitive. Comments: Do not use without physician supervision in patients with renal impairment due to increased risk of hypermagnesemia. Follow all directions on the product package. One of the most common uses of magnesium oxide supplements is constipation treatment. Its one of many forms of magnesium available for purchase in supplement form. 2019;121:167-173. doi:10.1007/s13760-019-01101-x, Kashihara Y, Terao Y, Yoda K, et al. These preparations provide 5-7 mEq (2.5-3.5 mmol or 60-84 mg) of magnesium per tablet. The as-needed dose is usually 10 mg but can range from 5-20 mg. Magnesium oxide and other inorganic salts of magnesium like magnesium carbonate are high in elemental magnesium, which is the total amount of magnesium in a supplement (3). The best way to get magnesium is through your diet and eating a variety of magnesium-rich foods, such as spinach, legumes, nuts, seeds, and whole grains. Carefully read a supplement's ingredient list and nutrition facts panel to know which ingredients and how much of each ingredient is included. information and will only use or disclose that information as set forth in our notice of Higher doses of the supplement usually over 1 gram are used to treat constipation, though daily doses as low as 250 mg may be enough for some people (5). Mango is a popular fruit whose skin is commonly removed before eating, though some argue that it should be consumed instead of tossed. Always speak with a healthcare provider before taking a supplement to ensure that the supplement and dosage are appropriate for your needs. You may report side effects to Health Canada at 1-866-234-2345. Too much magnesium in the blood can cause serious side effects. The following is the Recommended Dietary Allowance (RDA) for magnesium: Magnesium oxide supplements should be taken by mouth with meals to reduce the chances of stomach upset. Older research suggests the absorption rate is even lower in humans (4, 5). High doses of magnesium oxide may cause dangerously high blood magnesium levels, which is more likely in specific populations. In fact, studies have shown that people who experience frequent stress tend to have lower magnesium stores (17). If you are using magnesium oxide as a laxative, take it with a full glass (8 ounces [240 milliliters]) of cold water or fruit juice. All rights reserved. Potential side effects and drug interactions, 7 Signs and Symptoms of Magnesium Deficiency, 10 Magnesium-Rich Foods That Are Super Healthy, Natural Laxatives for Constipation: Everything You Need to Know. Uses: Acid indigestion, upset stomach Usual Adult Dose for Constipation Oral: For oral dosage form (capsules, chewable tablets, crystals for oral solution, extended-release tablets, enteric-coated tablets, powder for oral solution, tablets, oral solution): To prevent deficiency, the amount taken by mouth is based on normal daily recommended intakes (Note that the normal daily recommended intakes are expressed as an actual amount of magnesium. Daily doses are often between 2.5 and 5 milligrams (mg). Magnesium sulfate (intravenous and intramuscular) has been shown to be relatively effective for treating eclampsia and preeclampsia, although it has been considered the standard of care for decades.20 In 2003, two Cochrane reviews showed that magnesium use in patients with eclampsia was superior to that of phenytoin (Dilantin) and lytic cocktail,21,22 with another study showing magnesium to be more effective than nimodipine (Nimotop).23 A different 2003 Cochrane review showed that 1 to 2 g of intravenous magnesium sulfate per hour reduced the risk of eclampsia in patients with preeclampsia by more than one half.24 The use of magnesium does not appear to have harmful effects on the mother or infant in the short term.25, A well-known use of intravenous magnesium is for correcting the uncommon ventricular tachycardia of torsade de pointes.26 Results of a meta-analysis suggest that 1.2 to 10 g of intravenous magnesium sulfate is also a safe and effective strategy for the acute management of rapid atrial fibrillation.27 A six-week randomized, double-blind crossover trial showed that oral magnesium supplementation reduced the frequency of asymptomatic ventricular arrhythmia in patients with stable congestive heart failure secondary to coronary artery disease.28, A 2000 Cochrane review of magnesium sulfate for exacerbations of acute asthma in the emergency department found that evidence does not support routine use of intravenous magnesium in all patients with acute asthma; however, it appears safe and beneficial for severe acute asthma by improving peak expiratory flow rate and forced expiratory volume in one second.29 In a meta-analysis of acute asthma in children, intravenous magnesium demonstrated probable benefit in moderate to severe asthma in conjunction with standard bronchodilators and steroids30; however, a randomized controlled trial showed that oral magnesium added no clinical benefit to standard outpatient therapy for chronic stable asthma in adults.31 In a 2005 Cochrane review of inhaled magnesium sulfate in acute asthma, nebulized magnesium in addition to a beta2 agonist were shown to improve pulmonary function and trend toward benefit in fewer hospital admissions.32, Studies have found that patients with cluster headaches and classic or common migraine, especially menstrual migraine, have low levels of magnesium.33,34 A prospective, multicenter, double-blind randomized study conducted in Germany showed that a single daily dosage of 600 mg oral trimagnesium dicitrate significantly reduced the frequency of migraine compared with placebo, whereas a lower twice daily dosage was found ineffective.35,36 For acute treatment of migraine, intravenous magnesium sulfate showed a statistically significant improvement in the treatment of all symptoms in patients with aura, or as an adjuvant therapy for associated symptoms in patients without aura.37, Another common condition with several self-treatment options is dyspepsia, a key symptom of gastroesophageal reflux disease (GERD). Maximum SUPPLEMENT dose: 180 mg MgOx (110 mg elemental) per day Taking too much magnesium oxide may cause: If you have any of these symptoms after taking magnesium oxide, seek medical care right away. Magnesium is an essential mineral for optimal metabolic function. Maximum SUPPLEMENT dose (all ages, pregnancy or lactation): 574 mg MgOx (350 mg elemental) per day, Mag-Oxide, Uro-Mag, Mag-200, MagGel, Phillips' Cramp-free. Magnesium oxide, on the other hand, is not as well absorbed. Learn more about natural laxatives. Magnesium oxide is a form of magnesium commonly taken as a dietary supplement. information submitted for this request. 1990;9(1):48-55. doi:10.1080/07315724.1990.10720349, Mori H, Tack J, Suzuki H. Magnesium oxide in constipation. For Constipation For the condition of constipation, an adult and child patient would be prescribed a caplet (500 mg). Children 4 to 6 years of age65 mg per day. Unneeded medications should be disposed of in special ways to ensure that pets, children, and other people cannot consume them. Magnesium oxide has also been shown to prevent constipation after surgery, treat opioid-induced constipation, and improve functional constipation in children (21). A 2019 study confirmed this by testing 15 magnesium supplements and finding that a supplement containing only magnesium oxide had the lowest bioavailability (3). When taken in safe doses, magnesium can effectively prevent migraines for many people. Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Below, check out the tour dates, as well as a weird tour . Copyright 2023 American Academy of Family Physicians. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing. Magnesium oxide might help reducehigh blood pressure(hypertension) and lower the risk of stroke. Oral magnesium at 600 milligrams per day was needed to lower blood pressure in people with untreated hypertension. Duration of therapy: Up to 2 weeks 2023 Dotdash Media, Inc. All rights reserved, Verywell Health uses only high-quality sources, including peer-reviewed studies, to support the facts within our articles. Mayo Clinic on Incontinence - Mayo Clinic Press, Mayo Clinic on Hearing and Balance - Mayo Clinic Press, FREE Mayo Clinic Diet Assessment - Mayo Clinic Press, Mayo Clinic Health Letter - FREE book - Mayo Clinic Press, Magnesium Supplement (Oral Route, Parenteral Route). Despite these . The following side effects may get better over time as your body gets used to the medication. You should tell your provider about any health conditions you have and all medications youre taking to avoid interactions or adverse reactions. Severe deficiency may lead to hypocalcemia and hypokalemia.1 Conditions that may lead to hypomagnesemia include poorly-controlled diabetes mellitus; chronic malabsorptive problems(e.g., Crohndisease, gluten-sensitive enteropathy, regional enteritis); medication use (e.g., diuretics, antibiotics); alcoholism; and older age (e.g., decreased absorption of magnesium, increased renal exertion).1, There are challenges in diagnosing magnesium deficiency because of its distribution in the body. Instead, the best way to dispose of your medication is through a medicine take-back program. To use the sharing features on this page, please enable JavaScript. Magnesium toxicity: dizziness, flushed skin, low energy, difficulty breathing, muscle weakness, abnormal heartbeat. For individuals taking the extended-release form of this dietary supplement: For individuals taking the powder form of this dietary supplement: The dose medicines in this class will be different for different patients. has a different strength. The supplement has an osmotic effect, meaning it draws water into the intestines to cause a laxative effect that can help relieve constipation in both children and adults. Meanwhile, a supplement with both inorganic and organic magnesium salts magnesium oxide and magnesium glycerophosphate, respectively had the highest bioavailability (3). The Surprising Truth. Tell your doctor if symptoms of low magnesium blood levels (such as muscle cramps, tiredness, irritability, depression) last or get worse. For example, magnesium oxide is used to prevent migraine with daily 500-mg doses (12). Magnesium oxide is one of the most common forms sold in supplement form, either as a stand-alone supplement or in multinutrient products. 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