Modify Therapy/Monitor Closely. Use Caution/Monitor. Minor (1)levofloxacin increases levels of lorazepam by decreasing metabolism. Monitor Closely (1)haloperidol and levofloxacin both increase QTc interval. Gatifloxacin is most likely to produce dysglycemia; moxifloxacin is least likely. Ask your pharmacist about all the products you take.Carefully measure the dose using a special measuring device/spoon. selpercatinib increases toxicity of levofloxacin by QTc interval. There are also case reports of quinolones increasing phenytoin levels. Quinolone antibiotic administration may result in hyper- or hypoglycemia. Other (see comment). Use Caution/Monitor. Serious - Use Alternative (1)levofloxacin, vandetanib. Avoid or Use Alternate Drug. Use Caution/Monitor. magnesium supplement will decrease the level or effect of levofloxacin by Other (see comment). Avoid or Use Alternate Drug. Modify Therapy/Monitor Closely. levofloxacin increases effects of rosiglitazone by pharmacodynamic synergism. Increased risk of QT prolongation and cardiac arrhythmias. anagrelide and levofloxacin both increase QTc interval. Monitor Closely (1)levofloxacin and citalopram both increase QTc interval. Minor/Significance Unknown. Modify Therapy/Monitor Closely. Monitor Closely (1)zinc will decrease the level or effect of levofloxacin by cation binding in GI tract. Use Caution/Monitor. Minor (1)levofloxacin will decrease the level or effect of pyridoxine by altering intestinal flora. Use Caution/Monitor. Take this medication on an empty stomach (1 hour before or 2 hours after eating). If coadministration unavoidable, monitor for increased risk of QTc interval prolongation. Monitor Closely (1)triclabendazole and levofloxacin both increase QTc interval. Comment: Risk of CNS stimulation/seizure. Minor/Significance Unknown. levofloxacin and risperidone both increase QTc interval. Use Caution/Monitor. Comment: Risk of CNS stimulation/seizure. Monitor Closely (1)eluxadoline increases levels of levofloxacin by decreasing metabolism. Drugs that are known to prolong the QTc interval may have an increased the risk of ventricular arrhythmias. Quinolone antibiotic administration may result in hyper- or hypoglycemia. Other (see comment). ezogabine, levofloxacin. Other (see comment). This document does not contain all possible drug interactions. Monitor for ECG changes if therapy is initiated in patients with drugs known to prolong QT interval. rilpivirine increases toxicity of levofloxacin by QTc interval. Monitor Closely (1)thioridazine and levofloxacin both increase QTc interval. Comment: Risk of CNS stimulation/seizure. isoflurane and levofloxacin both increase QTc interval. Quinolone antibiotic administration may result in hyper- or hypoglycemia. Monitor Closely (1)leuprolide increases toxicity of levofloxacin by QTc interval. magnesium hydroxide decreases levels of levofloxacin by inhibition of GI absorption. levofloxacin increases levels of lormetazepam by decreasing metabolism. Other (see comment). Increases risk of torsades de pointes. Use Caution/Monitor. Mechanism: Displacement of GABA from receptors in brain. Use Caution/Monitor. Avoid or Use Alternate Drug. Modify Therapy/Monitor Closely. levofloxacin, fenoprofen. Coadministration with drugs that lower seizure threshold may increase this risk. Serious - Use Alternative (1)siponimod and levofloxacin both increase QTc interval. adagrasib, levofloxacin. Antibacterial agents may decrease efficacy if coadministered. Mechanism: Displacement of GABA from receptors in brain. Applies only to oral form of both agents. Modify Therapy/Monitor Closely. levofloxacin and quinine both increase QTc interval. Minor (1)levofloxacin will decrease the level or effect of biotin by altering intestinal flora. Eluxadoline may increase the systemic exposure of coadministered OATP1B1 substrates. Applies only to oral form of both agents. Use Caution/Monitor. Monitor Closely (1)osilodrostat and levofloxacin both increase QTc interval. Use Caution/Monitor. Coadministration of quinolone antibiotics and corticosteroids may increase risk of tendon rupture. Use Caution/Monitor. Administer oral levofloxacin 2 hr before or after administration of polyvalent cation containing products. Make sure lab personnel and all your doctors know you use this drug. Quinolone antibiotic administration may result in hyper- or hypoglycemia. Avoid or Use Alternate Drug. All material on this website is protected by copyright, Copyright 1994-2023 by WebMD LLC. Mechanism: Displacement of GABA from receptors in brain. levoketoconazole and levofloxacin both increase QTc interval. Avoid or Use Alternate Drug. Use Caution/Monitor. Use Caution/Monitor. Macimorelin causes an increase of ~11 msec in the corrected QT interval. Microbiota oral contains bacterial spores. ECG should be monitored closely. levofloxacin will decrease the level or effect of ethinylestradiol by altering intestinal flora. Gatifloxacin is most likely to produce dysglycemia; moxifloxacin is least likely. Quinolone antibiotic administration may result in hyper- or hypoglycemia. Minor (1)levofloxacin, acemetacin. ibutilide and levofloxacin both increase QTc interval. Avoid or Use Alternate Drug. Comment: Risk of CNS stimulation/seizure. Minor/Significance Unknown. clozapine and levofloxacin both increase QTc interval. Use Caution/Monitor. SIDE EFFECTS: See also Warning section.Nausea, diarrhea, headache, dizziness, lightheadedness, or trouble sleeping may occur. levofloxacin increases toxicity of amifampridine by Other (see comment). Monitor Closely (1)lapatinib and levofloxacin both increase QTc interval. Monitor Closely (1)lithium and levofloxacin both increase QTc interval. Use Caution/Monitor. Drugs that prolong the QTc interval and may potentiate the effects of beta2 agonists on the cardiovascular system; increased risk of ventricular arrhythmias. Minor/Significance Unknown. Gatifloxacin is most likely to produce dysglycemia; moxifloxacin is least likely. levofloxacin increases effects of insulin NPH by pharmacodynamic synergism. Applies only to oral forms of hormone. Slight and transient QT-prolongation observed with ezogabine, particularly when dose titrated to 1200 mg/day. If coadministration unavoidable, more frequent monitoring is recommended for such patients. If you experience any of the following symptoms, stop using levofloxacin injection and call your doctor immediately: seizures; tremors; dizziness; lightheadedness; headaches that won't go away (with or without blurred vision); difficulty falling asleep or staying asleep; nightmares; not trusting others or feeling that others want to hurt you; ha. QT prolongation can rarely cause serious (rarely fatal) fast/irregular heartbeat and other symptoms (such as severe dizziness, fainting) that need medical attention right away.The risk of QT prolongation may be increased if you have certain medical conditions or are taking other drugs that may cause QT prolongation. Minor/Significance Unknown. Monitor Closely (1)sucralfate decreases levels of levofloxacin by inhibition of GI absorption. Applies only to oral form of both agents. Rilpivirine should be used with caution when co-administered with a drug with a known risk of Torsades de Pointes. Comment: Amifampridine can cause seizures. levofloxacin increases effects of glimepiride by pharmacodynamic synergism. Use Caution/Monitor. Smoothie. Serious - Use Alternative (1)artemether and levofloxacin both increase QTc interval. Administer fluoroquinolones at least 2 hr before and no less than 6 hr after each dose to avoid chelation with magnesium. levofloxacin increases effects of warfarin by unspecified interaction mechanism. Minor/Significance Unknown. Avoid coadministration of trilaciclib (OCT2, MATE1, and MATE-2K inhibitor) with substrates where minimal increased concentration in kidney or blood may lead to serious or life-threatening toxicities. Increased phototoxicity. Either increases toxicity of the other by QTc interval. Avoid or Use Alternate Drug. Avoid or Use Alternate Drug. Rilpivirine should be used with caution when co-administered with a drug with a known risk of Torsades de Pointes. Each drug may increase the photosensitizing effect of the other. levofloxacin and pentamidine both increase QTc interval. Use Caution/Monitor. Mechanism: Displacement of GABA from receptors in brain. alfuzosin and levofloxacin both increase QTc interval. If concomitant use is required it's recommended that toremifene be interrupted. Monitor Closely (1)levofloxacin increases effects of warfarin by unspecified interaction mechanism. Use Caution/Monitor. Modify Therapy/Monitor Closely. Monitor Closely (1)levofloxacin and quinine both increase QTc interval. pharmacodynamic antagonism. Other (see comment). Avoid or Use Alternate Drug. Quinolone antibiotic administration may result in hyper- or hypoglycemia. Other (see comment). Monitor Closely (1)sodium sulfate/potassium sulfate/magnesium sulfate decreases levels of levofloxacin by inhibition of GI absorption. hydroxychloroquine sulfate and levofloxacin both increase QTc interval. gadobenate and levofloxacin both increase QTc interval. Panobinostat prescribing information states use with drugs known to prolong QTc is not recommended. Separate by 2 hours. Comment: Risk of CNS stimulation/seizure. Consult your doctor before breast-feeding. Mechanism: Displacement of GABA from receptors in brain. Npoje s vysokm obsahom antioxidantov, ako s vitamny C a E, preukzatene zlepuj erektiln funkciu tm, e brnia pokodeniu buniek, produkujcich oxid dusnat," hovor Pearlmanov. Monitor Closely (1)levofloxacin and moxifloxacin both increase QTc interval. Applies only to oral form of both agents. Serious - Use Alternative (1)adagrasib, levofloxacin. Comment: Risk of CNS stimulation/seizure. foscarnet and levofloxacin both increase QTc interval. Monitor Closely (1)droperidol and levofloxacin both increase QTc interval. These CBD candies offer a simple and flexible . Use Caution/Monitor. Minor/Significance Unknown. Use Caution/Monitor. levofloxacin, diclofenac. Use Caution/Monitor. Increases risk of torsades de pointes. At the maximum recommended dose, deutetrabenazine does not prolong QT interval to a clinically relevant extent. Avoid or Use Alternate Drug. Monitor Closely (1)levofloxacin, naproxen. Risk of tonic clonic seizure. levofloxacin, foscarnet. Exercise extreme caution when vilanterol coadministered with drugs that prolong QTc interval; adrenergic agonist effects on the cardiovascular system may be potentiated. Use Caution/Monitor. levofloxacin, tretinoin topical. Avoid or Use Alternate Drug. Administer oral quinolone antibiotics at least 1 hr before or 4 hr after lanthanum. amoxapine and levofloxacin both increase QTc interval. Applies only to oral forms of hormone. levofloxacin increases levels of chlordiazepoxide by decreasing metabolism. Minor/Significance Unknown. Avoid or Use Alternate Drug. Serious - Use Alternative (1)ivosidenib and levofloxacin both increase QTc interval. Serious - Use Alternative (1)levofloxacin, cholera vaccine. Applies only to oral form of both agents. Applies only to oral forms of hormone. prednisone and levofloxacin both increase Other (see comment). Applies only to oral form of both agents. levofloxacin will increase the level or effect of digoxin by altering intestinal flora. Gatifloxacin is most likely to produce dysglycemia; moxifloxacin is least likely. Other (see comment). Applies only to oral form of both agents. Use Caution/Monitor. Other (see comment). Comment: Risk of CNS stimulation/seizure. There are also case reports of quinolones increasing phenytoin levels. Monitor Closely (1)levofloxacin will decrease the level or effect of ethinylestradiol by altering intestinal flora. Monitor Closely (1)ezogabine, levofloxacin. Avoid or Use Alternate Drug. Serious - Use Alternative (1)levofloxacin, tretinoin topical. Use Caution/Monitor. crofelemer increases levels of levofloxacin by Other (see comment). Use Caution/Monitor. and formulary information changes. Talk to your doctor about using levofloxacin safely.Levofloxacin may rarely cause serious changes in blood sugar, especially if you have diabetes. levofloxacin and procainamide both increase QTc interval. Monitor Closely (1)ozanimod and levofloxacin both increase QTc interval. levofloxacin will decrease the level or effect of balsalazide by altering intestinal flora. Serious - Use Alternative (1)levofloxacin decreases effects of microbiota oral by pharmacodynamic antagonism. droperidol and levofloxacin both increase QTc interval. Minor/Significance Unknown. Monitor Closely (1)fluconazole and levofloxacin both increase QTc interval. Other (see comment). Use Caution/Monitor. Monitor Closely (1)levofloxacin and paliperidone both increase QTc interval. Gatifloxacin is most likely to produce dysglycemia; moxifloxacin is least likely. Use Caution/Monitor. Patients treated with selinexor may experience neurological toxicities. Avoid coadministration of QTc prolonging drugs with ivosidenib or replace with alternate therapies. Low risk of contraceptive failure. Modify Therapy/Monitor Closely. Monitor Closely (1)erythromycin ethylsuccinate and levofloxacin both increase QTc interval. levofloxacin will decrease the level or effect of estrogens conjugated synthetic by altering intestinal flora. Use Caution/Monitor. Mechanism: Displacement of GABA from receptors in brain. Uses. Modify Therapy/Monitor Closely. Coadministration of quinolone antibiotics and corticosteroids may increase risk of tendon rupture. Mechanism: Displacement of GABA from receptors in brain. Modify Therapy/Monitor Closely. Use Caution/Monitor. Applies only to oral form of both agents. Use Caution/Monitor. Other (see comment). Serious - Use Alternative (1)saquinavir increases levels of levofloxacin by QTc interval. levofloxacin will decrease the level or effect of dienogest/estradiol valerate by altering intestinal flora. Minor/Significance Unknown. Tell your health care professional that you are using levofloxacin before having any immunizations/vaccinations.Before having surgery, tell your doctor or dentist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products).Children may be at greater risk for joint/tendon problems while using this drug. Modify Therapy/Monitor Closely. Avoid or Use Alternate Drug. Serious - Use Alternative (1)buprenorphine, long-acting injection and levofloxacin both increase QTc interval. Separate by 2 hours. Some examples include: quinapril, sucralfate, vitamins/minerals (including iron, zinc), and products that contain magnesium, aluminum, or calcium (such as antacids, didanosine solution, calcium-enriched juice). Other (see comment). levofloxacin and methadone both increase QTc interval. Symptoms of overdose may include: severe dizziness. Monitor Closely (1)levofloxacin decreases effects of ethotoin by unknown mechanism. 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