Another study, this one in 2009, considered Lamictal as a treatment for binge-eating disorder. An interactive voice response system (IVRS) was used to assess quality of life and patient satisfaction with lamotrigine. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines. Several classes of medications have demonstrated efficacy in treating symptoms of bipolar disorder, including lithium, anticonvulsants, antipsychotics, and antidepressants. These episodes can include manic, depressive, and mixed episodes. Of the 1175 patients who received at least 1 dose of study medication, 1139 provided at least 1 clinical assessment during treatment. This medicine is available only with your doctor's prescription. Its available as the generic drug lamotrigine. Some examples of CNS depressants are antihistamines or medicine for allergies or colds, sedatives, tranquilizers, or sleeping medicine, prescription pain medicine or narcotics, medicine for seizures or barbiturates, muscle relaxants, or anesthetics, including some dental anesthetics. 1 People taking Effexor (venlafaxine) may experience a quick loss of a small amount of weight, 2 and in a 10-year-long study, Effexor was associated with below-average weight gain. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. Lamotrigine may be taken with or without food or on a full or empty stomach. the contents by NLM or the National Institutes of Health. Copyright: Merative US L.P. 1973, 2023. If you are taking the chewable dispersible tablets or tablets for suspension, they may be swallowed whole, chewed, and swallowed, or dispersed in a small amount of liquid and swallowed. (XR stands for extended release.) The drug is for use in adults, as well as children ages 16 years and older. Stable weight during lamotrigine therapy: a review of 32 studies. Commonly prescribed dosages are mentioned below, but be sure to always take the dosage your medical professional recommends. Medical hazards of obesity. The https:// ensures that you are connecting to the Ask your healthcare professional how you should dispose of any medicine you do not use. Disclosure: Thomas Thompson, MD, has disclosed that he is an employee of GlaxoSmithKline. Each persons experience of bipolar disorder is unique. After this, your doctor may gradually increase your dose as needed. Make sure you tell your doctor if you have any other medical problems, especially: Take this medicine only as directed by your doctor to help your condition as much as possible and to decrease the chance of unwanted effects. Rare but life threatening skin rashes have been reported in people taking Lamictal. For non-prescription products, read the label or package ingredients carefully. Safety data on weight and BMI were summarized for all patients who received at least 1 dose of study medication (ie, the safety population). The effects may be increased because of the slower removal of the medicine from the body. You may also experience swelling under your skin, often in your lips, eyelids, hands, or feet. [16] The purpose of this post hoc analysis of data from that trial was to examine patients with bipolar disorder in a naturalistic setting receiving lamotrigine as monotherapy or adjunctive therapy with or without concomitant valproate, lithium, antipsychotics, or antidepressants. Its important to follow the instructions they provide. It may also be used to help prevent the extreme mood swings of bipolar disorder in adults.Lamotrigine is known . Additionally, patients taking and not taking concomitant valproate, lithium, antipsychotics, or antidepressants experienced statistically significant improvement from baseline in their mean CGI-BP scores over 12 weeks of open-label lamotrigine treatment, with no statistically significant differences between groups. They may suggest a treatment for this side effect. If you have concerns about hair loss during your Lamictal treatment, you can talk with your medical professional. You should not start or stop using birth control pills or other female hormonal products while you are using this medicine until you have consulted your doctor. Can stopping Lamictal treatment cause withdrawal? Help is available right now: Not in the U.S.? Medical complications of obesity. Spearing MK, Post RM, Leverich GS, Brandt D, Nolen W. Modification of the Clinical Global Impressions (CGI) scale for use in bipolar illness (BP): the CGI-BP. However, the dose is usually not more than 400 mg a day. Those taking the placebo, meanwhile, lost around seven pounds, so while those taking Lamictal lost more weight, they didn't lose all that much more. Note: Certain factors may affect a medications side effects. In general, you should avoid or limit the use of alcohol while being treated with buPROPion. Lamotrigine is used alone or with other medications to prevent and control seizures. doi:10.1097/YIC.0b013e328329c7b5, Prabhavalkar KS, Poovanpallil NB, Bhatt LK. Print John Fedele/Blend Images/Getty Images If you're concerned that taking the medication Lamictal (lamotrigine) may cause you to gain weight, there's good news. After the tablet has melted, swallow or take a sip of water. Devinsky O, Vuong A, Hammer A, Barrett PS. It may also be helpful to refer to the medication guide for Lamictal. Weight loss was slightly more common than weight gain, but both side effects were rare. 2015;6:242. doi:10.3389/fphar.2015.00242. The mean weight at baseline was significantly higher for patients taking valproate than for those not taking valproate (difference, 14.2 47.77 lb; P < .0001) and in patients taking antipsychotics vs patients not taking antipsychotics (difference, 6.6 48.04 lb; P < .05). Quality-of-life scores improved significantly more in patients not receiving than in those receiving concomitant antipsychotics. (2021). Angel A, Roncari DA. For example, Lamictal typically doesnt give you energy. Portions of this document last updated: May 01, 2023, Original article: https://www.mayoclinic.org/drugs-supplements/lamotrigine-oral-route/side-effects/DRG-20067449. Inside Bipolar Podcast: What Is Rapid Cycling? To learn more, see Boxed warning: Serious skin rashes above. section above. Rare but life threatening skin rashes have been reported in people taking Lamictal. [17] Those currently being treated for bipolar disorder were eligible if they were being treated with a stable regimen of psychotropic medications that did not include lamotrigine and had been initiated at least 2 months before study entry. You may also have problems coordinating body movements. Children not taking valproic acid (Depakote), carbamazepine (Tegretol), phenobarbital (Luminal), phenytoin (Dilantin), or primidone (Mysoline) At first, 0.3 mg/kg of body weight of lamotrigine given in one dose or two smaller doses each day for 2 weeks, then 0.6 mg/kg of body weight divided into 2 smaller doses each day for 2 weeks. Weight considerations in psychotropic drug prescribing and switching. Still looking for answers? Accessibility How Lamictal works isnt fully understood. In a small clinical trial involving 40 people conducted in 2006, researchers randomly assigned the participants to receive either Lamictal or a placebo for up to 26 weeks. Like Lamictal, antipsychotics such as aripiprazole (Abilify) and other mood stabilizers may be used to treat bipolar disorder. Data were not available about the patients' symptoms and quality of life before treatment with their concomitant medications or about the duration of treatment with these medications. You can also discuss other treatments, forms of support, and resources that may benefit you. Practice guideline for the treatment of patients with bipolar disorder (revision). This is to lower your risk of a serious skin rash* from Lamictal. Randomized, placebo-controlled trial of olanzapine as maintenance therapy in patients with bipolar I disorder responding to acute treatment with olanzapine. By Marcia Purse Using buPROPion with alcohol may increase the risk of uncommon side effects such as seizures, hallucinations, delusions, paranoia, mood and behavioral changes, depression, suicidal thoughts, anxiety, and panic attacks. Finally, many patients were taking multiple concomitant medications, some of which may have affected weight or clinical response. Symptoms of depression include: Depressed mood - feeling sad, empty, or tearful As an. [46] However, patients who experience persistent subthreshold symptoms or breakthrough mood episodes may benefit from the addition to maintenance therapy of another mood-stabilizing agent, an atypical antipsychotic, or an antidepressant. It's also used as a mood stabilizer in bipolar disorder. Major depression is a common and treatable disease. Its important that you dont take more Lamictal than your medical professional recommends. Anorexia Nervosa Recovery: Meal Plans to Restore Nutritional Health, Hair Loss as a Bipolar Medication Side Effect, Medications Used to Treat Eating Disorders, What to Do If You Gain Weight While Taking Antidepressants, Eating Disorders and Hypothalamic Amenorrhea, Atypical Anorexia Nervosa: Causes, Symptom, and Treatment. If you take Lamictal and dont have bipolar I disorder or certain kinds of epilepsy or seizures, youre still at risk of side effects from the drug. The anticonvulsant lamotrigine was approved by the US Food and Drug Administration in 2003 for the maintenance treatment of bipolar I disorder in adults and is currently the only medication approved to delay the time to occurrence of depressive as well as manic, hypomanic, and mixed episodes in patients with bipolar I disorder. Lamictal can interact with several types of drugs, including: We havent listed all the types of drugs that may interact with Lamictal. The percentage of patients satisfied with their medication was summarized for the total subject sample and for each group of subjects. Its not advised to take Lamictal unless your medical professional has prescribed the drug for you. Its possible that people who have a gene called HLA*1502 have an increased risk of developing a serious rash while taking Lamictal. Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum. To view an interaction report containing 4 (or more) medications, please sign in or create an account. Management of bipolar depression with lamotrigine: an antiepileptic mood stabilizer. All participants in the study were to receive lamotrigine for 12 weeks, including a 5-week initiation/titration period and a 7-week continuation phase. Bipolar disorder is a chronic and disabling condition that affects nearly 4% of American adults at some point during their lives. I still feel depressed though. Weve listed some helpful suggestions below. Information is for End User's use only and may not be sold, redistributed or otherwise used for commercial purposes. The demographic composition of the study sample (for example, 90% were white) may limit generalizability to patients of other ethnicities. Lamictal is available in the following forms and strengths: * A suspension is a liquid with particles in it. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. Wait until the tablets are completely dispersed (about 1 minute), then swirl the solution and swallow it immediately. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine. Children younger than 13 years of ageUse and dose must be determined by your doctor. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding. Stopping this medicine suddenly may cause your seizures to return or to occur more often. Finally, some antidepressantsspecifically, Paxil(paroxetine) and Remeron(mirtazapine)are associated with weight gain.. Weight change associated with antiepileptic drugs. Mayo Clinic is a nonprofit organization and proceeds from Web advertising help support our mission. Pediatric Appropriate studies performed to date have not demonstrated pediatric-specific problems that would limit the usefulness of lamotrigine chewable tablets, disintegrating tablets, tablets for suspension, or tablets in children with certain types of seizures 2 years of age and older. Heart problems. Disclosure: Michael N. ZarZar, MD, has disclosed that he serves on the speaker's bureau for, and has received research funding from GlaxoSmithKline. Adults not taking valproic acid (Depakote) but taking carbamazepine (Tegretol), phenobarbital (Luminal), phenytoin (Dilantin), or primidone (Mysoline)At first, 50 milligrams (mg) of lamotrigine once a day for 2 weeks, then a total of 100 mg divided into 2 smaller doses each day for 2 weeks. On average, patients in the ITT population were mildly to moderately ill at baseline, with a mean CGI-BP overall severity score of 3.4 1.32, and were minimally to mildly ill after 12 weeks of open-label treatment with lamotrigine, with a mean score of 2.4 1.22 (P < .0001 for change from baseline). If you have other questions about how Lamictal compares with lithium, we suggest that you talk with your medical professional. The clinical relevance of these findings is not known. Evaluations at baseline and week 12 included the severity component of the Clinical Global Impression-Bipolar Version scale, the Quality of Life Enjoyment and Satisfaction Questionnaire Short Form, and weight and body mass index (BMI). These effects are known as interactions. You can ask your medical professional to explain anything that you find unclear. An official website of the United States government. Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. I slept so good felt great all day in my combo. Eight hundred sixty-seven patients (74%) completed the study (Table 1). 282 drugs Check with your doctor right away if you or your child start to have a stiff neck, confusion, drowsiness, fever, chills, headache, nausea, vomiting, rash, or sensitivity to light. Antiseizure medications . Lamictal is used to treat epilepsy in adults as well as some children who have: For this purpose, the table below details Lamictal dosages for adults, as well as children ages 12 years and older. After this, your doctor may gradually increase your dose as needed. In the ITT sample, the Q-LES-Q mean score as a percentage of the maximum possible score increased from 50.6 18.30 at baseline to 60.9 19.48 after 12 weeks of lamotrigine treatment, with a mean increase of 10.1 20.07 points (P < .0001). For this purpose, the Lamictal dosage youll likely take when first starting the treatment depends on the epilepsy drug you previously took. FOIA Silverstone T. Moclobemide vs. imipramine in bipolar depression: a multicentre double-blind clinical trial. Question posted by Smj2299 on 17 March 2018. Always consult your healthcare provider. Liver diseaseUse with caution. Kessler RC, Berglund P, Demler O, Jin R, Merikangas KR, Walters EE. Its thought that Lamictal works by stabilizing levels of certain compounds called amino acids. There were no changes in weight or BMI after lamotrigine monotherapy or adjuvant therapy. The boxed warning appears on the drugs label and alerts you to possible serious risks. These side effects can include a rash and drowsiness. Rarer side effects that could affect how you feel include memory problems and suicidal thoughts or behaviors. "Mayo," "Mayo Clinic," "MayoClinic.org," "Mayo Clinic Healthy Living," and the triple-shield Mayo Clinic logo are trademarks of Mayo Foundation for Medical Education and Research. Drug-Related Adverse Events (% of Patients) Occurring in 5% or More of Any Group. buPROPion food Applies to: Wellbutrin (bupropion) Using buPROPion with alcohol may increase the risk of uncommon side effects such as seizures, hallucinations, delusions, paranoia, mood and behavioral changes, depression, suicidal thoughts, anxiety, and panic attacks. The maximum dosage of Lamictal is 500 mg per day, in divided doses. It can also be used in the treatment of bipolar disorder (manic-depressive illness) in adults. Check with your doctor immediately if you or your child develop a rash, fever, flu-like symptoms, or swollen glands, or if your seizures becomes worse. (2020). These could be symptoms of a life threatening side effect: If you have a serious skin reaction while taking Lamictal, theyll typically have you stop taking the drug and suggest other treatments for your condition. Lamotrigine may cause serious allergic reactions affecting multiple body organs (eg, liver or kidney). The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive. Demographics, Concomitant Psychiatric Medication Use, and Patient Disposition (Safety Population). 2006;163(7):11991201. Safety and efficacy have not been established. This medicine can be used with other seizure medicines. The recommended dosage of Lamictal for this use is 250 mg twice per day. Federal government websites often end in .gov or .mil. For this purpose, Lamictal is prescribed while youre still taking another epilepsy drug but plan to stop the treatment with the other drug. All rights reserved. If you feel as if youre having a medical emergency, its vital to call 911 or your local emergency number right away. Lamictal is a brand-name drug. Be sure to follow your medical professionals instructions. Weight stayed level, and I had a sex drive again. These side effects may go away during treatment as your body adjusts to the medicine. Weight change associated with valproate and lamotrigine monotherapy in patients with epilepsy. Carvalho AF, et al. A guide to drug safety terms at FDA. Those taking Lamictal lost, on average, a little more than 10 pounds. If you drink alcohol, its recommended that you talk with your medical professional before you start taking Lamictal. Do not push the tablet through the foil. Patient satisfaction with medication may affect adherence to the treatment regimen, which is critical for preventing relapse in patients with bipolar disorder. These can include: Whether youre looking for a therapist, support group, or information about how to afford therapy, these resources may help: To receive weekly information about mental health, you may want to sign up for the Psych Central newsletter. The mean doses of lamotrigine SD for completers at week 12 were: 101.1 30.43 for the 179 patients receiving valproate; 191.4 57.51 for the 686 patients who were not taking concomitant valproate; 304.3 108.7 for the 41 patients receiving carbamazepine, phenytoin, primidone, or phenobarbital; 184.1 43.93 for the 646 patients not receiving valproate or carbamazepine (or phenytoin, primidone, or phenobarbital); 174.0 59.98 for the 207 receiving lithium; and 165.3 69.73 for the 659 patients not receiving lithium. For this medicine, the following should be considered: Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Lamictal shouldnt be taken to treat a sudden manic or mixed episode. This includes prescription or nonprescription (over-the-counter [OTC]) medicines and herbal or vitamin supplements. This study examined comparative effects of lamotrigine with and without concomitant medications. Zyprexa (olanzapine) tablets [package insert]. 2023 Psych Central, a Healthline Media Company. and transmitted securely. However, in all groups, there were no additional changes in weight at week 12 of open-label lamotrigine treatment, and there were no differences in weight change between groups (lamotrigine monotherapy vs adjunctive lamotrigine: adjusted mean difference, 0.58; 95% CI, 1.97 to 0.78; P = .4031; valproate vs no valproate: adjusted mean difference, 0.12; 95% CI, 1.19 to 1.44; P = .8567; lithium vs no lithium: adjusted mean difference, 0.24; 95% CI, 1.49 to 1.02; P = .7106; antipsychotics vs no antipsychotics: adjusted mean difference, 0.36; 95% CI, 0.80 to 1.52; P = .5450; antidepressants vs no antidepressants: adjusted mean difference, 0.19; 95% CI, 1.35 to 0.97; P = .7487). Are you using food to cope? Is prescribed while youre still taking another epilepsy drug you previously took continuation phase concomitant medications, please sign or. For medical advice, diagnosis or treatment use in adults, as well as ages... To refer to the treatment of bipolar disorder, including: We listed. 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White ) may limit generalizability to patients of other ethnicities: https: //www.mayoclinic.org/drugs-supplements/lamotrigine-oral-route/side-effects/DRG-20067449 problems suicidal! By your doctor 's prescription affects nearly 4 % of American adults at some point during their.! The medicines tablets are completely dispersed ( about 1 minute ), then swirl the solution and swallow immediately. Demonstrated efficacy in treating symptoms of depression include: Depressed mood - feeling sad empty... While youre still taking another epilepsy drug you previously took your body to! Treatment with olanzapine tablets are completely dispersed ( about 1 minute ), then swirl the and! Has melted, swallow or take a sip of water in 2009 considered! Include memory problems and suicidal thoughts or behaviors suggest a treatment for disorder... Continuation phase of subjects this medication while breastfeeding period and a 7-week phase... Gene called HLA * 1502 have an increased risk of developing a serious skin rash * from.... The tablet has melted, swallow or take a sip of water no in!: serious skin rashes have been reported in people taking Lamictal lost, on average, little... Of Health recommended dosage of Lamictal is 500 mg per day of water antipsychotics such as aripiprazole ( Abilify and!: //www.mayoclinic.org/drugs-supplements/lamotrigine-oral-route/side-effects/DRG-20067449 melted, swallow or take a sip of water used in the treatment bipolar... Continuation phase a little more than 400 mg a day or the National Institutes of Health taken treat... Potential significance and are not necessarily all-inclusive youre still taking another epilepsy drug but plan to stop treatment. And dose must be determined by your doctor may gradually increase your as. Placebo-Controlled trial of olanzapine as maintenance therapy in patients with bipolar I disorder to.