Heart disease and stroke:Studies indicate an increased risk of heart disease and stroke with estrogen (with or without progestins) for postmenopausal women. Do not start, stop, or change the dosage of any medicines without your doctor's approval. www.medbroadcast.com/drug/getdrug/Premarin-Vaginal-Cream, are allergic to conjugated estrogen or any ingredients of the medication, have a history of known or suspected estrogen-dependent tumours such as breast or uterine cancer, have abnormal liver test results caused by liver disease or liver problems, have undiagnosed abnormal vaginal bleeding, have active thrombophlebitis, thrombosis, or thromboembolic disorders (blood clotting problems), have or have had stroke, heart attack, or coronary heart disease, have certain hereditary blood clotting disorders (e.g., protein C, protein S, or antithrombin deficiency), have had partial or complete loss of vision due to blood vessel-related eye disease, high blood pressure (e.g., headaches, dizziness, vision problems, shortness of breath), signs of a blood clot in the arm or leg (tenderness, pain, swelling, warmth, or redness in the arm or leg) or lungs (difficulty breathing, sharp chest pain that is worse when breathing in, coughing, coughing up blood, sweating, or passing out), signs of depression (e.g., poor concentration, changes in weight, changes in sleep, decreased interest in activities, thoughts of suicide), signs of liver problems (e.g., nausea, vomiting, diarrhea, loss of appetite, weight loss, yellowing of the skin or whites of the eyes, dark urine, pale stools), symptoms of high blood sugar (e.g., frequent urination, increased thirst, excessive eating, unexplained weight loss, poor wound healing, infections, fruity breath odour), symptoms of gallbladder problems (e.g., severe, dull pain in the upper right part of the abdomen that comes and goes, nausea; vomiting; intolerance of fatty or greasy foods), thick, white vaginal discharge without odour or with a mild odour, unusual or unexpected uterine bleeding or spotting, severe leg pain or numbness affecting any part of the body, signs of a heart attack (e.g., chest pain or pressure, pain extending through shoulder and arm, nausea and vomiting, sweating), signs of a serious allergic reaction (e.g., abdominal cramps, difficulty breathing, nausea and vomiting, or swelling of the face and throat), signs of stroke (e.g., sudden or severe headache; sudden loss of coordination; vision changes; sudden slurring of speech; or unexplained weakness, numbness, or pain in arm or leg), worsening asthma symptoms (e.g., wheezing, coughing, shortness of breath, difficulty breathing). This is a decision you and your doctor will make. If your dose is different, do not change it unless your doctor tells you to do so. Estrogen should not be used to prevent heart disease, stroke, or dementia, because this medicine may actually increase your risk of developing these conditions. 2014;123:202. Do not use this medicine in larger or smaller amounts or for longer than recommended. What treatment options are available? Estrogen is necessary for many processes in the body. If you notice these effects, contact your doctor. Menopause is as unpleasant as can be, but there isnt a single woman around 50 who is going to avoid it as long as shes still breathing. Premarin Vaginal Cream is a female sex hormone (estrogen). How can I best manage these conditions together? New York, N.Y.: McGraw-Hill Education; 2018. https://accessmedicine.mhmedical.com. Premarin tablets contain conjugated estrogens, a mixture of estrogen hormones. It may also provide better direct relief of symptoms than oral estrogen does. All rights reserved. It may reduce the quality and amount of breast milk produced. Children:The safety and effectiveness of this medication have not been established for children. Conjugated estrogens vaginal cream is used to treat changes in and around the vagina (such as vaginal dryness, itching, and burning) caused by low estrogen levels or menopause. The dose of this medication is individualized to the person using the cream. If you miss a dose of this medicine, take it as soon as possible. Questions your doctor may ask include: Mayo Clinic does not endorse companies or products. When you refer them, Free shipping for life? Genitourinary syndrome of menopause (adult). Premarin brand vaginal cream product is usually applied according to a rotating schedule that alternates several weeks when the cream is applied every day with one week when the cream is not applied. 141: Management of Menopausal Symptoms. Maturitas. Before you begin using a medication, be sure to inform your doctor of any medical conditions or allergies you may have, any medications you are taking, whether you are pregnant or breast-feeding, and any other significant facts about your health. Consult your pharmacist if you are unsure if your product contains mineral oil. Last updated on Feb 21, 2022. 2023 Medicine.com All rights reserved. If possible, this medication should be stopped 4 to 6 weeks before major surgery. Find PREMARIN VAGINAL CREAM medical information: Search What medications, vitamins or other supplements do you take? Thats everything youll need to know for how to apply Premarin cream externally to treat vaginal dryness and dyspareunia. Symptoms of overdose may include: severe nausea/vomiting, unusual vaginal bleeding. Keep from freezing. Estrogen is a hormone that is produced by the ovaries. Tell your doctor or prescriber about all prescription, over-the-counter (non-prescription), and herbal medications you are taking. Premarin Vaginal Cream contains a mixture of conjugated estrogens, which are a mixture of sodium estrone sulfate and sodium equilin sulfate and other components, including sodium sulfate conjugates: 17 -dihydroequilin, 17 -estradiol, and 17 -dihydroequilin. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment. Available as a prescription ointment or gel, topical lidocaine can be used to lessen discomfort associated with sexual activity. A high-fat meal might keep it from absorbing as quickly. However for some women it also involves a lot of dryness and discomfort down there. Premarin cream provides relief, and that leads to the question of how to apply Premarin cream externally. Vardenafil (Levitra, Staxyn). This is done to check the uterus, ovaries and other organs. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. DHEA is a hormone that helps the body produce other hormones, including estrogen. You'll probably start by discussing your symptoms with your primary care provider. Therefore, they may not be effective in preventing pregnancy for women who use the cream. Seizures:Estrogens may cause an increase in seizures. Symptoms of ED include. of 1.06 oz (30 g) tube with plastic applicator(s) calibrated in 0.5 g increments to a maximum of 2 g (NDC 0046-0872-21). Estrogen may also be prescribed as a cream, vaginal ring, gel or spray. Sexually stimulating yourself promotes vaginal blood flow and more secretions, which will work out to you having less dryness. Do you douche or use feminine hygiene spray? This dose should be periodically reassessed by the healthcare provider. This document does not contain all possible drug interactions. Patients should be treated with the lowest effective dose. Talk with your doctor or pharmacist about which dosing schedule would work best for you if you are taking a progestin. Medicines are sometimes prescribed for conditions that are not mentioned in patient information leaflets. This medicine is available only with your doctor's prescription. Using this medicine may increase your risk for having blood clots, strokes, or heart attacks. The lowest dose that will treat the symptoms should be used. If you have risk factors for diabetes, your doctor will monitor your blood glucose regularly while taking this medication. Using Premarin Vaginal can increase your risk of blood clots, stroke, or heart attack. Do not use more of it, do not use it more often, and do not use it for a longer time than your doctor ordered. Premarin Vaginal Cream is a medicine that contains a mixture of estrogen hormones. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines. Key takeaways: Some of the common symptoms of menopause include vaginal dryness or irritation and painful sex. Bachman G, et al. Get medical help right away if you have any serious side effects, including: chest/jaw/left arm pain, unusual sweating, sudden/severe headache, weakness on one side of the body, confusion, trouble speaking, sudden vision changes (such as partial/complete blindness), pain/redness/swelling of legs, tingling/weakness/numbness in the arms/legs, trouble breathing, coughing up blood, sudden dizziness/fainting. Canada residents can call a provincial poison control center. Premarin Vaginal Cream can weaken the latex of a condom, diaphragm, or cervical cap. For treatment of atrophic vaginitis and kraurosis vulvae: AdultsAt first, use 0.5 gram (g) into the vagina once a day. If someone has overdosed and has serious symptoms such as passing out or trouble breathing, call 911. Conjugated estrogens vaginal cream belongs to the class of medications known asestrogen replacement therapy. Local oestrogen for vaginal atrophy in postmenopausal women. This medication should be used at the lowest effective dose and for the shortest amount of time. Contact your doctor immediately if you experience confusion, difficulty speaking, double vision, headaches, an inability to move arms, legs or facial muscle, or an inability to speak. Blood clotting disorders:Estrogen with or without progestins is associated with an increased risk of blood clots in the lungs and legs. Sunlight may worsen this effect. Premarin was first marketed in the US in 1942. Taken daily, this pill can help relieve painful sex symptoms in women with moderate to severe GSM. heart attack symptoms - chest pain or pressure, pain spreading to your jaw or shoulder, nausea, sweating; signs of a stroke - sudden numbness or weakness (especially on one side of the body), sudden severe headache, slurred speech, problems with vision or balance; signs of a blood clot - sudden vision loss, stabbing chest pain, feeling short of breath, coughing up blood, pain or warmth in one or both legs; jaundice (yellowing of the skin or eyes); memory problems, confusion, unusual behavior; high levels of calcium in your blood - nausea, vomiting, constipation, increased thirst or urination, muscle weakness, bone pain, lack of energy. Unscrew the applicator from the tube, and lie on the back with knees drawn up, and gently insert the applicator deeply into the vagina and press plunger downward to its original position. Avoid tanning booths and sunlamps. Call or email for assistance, Toll Free: 1-800-891-0844 Advertising revenue supports our not-for-profit mission. Menopause and post-menopause. Menopause can cause a variety of symptoms that vary in severity from one woman to the next, Doctors generally divide menopause into three stages: perimenopause, menopause and postmenopause, Apply for early access to the new Medicine.com Pharmacy. Mayo Clinic is a nonprofit organization and proceeds from Web advertising help support our mission. Talk to your doctor about the best birth control methods to use. Do not double the dose to catch up. Risk factors for dyspareunia after first childbirth. Premarin Vaginal Cream is used in the vagina to treat the vaginal symptoms of menopause such as dryness, burning, irritation, and painful sexual intercourse. There may be other factors, and while lower hormone levels are unavoidable you can order medication online from Canada if menopause medication is something youd struggle to afford. Overdose symptoms may include drowsiness, vomiting, stomach pain, breast pain, or vaginal bleeding. Estrogen is necessary for many processes in the body. This risk may continue even after you stop using the medicine. Follow your doctor's orders or the directions on the label. Note the following important information about estrogen replacement therapy:The Women's Health Initiative (WHI) study results indicated an increased risk of heart attack, stroke, breast cancer, blood clots in the lungs, and blood clots in the leg veins in postmenopausal women during 5 years of treatment with 0.625mg conjugated equine estrogens and 2.5mg medroxyprogesterone compared to women receiving sugar tablets. Pregnancy:Estrogen should not be used during pregnancy. Do not dispose of medications in wastewater (e.g. being able to get an erection, but not having it last long enough for sex. How does this medication work? Vaginal estrogen suppositories . If you experience symptoms of a heart attack (chest pain, tightness or pressure, sweating, nausea, feeling of impending doom) or stroke (sudden dizziness, headache, loss of speech, changes in vision, weakness or numbness in the arms and legs) while taking this medication, get immediate medical attention. Do not use Premarin Vaginal Cream for conditions for which it was not prescribed. This menopause treatment medication is super effective for addressing the symptom of dryness and irritation. Make sure laboratory personnel and all your doctors know you use this drug. Tell your doctor if your condition does not improve or if it worsens. Before using this medication, tell your doctor or pharmacist your medical history, especially of: vaginal bleeding of unknown cause, certain cancers (such as breast cancer, cancer of the uterus/ovaries), blood clots, stroke, heart disease (such as heart attack), liver disease, kidney disease, family medical history (especially breast lumps, cancer, blood clots), family or personal history of a certain swelling disorder (angioedema), blood clotting disorders (such as protein C or protein S deficiency), high blood pressure, diabetes, high cholesterol/triglyceride levels, obesity, lupus, underactive thyroid (hypothyroidism), mineral imbalance (low or high level of calcium in the blood), a certain hormone problem (hypoparathyroidism), uterus problems (such as fibroids, endometriosis), gallbladder disease, asthma, seizures, migraine headaches, mental/mood disorders (such as dementia, depression), certain blood disorder (porphyria). Taking a progestin as directed by your doctor can help decrease this risk. Once menopause is reached, the ovaries produce less estrogen and symptoms of menopause can occur. If it is almost time for your next dose, skip the missed dose and carry on with your regular dosing schedule. estrogen with or without progestins should not be used to prevent heart disease, heart attacks, or strokes. The dosage is based on your medical condition and response to treatment. If you have any questions, ask your doctor or pharmacist. If vaginal dryness is associated with other symptoms of menopause, such as moderate or severe hot flashes, your doctor may suggest estrogen pills, patches or gel, or a higher dose estrogen ring. For treatment of atrophic vaginitis and kraurosis vulvae: AdultsAt first, use 0.5 gram ( g ) into vagina... Cream externally severe nausea/vomiting, unusual vaginal bleeding a nonprofit organization and proceeds Web! 4 to 6 weeks before major surgery and carry on with your 's. 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