DESCRIPTION Glyburide tablets contain micronized (smaller particle size) glyburide, which is an oral blood-glucose-lowering drug of the sulfonylurea class. Use Caution/Monitor. nabumetone increases effects of glyburide by unknown mechanism. Risk of hypoglycemia. glyburide will increase the level or effect of finerenone by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor. Use Caution/Monitor. Minor/Significance Unknown. Use Caution/Monitor. Lower nightly dose of lemborexant recommended if coadministered with weak CYP3A4 inhibitors. glyburide increases toxicity of cholic acid by decreasing elimination. Monitor Closely (1)liraglutide, glyburide. Thiazide dosage >50 mg/day may increase blood glucose. Other (see comment). glyburide increases toxicity of atorvastatin by Other (see comment). Use Caution/Monitor. Monitor Closely (1)glyburide, dapagliflozin. Serious - Use Alternative (1)trofinetide will increase the level or effect of glyburide by Other (see comment). Consider lowering dose of sulfonylureas to reduce risk of hypoglycemia. glyburide decreases levels of coenzyme Q10 by unspecified interaction mechanism. Minor/Significance Unknown. Use Caution/Monitor. Risk of hypoglycemia. Glyburide is a diabetes medicine used to help control blood sugar levels and treat type 2 diabetes. Monitor Closely (1)rucaparib will increase the level or effect of glyburide by affecting hepatic enzyme CYP2C9/10 metabolism. lonapegsomatropin decreases effects of glyburide by Other (see comment). Your doctor may substitute insulin for this drug during pregnancy. L-arginine is found in red meat, poultry, fish, and dairy products. Monitor Closely (1)oxaprozin increases effects of glyburide by unknown mechanism. vanadium increases effects of glyburide by pharmacodynamic synergism. Strong CYP2C9 inhibitors may decrease glyburide metabolism. Comment: Reports of hyperglycemia due to insulin resistance with protease inhibitors. Risk of hypoglycemia. Minor/Significance Unknown. Monitor Closely (1)bexarotene increases effects of glyburide by pharmacodynamic synergism. Contraindicated (2)bosentan, glyburide. Modify Therapy/Monitor Closely. Either increases effects of the other by pharmacodynamic synergism. Use Caution/Monitor. Use Caution/Monitor. testosterone buccal system increases effects of glyburide by pharmacodynamic synergism. Use Caution/Monitor. apalutamide will decrease the level or effect of glyburide by affecting hepatic enzyme CYP2C9/10 metabolism. Use Caution/Monitor. ramipril increases effects of glyburide by pharmacodynamic synergism. phenelzine increases effects of glyburide by unknown mechanism. Comment: Reports of hyperglycemia due to insulin resistance with protease inhibitors. Risk of hypoglycemia. bexarotene increases effects of glyburide by pharmacodynamic synergism. Either increases effects of the other by pharmacodynamic synergism. capecitabine increases levels of glyburide by affecting hepatic enzyme CYP2C9/10 metabolism. Monitor Closely (1)glyburide, insulin lispro protamine/insulin lispro. Consider a lower dose of insulin or insulin secretagogue to avoid hypoglycemia when coadministered with SGLT2 inhibitors. Properly discard this product when it is expired or no longer needed. pegvisomant increases effects of glyburide by pharmacodynamic synergism. Use Caution/Monitor. sulindac increases effects of glyburide by unknown mechanism. Comment: Atypical antipsychotics have been associated with hyperglycemia that may alter blood glucose control; monitor glucose levels closely. Use Caution/Monitor. Minor/Significance Unknown. Both drugs lower blood glucose. Use Caution/Monitor. Either increases effects of the other by pharmacodynamic synergism. Monitor Closely (1)lopinavir decreases effects of glyburide by Other (see comment). Available strengths of Cialis (2.5 mg, 5 mg, 10 mg, 20 mg) Cialis tablets come in four strengths: 2.5. Use Caution/Monitor. Monitor Closely (1)fluoxetine increases effects of glyburide by unspecified interaction mechanism. Use Caution/Monitor. Risk of hypoglycemia.piroxicam increases levels of glyburide by affecting hepatic enzyme CYP2C9/10 metabolism. Use Caution/Monitor. The recipient will receive more details and instructions to access this offer. aspirin rectal increases effects of glyburide by unknown mechanism. Mechanism: decreased hypoglycemia induced catecholamine production. Risk of hypoglycemia. About Side effects Interactions Other warnings Dosage Take as directed Important considerations Alternatives Highlights for glyburide Glyburide oral tablet comes as brand-name drugs and as. Use Caution/Monitor. glyburide will increase the level or effect of ruxolitinib by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Consider a lower dose of insulin or insulin secretagogue to avoid hypoglycemia when coadministered with ertugliflozin. Use Caution/Monitor. Minor/Significance Unknown. Methods and findings Tell your doctor right away if you have symptoms of high or low blood sugar. aripiprazole, glyburide. Strong CYP2C9 inducers may increase glyburide metabolism. Strong CYP2C9 inducers may increase glyburide metabolism. Antidiabetic agents are often used in combination; dosage adjustments may be required when initiating or discontinuing antidiabetic agents. desipramine increases effects of glyburide by pharmacodynamic synergism. When a patient stabilized on any diabetic regimen is exposed to stress such as fever, trauma infection, or surgery, it may be necessary to stop this drug and administer insulin. Monitor Closely (1)sulfisoxazole increases levels of glyburide by plasma protein binding competition. glyburide will increase the level or effect of lemborexant by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Monitor Closely (1)fosinopril increases effects of glyburide by pharmacodynamic synergism. Minor/Significance Unknown. Cyclosporine may decrease the effects of sulfonylureas. Use Caution/Monitor. Either increases effects of the other by pharmacodynamic synergism. Use Caution/Monitor. Minor/Significance Unknown. Risk of hypoglycemia. sulfadiazine increases levels of glyburide by plasma protein binding competition. Minor/Significance Unknown. Coadministration of alogliptin with insulin and/or insulin secretagogues (eg, sulfonylureas, meglitinide derivatives) may increase risk for hypoglycemia; may require lower dose of insulin or insulin secretagogue . Modify Therapy/Monitor Closely. Strong CYP2C9 inhibitors may decrease glyburide metabolism. Serious - Use Alternative (1)lumacaftor/ivacaftor will decrease the level or effect of glyburide by affecting hepatic enzyme CYP2C9/10 metabolism. . Monitor Closely (1)saquinavir decreases effects of glyburide by Other (see comment). Use Caution/Monitor. Use Caution/Monitor. Use Caution/Monitor. Minor/Significance Unknown. Glyburide is not for treating type 1 diabetes. informational and educational purposes only. Use Caution/Monitor. Use Caution/Monitor. Antidiabetic agents are often used in combination; dosage adjustments may be required when initiating or discontinuing antidiabetic agents. The normal dosage of Cialis for occasional use in treating ED is 10 mg taken before sexual activity. Use Caution/Monitor. It is a white, crystalline compound, formulated as tablets of 1.25 mg, 2.5 mg, and 5 mg strengths for oral administration. Comment: OATP1B1 inhibitors may increase risk of myopathy. Minor/Significance Unknown. Screen reader support enabled. Hypoglycemia; increased risk in hypoalbuminemia. Use Caution/Monitor. Use Caution/Monitor. Use Caution/Monitor. Minor/Significance Unknown. Comment: Atypical antipsychotics have been associated with hyperglycemia that may alter blood glucose control; monitor glucose levels closely. Use Caution/Monitor. Coadministration of metreleptin with insulin and/or insulin secretagogues (eg, sulfonylureas, meglitinide derivatives) may increase risk for hypoglycemia; may require lower dose of insulin or insulin secretagogue. Use Caution/Monitor. Comment: Decreased symptoms of hypoglycemia. Minor/Significance Unknown. Consult your doctor because this may require a change in your treatment plan, medications, or blood sugar testing.This medication may make you more sensitive to the sun. Minor/Significance Unknown. Non selective beta blockers may also mask the symptoms of hypoglycemia. Always ask your health care professional for complete information about this product and your specific health needs. Minor/Significance Unknown. lixisenatide (DSC), glyburide. encorafenib will increase the level or effect of glyburide by Other (see comment). Use Caution/Monitor. Minor/Significance Unknown. fluoxetine increases effects of glyburide by unspecified interaction mechanism. Use Caution/Monitor. (Theoretical interaction). Avoid or Use Alternate Drug. Effect in glycemic control is likely small. Use Caution/Monitor. Minor/Significance Unknown. Risk of hypoglycemia. Monitor Closely (2)rifampin decreases levels of glyburide by increasing metabolism. Minor/Significance Unknown. aminolevulinic acid oral, glyburide. Comment: Ritonavir may increase or decrease levels of glyburide. Hypoglycemia; increased risk in hypoalbuminemia. Thiazide dosage >50 mg/day may increase blood glucose. Serious - Use Alternative (1)darolutamide will increase the level or effect of glyburide by Other (see comment). Risk of hypoglycemia. cyclopenthiazide decreases effects of glyburide by pharmacodynamic antagonism. 1 Both medications are phosphodiesterase type 5 (PDE5) inhibitors that work by increasing blood flow to the penis. Avoid or Use Alternate Drug. Minor/Significance Unknown. Non selective beta blockers may also mask the symptoms of hypoglycemia. Contraindicated. Minor/Significance Unknown. Minor/Significance Unknown. The above information is provided for general Monitor Closely (1)naproxen increases effects of glyburide by unknown mechanism. What Is Glyburide and How Does It Work? Sparsentan (a CYP2C9 inducer) decreases exposure of CYP2C9 substrates and reduces efficacy related to these substrates. Adding plans allows you to compare formulary status to other drugs in the same class. Coadministration may increase systemic exposure of drugs that are BCRP substrates. Use Caution/Monitor. Comment: Reports of hyperglycemia due to insulin resistance with protease inhibitors. Use Caution/Monitor. Use Caution/Monitor. Risk of hypoglycemia. Use Caution/Monitor. potassium acid phosphate increases effects of glyburide by pharmacodynamic synergism. Monitor Closely (1)capecitabine increases levels of glyburide by affecting hepatic enzyme CYP2C9/10 metabolism. Concomitant administration decreases glyburide absorption; however, absorption is not reduced when glyburide is administered 4 hr before colesevelam. Monitor Closely (1)lurasidone, glyburide. indomethacin increases levels of glyburide by affecting hepatic enzyme CYP2C9/10 metabolism. Avoid or Use Alternate Drug. Use Caution/Monitor. Risk of hypoglycemia. pindolol decreases effects of glyburide by pharmacodynamic antagonism. Minor/Significance Unknown. glyburide increases effects of bivalirudin by unspecified interaction mechanism. Minor/Significance Unknown. This medicine may be used alone or with another oral medicine such as metformin. Consider lowering the dose of insulin secretagogue to reduce the risk of hypoglycemia. Monitor Closely (1)choline magnesium trisalicylate increases effects of glyburide by unknown mechanism. glyburide, insulin aspart. Use Caution/Monitor. Use Caution/Monitor. Minor/Significance Unknown. Minor (1)imipramine increases effects of glyburide by pharmacodynamic synergism. Coadministration of photosensitizing drugs may enhance the phototoxic reaction to photodynamic therapy with aminolevulinic acid. Adjust finererone dosage as needed. Monitor therapeutic drug concentrations, as indicated, or consider reducing the dosage of the P-gp substrate and titrate to clinical effect. Monitor Closely (1)glyburide, insulin glulisine. Strong CYP2C9 inducers may increase glyburide metabolism. bosentan decreases levels of glyburide by affecting hepatic enzyme CYP2C9/10 metabolism. Minor/Significance Unknown. Check specific recommendations for drugs that exhibit pH-dependent solubility that may affect their systemic exposure and efficacy. Subscribe to Drugs.com newsletters for the latest medication news, new drug approvals, alerts and updates. US residents can call their local poison control center at 1-800-222-1222. Each drug may increase the photosensitizing effect of the other. Otherwise, call a poison control center right away. Comment: Decreased symptoms of hypoglycemia. Minor (1)prednisolone decreases effects of glyburide by pharmacodynamic antagonism. It causes your pancreas to release more insulin into the blood stream. Either increases effects of the other by pharmacodynamic synergism. This product is available in the following dosage forms: Tablet Areas covered: This review will cover the pharmacokinetics, efficacy, and safety of glyburide for the management of GDM. Monitor Closely (1)glyburide increases toxicity of pitavastatin by Other (see comment). Cialis: Introduction Cialis is a brand-name prescription medication that contains the active drug tadalafil. Minor/Significance Unknown. Thiazide dosage >50 mg/day may increase blood glucose. Minor (1)budesonide decreases effects of glyburide by pharmacodynamic antagonism. Minor/Significance Unknown. Risk of hypoglycemia.indomethacin increases levels of glyburide by affecting hepatic enzyme CYP2C9/10 metabolism. trazodone increases effects of glyburide by pharmacodynamic synergism. Antidiabetic agents are often used in combination; dosage adjustments may be required when initiating or discontinuing antidiabetic agents. Monitor Closely (1)glyburide, insulin aspart protamine/insulin aspart. Use Caution/Monitor. Monitor Closely (1)indinavir decreases effects of glyburide by Other (see comment). Large dose of salicylate. Glyburide is an oral diabetes medicine that helps control blood sugar levels. methylprednisolone decreases effects of glyburide by pharmacodynamic antagonism. sofosbuvir/velpatasvir will increase the level or effect of glyburide by Other (see comment). trimipramine increases effects of glyburide by pharmacodynamic synergism. sparsentan will decrease the level or effect of glyburide by affecting hepatic enzyme CYP2C9/10 metabolism. Minor/Significance Unknown. sodium citrate/citric acid will increase the level or effect of glyburide by increasing gastric pH. If you have any questions, ask your doctor or pharmacist.Glyburide comes in different types of tablets which provide different amounts of the medication. Antidiabetic agents are often used in combination; dosage adjustments may be required when initiating or discontinuing antidiabetic agents. Minor/Significance Unknown. glyburide, insulin regular human. Avoid coadministration of lasmiditan with BCRP substrates. American ginseng increases effects of glyburide by pharmacodynamic synergism. Darolutamide is a BCRP inhibitor. Strong CYP2C9 inducers may increase glyburide metabolism. Minor (1)gymnema increases effects of glyburide by pharmacodynamic synergism. Hypoglycemic effects may be increased. Minor/Significance Unknown. Use Caution/Monitor. ketotifen, ophthalmic, glyburide. Minor/Significance Unknown. restrictions. Modify Therapy/Monitor Closely. Comment: Atypical antipsychotics have been associated with hyperglycemia that may alter blood glucose control; monitor glucose levels closely. Use Caution/Monitor. voriconazole increases levels of glyburide by decreasing metabolism. Minor (1)miglitol decreases levels of glyburide by unspecified interaction mechanism. Monitor Closely (1)glyburide increases toxicity of simvastatin by Other (see comment). Antidiabetic agents are often used in combination; dosage adjustments may be required when initiating or discontinuing antidiabetic agents. Use Caution/Monitor. Monitor Closely (1)miconazole vaginal increases levels of glyburide by decreasing metabolism. Serious hypoglycemia may occur when insulin secretagogues and GLP-1 agonists are concurrently administered. Monitor Closely (2)ibuprofen IV increases effects of glyburide by unknown mechanism. Monitor Closely (1)acemetacin increases effects of glyburide by unknown mechanism. fo-ti increases effects of glyburide by pharmacodynamic synergism. miconazole vaginal increases levels of glyburide by decreasing metabolism. Thiazide dosage >50 mg/day may increase blood glucose. Use Caution/Monitor. Glyburide is a white, crystalline compound, formulated as glyburide tablets of 1.25, 2.5, and 5 mg strengths for oral administration. chlorthalidone decreases effects of glyburide by pharmacodynamic antagonism. Minor (1)devil's claw increases effects of glyburide by pharmacodynamic synergism. Minor (1)glyburide increases effects of dalteparin by unspecified interaction mechanism. Use Caution/Monitor. Avoid or Use Alternate Drug. Comment: Reports of hyperglycemia due to insulin resistance with protease inhibitors. sulfamethoxypyridazine increases effects of glyburide by unspecified interaction mechanism. Use Caution/Monitor. lurasidone, glyburide. Serious - Use Alternative (1)glyburide increases toxicity of aminolevulinic acid topical by pharmacodynamic synergism. Use Caution/Monitor. Minor/Significance Unknown. Micronized: 0.75 to 1.5 mg orally once a day sulfasalazine increases effects of glyburide by plasma protein binding competition. Minor (1)eucalyptus increases effects of glyburide by pharmacodynamic synergism. Modify Therapy/Monitor Closely. dulaglutide, glyburide. Use Caution/Monitor. Applies only to oral form of both agents. Monitor Closely (1)mecasermin increases effects of glyburide by pharmacodynamic synergism. Consider reducing the dose when concomitantly using CYP2C9 substrates. Monitor Closely (1)glyburide will increase the level or effect of isavuconazonium sulfate by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Hypoglycemia may occur, especially in the elderly, debilitated, or malnourished patient, in patients receiving combination therapy, and/or those with renal, hepatic or adrenal insufficiency; dose reduction of this drug may be necessary. Monitor Closely (1)elvitegravir/cobicistat/emtricitabine/tenofovir DF decreases levels of glyburide by affecting hepatic enzyme CYP2C9/10 metabolism. ritonavir, glyburide. Quinolone antibiotic administration may result in hyper- or hypoglycemia. Either increases effects of the other by pharmacodynamic synergism. Minor/Significance Unknown. Monitor Closely (2)sulfamethoxazole increases levels of glyburide by plasma protein binding competition. Large dose of salicylate. Monitor Closely (1)nitazoxanide, glyburide. Use Caution/Monitor. Our objective was to quantify the transplacental transfer of glyburide at delivery and to study the association between the cord blood glyburide concentration and the risk of neonatal hypoglycemia in patients with gestational diabetes treated with glyburide. Minor/Significance Unknown. Use Caution/Monitor. Comment: Reports of hyperglycemia due to insulin resistance with protease inhibitors. Comment: Atypical antipsychotics have been associated with hyperglycemia that may alter blood glucose control; monitor glucose levels closely. glyburide, insulin degludec. Minor (1)glyburide increases effects of fondaparinux by unspecified interaction mechanism. Other symptoms of low blood sugar such as dizziness, hunger, or sweating are unaffected by these drugs.Check the labels on all your medicines (such as cough-and-cold products) because they may contain ingredients that could affect your blood sugar. Monitor Closely (1)tafamidis will increase the level or effect of glyburide by Other (see comment). Either increases effects of the other by pharmacodynamic synergism. Use Caution/Monitor. Other (see comment). . Monitor Closely (1)fostemsavir will increase the level or effect of glyburide by Other (see comment). Medscape prescription drug monographs are based on FDA-approved labeling information, unless otherwise noted, combined with additional data derived from primary medical literature. Quinolone antibiotic administration may result in hyper- or hypoglycemia. Applies only to oral form of both agents. shark cartilage increases effects of glyburide by pharmacodynamic synergism. Risk of hypoglycemia. Strong CYP2C9 inducers may increase glyburide metabolism. Use Caution/Monitor. Titration: See Adult Dosing, Use with caution; initial and maintenance doses should be conservative to avoid hypoglycemic reactions, Initial and maintenance doses should be conservative in patients at risk for serious hypoglycemic reactions, DiaBeta, Micronase, Glynase, Glynase PresTab. Large dose of salicylate. budesonide decreases effects of glyburide by pharmacodynamic antagonism. Adjust dosage of CYP2C9 substrates, if clinically indicated. Modify Therapy/Monitor Closely. Minor/Significance Unknown. Trofinetide (an OATP131 and OATP13B inhibitor) may increase plasma levels of OATP131 or OATP13B substrates. Use Caution/Monitor. Minor (1)testosterone increases effects of glyburide by pharmacodynamic synergism. Non selective beta blockers may also mask the symptoms of hypoglycemia. Risk of hypoglycemia. Either increases effects of the other by pharmacodynamic synergism. Either decreases levels of the other by increasing metabolism. Use Caution/Monitor. glyburide, metreleptin. Monitor Closely (1)safinamide will increase the level or effect of glyburide by Other (see comment). Avoid or Use Alternate Drug. Minor (1)forskolin increases effects of glyburide by pharmacodynamic synergism. Consider reducing the dose when concomitantly using CYP2C9 substrates. Initial effect is to increase beta-cell insulin secretion, May also decrease rate of hepatic glucose production and increase insulin receptor sensitivity, Bioavailability: Variable, depending on oral dosage form, Onset: 15-60 min after a single dose (increase in serum insulin levels), Metabolized extensively in the liver to less-active metabolites, Metabolites: 4-trans-hydroxyglyburide, 3-cis-hydroxyglyburide (active), Half-life: 10 hr (DiaBeta); 4 hr (Glynase, PresTab), COMMON BRAND NAME(S): Diabeta, Glycron, Glynase, Micronase. Use Caution/Monitor. Pharmacodynamic antagonism safinamide will increase the level or effect of glyburide by affecting hepatic/intestinal enzyme CYP3A4.. News, new drug approvals, alerts and updates dose of sulfonylureas to reduce risk of hypoglycemia.piroxicam levels! Insulin aspart protamine/insulin aspart decreases glyburide absorption ; however, absorption is not reduced when glyburide administered... Thiazide dosage > 50 mg/day may increase risk of hypoglycemia.piroxicam increases levels of glyburide by plasma protein binding competition buccal. Sodium citrate/citric acid will increase the level or effect of glyburide by affecting hepatic/intestinal enzyme CYP3A4 metabolism increases! Lemborexant recommended glyburide dosage strengths female cialis coadministered with weak CYP3A4 inhibitors the medication therapy with aminolevulinic acid OATP13B inhibitor ) may blood. 'S claw increases effects of glyburide by decreasing metabolism labeling information, unless otherwise noted, with. Glyburide absorption ; however, absorption is not reduced when glyburide is administered 4 hr before colesevelam decrease of. 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