Do not increase your dose or use this drug more often or for longer than prescribed. Always carry the original prescription-labeled container with you. Learn about whats available, the benefits, and. You wont feel fenofibrate working, but your doctor will check your cholesterol levels using blood tests. This list is not complete. Although statin therapy plays an important role in improving the lipid profile of patients with dyslipidemia, approximately 10% to 22% of individuals in clinical studies experience muscle pain (myalgia) during statin therapy [5]. Npoje s vysokm obsahom antioxidantov, ako s vitamny C a E, preukzatene zlepuj erektiln funkciu tm, e brnia pokodeniu buniek, produkujcich oxid dusnat," hovor Pearlmanov. Combination lipid therapy in type 2 diabetes. AbbVie funded development of the publication by Complete Publication Solutions, LLC (Horsham, PA). 1b) [18]. If you notice hives, swelling of your lips or tongue, or difficulty breathing after using fenofibrate, stop using it and seek medical attention right away. Results were limited to English language, Clinical Trials, Humans, Reviews, and publication date between 1993 and 2012, yielding 46 citations of interest. TG and, generally, in HDL-C levels than the hydroxymethylglutaryl coenzyme A reductase inhibitors simvastatin 10 or 20 mg/day, pravastatin 20 mg/day or atorvastatin 10 or 40 mg/day. The list below does not include all possible drug interactions with fenofibrate. Fenofibrate is very similar to fenofibric acid. Dissolution enhancement of fenofibrate by micronization, cogrinding and spray-drying: comparison with commercial preparations. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.AcenocoumarolAnisindioneAtorvastatinColchicineDicumarolFluvastatinLovastatinPhenprocoumonPitavastatinPravastatinRosuvastatinSimvastatinWarfarinUsing this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. Seek medical attention right away if you develop fever, sudden muscle pain, cramps, weakness, or have dark red or brown-colored urine. Common fenofibrate side effects may include: This is not a complete list of side effects and others may occur. Antara: 43 mg orally once a day. Koh KK, Quon MJ, Han SH, Chung WJ, Ahn JY, Seo YH, Choi IS. Grundy SM, Cleeman JI, Merz CN, Brewer HB Jr, Clark LT, Hunninghake DB, Pasternak RC. Jones PH, Davidson MH, Kashyap ML, Kelly MT, Buttler SM, Setze CM, Sleep DJ. All forms of fenofibrate work the same to lower your lipids, but there are some differences between them. Pharmacokinetics and comparative bioavailability of two fenofibrate capsule formulations in healthy volunteers. Subsequently, insoluble drug delivery microparticle (IDD-P) tablets that used phospholipid agents that modify surface properties to prevent reaggregation were developed, thus preserving the expanded drug surface area of microparticles while accelerating dissolution, resulting in better absorption [21]. Drug encyclopedia Print fenofibrate micronized 134 mg capsule 4092 Medication name Uses How to use Side effects Precautions Drug interactions Overdose Notes Missed dose Storage Important note Information last revised August 2021. et al. Your provider might start you on a lower dose of fenofibrate and monitor your kidneys through blood tests. Heres what step therapy looks like. Even if you have no symptoms, tests can help your doctor determine if this medicine is effective. Each tablet contains 48 mg or 145 mg of fenofibrate. Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. Coadministration with meals was necessary to maximize bioavailability of early formulations. sharing sensitive information, make sure youre on a federal Dogs were administered the initial dose for 21 days and then returned . FOIA Executive Summary of The Third Report of The National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, And Treatment of High Blood Cholesterol In Adults (Adult Treatment Panel III) JAMA. You may need frequent medical tests. As a result, a higher amount of a drug stays in your body for a longer time. These benefits were maintained for up to 2 years in an open-label extension study of the combination therapies [56]. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.ColestipolCyclosporineEzetimibeRosiglitazone. These medications can bind to fenofibrate, preventing your body from fully absorbing the drug. Fenofibrate oral tablet is available as brand-name drugs and as a generic drug. Mix the medication with cat litter, dirt, coffee grounds, or other unwanted substance. Check with your doctor immediately if any of the following side effects occur: muscle cramps, spasms, stiffness, swelling, or weakness, pains in the stomach, side, or abdomen, possibly radiating to the back, swelling of the face, fingers, or lower legs. Store at room temperature between 20 and 25 degrees C (68 and 77 degrees F). Lipofen (fenofibrate). Swallow the capsules whole. Davidson MH, Jones PH. The event rate was slightly higher (17%) in patients with diabetes [9, 10]. US residents can call their local poison control center at 1-800-222-1222. It may take up to 2 months before you get the full benefit of this medication. If you take these drugs together, your doctor may do blood tests more often or change your dosage of warfarin. Muscle Pain From Statins? Truven Health and GoodRx make no representation or warranty as to the accuracy, reliability, timeliness, usefulness or completeness of any of the information contained in the products. The risk is higher if you take the drug along with statins. Triglide: 50 mg orally once a day. Fenofibrate can cause some serious health issues. This can help keep levels of this drug from building up too much in your body. Fenoglide: 40 to 120 mg once daily; maximum dose: 120 mg/day. Do not share this medication with others. Do not cut, crush or chew this medication. Fenofibrate may interact with certain medications or supplements. You should not take fenofibrate if you are allergic to it, or if you have: severe kidney disease (or if you are on dialysis); Do not breast-feed while using this medicine, and for at least 5 days after your last dose. It belongs to a group of medications called fibrates. Follow your diet, medication, and exercise routines very closely. Fenofibrate (Fig. Do not breast-feed while using this medicine, and for at least 5 days after your last dose. This medicine is a white dark green, oblong, capsule imprinted with "APO" and "F130". 2nd ed ed. A prescription for this medication is refillable. The authors concluded that patients treated in an outpatient clinical practice would have better lipid results if prescribed a fenofibrate that has a less restrictive dosing regimen. Cardiovascular disease (CVD), in general, and coronary heart disease (CHD), in particular, are leading causes of death in the United States [1]. . Let your doctor know immediately if you continue to experience these symptoms or if they worsen over time. Find the best statin alternatives here. However, subsequent meta-analyses (which incorporated these same studies) have highlighted the lipid-modifying benefit of fibrate treatment in patients with elevated triglycerides and low HDL-C [60-62]. The .gov means its official. Thus, although this study suggested differences in bioequivalence under the fasting and fed states, efficacy was less affected by administration with food and formed the basis for the indication to administer the drug without regard to meals. Statistically significant reductions of 4.6% to 5.1% for mean triglycerides and 2.3% to 2.8% for mean LDL-C were observed after switching from fenofibrate 160 mg to fenofibrate 145 mg (P 0.002). Although both formulations met bioequivalence criteria with their respective reference compound, after normalization, the fenofibric acid 135 mg formulation produced a 4.4% higher fenofibric acid exposure and an 11.3% lower maximum concentration than the fenofibrate 145 mg compound [40]. A class of drugs is a group of medications that work in a similar way. The dosage is based on your medical condition and response to treatment. Alongside diet and exercise, prescription drugs and supplements may help you lower your cholesterol. This is a serious condition that breaks down muscle. Since fenofibrate was first introduced, the main limitation has been the low bioavailability when taken orally, especially without a high-fat meal. Avoid alcohol. These results show that orally administered fenofibric acid has a significantly higher bioavailability than fenofibrate in 2 out of 4 sections of the gastrointestinal tract, suggesting that the fenofibric acid formulation has improved absorption characteristics compared with the nanocrystal fenofibrate formulation. The Lidose drug delivery technology uses a lipid excipient mixture to increase fenofibrate bioavailability by about 25% compared with the micronized form [37]. JTL is an employee of AbbVie and may hold AbbVie stock or options. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Dont put this medication in your cars glove compartment or leave it in the car. Take the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Take it as directed on the prescription label at the same time every day. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines. HHS Vulnerability Disclosure, Help These issues include: In addition to taking this drug, you should follow a heart-healthy diet to help control your cholesterol levels. Compare a few possible alternatives below. Lofibra and others: 160 mg to 200 mg orally once a day with food. The information contained in the Truven Health Micromedex products as delivered by GoodRx is intended as an educational aid only. Now, youll enjoy a streamlined experience created specifically for healthcare providers. Put it in the trash. If you notice any of the following unlikely but serious side effects, tell your doctor right away: nausea/vomiting that doesn't stop, loss of appetite, stomach/abdominal pain, yellowing eyes/skin, dark urine. Schima SM, Maciejewski SR, Hilleman DE, Williams MA, Mohiuddin SM. et al. A report about an ongoing trial of the drug from Raleigh-based Sprout Pharmaceuticals for treatment of low sexual desire in women finds in interim results that the so called 'female Viagra' can . Fenofibrate (generic). Fenofibrate is a medication taken by mouth and used to lower "bad" cholesterol (LDL) and raise "good" cholesterol (HDL). Long-term efficacy of adding fenofibric acid to moderate-dose statin therapy in patients with persistent elevated triglycerides. The following list contains some of the key side effects that may occur while taking fenofibrate. Accessibility ChildrenUse and dose must be determined by your doctor. How to Get Insurance to Pay for Your Non-Preferred Medication, Statin Alternatives You Can Take to Help Lower Your Cholesterol. Call your doctor for medical advice about side effects. 8600 Rockville Pike It works by decreasing bad cholesterol and fats (such as LDL, triglycerides) and increasing good cholesterol (HDL) in your blood. Rarely, this medication has caused severe lowering of HDL ("good" cholesterol) levels. Proteins released by these muscles can go into your blood and cause damage to your kidneys or heart. For women who are breastfeeding: Fenofibrate may pass into breast milk and cause side effects in a child who is breastfed. Gillian M. 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