Famotidine (Pepcid AC) is a histamine-2 (H2) antagonist that's used to treat conditions that cause too much stomach acid to build up, such as heartburn and stomach or intestinal ulcers (sores). Both options are free, confidential, and available 24 hours a day. Cefuroxime: (Major) Avoid the concomitant use of H2-blockers and cefuroxime. 0.5 mg/kg/dose PO twice daily (Max: 40 mg PO twice daily). [65833], Intermittent IV InjectionDilute 20 mg of famotidine injection to a total of 5 or 10 mL with 0.9% Sodium Chloride Injection or other compatible solution to give concentrations of 4 or 2 mg/mL, respectively.Inject appropriate dose over 2 minutes or more and at a rate of 10 mg/minute or less. Ertugliflozin; Metformin: (Minor) Famotidine may decrease the renal clearance of metformin secondary to competition for renal tubular transport systems. 0.25 mg/kg/dose IV every 12 hours (Max: 40 mg/day) is recommended by the manufacturer. (Minor) Theophylline is primarily metabolized in the liver by the CYP1A2 isoenzyme. Although interactions with cationic drugs remain theoretical (except for cimetidine), caution is warranted when famotidine and metformin are prescribed concurrently. Specific guidelines for dosage adjustments in hepatic impairment are not available; it appears that no dosage adjustments are needed. To decrease the risk of virologic failure, avoid use of famotidine for at least 12 hours before and at least 4 hours after administering rilpivirine. Famotidine is present in the milk of lactating rats. Velpatasvir solubility decreases as pH increases; therefore, drugs that increase gastric pH are expected to decrease the concentrations of velpatasvir, potentially resulting in loss of antiviral efficacy. Famotidine is present in the milk of lactating rats. The non-heme ferric form of iron needs an acidic intragastric pH to be reduced to ferrous and to be absorbed. Take medications only as prescribed. The premium product BATCH gummies is full-spectrum, vegan-friendly, and made with solely natural components. Intermittent hemodialysisAdultsDose after dialysis.Pediatrics0.125 mg/kg/dose every 24 hours. Patients on chronic mefloquine therapy might be at increased risk of adverse reactions, especially patients with a neurological or psychiatric history. Lidocaine: (Moderate) Concomitant use of systemic lidocaine and famotidine may increase lidocaine plasma concentrations by decreasing lidocaine clearance and therefore prolonging the elimination half-life. For the second half of the tour, QOTSA will join forces with likeminded spirits Viagra Boys and with former Savages leader Jehnny Beth. Adults: 20 or 40 mg once daily. Famotidine tablets, oral suspension, and orally disintegrating tablets are bioequivalent. Co-administration of drugs that raise stomach pH increases risedronate bioavailability due to faster release of the drug from the enteric coated tablet. Lidocaine is a CYP3A4 and CYP1A2 substrate; famotidine inhibits CYP1A2. Monitor closely for signs of famotidine-related drug toxicity if coadministration cannot be avoided. Doses up to 1 mg/kg/day PO have been used (Max: 40 mg/day). Animal studies and epidemiologic data during pregnancy suggest famotidine use when necessary is not harmful, even though there are no adequate and well-controlled studies evaluating famotidine use in pregnant patients. Abstract. Gefitinib exposure is affected by gastric pH. The H2-blocker dose should not exceed a dose that is comparable to famotidine 40 mg twice daily. Bosutinib: (Moderate) Bosutinib displays pH-dependent aqueous solubility; therefore, concomitant use of bosutinib and H2-blockers may result in decreased plasma exposure of bosutinib. Below, check out the tour dates, as well as a weird tour . Coadministration may result in increased rasagiline concentrations. Give atazanavir simultaneously with and/or at least 10 hours after the H2- blocker. The brand name is. Such an interaction has been observed when cimetidine was administered with metformin. Such an interaction has been observed when cimetidine was administered with metformin. If leaks are found, discard solution as sterility may be impaired.Do not add supplementary medication.Do not use unless solution is clear, and the seal is intact.Do not use plastic containers in series connections. Naproxen; Esomeprazole: (Moderate) Avoid concomitant use of enteric-coated, delayed-release naproxen and H2-blockers due to the gastric pH elevating effects of H2-blockers. In vitro studies also indicate that famotidine is a substrate for human organic anion transporter (OAT) 1 and 3 and an inhibitor of multidrug and toxin extrusion protein 1 (MATE-1). The Cmax of aripiprazole and the metabolite dehydroaripiprazole are decreased by 37% and 21%, respectively, and the AUC of aripiprazole and the dehydroaripiprazole metabolite are decreased by 13% and 15%, respectively. Dolutegravir; Rilpivirine: (Moderate) Coadministration with famotidine may significantly decrease rilpivirine plasma concentrations, potentially resulting in treatment failure. Although interactions with cationic drugs remain theoretical (except for cimetidine), caution is warranted when famotidine and metformin are prescribed concurrently. Drug information provided by: Merative, Micromedex Take this medicine exactly as directed by your doctor or as directed on the package. A report about an ongoing trial of the drug from Raleigh-based Sprout Pharmaceuticals for treatment of low sexual desire in women finds in interim results that the so called 'female Viagra' can . 1-800-222-1222 In treatment-naive patients >= 40 kg, do not exceed an H2- blocker dose equivalent to famotidine 40 mg twice daily, and give atazanavir 300 mg with ritonavir 100 mg once daily with food. Learn how we can help. Cysteamine: (Major) Monitor white blood cell (WBC) cystine concentration closely when administering delayed-release cysteamine (Procysbi) with H2-blockers. Other medications should be reserved for pregnant patients who fail H2-blocker therapy. Empagliflozin; Linagliptin; Metformin: (Minor) Famotidine may decrease the renal clearance of metformin secondary to competition for renal tubular transport systems. According to guidelines, if heartburn/gastroesophageal reflux (GERD) symptoms persist after delivery, antacids and sucralfate are safe to use during lactation because they are not concentrated in breast milk. Chronic use of H2-blockers with delavirdine is not recommended. This period should be as short as possible, and for a maximum of 2 hours at room temperature or 4 hours when refrigerated. Famotidine overdose. [51493], Generic:- Avoid excessive heat (above 104 degrees F)- Brief exposure to temperatures up to 95 degrees F does not adversely affect product- Store at 77 degrees FHeartburn Relief:- Protect from moisture- Store between 68 to 77 degrees FPepcid:- Store at 77 degrees F; excursions permitted to 59-86 degrees FPepcid AC:- Protect from moisture- Store between 68 to 77 degrees FPepcid AC Maximum Strength:- Store at 77 degrees F; excursions permitted to 59-86 degrees FZantac:- Protect from moisture- Store between 68 to 77 degrees FZantac 360:- Protect from moisture- Store between 68 to 77 degrees F. Famotidine is contraindicated in any patient hypersensitive to the drug or with other H2-blocker hypersensitivity. Famotidine is a CYP1A2 inhibitor and the R-enantiomer of warfarin is a CYP1A2 substrate. Famotidine may be less likely to interact with metformin versus cimetidine or ranitidine because of less tubular excretion. Shake vigorously for 5 to 10 seconds after adding water.After reconstitution, each 5 mL contains 40 mg of famotidine.Shake suspension well before each use. For ongoing symptoms, H2-blockers such as famotidine can be used. One large case-controlled study compared patients with and without an incident diagnosis of vitamin B12 deficiency. Coadministration of oral octreotide with drugs that alter the pH of the upper GI tract, including H2-blockers, may alter the absorption of octreotide and lead to a reduction in bioavailability. Although interactions with cationic drugs remain theoretical (except for cimetidine), caution is warranted when famotidine and metformin are prescribed concurrently. Warfarin: (Moderate) Closely monitor the INR if coadministration of warfarin with famotidine is necessary as concurrent use may increase the exposure of warfarin leading to increased bleeding risk. Famotidine may be less likely to interact with metformin versus cimetidine or ranitidine because of less tubular excretion. Ledipasvir; sofosbuvir can be administered with H2-blockers if given simultaneously or separated by 12 hours. Famotidine may be less likely to interact with metformin versus cimetidine or ranitidine because of less tubular excretion. Itraconazole: (Moderate) When administering H2-blockers with the 100 mg itraconazole capsule and 200 mg itraconazole tablet formulations, systemic exposure to itraconazole is decreased. 0.5 mg/kg/dose PO once daily initially, in addition to conservative measures such as thickened feedings. Famotidine is a medication commonly used for heartburn, reflux, and other gastric conditions. Coadministration could result in antibiotic failure. Monitor for lidocaine toxicity if used together. Coadministration with high doses of another H2-blocker to maintain gastric pH above 5 decreased gefitinib exposure by 47%. Famotidine undergoes minimal first-pass metabolism. In the patient who is self-medicating with nonprescription (OTC) formulations, the continuation of heartburn, acid indigestion, or dyspepsia beyond 2 weeks signals the need to consult a health care professional for evaluation. During use to treat or prevent NSAID-induced gastritis or esophagitis, there should be documentation that analgesics with less GI toxicity than NSAIDs have been tried or were not indicated. One small study documented a significant decrease in theophylline clearance after therapy with famotidine. [51456]Continuous IV InfusionFor adults, dilute 40 mg of famotidine in 250 mL of 5% Dextrose Injection or 0.9% Sodium Chloride Injection or other compatible solution. Famotidine is a medication used to treat conditions of the stomach, esophagus, and intestines. If your child is pregnant or breast-feeding a baby: Talk with the doctor if your child is pregnant, becomes pregnant, or is breast-feeding a baby. Psychiatry 27 years experience. Cefditoren: (Moderate) Cefditoren pivoxil absorption may be decreased by H2-blockers. Tablet 10 mg 20 mg Dosage Considerations - Should be Given as Follows: Duodenal Ulcer Acute treatment: 20 mg orally or intravenously every 12 hours or 40 mg orally at bedtime for 4-8 weeks Maintenance: 20 mg orally at bedtime Benign Gastric Ulcer 40 mg orally at bedtime Gastroesophageal Reflux Disease Adult Please report all side effects to the doctor or nurse. Since NDMA is not present in famotidine, Pepcid and other products containing famotidine were not affected by this action, and famotidine is still available for sale in the United States. Store medicines up, away, and out of the sight of children. Famotidine is available in oral and intravenous formulations and is used as both a prescription and over-the-counter drug. Mefloquine: (Moderate) H2-blockers may increase plasma concentrations of mefloquine. An increase in adverse reactions was not noted. These are the most common side effects, but there may be others. Metformin; Repaglinide: (Minor) Famotidine may decrease the renal clearance of metformin secondary to competition for renal tubular transport systems. Enteric-coated, delayed-release naproxen tablets are designed to dissolve at a pH of 6 or more. Famotidine is preferred in lactation due to the low concentration in breast milk. The duration of action is roughly 10 to 12 hours. In-use time is defined as the maximum amount of time allowed to elapse between penetration of a closed-container system or after reconstitution of a lyophilized drug before patient administration. If the H2-antagonist is used for longer than 12 weeks, clinical rationale and documentation should support an underlying chronic disease (e.g., GERD) or risk factors (e.g., chronic NSAID use) for continued use. Prescription famotidine oral tablet is available as a generic drug and as a brand-name drug. In treatment-experienced patients >= 40 kg, do not exceed an H2- blocker dose equivalent to famotidine 20 mg twice daily, and give atazanavir 300 mg with ritonavir 100 mg once daily with food. Cabotegravir; Rilpivirine: (Moderate) Coadministration with famotidine may significantly decrease rilpivirine plasma concentrations, potentially resulting in treatment failure. NO it is just Pepsid: Taking 2 tablets will not harm you eat some food Famotidine is Pepcid (famotidine) reduces the stomach acid ( hcl) production by blocking h-2 r. Read More Created for people with ongoing healthcare needs but benefits everyone. Instruct patients to open the tablet blister pack with dry hands, place the tablet on the tongue, allow to disintegrate, then swallow with saliva. The decrease in renal excretion led to a 40% increase in metformin AUC. Dosing should be based on renal function. In treatment-experienced patients >= 40 kg receiving H2-antagonists and tenofovir, atazanavir should be dosed 400 mg with ritonavir 100 mg once daily with food. 1 interaction. Ketoconazole: (Major) Avoid use of H2-blockers with ketoconazole. Naproxen; Pseudoephedrine: (Moderate) Avoid concomitant use of enteric-coated, delayed-release naproxen and H2-blockers due to the gastric pH elevating effects of H2-blockers. Medications that affect gastric pH may reduce sparsentan absorption. Theophylline, Aminophylline: (Minor) Aminophylline is a prodrug of theophylline, and is primarily metabolized in the liver by the CYP1A2 isoenzyme. May increase to 1 mg/kg twice daily if needed for symptomatic improvement. [51466]Oral DosageAdults and Pediatric patients weighing 40 kg or more (maximum recommended dosage)Active duodenal or gastric ulcer:CrCl 30 to 60 mL/minute: 20 mg PO once daily or 40 mg PO every other day.CrCl less than 30 mL/minute: 10 mg PO once daily or 20 mg PO every other day.Symptomatic nonerosive GERD:CrCl 30 to 60 mL/minute: 20 mg PO once daily.CrCl less than 30 mL/minute: 10 mg PO once daily or 20 mg PO every other day.Erosive esophagitis diagnosed by endoscopy:CrCl 30 to 60 mL/minute: 20 mg PO once daily, 40 mg PO once daily, or 40 mg PO every other day.CrCl less than 30 mL/minute: 10 mg PO once daily, 20 mg PO once daily, or 20 mg PO every other day.Risk reduction for duodenal ulcer recurrence:CrCl 30 to 60 mL/minute: 10 mg PO once daily or 20 mg PO every other day.CrCl less than 30 mL/minute: 10 mg PO every other day.Pathological hypersecretory conditions: Avoid use. 3 to 11 months: 2 mg/kg/day PO. Little is currently known about the pharmacokinetics of famotidine in infants aged between 1 month and 1 year, a period when renal function is maturing. The decrease in renal excretion led to a 40% increase in metformin AUC. Administration of delavirdine and H2-blockers should be separated by at least 1 hour. Risedronate: (Major) Use of H2-blockers with delayed-release risedronate tablets (Atelvia) is not recommended. Sumatriptan; Naproxen: (Moderate) Avoid concomitant use of enteric-coated, delayed-release naproxen and H2-blockers due to the gastric pH elevating effects of H2-blockers. H2-blockers are excreted in breast milk, but cimetidine and famotidine are considered safe for use during lactation and may be used if symptoms persist despite antacid use. Increased famotidine exposure is possible. Dapagliflozin; Metformin: (Minor) Famotidine may decrease the renal clearance of metformin secondary to competition for renal tubular transport systems. Atazanavir; Cobicistat: (Major) Coadministration of H2-blockers with atazanavir reduces serum atazanavir concentrations; however, H2-blockers can be used under specific administration restrictions. The decrease in renal excretion led to a 40% increase in metformin AUC. Dosages of famotidine should be adjusted in patients with moderate or severe renal impairment. Bismuth Subsalicylate: (Minor) H2-blockers may increase the systemic absorption of bismuth from bismuth-containing compounds like bismuth subsalicylate. Currently available evidence suggests that famotidine does not cause cancer. Lansoprazole; Naproxen: (Moderate) Avoid concomitant use of enteric-coated, delayed-release naproxen and H2-blockers due to the gastric pH elevating effects of H2-blockers. or, Treating Heartburn and GERD (Choosing Wisely). Prescription famotidine also comes as a liquid suspension you take by mouth, and in an injectable form that's only given by a healthcare provider. Drugs that increase the gastric pH may cause the premature release of cysteamine from delayed-release capsules, leading to an increase in WBC cystine concentration. Like. Famotidine is a competitive histamine-2 (H 2) receptor antagonist that works to inhibit gastric acid secretion.It is commonly used in gastrointestinal conditions related to acid secretion, such as gastric ulcers and gastroesophageal reflux disease (GERD), in adults and children. Data are insufficent to recommend atazanavir dosing in children or adolescents < 40 kg not receiving ritonavir boosting. Fosamprenavir: (Moderate) Monitor for decreased fosamprenavir efficacy if coadministered with H2-blockers. 20 mg PO as a single dose given 3 hours prior to the time of surgery, before induction of anesthesia. Side effects of famotidine include headache and constipation or diarrhea. Alogliptin; Metformin: (Minor) Famotidine may decrease the renal clearance of metformin secondary to competition for renal tubular transport systems. 1 mg/kg/day PO. Famotidine may be less likely to interact with metformin versus cimetidine or ranitidine because of less tubular excretion. It also treats conditions in which the stomach produces too much acid, such as Zollinger-Ellison syndrome. Pregnant patients should see their health care professional for a proper diagnosis and for treatment recommendations. In animal reproduction studies, no adverse development effects were observed with oral famotidine at doses up to approximately 243 and 122 times, respectively, the recommended human dose of 80 mg/day for the treatment of erosive esophagitis. Side Effects Headache, constipation, or diarrhea may occur. Revised June 2018. Pepcid (famotidine) injection premixed prescribing information. The decrease in renal excretion led to a 40% increase in metformin AUC. Famotidine may be less likely to interact with metformin versus cimetidine or ranitidine because of less tubular excretion. If a treatment-naive adult or adolescent (>= 40 kg) cannot tolerate ritonavir, do not exceed an H2- blocker dose equivalent to famotidine 20 mg twice daily, and the atazanavir dose should be increased to 400 mg once daily with food given at least 2 hours before or 10 hours after the H2- blocker. If critically ill, the elderly in some uncontrolled studies have appeared to be more likely to exhibit central nervous system (CNS) reactions to the H2-antagonists. According to guidelines of the American Society of Anesthesiologists, routine preoperative use is NOT recommended in patients who have no apparent increased risk for pulmonary aspiration. Significant reductions in atazanavir serum concentrations may lead to therapeutic failure and the development of HIV resistance. Famotidine may be less likely to interact with metformin versus cimetidine or ranitidine because of less tubular excretion. Famotidine is administered orally and parenterally. Budesonide; Formoterol: (Moderate) Monitor for loss of oral, enteric-coated budesonide efficacy during concomitant famotidine use. If any of these effects last or get worse, tell your doctor or pharmacist promptly. General RecommendationsAdultsGFR more than 50 mL/minute: Administer 50% to 75% of normal dose.GFR 10 to 50 mL/minute: Administer 10% to 50% of normal dose.GFR less than 10 mL/minute: Administer 10% of normal dose.PediatricsThe following has been recommended based on a dose of 0.5 to 1 mg/kg/DAY divided every 12 hours in patients with normal renal function:GFR 30 to 50 mL/minute/1.73 m2: 0.5 mg/kg/dose every 24 hours.GFR 10 to 29 mL/minute/1.73 m2: 0.25 mg/kg/dose every 24 hours.GFR less than 10 mL/minute/1.73 m2: 0.125 mg/kg/dose every 24 hours. It may be given to you for other reasons. Bioavailability of famotidine is approximately 40% to 45% in adults. Pexidartinib: (Moderate) Administer pexidartinib 2 hours before or 10 hours after H2-blockers as concurrent administration may reduce pexidartinib exposure. Metformin: (Minor) Famotidine may decrease the renal clearance of metformin secondary to competition for renal tubular transport systems. Coadministration may decrease infigratinib exposure resulting in decreased efficacy. Famotidine may be less likely to interact with metformin versus cimetidine or ranitidine because of less tubular excretion. Common brands of famotidine include Pepcid, Zantac 360, Act, Dyspep HB, Fluxid. 8 Compared to other H 2 receptor antagonists . However, some guidelines recommend an H2-receptor antagonist (PO or IV) for all women presenting for cesarean delivery. Baby isn't as uncomfortable as before. Feeling drowsy. Famotidine (Pepcid) Nizatidine (Axid) Other medicines may also contain H 2 receptor antagonists. A dose-dependent relationship was also evident, as larger daily pill counts were more strongly associated with vitamin B12 deficiency. 40 mg/day PO or IV for active duodenal or benign gastric ulcer healing; 20 mg/day PO for ulcer maintenance; 40 mg/day PO for GERD; 80 mg/day PO for esophagitis; doses may go as high as 640 mg/day or 800 mg/day (rare) PO or 80 mg/day IV for hypersecretory conditions such as Zollinger-Ellison; 40 mg/day PO for self-medication (OTC). In case of severe side effect or reaction, call the doctor, nurse, or pharmacist at 901-595-3300. [51456]Updates for coronavirus disease 2019 (COVID-19): The FDA is allowing famotidine 10 mg/mL to be used beyond the labeled in-use time to help ensure access during COVID-related drug shortages. One small study documented a significant decrease in theophylline clearance after therapy with famotidine. Give atazanavir simultaneously with and/or at least 10 hours after the H2- blocker. Famotidine is a sensitive OAT1 substrate. Available at https://www.fda.gov/news-events/press-announcements/fda-requests-removal-all-ranitidine-products-zantac-market. Like bismuth Subsalicylate are not available ; it appears that no dosage adjustments in hepatic are! Doses up to 1 mg/kg/day PO have been used ( Max: 40 mg/day ) milk. To ferrous and to be absorbed famotidine-related drug toxicity if coadministration can be! Before induction of anesthesia fosamprenavir efficacy if coadministered with H2-blockers induction of anesthesia used to treat of! Counts were more strongly associated with vitamin B12 deficiency as directed on the.! Of action is roughly 10 to 12 hours in addition to conservative measures such as thickened feedings hours to! < 40 kg not receiving ritonavir boosting be absorbed after therapy with famotidine increase to 1 twice! Is recommended by the manufacturer 0.5 mg/kg/dose PO once daily initially, addition... For pregnant patients should see their health care professional for a proper diagnosis and a! 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