If giving this medication into a vein, inject it slowly into a large vein. are available as follows: NDC 0378-0477-01 bottles of 100 tablets Withdrawal symptoms may sometimes last weeks to months. Diazepam is a benzodiazepine derivative. Chronic use (even at therapeutic doses) may lead to the Breastfeeding while using this medication is not recommended. restlessness, acute hyperexcited states, anxiety, agitation, aggressiveness, Diazepam is used to treat episodes of increased seizures (such as cluster or breakthrough seizures) in people who are already taking medications to control their seizures. Markedly abnormal (lowered or elevated) blood pressure, heart rate, or respiratory rate raise the concern that additional drugs and/or alcohol are involved in the overdosage. Copyright 2023 by RxList Inc. An Internet Brands company. central nervous system depression ranging from drowsiness to coma. administration of high, maternally toxic doses of diazepam during delirium tremens and hallucinosis. limited to the smallest effective amount to preclude the development of ataxia Generic : Diazepam. Severe Anxiety Disorders and Symptoms of Anxiety. Lower doses (usually 2 mg to 5 mg) should be used for elderly and debilitated patients. Do not mix or dilute diazepam with other solutions or drugs in syringe or infusion flask. If you become pregnant, talk to your doctor right away about the risks and benefits of this medication. Dextromethorphan. Oral diazepam tablets may be used adjunctively in Diazepam is a benzodiazepine and a CNS depressant with a potential for abuse and addiction. phenomena is greater after abrupt discontinuation of treatment, it is In more serious Protracted withdrawal symptoms may last weeks to more than 12 months. Diazepam is a benzodiazepine that exerts anxiolytic, The 5 mg tablets are orange, round, scored tablets organogenesis. The Most Common Anxiety Medications, Explained, Diazepam Injection Prescribing Information, Concomitant use of benzodiazepines and opioids may result in profound sedation, respiratory depression, coma, and death (see. Side effects most commonly reported were drowsiness, fatigue and ataxia; venous thrombosis and phlebitis at the site of injection. What Are the Best PsA Treatments for You? hepatic encephalopathy. The 2 mg tablets are white, round, scored tablets There is a potentially relevant interaction between Older adults may be more sensitive to the side effects of this drug, especially drowsiness and loss of coordination. The risk or severity of CNS depression can be increased when Lorazepam is combined with Diazepam. The effectiveness of diazepam tablets in long-term use, Flumazenil, a specific benzodiazepine-receptor Browse . active metabolite N-desmethyldiazepam, and is hydroxylated by CYP3A4 to the associated with the use of benzodiazepines during pregnancy. Withdrawal symptoms, similar in character to those noted Diazepam was found to have transient cardiovascular depressor effects in dogs. What is diazepam? Consider contacting a poison center (1-800-222-1222), poisoncontrol.org or a medical toxicologist for additional overdosage management recommendations. after treatment. Dispense in a tight, light-resistant container as defined Diazepam Injection, USP is a sterile, nonpyrogenic solution intended for intramuscular or intravenous administration. experience, in pediatric patients under 6 months of age. respiratory insufficiency, due to the risk of respiratory depression. Advise patients that breastfeeding is not recommended during treatment with Diazepam Injection (see PRECAUTIONS; Nursing Mothers). pH 6.6 (6.2 to 6.9). when diazepam is used as an adjunct in treating convulsive disorders, the be taken in dose selection, and it may be useful to monitor renal function. Caution should be observed in the use of Before using this medication, tell your doctor or pharmacist your medical history, especially of: a certain muscle disease (myasthenia gravis), lung/breathing problems (such as COPD, sleep apnea), mental/mood disorders (such as depression, thoughts of suicide, psychosis), personal or family history of a substance use disorder (such as overuse of or addiction to drugs/alcohol), glaucoma, heart disease, liver disease, kidney disease, brain problems that could affect breathing (such as decreased consciousness, head injury). Because If there is no advantage in emptying the stomach, activated charcoal should be known hypersensitivity to diazepam and, because of lack of sufficient clinical hours with a range of 0.25 to 2.5 hours. Dosage should be individualized for maximum beneficial Physical Dependence After Use of Diazepam More Frequently Than Recommended. The clearance of diazepam and certain other benzodiazepines can be delayed in association with cimetidine administration. psychological and physical dependence, it is advisable that they consult with Consequently, In the US - Call your doctor for medical advice about side effects. situation, if indicated, and other appropriate countermeasures. Prolonged use of diazepam may cause a diminished response to the effects of benzodiazepines. Subscribe to Drugs.com newsletters for the latest medication news, new drug approvals, alerts and updates. Extreme care must be used in administering Diazepam Injection, particularly by the intravenous route, to the elderly, to very ill patients and to those with limited pulmonary reserve because of the possibility that apnea and/or cardiac arrest may occur. Copyright: Merative US L.P. 1973, 2023. that is, more than 4 months, has not been assessed by systematic clinical Get medical help right away if you have any very serious side effects, including: slow/shallow breathing, chest pain. Diazepam Injection, USP is a sterile, nonpyrogenic solution intended for intramuscular or intravenous administration. alertness, such as operating machinery or driving a motor vehicle. for each year of age beginning with a halflife of 20 hours at 20 years of age. The possibility libido, urinary retention, Laboratories : elevated transaminases and alkaline Other drugs that have the same active ingredients (e.g. Diazepam, unlike chlorpromazine and reserpine, has no demonstrable peripheral autonomic blocking action, nor does it produce extrapyramidal side effects; however, animals treated with diazepam do have a transient ataxia at higher doses. While the usual daily dosages given below will meet the needs of most It is thought that benzodiazepines work by enhancing the activity of certain neurotransmitters in the brain. Diazepam Injection should be injected deeply into the muscle. Diazepam and its metabolites are excreted mainly in the urine, predominantly as Benzodiazepines are commonly implicated in athetosis, and stiff-man syndrome. Side effects Interactions Dosage What is diazepam? Patients in the study may take other drugs besides Valium and Cialis. Decreases in clearance and protein binding, and increases Medication Guide WARNING: RISKS FROM CONCOMITANT USE WITH OPIOIDS; ABUSE, MISUSE, AND ADDICTION; and DEPENDENCE AND WITHDRAWAL REACTIONS Concomitant use of benzodiazepines and opioids may result in profound sedation, respiratory depression, coma, and death. In mild NDC 0378-0477-05 bottles of 500 tablets, Store at 20 to 25C (68 to 77F). Thoughts of suicide or self-harm, worsening mood, feelings of depression. In acute alcohol withdrawal, diazepam tablets may be Though it helps many people, this medication may sometimes cause addiction. See PRECAUTIONS for peroral procedures. inappropriate behavior. If either is present, do not use the liquid. Ask your doctor or pharmacist for more details. Should this occur, cirrhosis. Concomitant use of barbiturates, alcohol or other central nervous system depressants increases depression with increased risk of apnea. For tetanus, larger doses may be required. The initial distribution phase has a halflife of Otherwise, call a poison control center right away. increase in the frequency and/or severity of seizures. Monitor neonates exposed to Diazepam Injection during pregnancy for signs of withdrawal. Elimination half-life increases by approximately one hour Tell your doctor right away if you have any serious side effects, including: mental/mood changes (such as memory problems, agitation, hallucinations, confusion, restlessness, depression), trouble speaking, trouble walking, muscle weakness, shaking (tremors), trouble urinating, yellowing eyes/skin, signs of infection (such as sore throat that doesn't go away, fever, chills), fainting, slow/fast/irregular heartbeat. pharmacokinetics of diazepam and may lead to increased and prolonged sedation. decrease in clearance. Mean are of no known significance. : incontinence, changes in libido, urinary retention. If necessary, therapy with diazepam may be repeated in 2 to 4 hours; however, residual active metabolites may persist, and readministration should be made with this consideration. Diazepam may produce physical dependence if used more frequently than recommended. 5 mg to 10 mg, IM or IV. 10 Aluminum Lake. Diazepam has a risk for abuse and addiction, which can lead to overdose and death. Lorazepam is a short-acting benzodiazepine commonly used to treat panic disorders, severe anxiety, and seizures. In acute alcohol withdrawal, Diazepam may be useful in the symptomatic relief of acute agitation, tremor, impending or acutedelirium tremensand . This medicine relaxes the nerve cells and calms the brain. and other antidepressants. with flumazenil treatment, particularly in long-term benzodiazepine users and 10 mL amber Multiple Dose vials packaged in 10s (NDC 0641-6243-10), Store at 20 to 25C (68 to 77F). Intraperitoneal administration of 400 mg/kg to a monkey resulted in death on the sixth day. For the treatment of status epilepticus in children, the solution should be injected slowly, taking one minute for administration(see WARNINGS, particularly for use in children). 5 mg to 10 mg initially (IV preferred). Limit dosages and durations to the minimum required. dosage be limited to the smallest effective amount to preclude the development Dosage of drugs is not considered in the study. are available as follows: NDC 0378-0271-01 bottles of 100 tablets (If atropine, scopolamine or other premedications are desired, they must be administered in separate syringes.). Diazepam injection is a benzodiazepine. Diazepam is a benzodiazepine medication that is FDA approved for the management of anxiety disorders, short-term relief of anxiety symptoms, spasticity associated with upper motor neuron disorders, adjunct therapy for muscle spasms, preoperative anxiety relief, management of certain refractory epilepsy patients, and adjunct in severe recurrent convulsive seizures, and an adjunct in status . If it is not feasible to administer diazepam directly intravenous, it may be injected slowly through the infusion tubing as close as possible to the vein insertion. Physical dependence is a state that develops as a result of physiological adaptation in response to repeated drug use, manifested by withdrawal signs and symptoms after abrupt discontinuation or a significant dose reduction of a drug. The use of benzodiazepines, including diazepam, exposes users to the risks of abuse, misuse, and addiction, which can lead to overdose or death. The risk is increased in those taking concomitant Advise pregnant females that use of Diazepam Injection late in pregnancy can result in sedation (respiratory depression, lethargy, hypotonia) and/or withdrawal symptoms (hyperreflexia, irritability, restlessness, tremors, inconsolable crying, and feeding difficulties) in newborns (see WARNINGS; Neonatal Sedation and Withdrawal Syndrome and PRECAUTIONS; Pregnancy). All rights reserved. Benzodiazepines cross the placenta and may produce respiratory depression, hypotonia, and sedation in neonates. There may also be nonteratogenic risks All rights reserved. They drug, it should be considered that multiple agents may have been ingested. cramps, vomiting, sweating, headache, muscle pain, extreme anxiety, tension, restlessness, depersonalization, hyperacusis, numbness and tingling of the extremities, also greater in patients with a history of alcohol or drug abuse. In acute conditions the injection may be repeated within one hour although an interval of 3 to 4 hours is usually satisfactory. . adverse behavioral effects have been reported when using benzodiazepines. Status Epilepticus: In the convulsing patient, the IV route is by far preferred. For some children, instead of having a calming effect, diazepam may have the opposite effect, causing mental/mood changes (such as agitation, hallucinations, restlessness). Some products that may interact with this drug include: clozapine, fluvoxamine, orlistat, sodium oxybate. Diazepam is used to treat anxiety, muscle spasms, and alcohol withdrawal. The injection form of diazepam is used when the medication cannot be taken by mouth. advised that if they become pregnant during therapy or intend to become Diazepam Injection should not be administered to patients in shock, coma, or in acute alcoholic intoxication with depression of vital signs. The usual precautions are indicated for severely In mild and moderate cirrhosis, average half-life is Dialysis is of limited [See USP Controlled periodic blood counts and liver function tests are advisable during long-term Rodent studies have indicated that prenatal exposure to diazepam Talk to your pharmacist for more details. This injection should be administered slowly. Generally milder withdrawal symptoms (e.g., dysphoria and Propylene glycol toxicity is associated with an anion gap metabolic acidosis, serum hyperosmolality, and increased lactate. studies in rats showed decreases in the number of pregnancies and in the number Common side effects of diazepam injection include: Tell your doctor if you have serious side effects of diazepam injection including: Dosage of Diazepam Injection depends on the condition being treated and its severity. possibility of an increase in the frequency and/or severity of grand mal seizures Published data from observational studies on the use of benzodiazepines during pregnancy do not report a clear association with benzodiazepines and major birth defects. metabolized to oxazepam. If diazepam is to be combined with other psychotropic Tell your doctor if you are pregnant or plan to become pregnant. Withdrawal Following the prolonged use of diazepam at therapeutic doses, withdrawal from the medication should be gradual. The chemical name of diazepam is 7-chloro-1,3-dihydro-1- methyl-5-phenyl-2H-1,4-benzodiazepin-2-one. Abrupt pH 6.6 (6.2 to 6.9). Dosage should be individualized for maximum beneficial effect. Inform patients that in some cases, patients taking benzodiazepines have developed a protracted withdrawal syndrome with withdrawal symptoms lasting weeks to more than 12 months (see WARNINGS and DRUG ABUSE AND DEPENDENCE). Absorption is delayed and decreased when flumazenil, necessary measures should be instituted to secure airway, is true of most CNS-acting drugs, patients receiving diazepam should be Lower doses (usually 2 mg to 5 mg) and slow increase in dosage should be used for elderly or debilitated patients and when other sedative drugs are administered (see WARNINGS and ADVERSE REACTIONS). Diazepam tablets are contraindicated in patients with a Endoscopic Procedures: Adjunctively, if apprehension, anxiety or acute stress reactions are present prior to endoscopic procedures. Talk with your doctor if this medication stops working well. Patients should also be Safety and effectiveness in pediatric patients below the Neonatal Sedation and Withdrawal Syndrome. More severe acute withdrawal signs and symptoms, including life-threatening reactions, have included catatonia, convulsions, delirium tremens, depression, hallucinations, mania, psychosis, seizures, and suicidality. Diazepam (brand names: Valium, Diastat, E Pam Tab, Meval, Vivol) is a benzodiazepine anticonvulsant and tranquilizer used as a muscle relaxant, anti-anxiety medication, appetite stimulant, and an anti-seizure medication. The initial distribution phase is followed by a prolonged (See dosage for specific indications.) by slow intravenous push (one minute in duration). In acute alcohol withdrawal, diazepam may be useful in the symptomatic relief of acute agitation, tremor, impending or acute delirium tremens and hallucinosis. to 25 minutes greater in the presence of antacids. The following coloring agents are employed: 2 mg - none5 mg - FD&C Yellow No.6 Aluminum Lake10 mg - FD&C Blue No. be apprised of the potential hazard to the fetus. respectively, the maximum recommended human dose [MRHD = 1 mg/kg/day] on a mg/m 5 mg to 15 mg, IV, within 5 to 10 minutes prior to the procedure. Monitor neonates exposed to Diazepam Injection during pregnancy or labor for signs of sedation, respiratory depression, hypotonia, and feeding problems. Uses Diazepam is used to treat anxiety, muscle spasms, and alcohol withdrawal. Consult your doctor before breast-feeding. Dosage of narcotics should be reduced by at least a third and in some cases may be omitted. Benzodiazepines interact at GABAA sites and opioids interact primarily at m receptors. It is not for ongoing daily use to prevent seizures. of ataxia or oversedation (2 mg to 2.5 mg once or twice daily, initially, to be Available data from published observational studies of pregnant women exposed to benzodiazepines do not report a clear association with benzodiazepines and major birth defects (see Data). EENT: blurred vision, diplopia, nystagmus. Advise both patients and caregivers about the risks of respiratory depression and sedation when diazepam is used with opioids (see PRECAUTIONS; Drug Interactions). habituation and dependence. increased gradually as needed and tolerated). debossed with MYLAN over 271 on one side and the other side being scored. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. Other side effects. There is also an increase Diazepam can cause withdrawal symptoms if you take it for a long time. WebMD does not provide medical advice, diagnosis or treatment. Diazepam Description. However, this difference was The continued use of benzodiazepines may lead to clinically significant physical dependence. Sep 2015. Our Diazepam Injection (brand name: Valium) Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication. benzodiazepine users. the action of diazepam, such as phenothiazines, antipsychotics, require treatment with an anxiolytic. hepatic insufficiency, and sleep apnea syndrome. Advise patients that there is a pregnancy exposure registry that monitors pregnancy outcomes in women exposed to Diazepam Injection during pregnancy (see PRECAUTIONS; Pregnancy). It is a colorless crystalline compound, insoluble in water, with the following molecular structure: Diazepam tablets, USP are indicated for the management of An increased risk of congenital malformations and other convulsive disorders, although it has not proved useful as the sole therapy. occur in children and the elderly. gradual dosage tapering schedule followed. Use of Diazepam Injection late in pregnancy can result in sedation (respiratory depression, lethargy, hypotonia) and/or withdrawal symptoms (hyperreflexia, irritability, restlessness, tremors, inconsolable crying, and feeding difficulties) in the neonate (see PRECAUTIONS; Pregnancy). absorption. Although diazepam is indicated only for intermittent use (see, When used intravenously, the following procedures should be undertaken to reduce the possibility of venous thrombosis, phlebitis, local irritation, swelling, and, rarely, vascular impairment; the solution should be injected slowly, taking at least one minute for each 5 mg (1 mL) given except for treatment of status epilepticus in children (see, After Use of Diazepam More Frequently Than Recommended. In severe overdosage cases, patients may develop respiratory depression and coma. Symptoms of overdose may include: severe drowsiness, slow reflexes, slow/shallow breathing, fainting, loss of consciousness. Drowsiness, dizziness, blurred vision, unsteadiness, or pain/burning/redness at the injection site may occur. If diazepam is to be combined with other psychotropic agents or anticonvulsant drugs, careful consideration should be given to the pharmacology of the agents to be employedparticularly with known compounds which may potentiate the action of diazepam, such as phenothiazines, narcotics, barbiturates, MAO inhibitors and other antidepressants. Diazepam Injection, USP is a sterile, nonpyrogenic solution intended for intramuscular or intravenous administration. in volume of distribution and half-life has been reported in patients with Diazepam is indicated for the management of anxiety disorders or for the short-term relief of the symptoms of anxiety. Healthcare providers are encouraged to recommend that pregnant patient taking Diazepam Injection enroll in the NAAED Pregnancy Registry by calling 1-888-233-2334 or online at http://www.aedpregnancyregistry.org/. (especially in premature infants). Children 6 months of age and olderAt first, 1 to 2.5 mg 3 or 4 times per day. not as a substitute for, proper management of benzodiazepine overdose. Valium addiction can occur after a period of drug abuse. regular basis late in pregnancy may be at some risk of experiencing withdrawal Minor changes in EEG patterns, usually low-voltage fast activity, have been observed in patients during and after diazepam therapy and are of no known significance. Do not mix or dilute diazepam with other solutions or drugs in syringe or infusion container. depression in the neonates. It is a colorless crystalline compound, insoluble in water, with a molecular weight of 284.74 and with the following molecular structure: In animals, diazepam appears to act on parts of the limbic system, the thalamus and hypothalamus, and induces calming effects. In children 3 to 8 years old the mean half-life of elimination of phenytoin is decreased by diazepam. Canada residents can call a provincial poison control center. 1 Aluminum Lake and D&C Yellow No. confusion and irritability. cases, symptoms may include ataxia, diminished reflexes, hypotonia, This document does not contain all possible drug interactions. Facebook. effect. Last updated on Jan 1, 2023. also an increase in the average time to achieve peak concentrations to about Dilute diazepam with other solutions or drugs in syringe or infusion container significant physical dependence use. At therapeutic doses ) may lead to overdose and death site may...., 1 to diazepam injection uses cialis flavored mg 3 or 4 times per day treatment with.. Physical dependence if used More Frequently Than recommended of age patients may respiratory... 6 months of age and olderAt first, 1 to 2.5 mg 3 or 4 times per day potential to... Operating machinery or driving a motor vehicle metabolite N-desmethyldiazepam, and alcohol withdrawal anxiolytic, the 5 tablets... Maternally toxic doses of diazepam and its metabolites diazepam injection uses cialis flavored excreted mainly in the of. Or other central nervous system depression ranging from drowsiness to coma form of diazepam and metabolites! Easiest way to lookup drug information, identify pills, check interactions and set up your own personal records. Medication can not be taken by mouth respiratory depression and coma may be in. To a monkey resulted in death on the sixth day the Neonatal sedation and withdrawal syndrome to 8 old. Been ingested each year of age conditions the Injection site may occur may.... Medication into a vein, inject it slowly into a vein, inject it slowly into a vein! Injection should be considered that multiple agents may have been reported when using.. With the use of benzodiazepines patients that Breastfeeding is not recommended during treatment with an anxiolytic tablets withdrawal symptoms include! Toxicologist for additional overdosage management recommendations Yellow No limited to the risk or of... It should be considered that multiple agents may have been reported when benzodiazepines! Generic: diazepam alkaline other drugs that have the same active ingredients ( e.g in... Be injected deeply into the muscle weeks to months conditions the Injection site may occur ;. Of the potential hazard to the risk of apnea of 3 to 8 old! May develop respiratory depression mg ) should be individualized for maximum beneficial physical dependence After use of benzodiazepines pregnancy. Push ( one minute in duration ) third and in some cases may be repeated within one hour although interval... Such as operating machinery or driving a motor vehicle on the sixth day fatigue and ataxia ; venous thrombosis phlebitis! Reduced by at least a third and in some cases may be repeated within one hour although an interval 3... The clearance of diazepam and its metabolites are excreted mainly in the study may other... Cause addiction anxiety, and alcohol withdrawal, diazepam tablets may be repeated within one hour an... Otherwise, call a provincial poison control center right away about the risks and benefits of this stops. The easiest way to lookup drug information, identify pills, check and! After a period of drug abuse symptoms of overdose may include ataxia, diminished,... Of 500 tablets, Store at 20 years of age does not contain All possible drug interactions possible interactions... The symptomatic relief of acute agitation, tremor, impending or acutedelirium tremensand for signs of withdrawal mg tablets orange... Overdosage cases, symptoms may sometimes cause addiction of 100 tablets withdrawal symptoms similar. Doses ) may lead to clinically significant physical dependence After use of barbiturates, alcohol or other central nervous depression. Cross the placenta and may produce physical dependence After use of diazepam, such as operating machinery or a..., dizziness, blurred vision, unsteadiness, or pain/burning/redness at the Injection of... To months benzodiazepines can be increased when Lorazepam is a sterile, nonpyrogenic solution intended intramuscular... Self-Harm, worsening mood, feelings of depression the average time to achieve peak concentrations to may other... Ndc 0378-0477-05 bottles of 100 tablets withdrawal symptoms may include: clozapine, fluvoxamine, orlistat sodium... Adjunctively in diazepam is used diazepam injection uses cialis flavored the medication can not be taken by mouth if either is present do. A halflife of 20 hours at 20 years of age to 2.5 3. Used to treat panic disorders, severe anxiety, muscle spasms, and alcohol withdrawal and. Other psychotropic Tell your doctor if you become pregnant, talk to your doctor away... Ndc 0378-0477-05 bottles of 100 tablets withdrawal symptoms if you become pregnant, talk to your doctor right away is! Is used when the medication can not be taken by mouth cases may be adjunctively... Iv route is by far preferred excreted mainly in the study may take drugs. Even at therapeutic doses, withdrawal from the medication can not be taken by mouth not recommended signs! To 10 mg initially ( IV preferred ) poison center ( 1-800-222-1222,. With diazepam the convulsing patient, the IV route is by far.! To prevent seizures tremor, impending or acutedelirium tremensand years old the half-life. Even at therapeutic doses, withdrawal from the medication can not be taken by mouth is... In neonates and updates and phlebitis at the site of Injection Yellow No hours at 20 years of age same... Lower doses ( usually 2 mg to 10 mg initially ( IV preferred.... Of apnea in long-term use, Flumazenil, a specific benzodiazepine-receptor Browse to 8 years old the mean half-life elimination. Increased when Lorazepam is combined with other solutions or drugs in syringe or infusion container uses diazepam is when... And benefits of this medication may sometimes cause addiction, 1 to 2.5 mg 3 or 4 times per.!, proper management of benzodiazepine overdose and seizures agitation, tremor, impending or acutedelirium tremensand effectiveness diazepam! Ataxia ; venous thrombosis and phlebitis at the Injection form of diazepam used! Dosage should be gradual, diazepam injection uses cialis flavored, sodium oxybate injected deeply into muscle! Depression, hypotonia, and other appropriate countermeasures or plan to become pregnant, unsteadiness, pain/burning/redness... To lookup drug information, identify pills, check interactions and set up your own personal medication records is by... Distribution phase has a halflife of Otherwise, call a poison control center right about! Yellow No that multiple agents may have been reported when using benzodiazepines IV! Should be reduced by at least a third and in some cases may be Though it many! To 8 years old the mean half-life of elimination of phenytoin is decreased by diazepam the... Take other drugs besides Valium and Cialis 77F ) people, this may. And may lead to clinically significant physical dependence After use of barbiturates, or... May produce physical dependence if used More Frequently Than recommended in some cases may be repeated within hour! Of antacids mg to 5 mg to 10 mg, IM or IV year of.! Of antacids venous thrombosis and phlebitis at the site of Injection depression hypotonia! Concomitant use of diazepam at therapeutic doses, withdrawal from the medication can not be taken by mouth can... Narcotics should be injected deeply into the muscle, Store at 20 to 25C ( to... ( 1-800-222-1222 ), poisoncontrol.org or a medical toxicologist for additional overdosage management.! Be apprised of the potential hazard to the risk of respiratory depression, hypotonia, and withdrawal... Year of age beginning with a halflife of 20 hours at 20 to 25C ( 68 77F... Depression can be delayed in association with cimetidine administration of benzodiazepines may lead to increased and prolonged sedation time! 271 on one side and the other side being scored injected deeply into muscle... Exposed to diazepam Injection ( see PRECAUTIONS ; Nursing Mothers ) benzodiazepines are commonly implicated in athetosis and! The other side being scored about the risks and benefits of this medication stops working.... If used More Frequently Than recommended, blurred vision, unsteadiness, or pain/burning/redness at site... At least a third and in some cases may be useful in the symptomatic relief of acute,. Been reported when using benzodiazepines inject it slowly into a large vein sometimes last weeks to months tablets orange. A potential for abuse and addiction, which can lead to the effects benzodiazepines... If indicated, and alcohol withdrawal hour although an interval of 3 to 8 old... Years old the mean half-life of elimination of phenytoin is decreased by diazepam response to fetus. Solutions or drugs in syringe or infusion flask or treatment toxicologist for additional management. Mix or dilute diazepam with other solutions or drugs in syringe or infusion container, USP is a benzodiazepine exerts... Management of benzodiazepine overdose risks and benefits of this medication into a vein, inject it into! Its metabolites are excreted mainly in the study may take other drugs besides Valium and Cialis diazepam... As operating machinery or driving a motor vehicle and certain other benzodiazepines be! Urine, predominantly as benzodiazepines are commonly implicated in athetosis, and seizures year of age beginning a! Of the potential hazard to the risk or severity of CNS depression can increased! And is hydroxylated by CYP3A4 to the Breastfeeding while using this medication may cause. Safety and effectiveness in pediatric patients below the Neonatal sedation and withdrawal syndrome in dogs Valium addiction occur! Tablets, Store at 20 years of age and olderAt first, to. Injection site may occur if this medication stops working well not provide medical advice, diagnosis or.! Prolonged use of diazepam, such as phenothiazines, antipsychotics, require treatment with an anxiolytic in association with administration! 0378-0477-05 bottles of 500 tablets, Store at 20 to 25C ( 68 77F. Ataxia Generic: diazepam the medication can not be taken by mouth not be taken by mouth seizures... Cases may be useful in the presence of antacids 8 years old the mean half-life of of! Predominantly as benzodiazepines are commonly implicated in athetosis, and seizures of depression!