Dosage form: tablet 2-5 mg IV/IM q3-4hr if necessary, for moderate anxiety disorders; 5-10 mg IV/IM q3-4hr for severe anxiety disorders. Its important to note that Diastat is not meant for self-administration. Tell your doctor if you have ongoing anxiety, depression, problems with memory or thinking, trouble sleeping, ringing in your ears, a burning or prickly feeling, or a crawling sensation under your skin. The brand Valium and generic diazepam can come in different forms, including a tablet, solution, and a concentrate (liquid) to take orally. The tablets are typically round and come in different colors depending on the manufacturer and the dosage, whether its a 2-mg, 5-mg, or 10-mg tablet. Your doctor will also monitor for opportunities to stop the benzodiazepine or opioid medication or change Diastat to another medication. What to know about focal (partial) seizures, Returning to the workplace after a seizure, Debra Sullivan, Ph.D., MSN, R.N., CNE, COI, What to know about temporal lobe epilepsy hallucinations, the severity and frequency of seizures youre using Diastat to treat, your age and body weight in kilograms (kg), 10 mg/2 ml, with a 4.4-centimeter (cm) tip, if the child weighs 6 to 10 kg, their dose is 5 mg, if the child weighs 11 to 15 kg, their dose is 7.5 mg, if the child weighs 16 to 20 kg, their dose is 10 mg, if the child weighs 21 to 25 kg, their dose is 12.5 mg, if the child weighs 26 to 30 kg, their dose is 15 mg, if the child weighs 31 to 35 kg, their dose is 17.5 mg, if the child weighs 36 to 44 kg, their dose is 20 mg, if the child weighs 10 to 16 kg, their dose is 5 mg, if the child weighs 17 to 25 kg, their dose is 7.5 mg, if the child weighs 26 to 33 kg, their dose is 10 mg, if the child weighs 34 to 41 kg, their dose is 12.5 mg, if the child weighs 42 to 50 kg, their dose is 15 mg, if the child weighs 51 to 58 kg, their dose is 17.5 mg, if the child weighs 59 to 74 kg, their dose is 20 mg, if the child weighs 14 to 25 kg, their dose is 5 mg, if the child weighs 26 to 37 kg, their dose is 7.5 mg, if the child weighs 38 to 50 kg, their dose is 10 mg, if the child weighs 51 to 62 kg, their dose is 12.5 mg, if the child weighs 63 to 75 kg, their dose is 15 mg, if the child weighs 76 to 87 kg, their dose is 17.5 mg, if the child weighs 88 to 111 kg, their dose is 20 mg, euphoria (a feeling of intense excitement or happiness). problems with balance or muscle movement. Sign up for free and stay up to date on research advancements, health tips, current health topics, and expertise on managing health. After taking a single tablet, some of the active ingredient of Cialis remains in your body for more than 2 days. 1 mg to 2.5 mg, 3 or 4 times daily initially; increase gradually as needed and tolerated, Discontinuation or Dosage Reduction of Diazepam. Before taking Diastat, talk with your doctor and pharmacist. Do not stop using diazepam without asking your doctor. Thank you, {{form.email}}, for signing up. For instance, some interactions can interfere with how well a drug works. Classics in Chemical Neuroscience: Diazepam (Valium) - PMC. This can cause serious side effects, such as seizures, trouble breathing, or coma. See the Diastat and Diastat Acudial for seizures section below. However, one study did find that brand-name Valium had a peak concentration and absorption that was higher than one type of generic diazepam. Diastat and Diastat Acudial are brand-name drugs that contain the active ingredient diazepam. Using Diastat or Diastat Acudial while also taking opioid or benzodiazepine medications may cause dangerous side effects. Is There a Difference Between Motrin and Advil? After you stop using diazepam, get medical help right away if you have symptoms such as: unusual muscle movements, being more active or talkative, sudden and severe changes in mood or behavior, confusion, hallucinations, seizures, suicidal thoughts or actions. Learn about the symptoms and causes of temporal lobe epilepsy hallucinations. You use Diastat as needed to treat refractory seizures. DESCRIPTION Valium (diazepam) is a benzodiazepine derivative. Avoid the use of grapefruit products. You should also avoid activities that could be dangerous to do while youre sleepy until you know how your body responds to Diastat. In fact, you should not use the drug to treat more than one seizure episode every 5 days. Everyday Health is among the federally registered trademarks of Everyday Health, Inc. and may not be used by third parties without explicit permission. Certain muscular diseases or respiratory illnesses can be made worse by using the drug; this also concerns mental health disorders like depression or psychosis. This can lower the amount of Diastat in your body, which can make the drug less effective. Diastat has boxed warnings related to these risks. Diazepam is used to relieve symptoms of anxiety and alcohol withdrawal. Tell your doctor if you feel an increased urge to use more of this medicine. If you have questions about drug interactions that may affect you, ask your doctor or pharmacist. If you think you have overdosed on diazepam, contact your emergency services immediately or the nearest poison control center. Its important to note that animal studies dont always predict what will happen in people. While insurers and Medicare do tend to cover generic diazepam, some insurers wont cover brand-name medications. And different types of seizures can cause different symptoms in different people. Phenothiazines are used to treat certain mental health conditions. Sleepiness as a side effect was also the most common reason people stopped using the drug. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. Theyre FDA-approved to treat seizures in people with refractory epilepsy. For more information on how the drug performed in clinical studies in this age group, see Diastats prescribing information. Any medical information published on this website is not intended as a substitute for informed medical advice and you should not take any action before consulting with a healthcare professional. This means you should receive it in addition to at least one other anti-epileptic drug. Measure liquid medicine with the supplied measuring device (not a kitchen spoon). Brand names: Valium, Valtoco, Diastat, Diastat AcuDial, DizacDrug classes: benzodiazepine anticonvulsants, benzodiazepines. They can give you tips on how to deal with any side effects that may concern or bother you. Instead, its sold under the generic name with a private label. Copyright MentalHealth.com, LLC 2023, Illness Anxiety Disorder (Hypochondriasis), Attention Deficit/Hyperactivity Disorder (ADHD), Obsessive-Compulsive Personality Disorder, https://www.nhs.uk/medicines/diazepam/about-diazepam/, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3990949/, https://medlineplus.gov/druginfo/meds/a682047.html, https://www.nih.gov/news-events/nih-research-matters/benzodiazepine-often-used-older-people-despite-risks, https://americanaddictioncenters.org/valium-treatment/how-long-in-system, https://www.nhs.uk/medicines/diazepam/common-questions-about-diazepam/, https://www.ncbi.nlm.nih.gov/books/NBK582671/, https://www.nhs.uk/medicines/diazepam/who-can-and-cannot-take-diazepam/, https://www.drugs.com/food-interactions/diazepam.html, https://www.accessdata.fda.gov/drugsatfda_docs/label/2016/013263s094lbl.pdf, https://www.fda.gov/drugs/disposal-unused-medicines-what-you-should-know/drug-disposal-fdas-flush-list-certain-medicines. Copyright: Merative US L.P. 1973, 2023. Valium is available for oral administration as tablets containing 2 mg, 5 mg or 10 mg diazepam. The drug works to slow or stop symptoms of a refractory seizure. * For more information about this side effect, see Side effect details below. The list below includes serious side effects reported by people using the drug. The inactive ingredients of brand-name Valium, manufactured by Roche, are: anhydrous lactose, corn starch, pregelatinized starch, and calcium stearate with the following dyes: 5-milligram tablets contain FD&C Yellow No. The current stance of the Food and Drug Administration (FDA) is to avoid using expired medications. Investigating the power of music for dementia. Some symptoms (such as sleepiness) were more common than others (such as slowed breathing). The Epilepsy Foundation has recommendations for managing anti-epileptic medications while traveling. . It may cause the following symptoms: If you experience any of these symptoms, call 911 (or your local emergency number) or visit an emergency room as soon as possible. Examples of phenothiazines include chlorpromazine and fluphenazine. With this condition, fluid cant drain out of your eye, and pressure inside your eye rapidly increases. Because you only use Diastat as needed, there are certain times when breastfeeding may or may not be safe, depending on when you received your last dose of the drug. Using the drug every day can actually increase the frequency or severity of seizures you experience. * This is a partial list of mild side effects from Diastat and Diastat Acudial. Speak to your healthcare provider to determine if the benefit of using diazepam for your condition outweighs the possible risks. Diazepam has the potential to cause dependency. See the Diastat and Diastat Acudial interactions section above for more information. privacy practices. No, you should not use Diastat every day. This helps prevent others, including children and pets, from taking the drug by accident. Usual Adult Dose for: Anxiety Alcohol Withdrawal Muscle Spasm Seizures Endoscopy or Radiology Premedication Status Epilepticus Light Anesthesia Usual Geriatric Dose for: Seizures Alcohol Withdrawal Anxiety Muscle Spasm Usual Pediatric Dose for: Seizures Status Epilepticus Anxiety Muscle Spasm Seizure Prophylaxis Tetanus You can use Diastat to treat up to 5 seizure episodes a month. Call 911 or your local emergency number if your symptoms feel life threatening or if you think youre having a medical emergency. [8]. For this use, Diastat can be given to people who are already following a stable dosage of at least one anti-epileptic drug and need additional seizure control. This is why it should not be used in conjunction with opioid drugs unless no other treatment is available. If youre sleepy after your Diastat treatment, you should avoid potentially dangerous activities until you know how your body responds to the drug. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. Your doctor can determine if any of your current medications are CNS depressants. If youre taking Diastat, its important to only use the drug as your doctor prescribes. Acudial refers to a special type of syringe used to administer Diastat gel. For examples of medications that may cause CNS depression if taken with Diastat, see the Diastat and Diastat Acudial interactions section below. 1. If you need emergency assistance, dial 911 immediately. Make your tax-deductible gift and be a part of the cutting-edge research and care that's changing medicine. In some milder cases, symptoms may include drowsiness, confusion, and lethargy. This medicine is available only with your doctor's prescription. The syringes have a special molded tip for application (no needle is used). Its half-life is estimated between 30 to 56 hours. Diastat and Diastat Acudial can interact with several other medications. You may have increased seizures or life-threatening withdrawal symptoms if you stop using the medicine suddenly after long-term use. This refers to epilepsy that causes seizures despite treatment with anti-epileptic medications. [12]. Talk with your healthcare provider and pharmacist if you have any questions about the potency of the medication. Diazepam is used to treat anxiety, alcohol withdrawal, muscle. Portions of this document last updated: May 01, 2023. The drug also helps prevent seizures for several hours after administration. Follow the directions on the prescription label very carefully, and do not exceed the prescribed dose. Diastat and Diastat Acudial may lead to misuse and addiction. This product is available in the following dosage forms: Portions of this document last updated: May 01, 2023. As with all medications, the cost of Diastat and Diastat Acudial can vary. This is not a complete list of side effects and others may occur. If you have unused medication that has gone past the expiration date, talk with your pharmacist about whether you might still be able to use it. Overdose of benzodiazepines in combination with other depressants (including alcohol and opioids) may be fatal. Make sure to talk with your doctor about your safety when driving or doing other activities that require your attention or may be dangerous. But its an exact copy of the active drug in the brand-name version. * Intravenous means the drug is given directly into a vein. In the United States, laws protect and assist people returning to the workplace after a seizure. Biopharm Drug Dispos. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. (Withdrawal symptoms are side effects that can occur when you stop taking a drug that your body has become dependent on. Some groups of people are at a higher risk of dependence than others. Other seizures may cause falling, shaking, or losing awareness of whats happening around you. This drug has boxed warnings. * Refractory means youre still experiencing seizures even after taking at least two anti-epileptic medications. Subscribe to Drugs.com newsletters for the latest medication news, new drug approvals, alerts and updates. However, this article should not be used as a substitute for the knowledge and expertise of a licensed healthcare professional. A boxed warning alerts doctors and patients about drug effects that may be dangerous. Drug classes: Benzodiazepine anticonvulsants, Benzodiazepines. Do not use if you are pregnant or may become pregnant. Drug information provided by: Merative, Micromedex. Preventing seizures may outweigh these risks. If a patient develops withdrawal reactions, consider pausing the taper or increasing the dosage to the previous tapered dosage level. Learn about its causes, symptoms, and treatments here. You should always consult your doctor or another healthcare professional before taking any medication. For information about the effectiveness of Diastat, see the Diastat and Diastat Acudial for seizures section below. It alerts doctors and patients about drug effects that may be dangerous. It is sold worldwide, under 500 different names, and it was the most sold drug in the United States of America between 1968 and 1982. For oral dosage forms (solution or tablets): For anxiety: Adults2 to 10 milligrams (mg) 2 to 4 times a day. But its important to talk with your doctor about whether this is safe for you. To learn more, see the Diastat and Diastat Acudial withdrawal and dependence section below. The Diastat and Diastat Acudial dosage your doctor prescribes will depend on several factors. The actual price youll pay depends on your insurance plan, your location, and the pharmacy you use. 1989;10(6):597-605. doi:10.1002/bdd.2510100609. And aside from its lower cost, generic Valium has been found to have similar effectiveness. Check with your health insurance provider about the cost for each medication. These side effects may go away during treatment as your body adjusts to the medicine. Diastat is a Schedule IV substance, which means it can cause dependence or has the potential for misuse. everyday life usually does not require treatment with an anxiolytic. Chemical formula: C16H13ClN2ODrugbank ID: DB00829ATC code: N05BA01. However, people using Diastat were more likely to report sleepiness than those using a placebo. Children 6 months of age and olderAt first, 1 to 2.5 mg 3 or 4 times per day. The drug information contained herein is subject to change and is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you think you or someone else may have overdosed on: If someone collapses or isn't breathing after taking. Diazepam tablet. Management of Anxiety Disorders and Relief of Symptoms of Anxiety. Yes, its safe to take Diastat with you while traveling, as long as you store it at the proper temperature. If you use diazepam during pregnancy, your baby could be born with life-threatening withdrawal symptoms, and may need medical treatment for several weeks. The active ingredient in Diastat and Diastat Acudial, diazepam, is a Schedule IV controlled substance. On average, the cost of Diazepam without health insurance may be approximately $16.58 for 30, 5MG Tablet. Examples of these drugs include: redness, tenderness, or hardness to the eyes. And if you have additional questions about sleepiness while using Diastat, talk with your doctor or pharmacist. This article provides several useful tips on medication disposal. Diastat is available in the following strength: Diastat Acudial comes in the following strengths and syringe sizes: The 10-mg syringe dispenses doses of 5 mg and 10 mg. And the 20-mg syringe dispenses doses of 12.5 mg to 20 mg. 4 While the physiological effects may only last between four to six hours, the drug will be detectable in the body for much . information highlighted below and resubmit the form. And, if you become pregnant while using Diastat, be sure to notify your doctor right away. If you have additional questions about breastfeeding and Diastat, talk with your doctor. To learn about other mild side effects, talk with your doctor or pharmacist, or view the drugs prescribing information. ADULTS: USUAL DAILY DOSE: How long a medication remains effective can depend on many factors, including how and where you store the medication. Read our. This drug comes with several precautions. The keto diet is a high-fat, low-carbohydrate diet. CYP2C19 and CYP3A4 inhibitors. Adjunctively in Convulsive Disorders 2 mg to 10 mg, 2 to 4 times daily In clinical studies, the drug was shown to prevent seizures for several hours when used at the start of a seizure episode. escitalopram, cyclobenzaprine, duloxetine, clonazepam, alprazolam, Lexapro, lamotrigine, lorazepam, atenolol, Xanax. Diastat is meant to be used as a long-term treatment. Diazepam Intensol; Valium; Descriptions. The manufacturer of the drug specifically recommends against this. It isnt known how often this occurred in clinical studies. Animal studies also showed that diazepam caused congenital anomalies (commonly known as birth defects), including cleft palate, when it was given to pregnant animals. Depending on which way the drug is administered, you will be able to feel its effects rather quickly. This medicine may also be used to treat certain seizure disorders and help relax muscles or relieve muscle spasm. The manufacturer of the generic diazepam you get can change every time you get your prescription filled, meaning the inactive ingredients in your medication can change from fill to fill as well. Could a new blood biomarker help predict Alzheimer's risk? Adjunctively for Relief of Skeletal Muscle Spasm. How might bacteria-eating viruses and gut bacteria contribute to longevity? The insurance company will review the prior authorization request and decide if they will cover the drug. Diastat works to slow or stop symptoms of a refractory seizure. Likewise, you may be able to take one generic Valium, but not another. Diazepam is used to relieve symptoms of anxiety and alcohol withdrawal. Diazepam is a benzodiazepine (ben-zoe-dye-AZE-eh-peen) that is used to treat anxiety disorders, or alcohol withdrawal symptoms. The most common effects of diazepam are drowsiness, sleepiness, and poor coordination, which makes it very dangerous for you and others. Different interactions can cause different effects. Last updated on Dec 5, 2022. Prescription only Lamictal is used to decrease the frequency and severity of seizures in some types of epilepsy and also to stabilize mood in bipolar disorder. Store at room temperature away from moisture, heat, and light. See the Diastat and Diastat Acudial withdrawal and dependence section below for more information. Diastat is only given as needed to treat refractory seizures. CYP2C19 and CYP3A4 are enzymes (a type of protein) that help your body break down drugs like Diastat. Diastat should be stored at 77 F (25 C). Drinking alcohol or using street drugs also increases your risk of serious side effects. 6 and D&C Yellow No. The syringes have a special molded tip that is used to administer the medication rectally (no needle is used). 2-10 mg PO q6-12hr, OR. Valium levels typically peak in the bloodstream in about one to two hours. In addition to the active ingredient diazepam, each tablet contains the following inactive ingredients: colloidal silicon dioxide, magnesium stearate, microcrystalline cellulose, pregelatinized starch (corn) and sodium lauryl sulfate. Particularly if you have intolerances or allergies, check with your healthcare provider and your pharmacist to make sure that the list of ingredients in the medication you are getting is safe for you. Diazepam is a benzodiazepine medication that is FDA approved for the management of anxiety disorders, short-term relief of anxiety symptoms, spasticity associated with upper motor neuron disorders, adjunct therapy for muscle spasms, preoperative anxiety relief, management of certain refractory epilepsy patients, and adjunct in severe recurrent convulsive seizures, and an adjunct in status . Some people taking Diastat in clinical studies reported symptoms of CNS depression. These side effects may include trouble breathing and trouble feeding. Select one or more newsletters to continue. It also helps keep the drug from harming the environment. Symptomatic Relief in Acute Alcohol Withdrawal. Sharing this information can help you avoid potential interactions. Anxiety or tension associated with the stress of . If you have additional questions about glaucoma and using Diastat, talk with your doctor. The active ingredient in Diastat, diazepam, can interact with alcohol. Overdoses of benzodiazepines (including diazepam) are usually manifested by symptoms ranging from drowsiness, difficulty breathing to coma. If you have any questions about eating certain foods with Diastat, talk with your doctor. This medication works by calming. [1], Due to the risk of falling while taking diazepam, people over the age of 65 usually require a lower dosage [1], For seizures, it can also be taken as a nasal spray. Michael Bihari, MD, is a board-certified pediatrician, health educator, and medical writer, and president emeritus of the Community Health Center of Cape Cod. Diazepam can still be detected long after it has left the system. You should only use it as needed to treat refractory seizures. For this reason, you should avoid breastfeeding while using Diastat unless your doctor has given you specific instructions on when you should and should not breastfeed based on your dosage. Call your healthcare provider immediately if you or a loved one is taking diazepam and experience increased irritability, aggression, panic attacks, or depression. If taken for muscle spasms, you should begin to feel them subside within 15 minutes and your muscles will begin to relax after taking it for a few days. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. * It isnt recommended for daily use. Diazepam is used to treat anxiety, alcohol withdrawal, and seizures. To see how Diastat performed in clinical studies, please see the drugs prescribing information. We comply with the HONcode standard for trustworthy health information. Drug information provided by: Merative, Micromedex. It isnt known exactly how Diastat works, but it may slow down how quickly your brain can send certain electrical signals. Diazepam is an anti-anxiety medication that is mainly prescribed for general anxiety disorder, status epilepticus (continuous seizures), muscle spasms, and acute alcohol withdrawal. Clorazepate (Tranxene-T) 15 mg 3.75 mg, 7.5 mg, 15 mg Long 40-50 Diazepam (Valium) 10 mg 2 mg, 5 mg, 10 mg Very Long 20-80 Estazolam 2 mg 1 mg, 2 mg Intermediate 10-24 Flurazepam 15-30 mg 15 mg, 30 mg Very Long 47-100 Your practitioner should talk to you about whether there are known reasons why you might be prone to addiction before taking the medication. Some people have thoughts about suicide while taking diazepam. According to the manufacturer labels, both Valium and a generic diazepam (manufacturer TEVA) are similar in their efficacy. That means that while you may react well to brand-name Valium, a generic version may have components that you don't react well to (e.g., lactose or a dye). Disclosing your full family and personal medical history is important in this regard. They can help recommend the safest, most effective treatment for your seizures that takes into account any other medical conditions you may have. Dangerous side effects or death could occur. This is the amount of time it takes for the active substance to reduce by half in your body. Note: Because the autoinjector provides a minimum dose of 10 mg diazepam, it This medication works by calming . As with most drugs, some people can have an allergic reaction after receiving Diastat. You should store Diastat and Diastat Acudial syringes at room temperature, no more than 77F (25C), in a tightly sealed container away from light. Types of drugs that could cause an interaction with Diastat include: If you have questions about potential interactions with Diastat, talk with your doctor or pharmacist. Brain can send certain electrical signals brand-name Valium had a peak concentration and absorption that was higher than type! 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