It works by decreasing appetite. Check in with your doctor after about 16 weeks of treatment with Contrave. Before approving coverage for Contrave, your insurance company may require you to get prior authorization. For instance, some interactions can interfere with how well a drug works. Overview Uses Dosage Side Effects Interactions Low-dose naltrexone therapy helps to relieve pain and fatigue associated with fibromyalgia and chronic fatigue syndrome . The absence of warnings or other information for a given drug does not indicate that the drug or drug combination is safe, effective, or appropriate for all patients or all specific uses. The most common, Stomach problems like nausea, vomiting, constipation or diarrhea, and stomach pain, Weight loss may increase the risk of low blood sugar (hypoglycemia) in people with. You may have tried various lifestyle changes, such as a reduced-calorie diet and increased exercise, and may be interested in trying a prescription medication to help with weight loss. PhenQ: Click Here To Buy (Official Website #2. This means that the drug is released more slowly into your body for a longer lasting effect. Prescription prices may vary from pharmacy to pharmacy and are subject to change. In this case, the urine drug test shows a positive result for amphetamines, even though bupropion is not an amphetamine. Before starting Contrave treatment, tell your doctor if you have closed-angle glaucoma. Suddenly stop drinking alcohol or taking certain medications. . Because of the seriousness of this side effect, Contrave is not approved for use in children. * An ER form of a drug slowly releases its active ingredients over a longer period of time. This drug comes with several precautions. This will be the dosage you follow until your doctor has you stop taking Contrave. This can increase the amount of SSRI in your body. Talk to your healthcare provider about lifestyle changes that you can employ while taking Contrave. Contrave Oral All generic drug interactions for naltrexone-bupropion oral (lists will include brand and generic names): 8 contraindicated drug interactions 31 serious drug interactions 188 significant drug interactions 33 minor drug interactions Patients and Caregivers Clinician Explanation If you become pregnant while taking Contrave, tell your doctor right away. The 988 Suicide and Crisis Lifeline is available 24 hours a day at 988. They may adjust your diabetes treatment plan. To learn about other mild side effects, talk with your doctor or pharmacist, or view Contraves medication guide. Contrave can be used (along with diet and exercise) as a long-term treatment for chronic weight management in adults with an initial body mass index (BMI) of: Contrave has not been studied along with other weight-loss medications, including prescription medicines, over-the-counter drugs, or dietary supplements. Like any drug, Contrave can cause side effects. If you have had an allergic reaction to Contrave or any of its ingredients, your doctor likely wont prescribe Contrave. The following table gives an overview of these two drugs. Do not take any other weight-loss medications (such as. A generic drug is an exact copy of the active drug in a brand-name medication. If you have questions about interactions that may affect you, talk with your doctor or pharmacist. Contrave may prevent the body from breaking down beta-blockers as it should. . Effects of naltrexone sustained-release/bupropion sustained-release combination therapy on body weight and glycemic parameters in overweight and obese patients with type 2 diabetes [published correction appears in Diabetes Care . Pricing Drug Information Is it safe to take Contrave for weight loss? It is based on sildenafil citrate and caffeine citrate (the active ingredients of Viagra and Caffeine citrate, respectively), and Viagra and Caffeine citrate (the brand names). These include: Note: For more information about the potential negative effects of Contrave, see the Contrave side effects section above. You can also call the American Association of Poison Control Centers at 800-222-1222 or use its online tool. Contrave-a combination of bupropion and naltrexone for weight loss. , heroin, or street drugs. This can include setting an alarm or using a timer. Generics tend to cost less than brand-name drugs. The exact effect of these products on Contrave may vary from person to person. Do not take Contrave with a high-fat meal. Before having a urine drug test for amphetamines, be sure your doctor knows youre taking Contrave. Both naltrexone and bupropion can help control feelings of pleasure you get when eating. These drugs include liraglutide (Saxenda) and semaglutide (Wegovy) and should be taken along with a balanced diet and exercise. One of these studies, the, Contrave Obesity Research I (COR-I) study. Patients should be advised to limit excessive caffeine intake during bupropion therapy. Having obesity doesn't mean you'll also have a high resting heart rate (RHR), but it does raise the risk that your RHR, blood pressure, cholesterol, The difference between overweight and obesity is determined by body mass index (BMI). There are currently no reports of Contrave interacting with vaccines. Examples of other drugs that contain bupropion include: Before starting Contrave treatment, tell your doctor if you take any of these medications. who take insulin or certain diabetes medications such as glyburide or glimepiride. With dependence, your body needs the drug to feel as you typically would.). It is not known if Contrave can increase the risk of heart problems or stroke, or of death caused by heart problems or stroke. These factors include if you take another drug that increases your risk of seizures or if you have a seizure disorder or a condition that may cause seizures. What to do if you start taking a new drug during your Contrave treatment. If you struggle with your weight, youre not alone. They can recommend a treatment other than Contrave for you. This condition is a medical emergency. Like other drugs, Contrave may have interactions. Contrave is used for weight management in people with weight-related conditions such as high blood pressure, diabetes, or high cholesterol, Saxenda aids in weight loss for adults and children 12 years of age and older by controlling appetite and slowing digestion, Phentermine side effects in females include menstrual cycle changes and lower sex drive, Wellbutrin (bupropion), Prozac (fluoxetine), and Effexor (venlafaxine), are antidepressants that are known to have a lower risk of weight gain and may even contribute to weight loss, You can buy phentermine online but follow these safety tips to avoid illegal or fake phentermine, Common Contrave side effects include nausea, constipation, and headache. The Contrave dosage your doctor prescribes will depend on several factors. Call 911 or your local emergency number if your symptoms feel life threatening or if you think youre having a medical emergency. These medications arent known to interact with each other. Note that the information below does not include all other possible interactions with Contrave. Small Batch Coffee & Tea Brewery. Theyll determine whether Contrave is right for you. A boxed warning alerts doctors and patients about drug effects that may be dangerous. Then theyll adjust it over time to reach the recommended daily dosage. Before its approval, Contrave was studied in several clinical trials. They may prescribe a lower dosage of Contrave than usual. If youre breastfeeding or plan to breastfeed, talk with your doctor. Interactions can also occur if you have certain health conditions. Contrave is also meant to be used in combination with a balanced diet and exercise. Tell them about all prescription, over-the-counter, and other drugs you take. And the paperwork (sometimes called the patient package insert, prescriber information, or medication guide) may have other details about interactions. You may hear a lot of talk about how to eat healthy, but getting started is another matter. If you have any questions about weight management and Contrave, talk with your doctor. Increased blood sugar monitoring may be required. DISCLAIMER: This drug information content is provided for informational purposes only and is not intended to be a substitute for professional medical advice, diagnosis, or treatment. If youre interested in this option, check with your doctor and your insurance company. Severe allergic reaction (symptoms such as hives, difficulty breathing, chest pain, or swelling of the face, lips, tongue, or throat require emergency medical help), Severe skin reactions (the following symptomsfever, sore throat, burning eyes, skin pain, red or purple rash, blistering or peeling skinrequire emergency medical attention), Take other medications that contain bupropion, Have an eating disorder or history of eating disorders (such as anorexia or bulimia), Take opioid-containing medicines or use medications to help you stop taking opioid pain medicines, Drink a lot of alcohol and then stop drinking, Take sleeping medicine, anxiety medicine, or anti-seizure medicine and stop taking it suddenly, Are taking a monoamine oxidase inhibitor (MAOI) medicine, Are allergic to naltrexone, bupropion, or any ingredient in Contrave. If youre interested in this option, check with your doctor or your insurance company. Understanding the Link Between Obesity and Skin Problems. To learn more about how Contrave and phentermine compare, talk with your doctor or pharmacist. You may wonder how Contrave compares with similar drugs, such as the brand-name prescription drug Saxenda. Although Contrave contains bupropion, which is an antidepressant, Contrave should not be used for depression, other mental health conditions, or for smoking cessation. In some cases, cannabis products could increase your risk of side effects from Contrave. This may raise your risk of side effects from Contrave. This study found that people who took Contrave: Lost more weight than those who took a placebo, Had improved blood sugar control as measured by hemoglobin A1C, Had improved triglycerides and HDL cholesterol, Contrave contains naltrexone (an opioid antagonist) and bupropion (an antidepressant). Or your doctor may prescribe a treatment other than Contrave for you. Taking Contrave with high fat meals increases the level of the drug in your body. This is because naltrexone can make opioids less effective than usual. For more information about eating a balanced diet, see this article. The drug information contained herein is subject to change and is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. They can tell you whether its safe to take this drug. You can help ease the symptoms of a hot flash by: For additional tips that may help with hot flashes, see this article. This study found: In the Contrave Obesity Research II (COR-II) study, participants took either Contrave or a placebo for 56 weeks. Both Contrave and amantadine can increase the level of a certain chemical called dopamine in your body. Before its approval, Contrave was studied in several clinical trials. For this reason, its still important to check with your doctor or pharmacist before taking any of these products while taking Contrave. If you have any symptoms of worsening depression or suicidal thoughts, contact your doctor right away. Nominate your favorite pharmacy staff for a Best of the Best award! Last medically reviewed on October 16, 2022. Taking an MAOI with Contrave could raise your risk of severely high blood pressure. You should take Contrave twice per day, once in the morning and once in the evening. They can give you tips on how to manage any side effects that may be concerning or bothersome. Treatment is available. Our Terms and Conditions and Privacy Policy have recently been updated. This can help manage cravings. Discuss caffeine intake with your healthcare provider. In clinical trials, some people taking Contrave reported having hot flashes. (Naltrexone is one of the active ingredients in bupropion.). The side effects of these drugs vary, though some are similar. Serious side effects specific to Saxenda include inflammation of the pancreas and gallbladder problems. A boxed warning is the most serious warning from the FDA. Contrave is actually two older drugs, combined: the antidepressant bupropion (Wellbutrin and generic), and the addiction-treatment drug, naltrexone (ReVia and generic). Specialty Coffees & Teas on Tap Get Your Growler Fills! Contrave may not be right for you if your body mass index (BMI) is below a certain level. for at least 7 to 10 days before starting Contrave. Naltrexone is an opioid antagonist. Depending on your health history and other drugs you may take, your doctor will prescribe the right weight-loss treatment for you. It is a stimulant and acts similar to amphetamine. People tend to make many mistakes when they try to lose weight. Contrave may pass into breast milk, which could cause side effects in a breastfed child. These are known as contraindications. If you take opioids, your doctor likely wont prescribe Contrave for you. The tablet should not be crushed, chewed, or cut. While taking Contrave, you should pay close attention to any unusual changes in your mood, behaviors, thoughts, or feelings. This date is typically 1 year from the date they dispensed the medication. Alcohol can increase the risk of seizures. Different interactions can cause different effects. This program is administered by Medical Security Card Company, LLC, Tucson, AZ. Due to these risks, your doctor may suggest you avoid alcohol while taking bupropion. When used improperly or without medical supervision, these medications can result in slowed breathing which can be life-threatening . But if your symptoms are severe, call 911 or your local emergency number, or go to the nearest emergency room right away. Taking Contrave with amantadine (Gocovri) can increase the risk of side effects from Contrave and amantadine. According to the, Centers for Disease Control and Prevention, (CDC), 73.6% of adults 20 years and older are overweight, and almost 42% of adults have. Carefully consider a patient's caffeine intake from all sources, including medicines. Contrave can cause mild or serious side effects. Having a high level of dopamine can raise your risk of side effects from either drug. Your doctor can recommend what to do if this happens. If recommended by your doctor, you may be able to receive a 90-day supply of Contrave, so theres less concern about running out of the medication. The insurance company will review the prior authorization request and decide if the drug will be covered. For more information and to find out if youre eligible to use this coupon card, visit the manufacturers site. Taking certain steps can help you avoid interactions with Contrave. Taking Contrave in these situations can increase your risk of seizures. To learn more about Contraves CurAccess program, see the manufacturers site. Examples of these medications include barbiturates, benzodiazepines, and seizure drugs. Week 2: The typical dose is 1 tablet by mouth . Contrave may increase the risk of suicidal thoughts and behaviors. Naltrexone is a medication that has been used to treat alcohol dependence and opioid-use disorder for more than 30 years. Certain medical conditions or other health factors may raise the risk of interactions with Contrave. In clinical trials, most people had significant weight loss 4 weeks after starting treatment with Contrave. Before taking Contrave, talk with your doctor and pharmacist. 2023 Healthline Media LLC. Then, the dose will be raised in the following weeks until you've reached a maintenance dose. Also ask loved ones, caregivers you may have, and healthcare professionals you may see to watch for such changes. Obesity is a health condition that can raise your risk of diseases like diabetes. You may wonder how Contrave compares with similar drugs, such as the generic prescription drug phentermine. Or they may prescribe a drug other than Contrave for you. Disclaimer: Healthline has made every effort to make certain that all information is factually correct, comprehensive, and up to date. Click here for more links and local resources. MNT is the registered trade mark of Healthline Media. Manufacturer Coupons and Offers Available. Taking Contrave with a meal that is high in fat can make you more likely to have a seizure. For example, both Contrave and Saxenda may increase the risk of suicidal thoughts and behaviors. This is because weight loss during pregnancy may cause harm to the fetus. If you think you may have a medical emergency, immediately call your physician or dial 911. Before taking Contrave, read the prescription label and information leaflets that come with your prescription. You could also download a reminder app on your phone. Any medical information published on this website is not intended as a substitute for informed medical advice and you should not take any action before consulting with a healthcare professional. Viagra Norvasc singulair Prilosec Zoloft . Always swallow the Contrave tablet whole. For more information about Contraves boxed warning, see the Contrave side effects section above. Is the ketogenic diet right for autoimmune conditions? Of the total drug interactions, 34 are major, and 288 are moderate. This medicine is used in people who are overweight or very overweight and who also . Buying Viagra Online: The 4 Best Online Sources of . Taking Contrave with selective serotonin reuptake inhibitors (SSRIs) can raise your risk of side effects from SSRIs. But only Contrave carries a boxed warning for this side effect. Participants took Contrave or a placebo and followed dietary and exercise modification advice. I got their nitro Simplicitea which is their mango black tea! To learn more about how Contrave and Saxenda compare, talk with your doctor or pharmacist. Examples of high fat foods include cheese and avocado. It is a combination medication that contains two active ingredients, naltrexone HCl and bupropion HCl. Contrave has a boxed warning, or black box warning, which is the most serious warning required by the US Food and Drug Administration (FDA). If your body is exposed to too much bupropion, you may have an increased risk of seizures. Type 2 diabetes. If youve had an allergic reaction. This feeling can occur either all over the body or in the upper part only. But Contrave contains bupropion, which, when combined with alcohol, may lead to changes in how you think, feel, or behave. If you have any concerns about how Contrave might make you feel, talk with your doctor or pharmacist. If you already have liver problems, your doctor will prescribe you a lower dose of Contrave. Its unknown whether Contrave is safe or effective to use with other weight-loss products. You can take Contrave with or without food. 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