Ebselen as a glutathione peroxidase imitator, is a great scavenger of peroxynitrite (9). The role of mannitol as a nephroprotectant in patients receiving cisplatin therapy. 1997;40:293308. A high number of cisplatin cycles was previously identified as a risk factor for renal toxicity [15]. 2023 BioMed Central Ltd unless otherwise stated. Jiang H, Zuo J, Li B, Chen R, Luo K, Xiang X, Lu S, Huang C, Liu L, Tang J, Gao F. Redox Biol. The following variables were found to be significantly associated with transient renal toxicity at univariable analysis: cirrhosis (p=0.027), hypertension (p=0.020), alcohol abuse (p=0.030), number of total cycles <4 (p=0.002) (Table3). Mannitol is used to reduce cisplatin-induced nephrotoxicity, which is controversial. You may report side effects to FDA at 1-800-FDA-1088. One study on rats showed that the combination of ebselen and allopurinol, which is a xanthine oxidase inhibitor with the potential to diminish ROS generation, reduced CIN. Yao X, Panichpisal K, Kurtzman N, Nugent K. Cisplatin nephrotoxicity: a review. Contrib Nephrol. Dose-dependent protection by lipoic acid against cisplatin-induced nephrotoxicity in rats: Antioxidant defense system. Five patients (3%) received concomitant treatment with metformin, 13 (7%) angiotensin converting enzyme and 28 (15%) with NSAIDs. Although we did not perform an analysis to support this, cases developing renal impairment often required supplementary outpatient visits for i.v. -, Latcha, S. et al. Aydin I, Agilli M, Aydin FN. Eur. Cisplatin is an effective chemotherapeutic agent for various solid tumours, but its use is limited by adverse effects in normal tissues. Dextrose hydration may promote cisplatin-induced nephrotoxicity in rats: Gender-related difference. Overall survival with cisplatin-gemcitabine and bevacizumab or placebo as first-line therapy for nonsquamous non-small-cell lung cancer: results from a randomised phase III trial (AVAiL). Would you like email updates of new search results? Provided by the Springer Nature SharedIt content-sharing initiative. The use of a risk prediction model successfully predicted the risk of nephrotoxicity throughout all cycles of cisplatin in an outpatient setting. 2000;20:376773. According to the results of this study, the amount of ARF incidence resulting from this drug in patients, who were hydrated with the mentioned protocol was 6.6% which is significantly less than the reported prevalence of this side-effect in patients, who are not hydrated (19). 10. Use Caution/Monitor. Epub 2017 Apr 5. In C57BL/6 mice, cisplatin treatment induced p53 . Disclaimer. [, Principal 7: There is controversy regarding the use of mannitol for diuresis. https://doi.org/10.1186/s40360-020-0398-3, DOI: https://doi.org/10.1186/s40360-020-0398-3. An official website of the United States government. Sanchez-Gonzalez PD, Lopez-Hernandez FJ, Lopez-Novoa JM, Morales AI. Regulated cell death pathways in kidney disease. Yoshida T, Niho S, Toda M, Goto K, Yoh K, Umemura S, et al. Administration of intravenous magnesium with hydration is recommended only when the serum level of magnesium is lower than normal Table 1.45. Santos NA, Bezerra CS, Martins NM, Curti C, Bianchi ML, Santos AC. IsfahanMN Institute of Basic and Applied Sciences Research, Isfahan, Iran. Daugaard G. Cisplatin nephrotoxicity: experimental and clinical studies. A number of potential therapeutic targets for cisplatin nephrotoxicity have been identified. Before Cancer Chemother Pharmacol. 2023 May;19(5):281-299. doi: 10.1038/s41581-023-00694-0. et al. Influence of magnesium and parathyroid hormone on cisplatin-induced nephrotoxicity in esophageal squamous cell carcinoma. Molecular mechanisms of cisplatin-induced nephrotoxicity: a balance on the knife edge between renoprotection and tumor toxicity. Risk factors for cisplatin-induced nephrotoxicity and potential of magnesium supplementation for renal protection. belatacept and cisplatin both increase immunosuppressive effects; risk of infection. Acute kidney injury, glomerular capillary endothelial injury, tubulointrestitial disease, and renal electrolyte disorders are the most frequent adverse effects of CP therapy, which are major causes of morbidity and mortality among cancer patients. Peroxisome proliferator-activated receptor alpha (PPAR-) is the transcription factor which controls lipid metabolism and glucose homeostasis; it is highly expressed in the kidneys and interacts with both MATE-1 and OCT-2. No funding was requested or received for the production of the present study. Cisplatin (cis-diamminedichloroplatinum II, CDDP) is one of the most effective chemotherapeutic agents. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. For this reason we decided to develop an outpatient cisplatin administration program. Your privacy choices/Manage cookies we use in the preference centre. Cisplatin-induced oxidative stress in the kidney may be prevented by natural antioxidant compounds. Background: Cisplatin is a major antineo- plastic drug for the treatment of solid tumors, but it has dose-dependent renal toxicity. Inclusion in an NLM database does not imply endorsement of, or agreement with, Privacy Since cisplatin is predominantly excreted in the kidneys, the accumulation of the cisplatin in the renal tubular cells directly sharing sensitive information, make sure youre on a federal official website and that any information you provide is encrypted However, treatment with cisplatin in cancer therapy has major side effects, such as nephrotoxic acute kidney injury. 1983;147:363. Cisplatin discontinuation rate was 27,7%, of which, 8.1% was due to renal toxicity. Further research using tumour-bearing animals, multi-omics and genome-wide association studies will enable a comprehensive understanding of the complex cellular and molecular mechanisms of cisplatin nephrotoxicity and potentially lead to the identification of specific targets to protect the kidney without compromising the chemotherapeutic efficacy of cisplatin. For the univariable analysis the statistical significance of the selected variables was calculated using Fishers exact or chi-squared, as appropriated. Mousavi SS, Zadeh MH, Shahbazian H, Khanzadeh A, Hayati F, Ghorbani A. et al. Beside the pathological mechanisms involve rise of upregulation of transforming growth factor-, endothelin-1, augmentation of oxidative stress, necrosis, apoptosis and increase in macrophage/monocyte infiltration into the renal cortex and medulla (1). 4,5 AKI is an established risk factor for short- and long-term morbidity . As a library, NLM provides access to scientific literature. However, cisplatin-induced nephrotoxicity is a major dose-limiting factor and a significant adverse event. Saline, mannitol, and furosemide hydration in acute cisplatin nephrotoxicity: a randomized trial. Hum Exp Toxicol. Cisplatin is an antineoplastic agent (cancer medicine). Mazaheri S, Nematbakhsh M, Bahadorani M, Pezeshki Z, Talebi A, Ghannadi AR, et al. EZ: statistical analysis, study design. 5.1 Nephrotoxicity . A number of pharmacologic agents including N-acetylcysteine, theophylline and have also been offered to prevent and or diminish renal toxicity of this drug, however none of them has an established role (12,13). J. Pharmacol. Received 2015 Jul 19; Accepted 2015 Aug 12. There are two major requirements and a major license. Npoje s vysokm obsahom antioxidantov, ako s vitamny C a E, preukzatene zlepuj erektiln funkciu tm, e brnia pokodeniu buniek, produkujcich oxid dusnat," hovor Pearlmanov. It has conclusively been shown differences in GFR between the two groups after the third cycle and also 1 month after the end of chemotherapy. Patients presenting these baseline characteristics may require more frequent post-cycle check-up visits and hydration treatment should be guaranteed as soon as a reduction of creatinine clearance is detected. Cisplatin is important chemotherapeutic agents used to treat solid tumors, including head, ovarian and neck, and testicular germ cell tumors, which its use is limited because of cisplatin-induced nephrotoxicity (CIN) that can be progressive in significant percent of patients. Drug-induced oxidative stress in cancer treatments: Angel or devil? 2,3 Acute kidney injury (AKI) occurs in up to 30% of children and 33% of adults treated with cisplatin. Delivery of antioxidants to mitochondria is one of the most important mechanism for prevention of CIN with the purpose of decreasing toxic oxidative stress injuries. The site is secure. Article Effect of enalapril in cisplatin-induced nephrotoxicity in rats; gender-related difference. Am. 2001;20:4539. Vitamin E, vitamin C, or losartan is not nephroprotectant against cisplatin-induced nephrotoxicity in presence of estrogen in ovariectomized rat model. 2005;148:10721. government site. In the early trials prior to the use of preventive measures, the amount of acute renal failure (ARF) incidence resulting from this drug was observed in more than 5o% of cases. Deletion of NADPH oxidase 2 attenuates cisplatin-induced acute kidney injury through reducing ROS-induced proximal tubular cell injury and inflammation. Age, gender, concurrent use of reninangiotensin system inhibitor drugs, the level of female sex hormone estrogen, and estimated GFR should be considered in the first step. Autophagy is a lysosomal degradation pathway that removes protein aggregates and damaged or dysfunctional cellular organelles for maintaining cell homeostasis. It is important to note that for many malignancies, cisplatin is used in combination with other drugs that may also be nephrotoxic. Bookshelf Taguchi T, Nazneen A, Abid MR, Razzaque MS. Cisplatin-associated nephrotoxicity and pathological events. A review. The local ethical review board approved this retrospective analysis (Comitato Etico Cantonale, Email address: dss-ce@ti.ch - Web page: https://www4.ti.ch/dss/dsp/us/ce/comitato/). Hollenberg NK, Adams DF, Solomon H, Chenitz WR, Burger BM, Abrams HL, et al. Based on the clinical evidences, to reduce the CP-induced nephrotoxicity, the CP prescribing should be accompanied by hydration of the patient. 26, 25 (2019). Sci. In addition, 3 patients received aminoglycoside antibiotics (2%), 2 patients received glycopeptides (1%) and 36 patients were treated with other antibiotics (19%). Google Scholar. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. Haghighi M, Nematbakhsh M, Talebi A, Nasri H, Ashrafi F, Roshanaei K, et al. Call your doctor for medical advice about side effects. Cisplatin (CP) is the most frequently used drug for cancer treatment. 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