Use Caution/Monitor. After thawing, shake well and squeeze the bag to check for leaks. Providencia spp. Cefotaxime sodium salt Write a review potency: 916-964 g per mg Synonym (s): Cefotaxime, Cefotaxim sodium salt Empirical Formula (Hill Notation): C16H16N5NaO7S2 CAS Number: 64485-93-4 Molecular Weight: 477.45 Beilstein: 5711411 EC Number: 264-915-9 MDL number: MFCD00079073 PubChem Substance ID: 24278336 NACRES: NA.85 25 VIAL, PATENT DELIVERY SYSTEM in 1 CARTON, 1 INJECTION, POWDER, FOR SOLUTION in 1 VIAL, PATENT DELIVERY SYSTEM. Cefotaxime for Injection, like other parenteral anti-infective drugs, may be locally irritating to tissues. Avoid or Use Alternate Drug. Serious - Use Alternative (1)cefotaxime decreases effects of BCG vaccine live by pharmacodynamic antagonism. Cefotaxime and its metabolites excreted principally in urine. Synopsis Cefotaxime is well established as an effective and well tolerated antibacterial drug for 3 times daily parenteral treatment of a variety of moderate to severe infections in hospitalised patients. It is given either by injection into a vein or muscle. Either increases toxicity of the other by nephrotoxicity and/or ototoxicity. (5) Skin and skin structure infections caused by Staphylococcus aureus (penicillinase and non-penicillinase producing), Staphylococcus epidermidis, Streptococcus pyogenes (Group A streptococci) and other streptococci, Enterococcus species, Acinetobacter species*, Escherichia coli, Citrobacter species (including C. freundii*), Enterobacter species, Klebsiella species, Proteus mirabilis, Proteus vulgaris*, Morganella morganii, Providencia rettgeri *, Pseudomonas species, Serratia marcescens, Bacteroides species, and anaerobic cocci (including Peptostreptococcus* species and Peptococcus species). Also, uncomplicated gonorrhea (cervical/urethral and rectal) caused by Neisseria gonorrhoeae, including penicillinase producing strains. Cefotaxime for injection is contraindicated in patients who have shown hypersensitivity to Cefotaxime sodium, or the cephalosporin group of antibiotics. cefotaxime will decrease the level or effect of bazedoxifene/conjugated estrogens by altering intestinal flora. Cefotaxime for injection was not mutagenic in the mouse micronucleus test or in the Ames test. As with other cephalosporins, Cefotaxime may potentiate the nephrotoxic effects of nephrotoxic drugs such as aminoglycosides, NSAIDs and furosemide. Monitor Closely (1)voclosporin, cefotaxime. Antibiotic medicines can cause diarrhea, which may be a sign of a new infection. Cefotaxime is used to treat a wide variety of bacterial infections. If you log out, you will be required to enter your username and password the next time you visit. Using antibiotics when they are not needed increases your risk of getting an infection later that resists antibiotic treatment. 500 mg for 1 dose. CLINICAL PHARMACOLOGY This drug is known to be substantially excreted by the kidney, and the risk of toxic reactions to this drug may be greater in patients with impaired renal function. This category also provides a buffer zone that prevents small uncontrolled technical factors from causing major discrepancies in interpretation. Antibacterial agents may decrease efficacy if coadministered. probenecid will increase the level or effect of cefotaxime by acidic (anionic) drug competition for renal tubular clearance. How to store Cefotaxime Netpharmalab 1g Powder for Solution for Injection or Infusion 6. Cefotaxime is used to treat many kinds of bacterial infections, including severe or life-threatening forms. The molecular formula is C16H16N5NaO7S2 and molecular weight is 477.45. Therefore, when cephalosporins are used in the treatment of patients with pelvic inflammatory disease and C. trachomatis is one of the suspected pathogens, appropriate anti-chlamydial coverage should be added. Medically reviewed by Drugs.com. cefotaxime will increase the level or effect of sulfasalazine by acidic (anionic) drug competition for renal tubular clearance. Cefotaxime is used to treat a wide variety of bacterial infections. pharmacodynamic antagonism. Use Caution/Monitor. Do not use two doses at one time. Your doctor may order certain lab tests to check your body's response to cefotaxime injection. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. These MICs provide estimates of the susceptibility of bacteria to antimicrobial compounds. Gastrointestinal (1.4%) - Colitis, diarrhea, nausea, and vomiting. Terminal serum half-life of cefotaxime and desacetylcefotaxime is 0.9-1.7 and 1.4-1.9 hours, respectively. Read and carefully follow any Instructions for Use provided with your medicine. (Viridans group streptococci), Acinetobacter spp. Administration of Cefotaxime in excess of 6 grams/day should be avoided in patients receiving probenecid (see CLINICAL PHARMACOLOGY, Drug Interactions). Proteus vulgaris 2 1 Enterococcus species may be intrinsically resistant to Cefotaxime. Cardiovascular System - Potentially life-threatening arrhythmias following rapid (less than 60 seconds) bolus administration via central venous catheter have been observed. Two other urinary metabolites (M2 and M3) account for about 20 to 25%. A report of Susceptible indicates that the antimicrobial drug is likely to inhibit growth of the pathogen if the antimicrobial drug reaches the concentration at the site of infection. It may also be used to prevent infection from certain surgeries. After mixing cefotaxime with a diluent, you may need to store the mixture in a refrigerator and use it within a certain number of days. (7) Bone and/or joint infections caused by Staphylococcus aureus (penicillinase and non-penicillinase producing strains), Streptococcus species (including S. pyogenes*), Pseudomonas species (including P. aeruginosa*), and Proteus mirabilis*. Significant mortality was seen at parenteral doses in excess of 6000 mg/kg/day in all groups. 0409-0812-01 Cefotaxime for Injection, USP 2 gram Carton of 25 vials. Streptococcus pneumoniae meningitis isolates. Additionally, no disulfiram-like reactions were reported in a study conducted in 22 healthy volunteers administered Cefotaxime for injection and ethanol. Females: 0.85 above value. It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. Most Specimens for bacteriologic culture should be obtained prior to therapy in order to isolate and identify causative organisms and to determine their susceptibilities to Cefotaxime. No evidence of embryotoxicity or teratogenicity was seen in these studies. Coadministration with antibiotics decreases efficacy by altering colonic bacterial flora needed to convert sodium picosulfate to active drug. To prevent postoperative infection in contaminated or potentially contaminated surgery, the recommended dose is a single 1 gram IV administered 30 to 90 minutes prior to start of surgery. rose hips will increase the level or effect of cefotaxime by acidic (anionic) drug competition for renal tubular clearance. Proteus mirabilis 2 Use Caution/Monitor. Cefotaxime sodium 500mg, 1g, 2g, 10g; IM or IV inj; sodium content 2.2mEq/g. The dosage is based on your medical condition and response to treatment.If you are using this medication at home, learn all preparation and usage instructions from your health care professional. In patients undergoing cesarean section, intraoperative (after clamping the umbilical cord) and postoperative use of Cefotaxime for Injection, USP may also reduce the incidence of certain postoperative infections. The administration of Cefotaxime for Injection, USP preoperatively reduces the incidence of certain infections in patients undergoing surgical procedures (e.g., abdominal or vaginal hysterectomy, gastrointestinal and genitourinary tract surgery) that may be classified as contaminated or potentially contaminated. Pharmaceutical form Applies to the following strengths: 500 mg; 1 g; 2 g; 10 g; 1 g/50 mL; 2 g/50 mL; 20 g Usual Adult Dose for: Bacteremia Septicemia Sepsis Cesarean Section Meningitis CNS Infection Pelvic Inflammatory Disease Endometritis Gonococcal Infection - Uncomplicated Infections commonly needing Npoje s vysokm obsahom antioxidantov, ako s vitamny C a E, preukzatene zlepuj erektiln funkciu tm, e brnia pokodeniu buniek, produkujcich oxid dusnat," hovor Pearlmanov. (See DOSAGE AND ADMINISTRATION section.). HOW TO USE: This medication is given by injection into a muscle or vein as directed by your doctor. However, the efficacy of Cefotaxime in treating clinical infections due to these microorganisms has not been established in adequate and well-controlled clinical trials. provider for the most current information. Special Populations Males: 72 x serum creatinine Ask your pharmacist any questions you have about cefotaxime injection. Carefully follow all mixing and storage instructions for cefotaxime. Use cefotaxime for the full prescribed length of time, even if your symptoms quickly improve. Other drugs may affect cefotaxime, including prescription and over-the-counter medicines, vitamins, and herbal products. Overdose symptoms may include weakness, cold feeling, pale skin, blue lips, or seizure (convulsions). In a couple of weeks, rock overlords Queens Of The Stone Age will return with their new album In Times New Roman; we've already posted the singles "Emotion Sickness" and "Carnavoyeur." MISSED DOSE: It is important to get each dose of this medication as scheduled. Slow intravenous injection . See DOSAGE AND ADMINISTRATION section. Neisseria meningitidis The pH of the injectable solutions usually ranges from 5.0 to 7.5. Repeated evaluation of the patient's condition is essential. During post-marketing surveillance, a potentially life-threatening arrhythmia was reported in each of six patients who received a rapid (less than 60 seconds) bolus injection of Cefotaxime through a central venous catheter. Minor/Significance Unknown. Because these reactions were reported voluntarily from a population of uncertain size, it is not possible to reliably estimate their frequency or establish a causal relationship to drug exposure. Keep all appointments with your doctor and the laboratory. This medication may be prescribed for other uses; ask your doctor or pharmacist for more information. Use Caution/Monitor. (1) Lower respiratory tract infections, including pneumonia, caused by Streptococcus pneumoniae (formerly Diplococcus pneumoniae), Streptococcus pyogenes* (Group A streptococci) and other streptococci (excluding enterococci, e.g., Enterococcus faecalis), Staphylococcus aureus (penicillinase and non-penicillinase producing), Escherichia coli, Klebsiella species, Haemophilus influenzae (including ampicillin resistant strains), Haemophilus parainfluenzae, Proteus mirabilis, Serratia marcescens*, Enterobacter species, indole positive Proteus and Pseudomonas species (including P. aeruginosa). Smoothie. Contraindicated. Careful medical history is necessary since CDAD has been reported to occur over two months after the administration of antibacterial agents. They do not treat viral infections (e.g., the common cold). Call your doctor at once if you have: severe stomach pain, diarrhea that is watery or bloody (even if it occurs months after your last dose); burning, irritation, or skin changes where the injection was given; dark urine, jaundice (yellowing of the skin or eyes); easy bruising, unusual bleeding, pale skin, cold hands and feet. If given by injection into a vein, inject the drug slowly over at least 3 minutes to avoid possible serious side effects (such as irregular heartbeat). You should begin to feel better during the first few days of treatment with cefotaxime injection. Nausea and vomiting have been reported rarely. Liver - Transient elevations in AST, ALT, serum LDH, and serum alkaline phosphatase levels have been reported. Instead, the best way to dispose of your medication is through a medicine take-back program. What Cefotaxime injection looks like and contents of the pack: Cefotaxime injection is a white to slightly yellow powder in a glass vial. tell your doctor if you are pregnant, plan to become pregnant, or are breastfeeding. Genitourinary System - Moniliasis, vaginitis. Methods of intravenous administration. Each vial contains Cefotaxime sodium equivalent to 1 gram or 2 gram of Cefotaxime. NOTE: As with antibiotic therapy in general, administration of Cefotaxime for injection should be continued for a minimum of 48 to 72 hours after the patient defervesces or after evidence of bacterial eradication has been obtained; a minimum of 10 days of treatment is recommended for infections caused by Group A beta-hemolytic streptococci in order to guard against the risk of rheumatic fever or glomerulonephritis; frequent bacteriologic and clinical appraisal is necessary during therapy of chronic urinary tract infection and may be required for several months after therapy has been completed; persistent infections may require treatment of several weeks and doses smaller than those indicated above should not be used. Citrobacter spp.2 chloramphenicol decreases effects of cefotaxime by pharmacodynamic antagonism. This belongs to a group of medicines Use of the drug in women of child-bearing potential requires that the anticipated benefit be weighed against the possible risks. Access your plan list on any device mobile or desktop. Cefotaxime for Injection, USP contains approximately 50.5 mg (2.2 mEq) of sodium per gram of Cefotaxime activity. When available, the clinical microbiology laboratory should provide the results of in vitro susceptibility test results for antimicrobial drug products used in resident hospitals to the physician as periodic reports that describe the susceptibility profile of nosocomial and community-acquired pathogens. Use Caution/Monitor. There was a dose-dependent increase in serum levels after the IV administration of 1 gram and 2 gram of Cefotaxime for injection (101.7 and 214.4 mcg/mL respectively) without alteration in the elimination half-life. Minimum Inhibitory Concentrations (mcq/mL). Kidney - As with some other cephalosporins, transient elevations of BUN have been occasionally observed with Cefotaxime for injection. If superinfection occurs during therapy, appropriate measures should be taken. Monitor Closely (1)cefotaxime will decrease the level or effect of ethinylestradiol by altering intestinal flora. Drug class: third generation cephalosporins. Minor (1)rose hips will increase the level or effect of cefotaxime by acidic (anionic) drug competition for renal tubular clearance. Last updated on Dec 22, 2022. Use Caution/Monitor. Sometimes after starting treatment with antibiotics, patients can develop watery and bloody stools (with or without stomach cramps and fever) even as late as two or more months after having taken the last dose of the antibiotic. Bacteroides spp, Citrobacter spp, Clostridium spp, Enterobacter spp, Escherichia coli, Haemophilus influenzae, Klebsiella spp, Moraxella catarrhalis, Morganella morganii, Neisseria gonorrhoeae, Neisseria meningitidis, Peptococcus spp, Peptostreptococcus spp, Proteus mirabilis, Providencia rettgeri, Pseudomonas spp, Serratia spp, Staphylococcus aureus, Streptococcus agalactiae, Streptococcus pneumoniae, Streptococcus pyogenes, 1 month-12 years: 50-180 mg/kg/day IV divided q4-6hr, levonorgestrel oral/ethinylestradiol/ferrous bisglycinate, sodium picosulfate/magnesium oxide/anhydrous citric acid. Please confirm that you would like to log out of Medscape. If you are using the injections at home, be sure you understand how to properly mix and store the medication. Liver - Hepatitis, jaundice, cholestasis, elevations of gamma GT and bilirubin. It is the sodium salt of 7- [2- (2-amino-4-thiazolyl . Cefotaxime for Injection should be prescribed with caution in individuals with a history of gastrointestinal disease, particularly colitis. Applies only to oral forms of hormone. This medicine can affect the results of certain medical tests. The zone size provides an estimate of the susceptibility of bacteria to antimicrobial compounds. Minor/Significance Unknown. Your doctor may need to change the doses of your medications or monitor you carefully for side effects. This drug is known to be substantially excreted by the kidney, and the risk of toxic reactions to this drug may be greater in patients with impaired renal function. Symptoms of pseudomembranous colitis can appear during or after antibiotic treatment. No overall differences in safety or effectiveness were observed between these subjects and younger subjects, and other reported clinical experience has not identified differences in responses between the elderly and younger patients, but greater sensitivity of some older individuals cannot be ruled out. . Avoid coadministration of cholera vaccine with systemic antibiotics since these agents may be active against the vaccine strain. Make sure you understand how to store your medication properly. When only serum creatinine is available, the following formula5 (based on sex, weight, and age of the patient) may be used to convert this value into creatinine clearance. Drug class: Third generation cephalosporins. Information last revised October 2021. Applies only to oral forms of hormone. NOTE: Cefotaxime for Injection, USP in the dry state should be stored at 20 to 25C (68 to 77F) [See USP Controlled Room Temperature]. The acute toxicity of Cefotaxime was evaluated in neonatal and adult mice and rats. Consult your pharmacist or local waste disposal company. Minor/Significance Unknown. Most Manufactured for: Modify Therapy/Monitor Closely. Monitor Closely (1)cefotaxime will decrease the level or effect of levonorgestrel oral/ethinylestradiol/ferrous bisglycinate by altering intestinal flora. Cefotaxime for injection in ADD-Vantage vial is intended for IV use only after reconstitution. Information is also available online at https://www.poisonhelp.org/help. Diarrhea is a common problem caused by antibiotics which usually ends when the antibiotic is discontinued. Either increases levels of the other by decreasing renal clearance. The MIC values obtained should be interpreted according to the criteria provided in Table 1. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. Leukopenia, neutropenia, granulocytopenia and, more rarely, bone marrow failure, pancytopenia, or agranulocytosis may develop during treatment with Cefotaxime for injection. There is a risk of reversible encephalopathy in cases of administration of high doses of beta-lactam antibiotics including Cefotaxime. Minor/Significance Unknown. Standardized susceptibility test procedures require the use of laboratory controls to monitor and ensure the accuracy and precision of supplies and reagents used in the assay, and the techniques of the individual performing the test1,2,3,4. Cefotaxime sodium has been shown to be active against most isolates of the following bacteria both in vitro and in clinical infections as described in the INDICATIONS AND USAGE section. Staphylococcus epidermidis Coadministration with drugs associated with nephrotoxicity may increase the risk for acute and/or chronic nephrotoxicity. Use Caution/Monitor. Antibiotics such as cefotaxime injection will not work for colds, flu, or other viral infections. Cefotaxime injection may also be used before surgery, and during and after a cesarean section, in order to prevent the patient from getting an infection. Cefotaxime for Injection, USP is supplied as follows: NDC Vial Package Factor, 0409-0811-01 Cefotaxime for Injection, USP 1 gram Carton of 25 vials Use Caution/Monitor. La Operacin Deluxe tiene mucho -o todo- que ver con el final de Slvame, previsto para el prximo viernes 23 de junio. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.This is not a complete list of possible side effects. Susceptibility to Cefotaxime will vary geographically and may change over time; local susceptibility data should be consulted, if available. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Share cases and questions with Physicians on Medscape consult. Minor/Significance Unknown. (8) Central nervous system infections, e.g., meningitis and ventriculitis, caused by Neisseria meningitidis, Haemophilus influenzae, Streptococcus pneumoniae, Klebsiella pneumoniae* and Escherichia coli*. Be sure to mention any of the following: amikacin, furosemide (Lasix), gentamicin, kanamycin, neomycin (Neo-Fradin), nonsteroidal anti-inflammatory medications (NSAIDs) such as ibuprofen (Advil, Motrin) and naproxen (Aleve), probenecid (Probalan), streptomycin, and tobramycin. Providencia rettgeri 2 cefotaxime decreases effects of sodium picosulfate/magnesium oxide/anhydrous citric acid by altering metabolism. A single 50 mg/kg dose of Cefotaxime for injection was administered as an intravenous infusion over a 10 to 15 minute period to 29 newborn infants grouped according to birth weight and age. Cefotaxime sodium has in vitro activity against a wide range of gram-positive and gram-negative organisms. Approximately 20 to 36% of an intravenously administered dose of 14C-Cefotaxime is excreted by the kidney as unchanged Cefotaxime and 15 to 25% as the desacetyl derivative, the major metabolite. He armed himself with a balaclava, latex gloves, condoms . Urinary tract infections caused by Enterococcus species, Staphylococcus epidermidis, Staphylococcus aureus*, (penicillinase and non-penicillinase producing), Citrobacter species, Enterobacter species, Escherichia coli, Klebsiella species, Proteus mirabilis, Proteus vulgaris*, Providencia stuartii, Morganella morganii*, Providencia rettgeri*, Serratia marcescens and Pseudomonas species (including P. aeruginosa). This document does not contain all possible drug interactions. The maximum daily dosage should not exceed 12 grams. However, if it is almost time for the next dose, skip the missed dose and continue your regular dosing schedule. Common side effects of cefotaxime may include: pain, bruising, swelling, or other irritation where the injection was given; This is not a complete list of side effects and others may occur. Applies only to oral forms of hormone. Enterobacter spp.2 20022002607-overviewDiseases & Conditions, encoded search term (cefotaxime (Claforan)) and cefotaxime (Claforan), Cross-Reactivity of Cefotetan and Ceftriaxone Antibodies, Associated With Hemolytic Anemia, With Other Cephalosporins and Penicillin, Pneumonia in the Pregnant Patient: A Synopsis, You Give Me Fever: Four Other Tickborne Illnesses. pharmacodynamic antagonism. commonly, these are "non-preferred" brand drugs or specialty It works by stopping the growth of bacteria. Cefotaxime injection is also available as a premixed product to be injected intravenously. Dosage form: injectable powder for injection (1 g; 10 g; 2 g; 500 mg) Your list will be saved and can be edited at any time. The CAS Registry Number is 64485-93-4. Photo: Andreas Neumann. Susceptible breakpoints are based on a dose of 1 gram q 8h in patients with normal renal function. Wait until Abx Tx complete to administer live bacterial vaccine. cefotaxime will increase the level or effect of choline magnesium trisalicylate by acidic (anionic) drug competition for renal tubular clearance. There are no other ingredients. Cefotaxime is a prescription medication used to treat the symptoms of Gonococcal Urethritis/Cervicitis, Gonorrhea, Rectal, Infections Caused by Susceptible Organisms and prophylaxis of surgical infection. Contraindicated. The premium product BATCH gummies is full-spectrum, vegan-friendly, and made with solely natural components. The most frequent adverse reactions (greater than 1%) are: Local (4.3%) - Injection site inflammation with IV administration. Low risk of contraceptive failure. 2 Most extended spectrum beta-lactamase (ESBL)-producing and carbapenemase-producing isolates are resistant to Cefotaxime. Cefotaxime, better known as Claforan, is an injectable antibiotic sometimes used for dogs and cats. In case of overdose, call the poison control helpline at 1-800-222-1222. All material on this website is protected by copyright, Copyright 1994-2023 by WebMD LLC. Women's health is once again the center of a political ping-pong match with evidence-based science on one side and anti-choice advocates on the other. Applies only to oral forms of hormone. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. Subscribe to Drugs.com newsletters for the latest medication news, new drug approvals, alerts and updates. 1. Monitor Closely (1)cefotaxime decreases effects of sodium picosulfate/magnesium oxide/anhydrous citric acid by altering metabolism. If you notice other effects not listed above, contact your doctor or pharmacist.In the US -Call your doctor for medical advice about side effects. Minor/Significance Unknown. Low risk of contraceptive failure. URL of this page: https://medlineplus.gov/druginfo/meds/a682765.html. 1g vial IV: 95: 24 hours: 7 days: 5 days: 2g vial IV: 180: 12 hours: 7 days: 5 days: 1g infusion bottle: 10-20: 24 hours: 10 days: 2g infusion bottle: 20-40: Medscape prescription drug monographs are based on FDA-approved labeling information, unless otherwise noted, combined with additional data derived from primary medical literature. By Neisseria gonorrhoeae, including severe or life-threatening forms dispose of your or... Https: //www.poisonhelp.org/help new infection ; local susceptibility data should be consulted, if it is the salt... Time ; local susceptibility data should be prescribed with caution in individuals with a history of gastrointestinal,! ( M2 and M3 ) account for about 20 to 25 % to slightly yellow in. Or if you are using the injections at home, be sure you understand how to cefotaxime. Effect of ethinylestradiol by altering colonic bacterial flora needed to convert sodium picosulfate to active drug, new drug,... Injection in ADD-Vantage vial is intended for medical advice, diagnosis or treatment please confirm that would! Decreasing renal clearance of 25 vials obtained should be avoided in patients who have hypersensitivity! 60 seconds ) bolus administration via central venous catheter have been observed the criteria provided Table. By nephrotoxicity and/or ototoxicity CDAD has been reported, respectively injectable solutions usually ranges 5.0. Serum creatinine Ask your doctor and the laboratory need to change the doses of beta-lactam antibiotics cefotaxime... 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