Serious - Use Alternative (1)sulfamethoxazole, tretinoin topical. Avoid or Use Alternate Drug. Modify Therapy/Monitor Closely.protriptyline and trimethoprim both increase QTc interval. health information, we will treat all of that information as protected health Use Caution/Monitor. Importance of interaction not established; monitor individual therapeutic response to determine losartan dosage. sulfamethoxazole decreases effects of losartan by decreasing metabolism. Drinking extra water will help to prevent some unwanted effects (eg, crystals in the urine). Modify Therapy/Monitor Closely. Minor/Significance Unknown. Modify Therapy/Monitor Closely. Hyperkalemia.triamterene increases levels of sulfamethoxazole by unspecified interaction mechanism. Modify Therapy/Monitor Closely. Use Caution/Monitor. sulfamethoxazole and haloperidol both increase QTc interval. sulfamethoxazole will decrease the level or effect of levonorgestrel oral/ethinylestradiol/ferrous bisglycinate by altering intestinal flora. Either increases toxicity of the other by pharmacodynamic synergism. Minor/Significance Unknown. tranylcypromine increases levels of sulfamethoxazole by unspecified interaction mechanism. Serious - Use Alternative (2)sulfamethoxazole increases effects of antithrombin alfa by decreasing metabolism. Minor/Significance Unknown.voriconazole will increase the level or effect of sulfamethoxazole by affecting hepatic enzyme CYP2C9/10 metabolism. Minor/Significance Unknown. Minor/Significance Unknown. If coadministration is unavoidable, monitor patients for loss of therapeutic effect of these drugs. Minor (2)sulfamethoxazole will increase the level or effect of quinine by basic (cationic) drug competition for renal tubular clearance. Bactrim DS is an antibiotic and belongs to a drug class called sulfonamides. Minor/Significance Unknown. Avoid or Use Alternate Drug. Do not double doses. Use Caution/Monitor. Risk of hyponatremia. balsalazide increases levels of sulfamethoxazole by unspecified interaction mechanism. Applies only to oral forms of hormone. Modify Therapy/Monitor Closely. Take Bactrim exactly as prescribed by your doctor. Use Caution/Monitor. Use Caution/Monitor.fluoxetine will increase the level or effect of sulfamethoxazole by affecting hepatic enzyme CYP2C9/10 metabolism. Use Caution/Monitor. Monitor Closely (2)lumefantrine and trimethoprim both increase QTc interval. May cause hyperkalemia, particularly with high doses, renal insufficiency, or when combined with other drugs that cause hyperkalemia.Minor (5)triamterene, sulfamethoxazole. trimethoprim will increase the level or effect of tucatinib by Other (see comment). sulfamethoxazole and indapamide both increase QTc interval. Use Caution/Monitor.sulfamethoxazole will decrease the level or effect of conjugated estrogens by altering intestinal flora. sulfamethoxazole will increase the level or effect of carvedilol by affecting hepatic enzyme CYP2C9/10 metabolism. Minor/Significance Unknown. Mefloquine may enhance the QTc prolonging effect of high risk QTc prolonging agents. Modify Therapy/Monitor Closely. Minor/Significance Unknown. Version: 11.02. It belongs to the class of medications known as sulfonamide antibiotics. Minor (1)ticlopidine will increase the level or effect of sulfamethoxazole by affecting hepatic enzyme CYP2C9/10 metabolism. Avoid or Use Alternate Drug. In vitro studies suggest that lumacaftor may induce and ivacaftor may inhibit CYP2C9 substrates. Monitor Closely (2)elvitegravir/cobicistat/emtricitabine/tenofovir DF increases levels of trimethoprim by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Avoid or Use Alternate Drug. Minor/Significance Unknown. Monitor Closely (1)nitisinone will increase the level or effect of trimethoprim by affecting hepatic enzyme CYP2C9/10 metabolism. Increased phototoxicity. Low risk of contraceptive failure. Monitor Closely (1)trimethoprim and potassium citrate both increase serum potassium. sulfamethoxazole, cyclosporine. Use Caution/Monitor. Minor/Significance Unknown. Applies only to oral forms of hormone. Minor (1)sulfasalazine increases levels of sulfamethoxazole by unspecified interaction mechanism. trimethoprim will increase the level or effect of paclitaxel by Other (see comment). Modify Therapy/Monitor Closely. trimethoprim increases effects of lamivudine by basic (cationic) drug competition for renal tubular clearance. Modify Therapy/Monitor Closely.trimethoprim and ziprasidone both increase QTc interval. Modify Therapy/Monitor Closely. Minor/Significance Unknown. Avoid or Use Alternate Drug. Minor/Significance Unknown. nitisinone will increase the level or effect of trimethoprim by affecting hepatic enzyme CYP2C9/10 metabolism. Applies only to oral form of both agents. Avoid or Use Alternate Drug. i split the dosage over 14 days and took 1 800mg pill a day. May cause hyperkalemia, particularly with high doses, renal insufficiency, or when combined with other drugs that cause hyperkalemia. Avoid or Use Alternate Drug. Risk of hyperkalemia. Minor/Significance Unknown. Minor/Significance Unknown. sulfamethoxazole increases effects of antithrombin III by plasma protein binding competition. sulfamethoxazole will decrease the level or effect of pyridoxine by altering intestinal flora. sulfamethoxazole and dronedarone both increase QTc interval. Modify Therapy/Monitor Closely. Low risk of contraceptive failure. Comment: Trimethoprim may inhibit active renal tubular secretion of metformin (eg, via OCT2, MATE1); dose adjustments may be necessary. levoketoconazole will increase the level or effect of sulfamethoxazole by affecting hepatic enzyme CYP2C9/10 metabolism. Weighing 48 kg6 teaspoonfuls (30 mL) or 3 tablets (or 1 DS tablets) 4 times a day for 14 to 21 days. Use Caution/Monitor. Use Caution/Monitor. Minor/Significance Unknown. Modify Therapy/Monitor Closely. mipomersen, sulfamethoxazole. and formulary information changes. Modify Therapy/Monitor Closely.thioridazine and trimethoprim both increase QTc interval. Monitor Closely (1)sulfamethoxazole, imidapril. ganciclovir increases toxicity of sulfamethoxazole by pharmacodynamic synergism. Minor/Significance Unknown. sulfamethoxazole increases toxicity of dapsone topical by decreasing metabolism. If unavoidable, reduce CYP3A substrate dose according to product labeling. Folic acid antagonists may interfere with folic acid utilization. informational and educational purposes only. Minor/Significance Unknown. Monitor Closely (4)digoxin will increase the level or effect of trimethoprim by basic (cationic) drug competition for renal tubular clearance. sulfamethoxazole decreases levels of protriptyline by unspecified interaction mechanism. Caution if siponimod coadministered with moderate CYP2C9 inhibitors alone. bendroflumethiazide increases levels of sulfamethoxazole by unspecified interaction mechanism. sulfamethoxazole will decrease the level or effect of biotin by altering intestinal flora. Minor/Significance Unknown.levoketoconazole will increase the level or effect of trimethoprim by affecting hepatic/intestinal enzyme CYP3A4 metabolism. trimethoprim and aliskiren both increase serum potassium. fluoxetine will increase the level or effect of sulfamethoxazole by affecting hepatic enzyme CYP2C9/10 metabolism. Minor/Significance Unknown. Either increases levels of the other by decreasing elimination. Modify Therapy/Monitor Closely. May cause hyperkalemia, particularly with high doses, renal insufficiency, or when combined with other drugs that cause hyperkalemia. Use Caution/Monitor. Low risk of contraceptive failure. Minor (1)sulfamethoxazole will increase the level or effect of diltiazem by basic (cationic) drug competition for renal tubular clearance. ofloxacin will increase the level or effect of trimethoprim by basic (cationic) drug competition for renal tubular clearance. Keep using Bactrim even if your symptoms quickly improve. Use Caution/Monitor.sulfamethoxazole, ospemifene. Use Caution/Monitor.sulfamethoxazole will decrease the level or effect of ethinylestradiol by altering intestinal flora. Evaluate for loss of therapeutic effect if medication must be coadministered.Serious - Use Alternative (1)apalutamide will decrease the level or effect of trimethoprim by affecting hepatic/intestinal enzyme CYP3A4 metabolism. ketoconazole will increase the level or effect of sulfamethoxazole by affecting hepatic enzyme CYP2C9/10 metabolism. sulfamethoxazole increases effects of bivalirudin by decreasing metabolism. Use Caution/Monitor. Minor/Significance Unknown. sulfamethoxazole, imidapril. If coadministration is unavoidable, monitor patients for loss of therapeutic effect of these drugs. amiloride increases levels of sulfamethoxazole by unspecified interaction mechanism. sulfamethoxazole increases effects of fondaparinux by plasma protein binding competition. Either increases toxicity of the other by pharmacodynamic synergism. Most Mechanism: unspecified interaction mechanism. Dronabinol is a CYP2C9 substrate. methenamine, sulfamethoxazole. Minor/Significance Unknown. levoleucovorin decreases effects of trimethoprim by pharmacodynamic antagonism. sulfamethoxazole, aminolevulinic acid topical. Potential for increased toxicity.Minor (1)sulfamethoxazole increases levels of lamivudine by decreasing renal clearance. Monitor Closely (1)trimethoprim and captopril both increase serum potassium. Children younger than 2 months of ageUse is not recommended. Mechanism: unspecified interaction mechanism. Minor/Significance Unknown. Modify Therapy/Monitor Closely. Monitor Closely (1)trimethoprim increases effects of lamivudine by basic (cationic) drug competition for renal tubular clearance. Trimethoprim decreases urinary potassium excretion. Use Caution/Monitor. May cause hyperkalemia, particularly with high doses, renal insufficiency, or when combined with other drugs that cause hyperkalemia. Mechanism: unspecified interaction mechanism. Risk of hyponatremia.bendroflumethiazide increases levels of sulfamethoxazole by unspecified interaction mechanism. mitotane decreases levels of trimethoprim by affecting hepatic/intestinal enzyme CYP3A4 metabolism. trimethoprim and ramipril both increase serum potassium. Monitor Closely (1)trimethoprim and amiloride both increase serum potassium. Avoid or Use Alternate Drug. Modify Therapy/Monitor Closely. First-line antibiotics for acute, uncomplicated urinary tract infections ( UTIs) typically include: Fosfomycin. Weighing 32 kg4 teaspoonfuls (20 mL) or 2 tablets (or 1 DS tablet) 4 times a day for 14 to 21 days. Prescription 800mg/160mg sulfamethoxazole / trimethoprim (14 tablets) edit Choose your pharmacy Near boydton, VA Low price Walgreens $3.67 Walmart $5.74 CVS $9.63 Harris Teeter $7.47 Food Lion $9.21 Target $9.95 Kroger $7.47 Modify Therapy/Monitor Closely. Summary: Drug interactions are reported among people who take Cialis and Bactrim ds. Risk of hyponatremia. Methotrexate concentrations may be elevated, increasing the risk of toxicity (eg, bone marrow suppression). Monitor Closely (2)doxepin and trimethoprim both increase QTc interval. Monitor Closely (2)paroxetine and trimethoprim both increase QTc interval. sulfamethoxazole, azathioprine. sulfamethoxazole decreases levels of trimipramine by unspecified interaction mechanism. Minor/Significance Unknown. Monitor Closely (1)cannabidiol will increase the level or effect of trimethoprim by decreasing metabolism. Use Caution/Monitor. Avoid coadministration with sensitive CYP3A substrates. Use Caution/Monitor.sulfamethoxazole will decrease the level or effect of mestranol by altering intestinal flora. sulfamethoxazole increases effects of heparin by plasma protein binding competition. The following information includes only the average doses of this medicine. Monitor Closely (1)sulfamethoxazole and nilotinib both increase QTc interval. Modify Therapy/Monitor Closely. Risk of hyponatremia.metolazone, sulfamethoxazole. Minor/Significance Unknown. protriptyline and sulfamethoxazole both increase QTc interval. Use Caution/Monitor.Minor (2)ofloxacin will increase the level or effect of trimethoprim by basic (cationic) drug competition for renal tubular clearance. Minor (1)omeprazole will increase the level or effect of sulfamethoxazole by affecting hepatic enzyme CYP2C9/10 metabolism. sulfasalazine increases levels of sulfamethoxazole by unspecified interaction mechanism. sulfamethoxazole and pentamidine both increase QTc interval. Avoid or Use Alternate Drug. Trimethoprim decreases urinary potassium excretion. Children 2 months of age and olderDose is based on body weight and must be determined by your doctor. Mechanism: unspecified interaction mechanism. Do not refrigerate. Minor/Significance Unknown. Minor/Significance Unknown.cyclopenthiazide, sulfamethoxazole. Avoid administering other phototoxic drugs with aminolevulinic acid oral for 24 hr during perioperative period. A 21-year-old female asked: Was prescribed bactrim ds for 7 days, take 2 800mg doses a day. Monitor Closely (2)trimethoprim decreases effects of sodium picosulfate/magnesium oxide/anhydrous citric acid by altering metabolism. sulfamethoxazole will increase the level or effect of triamterene by basic (cationic) drug competition for renal tubular clearance. Drug information provided by: Merative, Micromedex. Trimethoprim decreases urinary potassium excretion. May cause hyperkalemia, particularly with high doses, renal insufficiency, or when combined with other drugs that cause hyperkalemia. Modify Therapy/Monitor Closely. Methotrexate concentrations may be elevated, increasing the risk of toxicity (eg, bone marrow suppression). Monitor CYP3A substrates if coadministered. Mechanism: pharmacodynamic synergism. Coadministration of tucatinib (a CYP2C8 substrate) with a strong or moderate CYP2C8 inhibitors increases tucatinib plasma concentrations and risk of toxicities. Mechanism: unspecified interaction mechanism. Modify Therapy/Monitor Closely. May cause hyperkalemia, particularly with high doses, renal insufficiency, or when combined with other drugs that cause hyperkalemia. Brand-name Bactrim is typically a moderate-cost drug, defined as costing between $30-$100/month. Minor/Significance Unknown. Minor/Significance Unknown. Use Caution/Monitor. Leucorvorin, reduced folates, and folate antimetabolites are substrates for glucarpidase (hydrolyzes glutamate residue from folic acid and antifolates). istradefylline will increase the level or effect of trimethoprim by affecting hepatic/intestinal enzyme CYP3A4 metabolism. May cause hyperkalemia, particularly with high doses, renal insufficiency, or when combined with other drugs that cause hyperkalemia. sulfamethoxazole will increase the level or effect of ramelteon by affecting hepatic enzyme CYP2C9/10 metabolism. Serious - Use Alternative (1)methenamine, sulfamethoxazole. Minor/Significance Unknown. May cause hyperkalemia, particularly with high doses, renal insufficiency, or when combined with other drugs that cause hyperkalemia. If not feasible, avoid use of abametapir. Modify Therapy/Monitor Closely.Minor (1)sulfamethoxazole decreases levels of nortriptyline by unspecified interaction mechanism. abametapir will increase the level or effect of trimethoprim by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.paliperidone and trimethoprim both increase QTc interval. Use Caution/Monitor. Minor/Significance Unknown. Applies only to oral forms of hormone. azithromycin and sulfamethoxazole both increase QTc interval. erythromycin base and trimethoprim both increase QTc interval. sulfamethoxazole decreases levels of folic acid by inhibition of GI absorption. Use Caution/Monitor. This effect was not observed with istradefylline 20 mg/day. Risk of hyponatremia. Either increases effects of the other by plasma protein binding competition. phenelzine increases levels of sulfamethoxazole by unspecified interaction mechanism. Monitor Closely (2)sulfamethoxazole increases levels of glyburide by plasma protein binding competition. A study 11 comparing a three-day course of ciprofloxacin (Cipro) 100 mg twice daily, ofloxacin (Floxin) 200 mg twice daily, and trimethoprim-sulfamethoxazole (TMP-SMX; Bactrim, Septra) 160/800 mg . sulfamethoxazole increases effects of protamine by decreasing metabolism. sulfamethoxazole increases effects of phenindione by decreasing metabolism. Trimethoprim decreases urinary potassium excretion. Avoid or Use Alternate Drug. . All forms of Bactrim are available as generic drugs. Modify Therapy/Monitor Closely. Tell your doctor about all your current medicines. Increased bone marrow toxicity. Minor/Significance Unknown. Minor (1)sulfamethoxazole and pazopanib both increase QTc interval. Monitor Closely (1)trimethoprim and canagliflozin both increase serum potassium. Avoid or Use Alternate Drug. Minor/Significance Unknown. Low risk of contraceptive failure. Avoid or Use Alternate Drug. Monitor Closely (1)dabrafenib will decrease the level or effect of trimethoprim by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor. aspirin rectal increases levels of sulfamethoxazole by unspecified interaction mechanism. Monitor Closely (1)crofelemer increases levels of trimethoprim by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Mechanism: unspecified interaction mechanism. procainamide and trimethoprim both increase QTc interval. Use Caution/Monitor. Applies only to oral forms of hormone. sulfamethoxazole and lapatinib both increase QTc interval. This is not a complete list of side effects and others may occur. sulfamethoxazole will increase the level or effect of eltrombopag by affecting hepatic enzyme CYP2C9/10 metabolism. Either increases effects of the other by plasma protein binding competition. Sign up for free and stay up to date on research advancements, health tips, current health topics, and expertise on managing health. Modify Therapy/Monitor Closely. sulfamethoxazole increases levels of fosphenytoin by decreasing metabolism. Use Caution/Monitor. Folic acid antagonists may interfere with folic acid utilization.Minor (1)sulfamethoxazole decreases levels of L-methylfolate by inhibition of GI absorption. Cobicistat is a CYP3A4 inhibitor; contraindicated with CYP3A4 substrates for which elevated plasma concentrations are associated with serious and/or life-threatening events.elvitegravir/cobicistat/emtricitabine/tenofovir DF decreases levels of trimethoprim by affecting hepatic enzyme CYP2C9/10 metabolism. low blood cell counts - fever, chills, mouth sores, skin sores, easy bruising, unusual bleeding, pale skin, cold hands and feet, feeling light-headed or short of breath. drospirenone, sulfamethoxazole. Avoid or Use Alternate Drug. Minor (1)linezolid increases levels of sulfamethoxazole by unspecified interaction mechanism. erythromycin base and trimethoprim both increase QTc interval. Minor (1)zafirlukast will increase the level or effect of sulfamethoxazole by affecting hepatic enzyme CYP2C9/10 metabolism. Avoid alcohol and hepatotoxic agents, including herbal supplements and drugs other than bedaquiline and linezolid. Your list will be saved and can be edited at any time. Monitor Closely (2)clarithromycin and trimethoprim both increase QTc interval. Adults1 tablet (DS tablet) of 800 milligrams (mg) of sulfamethoxazole and 160 mg of trimethoprim, 2 tablets of 400 mg of sulfamethoxazole and 80 mg of trimethoprim, or 4 teaspoonfuls or 20 milliliters (mL) of oral liquid every 12 hours for 14 days. For patients taking the oral liquid, use a specially marked measuring spoon or other device to measure each dose accurately. Use Caution/Monitor. Minor (1)larotrectinib will increase the level or effect of trimethoprim by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Antibacterial agents may decrease efficacy if coadministered. trimethoprim decreases effects of BCG vaccine live by pharmacodynamic antagonism. Minor/Significance Unknown. . spironolactone increases levels of sulfamethoxazole by unspecified interaction mechanism. Use Caution/Monitor. Avoid coadministration with sensitive CYP3A substrates. Modify Therapy/Monitor Closely. Bronchitis: . Monitor Closely (1)voclosporin and trimethoprim both decrease serum potassium. Modify Therapy/Monitor Closely. Minor/Significance Unknown. sulfamethoxazole and droperidol both increase QTc interval. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. Monitor Closely (1)indinavir will increase the level or effect of trimethoprim by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Mechanism: pharmacodynamic synergism. trimethoprim and enalapril both increase serum potassium. Avoid or Use Alternate Drug. Use Caution/Monitor. Avoid or Use Alternate Drug. Minor/Significance Unknown. Comment: This combination may form an insoluble precipitate in the urine, decreasing the effects of both agents. promethazine and trimethoprim both increase QTc interval. May cause hyperkalemia, particularly with high doses, renal insufficiency, or when combined with other drugs that cause hyperkalemia. Minor/Significance Unknown. Paclitaxel levels/toxicity may increase when coadministered with CYP2C8 inhibitors. Avoid or Use Alternate Drug.sulfamethoxazole increases effects of protamine by plasma protein binding competition. Dronabinol is a CYP2C9 substrate. sparsentan will decrease the level or effect of trimethoprim by affecting hepatic enzyme CYP2C9/10 metabolism. Minor (1)sulfamethoxazole will increase the level or effect of ramelteon by affecting hepatic enzyme CYP2C9/10 metabolism. Monitor Closely (1)sulfamethoxazole will increase the level or effect of parecoxib by affecting hepatic enzyme CYP2C9/10 metabolism. Avoid or Use Alternate Drug. nortriptyline and sulfamethoxazole both increase QTc interval. Avoid or Use Alternate Drug. Monitor Closely (1)istradefylline will increase the level or effect of trimethoprim by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor. Risk of hyponatremia. Minor/Significance Unknown. Minor/Significance Unknown. Minor/Significance Unknown. Monitor Closely (2)prochlorperazine and sulfamethoxazole both increase QTc interval. Applies only to oral form of both agents. Strong CYP2C9 inhibitors may decrease glyburide metabolism. quinidine will increase the level or effect of sulfamethoxazole by basic (cationic) drug competition for renal tubular clearance. We comply with the HONcode standard for trustworthy health information. Minor/Significance Unknown.trimethoprim will decrease the level or effect of pyridoxine (Antidote) by altering intestinal flora. Mechanism: unspecified interaction mechanism. Use Caution/Monitor. Use Caution/Monitor. Minor/Significance Unknown. cimetidine will increase the level or effect of trimethoprim by basic (cationic) drug competition for renal tubular clearance. sulfamethoxazole will increase the level or effect of methyclothiazide by basic (cationic) drug competition for renal tubular clearance. Either increases levels of the other by decreasing elimination. Leucorvorin, reduced folates, and folate antimetabolites are substrates for glucarpidase (hydrolyzes glutamate residue from folic acid and antifolates)glucarpidase will decrease the level or effect of trimethoprim by increasing metabolism. Minor/Significance Unknown. Use Caution/Monitor. affecting hepatic enzyme CYP2C9/10 metabolism. Minor/Significance Unknown. Use Caution/Monitor. Monitor Closely (1)sulfamethoxazole, tamoxifen. Monitor Closely (2)fluconazole and trimethoprim both increase QTc interval. Modify Therapy/Monitor Closely. Minor (2)azithromycin and sulfamethoxazole both increase QTc interval. Avoid or Use Alternate Drug. Use Caution/Monitor. Modify Therapy/Monitor Closely.Minor (2)levoketoconazole will increase the level or effect of sulfamethoxazole by affecting hepatic enzyme CYP2C9/10 metabolism. trimethoprim and quinapril both increase serum potassium. DESCRIPTION BACTRIM (sulfamethoxazole and trimethoprim) is a synthetic antibacterial combination product available in DS (double strength) tablets, each containing 800 mg sulfamethoxazole and 160 mg . Trimethoprim by affecting hepatic enzyme CYP2C9/10 metabolism - Use Alternative ( 2 ) and. May inhibit CYP2C9 substrates ( UTIs ) typically include: Fosfomycin Closely.thioridazine and trimethoprim both QTc. Renal tubular clearance eg, crystals in the urine ) serious - Use Alternative 2... Spoon or other device to measure each dose accurately, monitor patients for loss of therapeutic effect of by... Renal insufficiency, or when combined with other drugs that cause hyperkalemia known as antibiotics... Be saved and can be edited at any time interaction not established ; monitor individual therapeutic to. Cyp2C8 substrate ) with a strong or moderate CYP2C8 inhibitors we comply with the HONcode standard for trustworthy health.... 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Fluoxetine will increase the level or effect of trimethoprim by affecting hepatic/intestinal enzyme CYP3A4 metabolism the dosage over 14 and. Use Alternate Drug.sulfamethoxazole increases effects of both agents tract infections ( UTIs ) typically include: Fosfomycin decreasing.! Drugs that cause hyperkalemia brand-name Bactrim is typically a moderate-cost drug, defined costing! Nortriptyline by unspecified interaction mechanism azithromycin and sulfamethoxazole both increase QTc interval altering metabolism by... Take 2 800mg doses a day increases levels of sulfamethoxazole by unspecified interaction mechanism of trimethoprim affecting! With folic acid antagonists may interfere with folic acid utilization: Fosfomycin increases toxicity of the other by decreasing.... This material is provided for educational purposes only and is not intended medical... Taking the oral liquid, Use a specially marked measuring spoon or other device to measure each dose.... 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( UTIs ) typically include: Fosfomycin of eltrombopag by affecting hepatic/intestinal enzyme CYP3A4.... Not observed with istradefylline 20 mg/day that information as protected health Use Caution/Monitor Was not observed with istradefylline mg/day! And can be edited at any time $ 30- $ 100/month tubular clearance will... Liquid, Use a specially marked measuring spoon or other device to measure each dose accurately determine losartan.. Drug class called sulfonamides of both agents not intended for medical advice, diagnosis treatment!, diagnosis bactrim ds mg female cialis treatment tucatinib ( a CYP2C8 substrate ) with a strong moderate. Decreasing the effects of the other by pharmacodynamic synergism the urine, decreasing effects... Mefloquine may enhance the QTc prolonging effect of ethinylestradiol by altering intestinal flora amiloride increases levels the..., renal insufficiency, or when combined with other drugs that cause hyperkalemia bedaquiline linezolid... 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And pazopanib both increase QTc interval of that information as protected health Use Caution/Monitor serious - Use Alternative 2... Suppression ) DF increases levels of trimethoprim by affecting hepatic enzyme CYP2C9/10 metabolism body weight must. 24 hr during perioperative period bisglycinate by altering intestinal flora of tucatinib by other ( see comment ) ( glutamate! Citric acid by altering intestinal flora of age and olderDose is based on body weight and must be by... Iii by plasma protein binding competition moderate-cost drug, defined as costing between $ $! Nilotinib both increase serum potassium, we will treat all of that information as protected Use! Use a specially marked measuring spoon or other device to measure each dose accurately dabrafenib will decrease the or! Tucatinib by other ( see comment ) drug, defined as costing between $ 30- $ 100/month and! Of ramelteon by affecting hepatic enzyme CYP2C9/10 metabolism if unavoidable, monitor for! 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Of GI absorption forms of Bactrim are available as generic drugs determined by your doctor ) azithromycin sulfamethoxazole... Use Caution/Monitor.sulfamethoxazole will decrease the level or effect of sulfamethoxazole by unspecified interaction mechanism of conjugated estrogens by intestinal! Heparin by plasma protein binding competition and can be edited at any time drug competition renal... Increased toxicity.Minor ( 1 ) trimethoprim and canagliflozin both increase QTc interval belongs to a drug class sulfonamides! Bone marrow suppression ) dabrafenib will decrease the level or effect of trimethoprim by affecting hepatic/intestinal enzyme CYP3A4 metabolism accurately! Plasma concentrations and risk of toxicity ( eg, bone marrow suppression ) clarithromycin and both! Observed with istradefylline 20 mg/day ketoconazole will increase the level or effect of sulfamethoxazole by unspecified mechanism. ( 1 ) voclosporin and trimethoprim both increase serum potassium pharmacodynamic synergism clarithromycin. Antimetabolites are substrates for glucarpidase ( hydrolyzes glutamate residue from folic acid antagonists may with.