[4] This includes ventricular tachycardia (VT), ventricular fibrillation (VF), and wide complex tachycardia, as well as atrial fibrillation and paroxysmal supraventricular tachycardia. In the rabbit, 75 mg/kg/day (approximately 2.7 times the maximum recommended human maintenance dose1) caused abortions in greater than 90% of the animals. Bickford CL, Spencer AP. Risk of arrhythmias may increase during labor and delivery. Increased digoxin concentration. It has a pH of 4.08. Pulmonary toxicity has been fatal about 10% of the time. 2019;124:188993. The incidence of severe side effects in this group is low. Your doctor may decrease your dose during your treatment if you develop side effects. Amiodarone hydrochloride tablets can cause serious side effects that can lead to death, including: Amiodarone hydrochloride tablets can cause other serious side effects. 2005;26:24957. Amiodarone is a benzofuran derivative: 2-butyl-3-benzofuranyl 4-[2-(diethylamino)-ethoxy]-3,5-diiodophenyl ketone hydrochloride. In the rat, doses of 50 mg/kg/day or more were associated with slight displacement of the testes and an increased incidence of incomplete ossification of some skull and digital bones; at 100 mg/kg/day or more, fetal body weights were reduced; at 200 mg/kg/day, there was an increased incidence of fetal resorption. Talk to your doctor about the risks of using this medication for your condition. 2013;37:113256. Renal: renal impairment, renal insufficiency, acute renal failure. Because of the long half-life of Amiodarone (15 to 142 days) and its active metabolite desethylAmiodarone (14 to 75 days), adverse reactions and drug interactions can persist for several weeks following Amiodarone discontinuation [see Clinical Pharmacology (12.3)]. Amiodarone or an implantable cardioverterdefibrillator for congestive heart failure. This medicine is used in patients who have already been treated with other medicines that did not work well. What special dietary instructions should I follow? Amiodarone hydrochloride inhibits peripheral conversion of thyroxine (T4) to triiodothyronine (T3) and may cause increased thyroxine levels, decreased T3 levels, and increased levels of inactive reverse T3 (rT3) in clinically euthyroid patients. Aliment Pharmacol Ther. Ask your pharmacist or check the Medication Guide for a list of the ingredients. Proper Use. Isr Med Assoc J. Cardiac: hypotension (sometimes fatal), sinus arrest. Pulmonary toxicity has been fatal about 10% of the time. Goldschlager N, Epstein AE, Naccarelli GV, Olshansky B, Singh B, Collard HR, et al. In surveys of almost 5,000 patients treated in open U.S. studies and in published reports of treatment with Amiodarone hydrochloride tablets, the adverse reactions most frequently requiring discontinuation of Amiodarone hydrochloride included pulmonary infiltrates or fibrosis, paroxysmal ventricular tachycardia, congestive heart failure, and elevation of liver enzymes. Immune: anaphylactic/anaphylactoid reaction (including shock), angioedema. Dorian P, Cass D, Schwartz B, Cooper R, Gelaznikas R, Barr A. Amiodarone as compared with lidocaine for shock-resistant ventricular fibrillation. Be sure to tell every health care provider who treats you or prescribes any medication for you during this time that you have recently stopped taking amiodarone. Paxlovid interacts with many medications. [48] Today the mechanisms of action of amiodarone and sotalol have been investigated in more detail. Amiodarone Contraindications. Sinus bradycardia has been reported with oral Amiodarone in combination with lidocaine given for local anesthesia. What is the most important information I should know about Amiodarone hydrochloride tablets? For full prescribing information, please visit www.taro.com. [31], Use during pregnancy may result in a number of problems in the infant including thyroid problems, heart problems, neurological problems, and preterm birth. 1986;46:82530. The safety and effectiveness of Amiodarone hydrochloride tablets in pediatric patients have not been established. plan to avoid unnecessary or prolonged exposure to sunlight or sunlamps and to wear protective clothing, sunglasses, and sunscreen. These deposits typically do not cause any symptoms. Rushworth GF, Lambrakis P, Leslie SJ. 6 lake (200 and 300 mg only), lactose anhydrous, magnesium stearate and povidone. Initiate Amiodarone hydrochloride tablets in a clinical setting where continuous electrocardiograms and cardiac resuscitation are available, Amiodarone Hydrochloride Tablets USP, 200 mg, https://www.taro.com/usa-medication-guides. Amiodarone Hydrochloride Tablets USP, 200 mg are round, flat, beveled edge, light orange tablets; one side plain, the second side scored and engraved with "TARO" above the score and "56" below the score line and are available as follows: Overbagged with 10 tablets per bag, NDC 55154-3365-0. Induced abnormalities in thyroid function are common. Subscribe to Drugs.com newsletters for the latest medication news, new drug approvals, alerts and updates. 1984;4:1116. clinical relevance and management of drug-related QT interval prolongation. Sapp JL, Wells GA, Parkash R, Stevenson WG, Blier L, Sarrazin J-F, et al. USP dissolution test pending. Amiodarone is an inhibitor of certain cytochrome P-450 enzymes. In some clinically hypothyroid Amiodarone-treated patients, free thyroxine index values may be normal. Shea P, Lal R, Kim SS, Schechtman K, Ruffy R. Flecainide and amiodarone interaction. [4] It works partly by increasing the time before a heart cell can contract again. 1987;42:2904. 2016;36:2306. Lercanidipine. Amiodarone hydrochloride prolongs the duration of the action potential of all cardiac fibers while causing minimal reduction of dV/dt (maximal upstroke velocity of the action potential). 2006;36:28993. 1995;333:7782. - 144.91.80.228. Hematologic: hemolytic anemia, aplastic anemia, pancytopenia, neutropenia, thrombocytopenia, agranulocytosis, granuloma. Comparison of -blockers, amiodarone plus -Blockers, or sotalol for prevention of shocks from implantable cardioverter defibrillators: the OPTIC study: a randomized trial. The refractory period is prolonged in all cardiac tissues. J Clin Pharmacol. The digoxin-amiodarone interaction. Coadministration increases prothrombin time by 100% after 3 to 4 days. F.A. It is a cardiovascular drug used for the treatment of cardiac dysrhythmias. Amiodarone is widely prescribed, largely due to its efficacy in the management of both supraventricular and ventricular arrhythmias. Amiodarone taken concomitantly with digoxin increases the serum digoxin concentration by 70% after one day. The American Society of Health-System Pharmacists, 4500 East-West Highway, Suite 900, Bethesda, Maryland. Ask your pharmacist any questions you have about refilling your prescription. Cadrin-Tourigny J, Wyse DG, Roy D, Blondeau L, Levesque S, Talajic M, et al. Store it at room temperature and away from light, excess heat and moisture (not in the bathroom). As a doctoral candidate at Oxford University, Bramah Singh determined that amiodarone and sotalol had antiarrhythmic properties and belonged to a new class of antiarrhythmic agents (what would become the class III antiarrhythmic agents). Gonzalez-Rothi RJ, Hannan SE, Hood CI, Franzini DA. Amiodarone may cause your arrhythmia (irregular heart rhythm) to worsen or may cause you to develop new arrhythmias. This reduces the clearance of many drugs, including the following: In 2015, Gilead Sciences warned health care providers about people that began taking the hepatitis C drugs ledipasvir/sofosbuvir or sofosbuvir along with amiodarone, who developed abnormally slow heartbeats or died of cardiac arrest.[38]. The discoloration will slowly improve upon cessation of the medication, however, the skin color may not return completely. Do not breastfeed while you are taking amiodarone. Pharmacol Ther B. [cited 2020 Jan 30]; Available from: https://academic.oup.com/eurheartj/advance-article/doi/10.1093/eurheartj/ehz467/5556821. Shuktika Nandkeolyar. The metabolism of amiodarone is inhibited by grapefruit juice, leading to elevated serum levels of amiodarone. Repeat history, physical exam, and chest X-ray every 3 to 6 months [see Warnings and Precautions 5.2)]. Cutaneous adverse reactions of amiodarone. Once adequate arrhythmia control is achieved, or if side effects become prominent, reduce Amiodarone hydrochloride tablets dose to 600 to 800 mg/day for one month and then to the maintenance dose, usually 400 mg/day. Clopidogrel, an inactive thienopyridine prodrug, is metabolized in the liver by CYP3A to an active metabolite. [cited 2019 Jun 8]. Exposed skin may turn blue-gray and may not return to normal even after you stop taking this medication. Talk to your doctor about the risks of taking amiodarone. Dixon DL, Dunn SP, Kelly MS, McLlarky TR, Brown RE. If you get serious side effects during treatment you may need to stop Amiodarone hydrochloride tablets, have your dose changed, or get medical treatment. Although no dosage adjustment for patients with renal, hepatic, or cardiac abnormalities has been defined during chronic treatment with oral Amiodarone, close clinical monitoring is prudent for elderly patients and those with severe left ventricular dysfunction. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5963785/. You may need a dose adjustment or more frequent monitoring by your doctor to safely use both medications. Amiodarone belongs to the group of medicines known as antiarrhythmics. Circulation. Postgrad Med J. Pulmonary toxicity secondary to Amiodarone hydrochloride may result from either indirect or direct toxicity as represented by hypersensitivity pneumonitis (including eosinophilic pneumonia) or interstitial/alveolar pneumonitis, respectively. 2016;374:171122. Hypothyrodism may be primary or subsequent to resolution of preceding Amiodarone hydrochloride-induced hyperthyroidism. 2016;133:163744. 200 mg tablets: round, flat, beveled edge, light orange tablets; one side plain, the second side scored and engraved with "TARO" above the score and "56" below the score line. [2][51] This makes amiodarone one of the few drugs approved by the FDA without rigorous randomized clinical trials. The major metabolite of amiodarone is desethylamiodarone (DEA), which also has antiarrhythmic properties. Fentanyl in combination with Amiodarone may cause hypotension, bradycardia, and decreased cardiac output. It may harm them. What are Amiodarone hydrochloride tablets? You will probably be hospitalized for one week or longer when you begin your treatment with amiodarone. 2017;15:44653. Shoshana Zevin, in Cardiac Intensive Care (Third Edition), 2019. 2012;125:44753. These are not all the possible side effects of Amiodarone hydrochloride tablets. Drug information provided by: Merative, Micromedex You will receive your first dose of this medicine in the hospital. Based on papers written by Rosenbaum developing Singh's theories, physicians in the United States began prescribing amiodarone to their patients with potentially life-threatening arrhythmias in the late 1970s. Also Arycor in South Africa (Produced by Winthrop Pharmaceuticals.). In general, when the drug is resumed after recurrence of the arrhythmia, control is established relatively rapidly compared to the initial response, presumably because tissue stores were not wholly depleted. Am J Cardiol. 1986;111:12414. If administered outside of the standard concentration of 900mg/500mL it should be administered using a 0.22 micron filter to prevent precipitate from reaching the patient. Panchal Ashish R, Berg Katherine M, Kudenchuk Peter J, Marina Del Rios, Hirsch Karen G, Link Mark S, et al. Cholestyramine reduces enterohepatic circulation of Amiodarone thereby increasing its elimination. grapefruit juice, certain fluoroquinolone and macrolide antibiotics, azole antifungals, cimetidine, certain protease inhibitors. 2001;12:3726. Amiodarone is available in oral and intravenous formulations. Kumar S, Bangalore S, Kumari R, Grosu H, Jean R. Amiodarone-induced acute respiratory distress syndrome masquerading as acute heart failure. Loratadine, a non-sedating antihistaminic, is metabolized primarily by CYP3A and its metabolism can be inhibited by Amiodarone. The development of maximal ventricular class III effects after oral Amiodarone hydrochloride administration in humans correlates more closely with DEA accumulation over time than with Amiodarone accumulation. Below, check out the tour dates, as well as a weird tour . Like other antiarrhythmic drugs of this class, amiodarone works primarily by blocking potassium rectifier currents responsible for the repolarization of the heart during phase 3 of the cardiac action potential. The Vaughan Williams classification system imperfectly classifies the medication as a class III antiarrhythmic because of its predominant potassium channel blockade that increases the cardiac action potential duration . Amiodarone Indication. The effects of food upon the bioavailability of Amiodarone hydrochloride have been studied in 30 healthy subjects who received a single 600-mg dose immediately after consuming a high-fat meal and following an overnight fast. Eur Heart J [Internet]. [9][10], Amiodarone has been used both in the treatment of acute life-threatening arrhythmias as well as the long term suppression of arrhythmias. Administration of Amiodarone hydrochloride tablets in divided doses with meals is suggested for total daily doses of 1000 mg or higher, or when gastrointestinal intolerance occurs. [20][21], Thyroid function should be checked at least every six months. Amiodarone is categorized as a class III antiarrhythmic agent, and prolongs phase 3 of the cardiac action potential, the repolarization phase where there is normally decreased calcium permeability and increased potassium permeability. Circulation. Cardiovasc Drug Ther. The most specific test of pulmonary toxicity due to amiodarone is a dramatically decreased DLCO noted on pulmonary function testing. These individuals should be cardioverted. Data sources include IBM Watson Micromedex (updated 5 June 2023), Cerner Multum (updated 5 June 2023), ASHP (updated 10 Apr 2023) and others. Advise the patient to read the FDA-approved patient labeling (Medication Guide). Intravenous amiodarone for the pharmacological termination of haemodynamically-tolerated sustained ventricular tachycardia: is bolus dose amiodarone an appropriate first-line treatment? It has numerous other effects, however, including actions that are similar to those of antiarrhythmic classes Ia, II, and IV. This helps keep your heart rhythm normal. Obtain baseline and periodic liver transaminases. [15] Both under- and overactivity of the thyroid may occur. Endocrine and metabolic: thyroid nodules/thyroid cancer, syndrome of inappropriate antidiuretic hormone secretion (SIADH). [53], Amiodarone IV should be administered via a central venous catheter. Advise pregnant women of the potential risk to a fetus. 2019 ESC Guidelines for the management of patients with supraventricular tachycardiaThe Task Force for the management of patients with supraventricular tachycardia of the European Society of Cardiology (ESC)Developed in collaboration with the Association for European Paediatric and Congenital Cardiology (AEPC). Increased plasma levels of cyclosporine have been reported resulting in elevated creatinine, despite reduction of cyclosporine dose. Amiodarone may cause lung damage that can be serious or life-threatening. In India, amiodarone is marketed (produced by Cipla Pharmaceutical) under the brand name Tachyra. Correspondence to Davis PT Collection. OReilly RA, Trager WF, Rettie AE, Goulart DA. Correct hypokalemia, hypomagnesemia, and hypocalcemia before initiating treatment. You may need to be closely monitored or even hospitalized when you stop taking amiodarone. 2019;29:28595. Do not take Amiodarone hydrochloride tablets if you: Before taking Amiodarone hydrochloride tablets, tell your healthcare provider about all of your medical conditions, including if you: Tell your healthcare provider about all the medicines you take including prescription and over-the-counter medicines, vitamins, and herbal supplements. Singh SN, Fletcher RD, Fisher SG, Singh BN, Lewis HD, Deedwania PC, et al. Amiodarone for resuscitation after out-of-hospital cardiac arrest due to ventricular fibrillation. Musculoskeletal: myopathy, muscle weakness, rhabdomyolysis. The area under the plasma concentration-time curve (AUC) and the peak plasma concentration (Cmax) of Amiodarone hydrochloride increased by 2.3 (range 1.7 to 3.6) and 3.8 (range 2.7 to 4.4) times, respectively, in the presence of food. Eur J Intern Med. N Engl J Med. This effect is due to a combination of blocking the peak sodium current, but also contributing to an increased persistent sodium current. This Medication Guide has been approved by the U.S. Food and Drug Administration. Marill KA, deSouza IS, Nishijima DK, Senecal EL, Setnik GS, Stair TO, et al. Treat hypotension with inadequate tissue perfusion with positive inotropic and vasopressor agents. [1] Accumulation of amiodarone and DEA occurs in adipose tissue and highly perfused organs (i.e. Haverkamp W, Israel C, Parwani A. Klinische Besonderheiten der Therapie mit Amiodaron. Ventricular Arrhythmias, Second line agent for Atrial arrhythmias. Avoid concomitant use. Amiodarone or procainamide for the termination of sustained stable ventricular tachycardia: an historical multicenter comparison. Connolly Stuart J. Evidence-based analysis of amiodarone efficacy and safety. Holm J, Lindh JD, Andersson ML, Mannheimer B. Nitrous acid: The risk or severity of adverse effects can be increased when Amiodarone is combined with Nitrous acid. Reduce digoxin by half or discontinue. Talk with your healthcare provider before you stop taking Amiodarone hydrochloride tablets. Clin Pharmacol Ther. Regular ophthalmic examination, including funduscopy and slit-lamp examination, is recommended during administration of Amiodarone hydrochloride tablets [see Adverse Reactions (6.1)]. It has a role as a cardiovascular drug. These changes should not require discontinuation of Amiodarone hydrochloride tablets as they are evidence of its pharmacological action, although Amiodarone hydrochloride tablets can cause marked sinus bradycardia or sinus arrest and heart block [see Warnings and Precautions (5.4)]. Bottles of 90 NDC 65862-732-90. Help to use EasyBib Plus . 2018 [cited 2020 Jan 30];13. Amiodarone is extensively metabolized in the liver by cytochrome P450 3A4 and can affect the metabolism of numerous other drugs. Consistent with the slow rate of elimination, antiarrhythmic effects persist for weeks or months after Amiodarone hydrochloride is discontinued, but the time of recurrence is variable and unpredictable. Increased plasma concentration of HMG-CoA reductase inhibitor. Amiodarone hydrochloride tablets can cause pulmonary toxicity (hypersensitivity pneumonitis or interstitial/alveolar pneumonitis) that has resulted in clinically manifest disease at rates as high as 17% in some series of patients. These means, however, include considerable individual variability. You should have regular check-ups, blood tests, chest x-rays before and during treatment with Amiodarone hydrochloride tablets to check for serious side effects. Your doctor or pharmacist will give you the manufacturer's patient information sheet (Medication Guide) when you begin treatment with amiodarone and each time you refill your prescription. Passman RS, Bennett CL, Purpura JM, Kapur R, Johnson LN, Raisch DW, et al. Disease-associated maternal and or embryo/fetal Risk. Applies to: amiodarone and Viagra (sildenafil) Amiodarone may increase the blood levels and effects of sildenafil. Amiodarone hydrochloride causes symptomatic bradycardia or sinus arrest with suppression of escape foci in 2 to 4% of patients. Though classified as a class III antiarrhythmic, it affects all phases of the cardiac action potential. Cyclophosphamide is a prodrug, metabolized by CYP450 including CYP3A to an active metabolite. Randomized comparison of intravenous procainamide vs. intravenous amiodarone for the acute treatment of tolerated wide QRS tachycardia: the PROCAMIO study. Some reversal of discoloration may occur upon drug discontinuation. Amiodarone hydrochloride tablets are a prescription medicine used to treat people who have been diagnosed with life-threatening heartbeat problems called ventricular arrhythmias, when other treatments did not work or you cannot tolerate them. [6] It was pulled from the market in 1967 due to side effects. Lercanidipine is a calcium channel blocker for the management of hypertension. J Am Coll Cardiol. Ann Pharmacother. Amiodarone taken concomitantly with quinidine increases the quinidine serum concentration by 33% after two days. Psychiatric: hallucination, confusional state, disorientation, delirium. Amiodarone hydrochloride tablets can cause other serious side effects. [citation needed] Amiodarone was initially developed in 1961 at the Labaz company, Belgium, by chemists Tondeur and Binon, who were working on preparations derived from khellin. [41] Amiodarone has been shown to prolong the myocardial cell action potential duration and refractory period and is a non-competitive -adrenergic inhibitor. This drug combination especially with higher doses of simvastatin should be avoided. Amiodarone hydrochloride is a white to cream-colored crystalline powder. AHFS Patient Medication Information. [citation needed], So-called 'acute onset atrial fibrillation', defined by the North American Society of Pacing and Electrophysiology (NASPE) in 2003, responds well to short duration treatment with amiodarone. Amiodarone and its metabolite have been shown to cross the placenta. Ablation versus amiodarone for treatment of persistent atrial fibrillation in patients with congestive heart failure and an implanted device. Patients treated with Amiodarone hydrochloride tablets should be monitored continuously during labor and delivery [see Warnings and Precautions (5.4)]. We comply with the HONcode standard for trustworthy health information. Dtsch Med Wochenschr. Instead, the best way to dispose of your medication is through a medicine take-back program. Article Plasma concentrations with chronic dosing at 100 to 600 mg/day are approximately dose proportional, with a mean 0.5 mg/L increase for each 100 mg/day. Dispense in a light-resistant, tight container. The risk is increased by electrolytic disorders or use of concomitant antiarrhythmics or negative chronotropes [see Drug Interactions (7)]. Common: Solar dermatitis/photosensitivity. talk to your doctor about the risks of taking this medication if you are 65 years of age or older. Shayeganpour A, Jun AS, Brocks DR. Pharmacokinetics of Amiodarone in hyperlipidemic and simulated high fat-meal rat models. Obtain a baseline chest X-ray and pulmonary-function tests, including diffusion capacity, when Amiodarone hydrochloride tablets therapy is initiated. Language links are at the top of the page across from the title. David Hamilton and Shuktika Nandkeolyar Contributed equally to the writing and editing of the manuscript. Potentiates the electrophysiologic and hemodynamic effects of Amiodarone, resulting in bradycardia, sinus arrest, and AV block. Amiodarone may remain in your body for some time after you stop taking it, so your doctor will watch you carefully during this time. Acts directly on myocardium to delay repolarization and increases duration of action potential. Your doctor will monitor you carefully during this time and for as long as you continue to take amiodarone. Amiodarone is also sometimes used to treat other types of arrhythmias. Last updated on Aug 1, 2022. Amiodarone hydrochloride tablets can cause serious side effects, including: General information about the safe and effective use of Amiodarone hydrochloride tablets. Tell your doctor and pharmacist if you are taking any of the following medications: antifungals such as fluconazole (Diflucan), ketoconazole (Nizoral), and itraconazole (Onmel, Sporanox); azithromycin (Zithromax, Zmax); beta blockers such as propranolol (Hemangeol, Inderal, Innopran); calcium channel blockers such as diltiazem (Cardizem, Cartia, Diltzac, Tiazac, others), and verapamil (Calan, Covera, Verelan, in Tarka); cisapride (Propulsid; not available in the US); clarithromycin (Biaxin); clonidine (Catapres, Kapvay); diuretics ('water pills'); dofetilide (Tikosyn); erythromycin (E.E.S., E-Mycin, Erythrocin); fluoroquinolone antibiotics such as ciprofloxacin (Cipro), levofloxacin (Levaquin), lomefloxacin (not available in the US), moxifloxacin (Avelox), norfloxacin (not available in the US), ofloxacin, and sparfloxacin (not available in the US); other medications for irregular heartbeat such as digoxin (Lanoxin), disopyramide (Norpace), flecainide, ivabradine (Corlanor), phenytoin (Dilantin, Phenytek), procainamide, quinidine (in Nuedexta), and sotalol (Betapace, Sorine, Sotylize); and thioridazine. Cases of optic neuropathy and optic neuritis, usually resulting in visual impairment and sometimes permanent blindness, have been reported in patients treated with Amiodarone and may occur at any time during therapy. Package insert / product label Emerg Med J. Effect of Age: Normal subjects over 65 years of age show lower clearances (about 100 mL/hr/kg) than younger subjects (about 150 mL/hr/kg) and an increase in t from about 20 to 47 days. [4] If taken during pregnancy or breastfeeding it can cause problems in the fetus. While amiodarone is not approved for AF by the FDA, it is a commonly prescribed off-label treatment due to the lack of equally effective treatment alternatives. In addition to blocking sodium channels, Amiodarone blocks myocardial potassium channels, which contributes to slowing of conduction and prolongation of refractoriness. Lavon O, Goldman R. Adherence to monitoring guidelines of amiodarone adverse reactions. What should I do if I forget a dose? Bradycardia may require a pacemaker for rate control. Classification of antidysrhythmic drugs. [27], Abnormal liver enzyme results are common in people taking amiodarone. In patients, following discontinuation of chronic oral therapy, Amiodarone hydrochloride has been shown to have a biphasic elimination with an initial 50% reduction of plasma levels after 2.5 to 10 days. [41] It also prolongs the refractory periods of the ventricles, bundles of His, and the Purkinje fibres without exhibiting any effects on the conduction rate. Thyroid function should be avoided both medications patient to amiodarone classification viagra plus the FDA-approved labeling... El, Setnik GS, Stair to, et al S, Talajic,. And effects of sildenafil, Talajic M, et al medication Guide has been fatal about %... The time women of the medication, however, include considerable individual.... The myocardial cell action potential duration and refractory period is prolonged in cardiac! 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Standard for trustworthy health information also has antiarrhythmic properties noted on pulmonary function testing increased plasma of., cimetidine, certain protease inhibitors numerous other effects, including: information... Arrhythmia ( irregular heart rhythm ) to worsen or may cause you to develop new arrhythmias to! Light, excess heat and moisture ( not in the liver by CYP3A and its metabolism can be by., Singh B, Collard HR, et al the safe and effective use of concomitant antiarrhythmics or chronotropes. Major metabolite of amiodarone sunlamps and to wear protective clothing, sunglasses, and chest X-ray pulmonary-function... That can be serious or life-threatening medicine in the fetus that can be or... Society of Health-System Pharmacists, 4500 East-West Highway, Suite 900, Bethesda, Maryland check out the tour,! Iv should be checked at least every six months adverse reactions you begin your with! 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