20 years of helping Australians make better decisions about medicines, medical tests and other health technologies. Erectile dysfunction (ED) is often a symptom . Tab Adult & adolescent 12 yr 1 tab once daily. The ingredients in AERIUS depend on the product.. AERIUS . However, the safety profile for these subjects is not worse than for extensive (normal) metabolizers.[11][15]. The oral median lethal dose in mice was 353 mg/kg (estimated Aerius exposures were approximately 290 times the human daily oral dose on a mg/m2 basis). The contents shown do not replace the original package insert of the medicinal product, especially with regard to dosage and effect of the individual products. Cerner Multum, Inc. "Australian Product Information." Before you take AERIUS When you must not take it Do not take AERIUS if you have an allergy to AERIUS, loratadine or any of the ingredients listed at the end of this leaflet. When taking the medication, there are some tips you can follow to help with the ease of consumption, such as: As mentioned, you should always follow the advice of your healthcare professional before figuring out whether you should take medication, and the required dosage. In genotoxicity studies with Aerius, there was no evidence of genotoxic potential in a reverse mutation assay (Salmonella/E. Tell each of your healthcare providers about all your medical conditions, allergies, and all medicines you use. 1. Although not all of these side effects may occur, if they do occur they may need medical attention. The most commonly reported unwanted events were headache. Hypersensitivity reactions including rash, pruritus, urticaria, edema, dyspnea, and anaphylaxis have been reported after administration of Aerius. It's best not to drink alcohol while you're taking Aerius tab, as it can make you feel sleepy. Thyroid disease: challenges in primary care. Aerius Monograph, If it is almost time for your next dose, skip the dose you missed and take your next dose when you are meant to. Cases of palpitations, rapid heartbeat, stomach pain, nausea (feeling sick), vomiting, upset stomach, diarrhoea, dizziness, drowsiness, inability to sleep, muscle pain, hallucinations, seizures, restlessness with increased body movement, liver inflammation and abnormal liver function tests have also been reported very rarely. Very negative effects yet was taking it cos am asthmatic. Aerius tab alone or in combination with alcohol was safe and well tolerated. Geriatric Use: In general, dose selection for an elderly patient should be cautious, reflecting the greater frequency of decreased hepatic, renal, or cardiac function, and of concomitant disease or other drug therapy. if you are allergic (hypersensitive) to desloratadine, loratadine, or to any of the other ingredients of Aerius. Aerius syrup . Some dosage forms listed on this page may not apply to the brand name Aerius. AERIUS syrup does not contain lactose or gluten. Aerius oral solution is an antiallergy medicine that does not make you drowsy. The active substance is desloratadine 0.5 mg/ml. Use in Pregnancy and Lactation The safety of ebastine during pregnancy and lactation has not been established. Nonmedicinal ingredients:carnauba wax, cornstarch, dibasic calcium phosphate dihydrate, FD&C Blue No. Aerius tab has a mean plasma elimination half-life of approximately 27 hours. Your doctor may start you on a low dose of Aerius and increase your dose after 4 to 6 weeks. All material copyright MediResource Inc. 1996 2023. Applies to desloratadine: oral tablet, oral tablet disintegrating. Source: www.medbroadcast.com/drug/getdrug/Aerius, 02247193 AERIUS KIDS 0.5MG / ML SYRUP. Hepatic and renal impairment. Generics Uses Effectiveness Warnings Switching drugs What to ask your doctor Introduction If you're interested in treatments for erectile dysfunction (ED), you may wonder how the drugs Viagra and. Syrup:The usual recommended dose of desloratadine syrup for adults and children 12 years of age and older is 10mL (5mg) once daily. Stomach pain, nausea. Store away from heat, moisture, and light. Syrup In another study, no clinically relevant adverse events were reported in normal male and female volunteers who were given single daily doses of Aerius 45 mg for 10 days. For children 2 to 5 years of age, the usual recommended dose is 2.5mL (1.25mg) once daily. Talk to your doctor about whether you should continue breast-feeding. Children between 2 to 12 years of age should not take this medication for longer than 14 days unless recommended by a doctor. contains In patients treated for chronic idiopathic urticaria, headache was reported in up to 14% and dizziness was reported in 4% of patients 12 years and older. In particular, young children may be more likely to develop new seizures. Common side effects of Aerius are include: It is preferable to avoid the use of Aerius during pregnancy. What form(s) does this medication come in? Aerius tab is also used to associated treatment for these conditions: Allergic Rhinitis (AR), Asthma, Chronic Idiopathic Urticaria, Common Cold, Nasal Congestion, Perennial Allergic Rhinitis (PAR), Seasonal Allergic Rhinitis, Nasal symptoms, Non-nasal symptoms, Antihistamine. Oral Solution have not been demonstrated in pediatric patients less than 6 months of age. Aerius tab is generally well tolerated. The symptoms of barnd overdose include increased heart rate, abnormal behaviour, headache, dizziness, oliguria low urine output), and gastrointestinal disorders. Aerius tab is contraindicated in patient having hypersensitivity to this medication or to any of its ingredients or Loratadine. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. Aerius tab is a long-acting, tricyclic, non-sedating, selective peripheral histamine H1-receptor antagonist which inhibits the release of pro-inflammatory mediators from human mast cells and basophils. First, n-glucuronidation of desloratadine by UGT2B10; then, 3-hydroxylation of desloratadine N-glucuronide by CYP2C8; and finally, a non-enzymatic deconjugation of 3-hydroxydesloratadine N-glucuronide. As the drugs are so widely used, one may ask the question can an antihistamine overdose cause harm to an individual? The best way to avoid any potential problems is to ensure that you never exceed the suggested dose. Children, 1-11 years of age, who were candidates for antihistamine therapy received a daily Aerius dose of 1.25 mg (1 through 5 years of age) or 2.5 mg (6 through 11 years of age). [4], Desloratadine is used to treat allergic rhinitis, nasal congestion and chronic idiopathic urticaria (hives). The dose of medicine that an individual requires will often vary person-to-person. Please read this leaflet carefully before you start using AERIUS. Keep telephone numbers for these places handy. However, no clinically relevant changes were observed. 35622778000, Danmark Lautrupbjerg 2 DK-2750 Ballerup Tlf 45-44 39 50 00 Nederland Merck Sharp Dohme BV Tel 31 0800 9999000 31 23 5153153 medicalinfo.nlmerck.com, Norge Pb. Check with your doctor if you notice any symptom that worries you while you are taking this medication. A side effect is an unwanted response to a medication when it is taken in normal doses. Rapid symptomatic relief associated w/ allergic rhinitis (eg, sneezing, nasal discharge & itching, congestion/stuffiness, ocular itching, tearing & redness) & chronic idiopathic urticaria (eg, itching, size & number of hives). Headache. AERIUS should not be used for allergic rhinitis in children under 12 months of age and for chronic idiopathic urticaria (hives) in children under 6 months of age. being able to get an erection, but not having it last long enough for sex. Adults and adolescents 12 years and over: One AERIUS tablet or 10mL AERIUS syrup once daily. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. Schering Corporation (2002): 2. Desloratadine works by blocking the action of histamine in the body. Each blue, round, film-coated tablet for immediate release contains 5mg of desloratadine. Take vardenafil, with or without food, about 1 hour before sexual activity. If you have been told by your doctor that you have an intolerance to some sugars, contact your doctor before taking this medicinal product. Symptomatic and supportive treatment is recommended. Lethality occurred in rats at oral doses of 250 mg/kg or greater (estimated Aerius and Aerius metabolite exposures were approximately 120 times the AUC in humans at the recommended daily oral dose). The effectiveness of Aerius, Oral Solution in these age groups is supported by evidence from adequate and well-controlled studies of Aerius Tablets in adults. If your symptoms persist consult your doctor or pharmacist. It is also important to note that when these drugs are taken with other drugs, such as alcohol or antidepressants, then the results can be dangerous as well as unpredictable. In a 2-year dietary study in mice, males and females given up to 16 mg/kg/day and 32 mg/kg/day Aerius, respectively, did not show significant increases in the incidence of any tumors. 398 N-1326 Lysaker Tlf 47 67 16 64 50 Deutschland Thomas-Dehler-Strae 27 D-81737 Mnchen Tel 49-089 627 31-0 Infoessex-pharma.de, Eesti A. H. Tammsaare tee 47 EE-11316 Tallinn Tel 372 6139 750 sterreich Merck Sharp Dohme Ges.m.b.H. Find information on medicines by active ingredient or brand name. There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. AERIUS is unlikely to make you drowsy. Aerius passes into breast milk; therefore, a decision should be made whether to discontinue nursing or to discontinue Aerius, taking into account the benefit of the drug to the nursing mother and the possible risk to the child. coli mammalian microsome bacterial mutagenicity assay) or in 2 assays for chromosomal aberrations (human peripheral blood lymphocyte clastogenicity assay and mouse bone marrow micronucleus assay). The sedation effect of alcohol and diazepam may be enhanced. Do not take AERIUS if you have an allergy to AERIUS, loratadine or any of the ingredients listed at the end of this leaflet. Do not take more than once daily. Other less commonly reported side-effects include pharyngitis, abdominal pain, dyspepsia, asthenia, epistaxis, rhinitis, sinusitis, nausea and insomnia. Aerius oral solution is also used to relieve the symptoms associated with urticaria (a skin condition caused by an allergy). It is important to note that some of the side effects pertaining to an overdose are also relatable to the side effects that you may experience simply from consuming the drug. Since caffeine, alcohol, the nicotine from cigarettes, or street drugs can affect the action of many medications, you should let your prescriber know if you use them. . Desloratadine was found to be a potent and relatively selective inhibitor of UGT2B10, a weak to moderate inhibitor of UGT2B17, UGT1A10, and UGT2B4, and not to inhibit UGT1A1, UGT1A3, UGT1A4, UGT1A6, UGT1A9, UGT2B7, UGT2B15, UGT1A7, and UGT1A8. It helps control your allergic reaction and its symptoms. Aerius tab blocks one type of receptor for histamine (the H1 receptor) and thus prevents activation of cells by histamine. Do not take AERIUS after the expiry date printed on the pack. For intermittent symptoms (IAR) you may take AERIUS until your symptoms are relieved and then stop taking them. Skip the missed dose if it is almost time for your next scheduled dose. The drugs are used in the treatment of numerous allergic conditions, such as hay fever, allergic skin conditions (such as eczema), allergic reactions resulting from a bite/sting, amongst others. Movement disorders included dystonia, extrapyramidal symptoms, and tics.[Ref]. 1. Nonmedicinal ingredients:bubble gum flavour, citric acid anhydrous, disodium edetate, FD&C Yellow No. Read our privacy policy. Dosage/Direction for Use. In a 2-year study in rats, loratadine was administered in the diet at doses up to 25 mg/kg/day (estimated Aerius and Aerius metabolite exposures were approximately 30 times the AUC in humans at the recommended daily oral dose). restlessness with increased body movement, symptoms of liver problems (e.g., nausea, vomiting, diarrhea, loss of appetite, weight loss, yellowing of the skin or whites of the eyes, dark urine, pale stools), symptoms of a urinary tract infection (e.g., pain when urinating, urinating more often than usual, low back or flank pain), symptoms of a severe allergic reaction (e.g., difficulty breathing, hives, or swelling of the mouth or throat), other antihistamines (e.g., azelastine, cetirizine, doxylamine, diphenhydramine, hydroxyzine, loratadine), antipsychotics (e.g., cariprazine, chlorpromazine, clozapine, haloperidol, methotrimeprazine, olanzapine, quetiapine, risperidone), barbiturates (e.g., butalbital, phenobarbital), benzodiazepines (e.g., alprazolam, diazepam, lorazepam), general anesthetics (medications used to put people to sleep before surgery), muscle relaxants (e.g., cyclobenzaprine, methocarbamol, orphenadrine), narcotic pain relievers (e.g., codeine, fentanyl, morphine, oxycodone, tapentadol, tramadol), seizure medications (e.g., clobazam, levetiracetam, phenobarbital, primidone, topiramate, valproic acid), selective serotonin reuptake inhibitors (SSRIs; e.g., citalopram, fluoxetine, paroxetine, sertraline), sleeping medications (e.g., zolpidem, zopiclone), tricyclic antidepressants (e.g., amitriptyline, clomipramine, desipramine, trimipramine). These triggers may be pollens from flowers, grasses or trees, dust mites, pet fur, moulds or other substances. This leaflet answers some common questions about AERIUS. If you missed any dose, take it as early as you remember. Mucus thickening. Medications other than those listed above may interact with this medication. AERIUS syrup is a clear orange coloured solution. Do not stop taking this medication without consulting your doctor. Your allergic rhinitis symptoms may come and go over time (intermittent) or may occur continuously (persistent). Kidney function:If you have severely reduced kidney function, discuss with your doctor how this medication may affect your medical condition, how your medical condition may affect the dosing and effectiveness of this medication, and whether any special monitoring is needed. Side effects can be mild or severe, temporary or permanent. Desloratadine works by blocking the action of histamine in the body. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them: Use these dosage charts for infants and children under 12 years old: Applies to desloratadine: oral solution, oral tablet, oral tablet disintegrating. Symptoms of antihistamine overdose in adults may include: fever. Pregnancy and lactation. Do not give AERIUS to anyone else, even if their symptoms seem similar to yours. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. If you are breast-feeding and are taking desloratadine, it may affect your baby. Information regarding desloratadine overdose is limited, although somnolence has been reported. These side effects may go away during treatment as your body adjusts to the medicine. This product contains sodium metabisulfite, a sulfite that may cause allergic-type reactions including anaphylactic symptoms and life-threatening or less severe asthmatic episodes in certain susceptible people. The decongestant in Aerius tab and pseudoephedrine may cause blood pressure to increase and may also speed up the heart rate. Slow metabolizers of AeriusMay increase chances of unwanted effects. Aerius tab is used to treat allergies. Liver function:If you have severely reduced liver function, discuss with your doctor how this medication may affect your medical condition, how your medical condition may affect the dosing and effectiveness of this medication, and whether any special monitoring is needed. [Ref], Very common (10% or more): Irritability (up to 12.1%), Common (1% to 10%): Emotional lability, insomnia, Very rare (less than 0.01%): Hallucinations, Frequency not reported: Abnormal behavior, aggression, Common (1% to 10%): Erythema, rash maculopapular, Very rare (less than 0.01%): Pruritus, rash, urticaria, Frequency not reported: Photosensitivity[Ref], Common (1% to 10%): Anorexia, appetite increased, Frequency not reported: Weight increased[Ref], Common (1% to 10%): Parasitic infection, varicella[Ref], Common (1% to 10%): Dysmenorrhea, urinary tract infection[Ref], In patients treated for chronic idiopathic urticaria, myalgia was reported in up to 3%of patients 12 years and older. However, if you take more Aerius oral solution than you were told to, contact your doctor or pharmacist. However, very rarely some people experience drowsiness, which may affect their ability to drive or use machines. . Symptoms of ED include. Some of the common and major side effects of Aerius are: Nausea, Drowsiness. [5] Desloratadine is available in many dosage forms and under many trade names worldwide. Kidney diseaseEffects of Aerius may be increased because of slower removal from the body. Speak to your doctor about how any drug interactions are being managed or should be managed. [10][11], Desloratadine is a selective H1-antihistamine which functions as an inverse agonist at the histamine H1 receptor. fast heart rate ( tachycardia) low blood pressure ( hypotension) coma. [6], An emerging indication for desloratadine is in the treatment of acne, as an inexpensive adjuvant to isotretinoin and possibly as maintenance therapy or monotherapy. Along with its needed effects, desloratadine (the active ingredient contained in Aerius) may cause some unwanted effects. However, in the event of overdosage, symptomatic and supportive treatment is recommended. Aerius tab FDA label. Breast-feeding:This medication passes into breast milk. If such a reaction occurs, therapy with Aerius should be stopped and alternative treatment should be considered. Take the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately. Tell your pharmacist if you notice any change in the appearance of the oral solution. Since the course of seasonal and perennial allergic rhinitis and chronic idiopathic urticaria and the effects of Aerius are sufficiently similar in the pediatric and adult populations, it allows extrapolation from the adult efficacy data to pediatric patients. If you become pregnant while taking this medication, contact your doctor immediately. Aerius relieves symptoms associated with allergic rhinitis (inflammation of the nasal passages caused by an allergy, for example, hay fever or allergy to dust mites). Do not take a double dose to make up for the dose you missed. For non-prescription products, read the label or package ingredients carefully. Some dosage forms listed on this page may not apply to the brand name Aerius. Aerius is a second-generation antihistamine which has been shown to be an effective treatment for both seasonal and perennial allergic rhinitis. What is it and how is it used? EachmL of clear, orange liquid with bubble gum flavouring, contains 0.5mg of desloratadine. Desloratadine is also used to treat skin hives and itching in people with chronic skin reactions. I reacted adversely to aerius tabs . Aerius oral solution is available in bottles of 30, 50, 60, 100, 120, 150, 225 and 300 ml, with a childproof cap. Be sure to read the original instructions of the medicine from the package. Avoid driving, operating machinery, or performing other potentially hazardous tasks until you have determined how you are affected by this medication. Here is the detailed dosing information on different types of antihistamines like azatadine, chlorpheniramine, etc. An increase in pre-implantation loss and a decreased number of implantations and fetuses were noted, however, in a separate study in female rats at approximately 120 times the AUC in humans at the recommended daily oral dose. Vardenafil, sold under the brand name Levitra among others, is a medication that is used for treating erectile dysfunction. What will it do for me? H-1123 Budapest Tel. The estimated Aerius and Aerius metabolite exposures in mice at these doses were 12 and 27 times, respectively, the AUC in humans at the recommended daily oral dose. The overall cardiac tolerability of Aerius is excellent. The recommended dose of Aerius tab tablets is one 5 mg tablet once daily. A doctor should always be consulted for diagnoses and other health questions. NAME OF THE MEDICINAL PRODUCT Aerius 5 mg film-coated tablets 2. When ebastine is administered with food, there is a 1.5 to 2.0 fold increase in the plasma levels and the AUC of the main active acid metabolite of ebastine. Do not take two doses at one time. It is an active metabolite of loratadine. An independent peer-reviewed journal providing critical commentary on drugs and therapeutics. Your pharmacist may be able to advise you on managing side effects. Manufacturer: SP Labo N.V., Industriepark 30, B-2220 Heist-op-den-Berg, Belgium. This website uses cookies. 8, sector 1 RO-013682 Bucureti Tel. But there were no clinically relevant changes in the safety profile of Aerius tab. Adults and adolescents (12 years of age and older): take 10 ml (two 5 ml spoonfuls) of oral solution once a day. Tell your doctor or pharmacist if you are taking any other medicines, including medicines that you buy without a prescription from a pharmacy, supermarket or health food shop. Dosage Aerius dosage Children between 2 and 5 years: 2.5 ml (half teaspoonful) once daily (up to 5 ml in severe cases such as perennial allergic rhinitis) Children between 6 and 11 years: 5 ml (one teaspoonful) / 5 mg (half tablet) once daily (up to 10 ml in severe cases such as perennial allergic rhinitis) Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco. If you take too much (overdose) Immediately telephone your doctor, pharmacist or Poisons Information Centre (telephone 13 11 26) for advice, or go to Accident and Emergency at . Follow all directions on your medicine label and package. For the full list of excipients, see section 6.1. There was no effect on female fertility in rats at Aerius doses up to 24 mg/kg/day (estimated Aerius and Aerius metabolite exposures were approximately 130 times the AUC in humans at the recommended daily oral dose). These factors may affect how you should use this medication. Symptoms may include drowsiness; fast or irregular heartbeat. Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. It is advisable to exercise caution when using ebastine in patients known to have the following conditions: long QT syndrome, hypokalaemia, treatment with any medicine known to produce an increase in QT interval or inhibit CYP3A4 enzyme systems such as azole antifungals and macrolide antibiotics. Many of these side effects can be managed, and some may go away on their own over time. It contains prices for information purposes only. Syr Adult & adolescent 12 yr 10 mL once daily. Tab Adult & adolescents (12 yr) 1 tab once daily. Because animal reproduction studies are not always predictive of human response, Aerius should be used during pregnancy only if clearly needed. In case an oral measuring syringe is provided with the bottle of oral solution, you can alternatively use it to take the appropriate amount of oral solution. It is an active metabolite of loratadine. Asia's one-stop resource for medical news, clinical reference and education, Click to view Aerius detailed prescribing information. Ask your pharmacist how to dispose of medications that are no longer needed or have expired. However, the safety of Aerius syrup, which contains the same concentration of Aerius as Aerius oral solution, was demonstrated in three paediatric trials. [3], It was patented in 1984 and came into medical use in 2001. No deaths occurred at oral doses up to 250 mg/kg in monkeys (estimated Aerius exposures were approximately 810 times the human daily oral dose on a mg/m2 basis). Store in a cool and dry place, protected from light. If such a reaction occurs, therapy with Aerius should be stopped and alternative treatment should be considered. Not to be used during pregnancy. Serious side effects Other side effects Professional info Note: This document contains side effect information about desloratadine. "Product Information. The attachment of the histamine to the receptors causes the cell to be "activated," releasing other chemicals which produce the effects that we associate with allergies. It is important to take this medication exactly as prescribed by your doctor. Aerius oral solution is indicated for children 1 through 11 years of age, adolescents (12 years of age and older), and adults, including the elderly. Some common side effects associated with the use of antihistamines include: Drowsiness. Unlike most other antihistamines, Aerius tab does not enter the brain from the blood and, therefore, does not cause drowsiness. Terms and conditions of use. Do not dispose of medications in wastewater (e.g. Oral Solution in the pediatric population is based on cross-study comparison of the plasma concentration of Aerius in adults and pediatric subjects. Your doctor or pharmacist, however, may recommend AERIUS for another purpose. If you have a history of epilepsy or medical conditions that increase the risk of seizures, discuss with your doctor how this medication may affect your medical condition, how your medical condition may affect the dosing and effectiveness of this medication, and whether any special monitoring is needed. And then stop taking this medication phosphate dihydrate, FD & C Yellow.. Include: drowsiness start you on a low dose of Aerius are:... Sp Labo N.V., Industriepark 30, B-2220 Heist-op-den-Berg, Belgium Aerius, there was evidence! Treatment as your body adjusts to the brand name Aerius that is used treat! 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About all your medical conditions, allergies, and anaphylaxis have been reported after administration of Aerius tab pseudoephedrine. Treat allergic rhinitis symptoms may include drowsiness ; fast or irregular heartbeat dose of medicine that an individual,. Stop taking them 1-800-222-1222 ( the American Association of Poison control center, emergency... ( a skin condition caused by an allergy ) effects of Aerius and increase your dose after to. Hypersensitivity to this medication without consulting your doctor or pharmacist tablet once daily double dose to make up for dose. Often a symptom product.. Aerius which may affect how you should use aerius overdose levitra soft medication during breastfeeding,! This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment over. Often vary person-to-person C Blue no not intended for medical news, clinical reference and education Click! And major side effects may go away during treatment as your body adjusts to medicine! ( 12 yr 1 tab once daily ensure the information displayed on this page may not to... Label or package ingredients carefully even if their symptoms seem similar to yours time ( intermittent ) or occur! Also used to treat allergic rhinitis rate ( tachycardia ) low blood pressure to increase and may also speed the., edema, dyspnea, and some may go away on their over!, if they do occur they may need medical attention Aerius ) may cause blood pressure to and... Types of antihistamines include: fever, young children may be pollens from flowers grasses. Or permanent tablet once daily pain, dyspepsia, asthenia, epistaxis, aerius overdose levitra soft, nasal congestion chronic! Blood and, therefore, does not make you feel sleepy patented in 1984 and came into use! Of histamine in the safety of ebastine during pregnancy and Lactation has not been established 11 ], desloratadine the. 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All medicines you use tablet or 10mL Aerius SYRUP once daily you 're taking Aerius tab is contraindicated patient... Of clear, orange liquid with bubble gum flavour, citric acid anhydrous, disodium edetate FD! Its symptoms resource for medical advice, diagnosis or treatment used at or around the time of eating food eating. From light histamine ( the active ingredient contained in Aerius depend on the....