Nucleoside and Nucleotide DNA Polymerase Inhibitor AntiviralsTopical Antivirals, Synthetic antiviral with activity against herpes simplex virus type 1 and 2 and varicella-zoster virusUsed to treat herpes labialis, herpes genitalis, herpes simplex encephalitis, herpes simplex keratitis, neonatal herpes infection, chickenpox (varicella), shingles (zoster)Potent activity against herpes simplex viruses type 1 and 2 and much less activity against varicella-zoster virus, Sitavig, Zovirax, Zovirax Cream, Zovirax Ointment, Zovirax Powder, Zovirax Suspension, Acyclovir/Acyclovir Sodium Intravenous Inj Sol: 1mL, 50mgAcyclovir/Acyclovir Sodium/Zovirax/Zovirax Powder Intravenous Inj Pwd F/Sol: 500mgAcyclovir/Zovirax Oral Cap: 200mgAcyclovir/Zovirax Oral Tab: 400mg, 800mgAcyclovir/Zovirax/Zovirax Cream Topical Cream: 5%Acyclovir/Zovirax/Zovirax Ointment Topical Ointment: 5%Acyclovir/Zovirax/Zovirax Suspension Oral Susp: 5mL, 200mgSitavig Buccal Tablet, SL: 50mg. Tenofovir containing products should be avoided with concurrent or recent use of a nephrotoxic agent; patients receiving concomitant nephrotoxic agents should be carefully monitored for changes in serum creatinine and phosphorus, and urine glucose and protein. Acyclovir is minimally lipophilic and distributes primarily to extracellular fluid. Store the diluted infusion solution at room temperature, 15 to 25 degrees C (59 to 77 degrees F). Periodic monitoring of renal function tests and urine output is particularly important in patients judged to have a potential risk for developing acute renal failure. Probenecid; Colchicine: (Moderate) Probenecid decreases the renal tubular secretion of acyclovir and can increase serum and CSF concentrations of acyclovir, increasing the potential for toxicity. The concentration of acyclovir triphosphate is 40- to 100- times higher in HSV-infected cells than non-infected cells. Tenofovir is primarily excreted via the kidneys by a combination of glomerular filtration and active tubular secretion. [34362] The FDA-approved labeling recommends using ideal body weight when dosing obese adult patients. Adjust the dosing schedule so that a dose is administered after each dialysis session. 20 to 80 mg/kg/day (Max: 1,200 mg/day) PO divided 3 times daily for 7 to 10 days plus topical ophthalmic steroid, then 20 to 80 mg/kg/day (Max: 800 mg/day) PO divided twice daily for the duration of topical ophthalmic steroid use. For neonates born to mothers with no history of genital HSV preceding pregnancy, acyclovir should be initiated by 24 hours of age prior to HSV virology testing results. Monitor patients for changes in renal function if these drugs are coadministered. The duration of therapy is not well defined and should be based on clinical, virologic, and immunologic responses in consultation with an ophthalmologist. Concurrent administration with drugs that decrease renal function may increase concentrations of tenofovir. 800 mg PO 3 to 5 times daily for 7 to 10 days plus topical ophthalmic steroid, then 400 mg PO twice daily for the duration of topical ophthalmic steroid use. Inotersen: (Moderate) Use caution with concomitant use of inotersen and acyclovir due to the risk of glomerulonephritis and nephrotoxicity. 10 mg/kg/dose IV every 8 hours for 7 to 10 days for severe or complicated infections. Theophylline is primarily metabolized by CYP1A2; acyclovir is a weak inhibitor of CYP1A2. [34408] The FDA-approved labeling recommends the use of ideal body weight when dosing obese adult patients.[34408]. Concurrent administration with drugs that decrease renal function may increase concentrations of tenofovir. ReconstitutionReconstitute 500 mg or 1 g vial with 10 or 20 mL, respectively, of sterile water for injection (preservative-free) to give a concentration of 50 mg/mL. However, even with safe sex practices, it's still possible to spread genital herpes.. Involvement of an experienced ophthalmologist is recommended. 10 mg/kg/dose IV every 8 hours for 7 to 10 days. [23936] [56888] [56889] [56898] Prophylaxis with acyclovir has been shown to decrease the rate of CMV infection and improve survival in hematopoietic cell transplantation (HSCT) recipients. Tenofovir is primarily excreted via the kidneys by a combination of glomerular filtration and active tubular secretion. Carefully monitor renal function during concomitant therapy. HSV testing should be obtained prior to treatment. These are general recommendations only and therapy should be individualized based on therapeutic drug monitoring; some patients may require higher doses to optimize therapy. Also, closely monitor renal function. Renal impairment, which may include hypophosphatemia, has been reported with the use of tenofovir disoproxil fumarate; a majority of the cases occurred in patients who had underlying systemic or renal disease or who are concurrently taking nephrotoxic agents. Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Disoproxil Fumarate: (Moderate) Monitor for acyclovir or emtricitabine-related adverse events during concomitant use. [34408] Similar consideration should be given to pediatric patients. [34408] Use ideal body weight when dosing persons with obesity.[34408]. 12.5 to 15 mg/kg/dose IV every 8 hours for 10 to 14 days. In addition, use with drugs that are also eliminated by active tubular secretion may increase concentrations of the co-administered drug. The FDA-approved labeling recommends using ideal body weight when dosing obese adult patients. Acyclovir is effective only against actively replicating viruses; therefore, it does not eliminate the latent herpes virus genome. 10 mg/kg/dose IV every 8 hours for 7 to 10 days. Taking these drugs together may increase the serum concentration of theophylline. Intermittent hemodialysisFor IV dosing, 2.5 to 5 mg/kg/dose IV every 24 hours (based on usual dose of 5 to 10 mg/kg/dose IV every 8 hours, and the assumption of 3 complete hemodialysis sessions/week). Until more data are known, clinicians should be prepared to make adjustments in hydantoin dosing if acyclovir therapy is added or discontinued. Initiate at first sign of symptoms (i.e., within 24 hours).[34361]. Acyclovir is a synthetic purine deoxynucleoside analogue with inhibitory activity against herpes simplex virus types 1 (HSV-1), 2 (HSV-2), and varicella-zoster virus (VZV). This interaction would appear to be more significant for parenteral acyclovir. Initiate therapy at the first sign of symptoms (i.e., within 24 hours). In addition, use with drugs that are also eliminated by active tubular secretion may increase concentrations of the co-administered drug. However, the glucuronide metabolite of mycophenolate (MPAG) and acyclovir AUCs were increased 10.6% and 21.9%, respectively. Synopsis Acyclovir (aciclovir) is a nucleoside antiviral drug with antiviral activity in vitro against members of the herpes group of DNA viruses. Therefore, when possible, a washout period between the use of the antiviral medication and the vaccines is recommended. 1,000 mg/day PO divided into 3 to 5 doses following IV therapy to complete at least 10 days of total therapy or until lesions are completely healed. On the same side of the mouth as the herpes labialis symptoms, immediately apply the rounded side of the tablet to the upper gum above the incisor tooth (canine fossa). Methotrexate: (Moderate) Avoid concomitant use of methotrexate with acyclovir due to the risk of additive nephrotoxicity as well as an increased risk of severe methotrexate-related adverse reactions. The clinical significance of these pharmacokinetic interactions is unknown; however, no dosage adjustments are recommended for patients with normal renal function. 800 mg PO 5 times daily for 5 to 7 days beginning 7 to 10 days after exposure is recommended by some experts when passive immunization with varicella zoster immunoglobulin (VariZIG) is not feasible; however, this intervention has not been studied in persons living with HIV. [34408] The only known urinary metabolite is 9-[(carboxy-methoxy)methyl]guanine, which accounts for 8.5% to 14% of the dose in patients with normal renal function. [34362] The FDA-approved dosage is 800 mg PO 4 times daily for 5 days. Among patients over 60 years old, 10 of 10 in the treatment group had complete recovery, as compared with 5 of 12 patients in the control group (p < .01). (Moderate) Monitor for changes in renal function if tenofovir alafenamide is administered in combination with a nephrotoxic agent, such as acyclovir. Similar considerations should be given to pediatric patients. After a prolonged period (e.g., 1 year) of prophylaxis, consider stopping prophylaxis and assess patient to determine if additional prophylaxis is required. PDR.net is to be used only as a reference aid. It is also used to prevent having regular outbreaks of genital herpes. The dose size per application will vary depending upon the lesion area but should be approximately 0.5-inch ribbon of ointment per 4 square inches of surface area. Repeat CSF HSV PCR again near the anticipated end of the treatment course to determine whether cessation of therapy is appropriate. 80 mg/kg/day (Max: 1,600 mg/day) PO in 2 to 3 divided doses during the period of risk. Encephalopathic changes have been associated with systemic acyclovir use. Monitor for renal toxicity if concomitant use is required. If concomitant use is unavoidable, closely monitor for adverse reactions. [28977], 400 mg PO 3 times daily for 7 to 10 days or until clinical resolution.[34362]. [34408] Similar consideration should be given to pediatric patients. Hydantoins: (Minor) In a single case report, the addition of acyclovir to a regimen of phenytoin and valproate led to a clinically significant decrease in phenytoin serum concentrations and loss of seizure control. Mean peak acyclovir plasma concentrations have been shown to be directly proportional to the dose administered. Doses may be lower for children. Dosage reduction may be necessary if renal impairment occurs. The FDA-approved labeling recommends the use of ideal body weight when dosing obese adult patients. 5 mg/kg/dose IV every 8 hours. [34408] Similar consideration should be given to pediatric patients. Concomitant use may increase acyclovir or emtricitabine concentrations. Measles Virus; Mumps Virus; Rubella Virus; Varicella Virus Vaccine, Live: (Major) If possible, discontinue acyclovir at least 24 hours before administration of the varicella-zoster virus vaccine, live. 400 mg PO 3 times daily for 5 to 10 days. PlasmapheresisAdminister IV doses at least 3 hours before plasmapheresis. Coadministration of tenofovir alafenamide with a drug that reduces renal function or competes for active tubular secretion may increase concentrations of tenofovir and other renally eliminated drugs, thus, increasing the risk of adverse reactions. 10 mg/kg/dose IV every 8 hours for 7 to 10 days. For patients receiving 800 mg PO 5 times per day, the dosage interval should be extended to every 8 hours. Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Alafenamide: (Moderate) Monitor for acyclovir or emtricitabine-related adverse events during concomitant use. Valacyclovir is available only with your doctor's prescription. 400 mg PO 3 times daily for 7 to 10 days plus topical ophthalmic steroid, then 400 mg PO twice daily as long-term prophylaxis. For CVVH, a dose of 5 to 10 mg/kg/dose IV every 24 hours has been recommended. Do NOT refrigerate. The FDA-approved labeling recommends the use of ideal body weight when dosing obese adult patients. Clinical practice guidelines suggest an antiviral plus oral corticosteroid within 72 hours of symptom onset to modestly increase probability of functional facial nerve recovery. Of note, the decrease in bioavailability is a function of the dose and not the dosage form. Cisplatin can cause nephrotoxicity. [34408] Similar consideration should be given to pediatric patients. Dosage was adjusted for patients with compromised renal function. 20 mg/kg/dose IV every 8 hours. 400 mg PO 3 times daily for 7 to 10 days or until clinical resolution. In the second study, absorption of acyclovir ointment was evaluated in 11 patients with localized varicella-zoster infections. 400 mg PO twice daily for at least 12 months. In order to prevent crystalluria, patients should be well-hydrated to maintain a high urine volume and avoid dehydration during therapy with acyclovir. tablet 400mg 800mg capsule 200mg Genital Herpes Initial treatment: 200 mg PO q4hr while awake (5 times daily) for 10 days or 400 mg PO q8hr for 7-10 days Intermittent treatment for recurrence: 200. Nonsteroidal antiinflammatory drugs: (Moderate) Monitor patients for signs of worsening renal function during coadministration of acyclovir and nonsteroidal antiinflammatory drugs. Ioversol: (Moderate) Concomitant use of acyclovir and contrast agents should be avoided when possible, as use of these drugs together may increase the risk for nephrotoxicity. Smoothie. [34408], 10 mg/kg/dose IV every 8 hours for 14 to 21 days. Acyclovir is used to decrease pain and speed the healing of sores or blisters in people who have varicella (chickenpox), herpes zoster (shingles; a rash that can occur in people who have had chickenpox in the past), and first-time or repeat outbreaks of genital herpes (a herpes virus infection that causes sores to form around the genitals and re. OR . acyclovir dose: Adjusted body weight = 0.4(Actual Weight - Ideal Weight) + Ideal Weight Adjust vancomycin, meropenem, acyclovir, TMP-SMX and aztreonam in patients with renal dysfunction CT prior to lumbar puncture if: o Immunocompromi sed o History of CNS disease (mass lesion, stroke) o New onset seizures o Papilledema This drug does not cure herpes infections. Alternative regimens have ranged from 200 mg PO 3 times daily to 200 mg PO 5 times daily. The tablet remains adhered for a median duration of 14 hours and, although the effects of food have not been formally studied, patients were allowed to eat and drink during clinical studies.[54268]. Theophylline, Aminophylline: (Minor) Caution is advised when administering theophylline, aminophylline with acyclovir. Monitor for renal toxicity if concomitant use is required. The FDA-approved labeling recommends the use of ideal body weight when dosing obese adult patients. Carefully monitor renal function during concomitant therapy. Coadministration of drugs that reduce renal function or compete for active tubular secretion, such as acyclovir and emtricitabine, may increase the risk of adverse reactions. [34408]Intermittent IV InfusionInfuse slowly IV over at least 1 hour to minimize the risk of adverse reactions.Monitor IV site for signs of phlebitis.[34408]. Warnings Do not take more or less than prescribed. The premium product BATCH gummies is full-spectrum, vegan-friendly, and made with solely natural components. Adefovir: (Moderate) Chronic coadministration of adefovir with nephrotoxic drugs, such as acyclovir, may increase the risk of developing nephrotoxicity, even in patients who have normal renal function. [34408] Similar consideration should be given to pediatric patients. Tenofovir is primarily excreted via the kidneys by a combination of glomerular filtration and active tubular secretion. Renal impairment, which may include hypophosphatemia, has been reported with the use of tenofovir disoproxil fumarate; a majority of the cases occurred in patients who had underlying systemic or renal disease or who are concurrently taking nephrotoxic agents. Prophylaxis with acyclovir has been shown to decrease the rate of CMV infection and improve survival in hematopoietic cell transplantation (HSCT) recipients. In the first study, patients were administered a 1-cm strip (25 mg acyclovir) dose 4-times daily for 7 days to an intact skin surface area of 4.5 square inches. [24464] These concentrations would potentially expose the nursing infant to a dose of acyclovir as high as 0.3 mg/kg/day. Do not apply the topical ointment or cream to the eye.Use a finger cot or rubber glove when applying to avoid transmission of the virus to other sites or persons.Wash hands thoroughly after administration. In patients with HIV, guidelines recommend waiting at least 72 hours after the last dose of acyclovir before administering varicella vaccines. Acyclovir 200 mg orally 5 times/day is also effective but is not recommended because of the frequency of dosing. [recurrence] Dose: 800 mg PO tid x2 days; Start: ASAP after sx onset; Alt: 800 mg PO bid x5 days [suppression] Dose: 400 mg PO bid; Info: reassess tx need at 1y orolabial HSV, immunocompetent pts [1st episode] [34213] Use ideal body weight when dosing persons with obesity.[34408]. For prevention of early reactivation in HCT recipients, initiate therapy beginning 1 day prior to transplant and continue until marrow engraftment. Do not crush, chew, suck, or swallow the tablet.If adhesion does not occur or the tablet falls off within the first 6 hours, immediately reposition the same tablet. Tenofovir containing products should be avoided with concurrent or recent use of a nephrotoxic agent; patients receiving concomitant nephrotoxic agents should be carefully monitored for changes in serum creatinine and phosphorus, and urine glucose and protein. May switch to oral therapy after defervescence if there is no evidence of visceral involvement. Acyclovir can cause renal impairment or renal failure, which may be additive when used with cisplatin. The use of ideal body weight is recommended when dosing obese adults.[34408]. 40 to 80 mg/kg/day (Max: 1,200 mg/day) PO in 3 to 4 divided doses for 7 to 10 days or until clinical resolution. Tenofovir containing products should be avoided with concurrent or recent use of a nephrotoxic agent; patients receiving concomitant nephrotoxic agents should be carefully monitored for changes in serum creatinine and phosphorus, and urine glucose and protein. [51529] The elimination half-life of acyclovir in patients with normal renal function is 2.5 to 3.3 hours. 30 mg/kg/day IV per FDA-approved product labeling; however, up to 45 mg/kg/day IV is used off-label. Coadministration of drugs that reduce renal function or compete for active tubular secretion, such as acyclovir and emtricitabine, may increase the risk of adverse reactions. A 500 mg maternal dosage of valacyclovir hydrochloride twice daily would provide a nursing infant with an oral acyclovir dosage of approximately 0.6 mg/kg/day. The FDA-approved dosage is 200 mg PO every 4 hours, 5 times daily, for 5 days. Visually inspect parenteral products for particulate matter and discoloration prior to administration whenever solution and container permit. Elderly patients are also more likely to have CNS adverse events (e.g., somnolence, hallucinations, confusion, or coma) possibly related to changes in renal function. 10 mg/kg/dose or 500 mg/m2/dose IV every 8 hours for 7 to 10 days and until there are no new lesions for 48 hours for severe or complicated infections or for those with severe immunosuppression. [34408] Similar considerations should be given to pediatric patients. NOTE: Intravenous acyclovir is recommended for those with severe infection requiring hospitalization, including pregnant patients. 400 mg PO twice daily plus topical ophthalmic steroid for at least 10 weeks, then 400 mg PO twice daily as long-term prophylaxis. [34361] The FDA-approved dose is 20 mg/kg/dose IV every 8 hours for 10 days. 400 mg PO 3 times daily for 7 to 10 days or until clinical resolution. Involvement of an experienced ophthalmologist is recommended. Avoid use of systemic acyclovir during pregnancy unless the potential benefits outweigh the possible risks to the fetus. Peritoneal dialysisFor IV dosing, 5 mg/kg/dose IV every 24 hours. Care should be taken in using tacrolimus with other nephrotoxic drugs, including acyclovir. There were 749 pregnancies followed in women exposed to systemic acyclovir during the first trimester of pregnancy resulting in 756 outcomes. Vhody smoothies zvisia od toho, o do nich dte. Emtricitabine; Rilpivirine; Tenofovir alafenamide: (Moderate) Monitor for acyclovir or emtricitabine-related adverse events during concomitant use. The duration of therapy is not well defined and should be based on clinical, virologic, and immunologic responses in consultation with ophthalmologist. Thymidine kinase negative variants of herpes virus may cause severe disease in infants and immunocompromised patients. 30 mg/kg/day IV per FDA-approved product labeling; however, up to 45 mg/kg/day IV is used off-label; 4,000 mg/day PO; 50 mg/dose buccal. Telbivudine: (Moderate) Drugs that alter renal function such as acyclovir may alter telbivudine plasma concentrations because telbivudine is eliminated primarily by renal excretion. to a friend, relative, colleague or yourself. Consider longer duration if lesions are slow to resolve. 10 mg/kg/dose IV every 8 hours for at least 7 days or until clinical improvement, then oral antiviral therapy to complete at least 10 days of total therapy or until lesions are completely healed. Amphotericin B: (Moderate) Concurrent use of amphotericin B and other nephrotoxic medications, including acyclovir, may enhance the potential for drug-induced renal toxicity. 400 mg PO 3 times daily for 5 to 10 days or until clinical resolution. 10 mg/kg/dose IV every 8 hours plus ganciclovir intravitreal injection and/or foscarnet intravitreal injection. For extensive cutaneous lesions or visceral involvement in persons living with HIV, oral acyclovir may be used as stepdown therapy after IV acyclovir to complete 10 to 14 days of therapy. [28977] Similar consideration should be given to pediatric patients. Acyclovir has a relatively short serum half-life and is quickly cleared from the body. Initiate therapy within 48 to 72 hours of rash onset. Percutaneous absorption of acyclovir 5% ointment was evaluated in 2 clinical pharmacology studies. [34408] Similar consideration should be given to pediatric patients. Tenofovir is primarily excreted via the kidneys by a combination of glomerular filtration and active tubular secretion. 20 mg/kg/dose (Max: 400 mg/dose) PO 4 times daily for 5 to 7 days.[34361]. 400 mg PO twice daily. Do NOT use bacteriostatic water for injection (contains paraben or benzyl alcohol).Further dilution is required prior to administration.Storage: Use reconstituted solutions within 12 hours. Patients predisposed to acute renal failure include patients receiving known nephrotoxic drugs like acyclovir. 10 mg/kg/dose IV every 8 hours for 7 to 10 days. Generic NameAcyclovir Dosage Form and StrengthPowder for IV administration (50 mg/mL after reconstitution) Route of AdministrationIV infusion Proposed IndicationTreatment of herpes simplex virus. Although level of immune reconstitution should be a consideration, specific CD4 thresholds have not been determined.[34361]. 5 to 10 mg/kg/dose IV every 8 hours for at least 7 days or until clinical improvement, then oral antiviral therapy to complete at least 10 days of total therapy or until lesions are completely healed. 20 mg/kg/dose (Max: 400 mg/dose) PO 4 times daily for 5 to 7 days. In general, acyclovir is not recommended for routine use for the treatment of varicella infections in otherwise healthy children at low risk for complications; consider for those at increased risk of moderate to severe varicella.[28977]. Carefully monitor renal function during concomitant therapy. Absolute neutrophil counts should be assessed 2 to 4 weeks after suppressive therapy start and then monthly thereafter during treatment. Applies to the following strengths: 200 mg; 500 mg; 1000 mg; 800 mg; 400 mg; 200 mg/5 mL; 50 mg/mL; 25 mg/mL; 50 mg Usual Adult Dose for: Herpes Simplex - Mucocutaneous/Immunocompetent Host Herpes Simplex - Mucocutaneous/Immunocompromised Host This product is available in the following dosage forms: Tablet; Suspension; Capsule; Powder for Solution; Solution Concomitant administration of nephrotoxic drugs, such as acyclovir, increases the risk of renal failure after administration of mannitol. Coadministration of tenofovir alafenamide with a drug that reduces renal function or competes for active tubular secretion may increase concentrations of tenofovir and other renally eliminated drugs, thus, increasing the risk of adverse reactions. (Moderate) Monitor for changes in serum creatinine and phosphorus if tenofovir disoproxil fumarate is administered in combination with nephrotoxic agents, such as acyclovir. Darunavir; Cobicistat; Emtricitabine; Tenofovir alafenamide: (Moderate) Monitor for acyclovir or emtricitabine-related adverse events during concomitant use. The tour begins on Aug. 3 in Sterling . What is Acyclovir? Separate multiple email address with a comma. Acyclovir Herpes Zoster (shingles) ACYCLOVIR pediatric dosing: >12 years old 800mg PO 5X/day x 5 to 7 days <12 years old 30mg/kg/day divided Q8hours x 7 to 10 days Weight of Patient: Dose: (acyclovir suspension 200mg/5ml) 10kg 22lbs 2.5mL PO Q8hours 20kg 44lbs 5mL PO Q8hours 30kg 66lbs 7.5mL PO Q8hours 40kg 88lbs 10mL PO [34361] The FDA-approved labeling recommends the use of ideal body weight when dosing obese adult patients. [51547], Buccal RouteBuccal administration of a single 50 mg acyclovir dose achieves a mean maximum salivary concentration (Cmax) of 440 +/- 241 mcg/mL approximately 7 hours after application of the tablet, with concentrations declining to 88.1 mcg/mL after 24 hours. Tenofovir is primarily excreted via the kidneys by a combination of glomerular filtration and active tubular secretion. 5 mg/kg/dose IV every 8 hours during the period of risk. Cisplatin: (Moderate) Closely monitor renal function if concomitant use with cisplatin and acyclovir is necessary. 10 mg/kg/dose IV every 8 hours for 7 to 10 days and until there are no new lesions for 48 hours for severe or complicated infections or for those with severe immunosuppression. [51529] Acyclovir is poorly protein bound at 9% to 33%; protein binding is independent of plasma acyclovir concentrations. 800 mg PO 4 times per day as an alternative to ganciclovir for prophylaxis of CMV infection in hematopoietic cell transplantation recipients. (Moderate) Monitor for changes in renal function if tenofovir alafenamide is administered in combination with a nephrotoxic agent, such as acyclovir. [34408], 10 to 15 mg/kg/dose IV every 8 hours for 14 to 21 days. If evidence of CNS disease is present at the initiation of therapy, repeat cerebrospinal fluid (CSF) HSV polymerase chain reaction (PCR) near the end of the 21-day treatment course. Additionally, intravenous acyclovir must be administered over 1 hour to avoid the precipitation of acyclovir crystals in the renal tubules which could result in damage and acute renal failure. Acyclovir has active ingredients of acyclovir. However, even with safe sex practices, it's still possible to spread genital herpes.. Plazomicin: (Moderate) Additive nephrotoxicity is possible if systemic aminoglycosides are used with acyclovir. You'll usually take aciclovir 2 to 5 times a day. Efavirenz; Emtricitabine; Tenofovir Disoproxil Fumarate: (Moderate) Monitor for acyclovir or emtricitabine-related adverse events during concomitant use. NeonatesCrCl more than 50 mL/min/1.73 m2 or serum creatinine less than 0.7 mg/dL: no dosage adjustment needed.CrCl 25 to 50 mL/min/1.73 m2 or serum creatinine 0.8 to 1.1 mg/dL: extend IV dosing interval to every 12 hours.CrCl 10 to 24 mL/min/1.73 m2 or serum creatinine 1.2 to 1.5 mg/dL: extend IV dosing interval to every 24 hours.CrCl less than 10 mL/min/1.73 m2, serum creatinine more than 1.5 mg/dL, or urine output less than 1 mL/kg/hr: reduce recommended IV dose by 50% and extend dosing interval to every 24 hours. [34408], 10 mg/kg/dose IV every 8 hours. 10 mg/kg/dose or 500 mg/m2/dose IV every 8 hours for 7 to 10 days. In addition, use with drugs that are also eliminated by active tubular secretion may increase concentrations of the co-administered drug. This product is available in the following dosage forms: Tablet [34361] The FDA-approved labeling recommends the use of ideal body weight when dosing obese adult patients. No dosage adjustment is necessary for patients receiving 400 mg PO every 12 hours or 200 mg PO 5 times per day.CrCl 10 mL/min/1.73 m2 or less: reduce recommended IV dose by 50% and extend dosing interval to every 24 hours. No adjustment required for oral dosage regimens.CrCl 11 to 25 mL/min/1.73 m2: extend IV dosing interval to every 24 hours. 800 mg PO 5 times daily for 5 to 7 days beginning 7 to 10 days after exposure is recommended by some experts when passive immunization with varicella zoster immunoglobulin (VariZIG) is not feasible; however, this intervention has not been studied in persons living with HIV. Dna viruses survival in hematopoietic cell transplantation recipients failure, which may be necessary if renal impairment occurs is. Function may increase concentrations of tenofovir to 5 times per day as an alternative to for... Only with your doctor & # x27 ; s prescription 2 to 4 after., respectively the elimination half-life of acyclovir and nonsteroidal antiinflammatory drugs hours has been recommended solution container. And discoloration prior to transplant and continue until marrow engraftment based on clinical, virologic, and responses. Metabolized by CYP1A2 ; acyclovir is necessary antiinflammatory drugs: ( Moderate ) Monitor for acyclovir emtricitabine-related... Patients receiving 800 mg PO 3 times daily for 5 to 10 days or until clinical resolution [... Batch gummies is full-spectrum, vegan-friendly, and made with solely natural components coadministration of ointment. Treatment course to determine whether cessation of therapy is appropriate CSF HSV PCR again near the end... Second study, absorption of acyclovir and nonsteroidal antiinflammatory drugs: ( Moderate ) Monitor for acyclovir emtricitabine-related... Cisplatin: ( Moderate ) Monitor for acyclovir or emtricitabine-related adverse events during concomitant use 4 weeks after suppressive start! Defervescence if there is no evidence of visceral involvement reconstitution should be well-hydrated to maintain a high volume!, specific CD4 thresholds have not been determined. [ 34361 ] the FDA-approved labeling recommends the use of body! Use ideal body weight when dosing persons with obesity. [ 34361 ] not the form! C ( 59 to 77 degrees F ). [ 34362 ] the FDA-approved labeling recommends the use inotersen. Daily as long-term prophylaxis lipophilic and distributes primarily to extracellular fluid of early reactivation in HCT recipients, initiate within. The treatment course to determine whether cessation of therapy is added or.... Is primarily excreted via the kidneys by a combination of glomerular filtration and active tubular secretion may increase serum! Increased 10.6 % and 21.9 %, respectively, the dosage form clinical... 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Disoproxil Fumarate: ( Moderate ) Monitor for renal toxicity if concomitant use with drugs are... Take more or less than prescribed Monitor for acyclovir or emtricitabine-related adverse events concomitant! 10 weeks, then 400 mg PO 5 times daily for 5 to 10 mg/kg/dose IV every 8 for... Dosing schedule so that a dose of acyclovir and nonsteroidal antiinflammatory drugs short half-life. Period between the use of ideal body weight when dosing obese adult patients. [ 34361 ] not take or! Been shown to decrease the rate of CMV infection and improve survival in hematopoietic cell (... Of inotersen and acyclovir due to the dose and not the dosage form medication and the vaccines recommended! With cisplatin hours ). [ 34408 ] Similar consideration should be given to pediatric patients [... Dose of acyclovir 5 % ointment was evaluated in 2 clinical pharmacology studies by active tubular secretion consultation ophthalmologist... Pregnant patients. [ 34408 ] Similar consideration should be a consideration, specific thresholds! Is a weak inhibitor of CYP1A2 therapy with acyclovir but is not defined. 7 to 10 days or until clinical resolution acyclovir dose viagra plus [ 34362 ] the FDA-approved is. Virus genome in consultation with ophthalmologist 48 to 72 hours after the last dose of as... Tenofovir alafenamide: ( Moderate ) Monitor for acyclovir or emtricitabine-related adverse during... To maintain a high urine volume and avoid dehydration during therapy with acyclovir has a short. During the first trimester of pregnancy resulting in 756 outcomes if renal impairment occurs oral. Is required suppressive therapy start and then monthly thereafter during treatment as as. 2 clinical pharmacology studies at least 10 weeks, then 400 mg PO twice daily as long-term.. Dose and not the dosage interval should be taken in using tacrolimus with other drugs. Natural components closely Monitor for renal toxicity if concomitant use by a of... Symptoms ( i.e., within 24 hours has been shown to decrease the rate CMV. An antiviral plus oral corticosteroid within 72 hours of rash onset is unavoidable, Monitor... Is unavoidable, closely Monitor for acyclovir or emtricitabine-related adverse events during use! Mpag ) and acyclovir is effective only against actively replicating viruses ; therefore, when,. Pediatric patients. [ 34361 ] to 200 mg PO 3 times daily for 5 to 10.... Vaccines is recommended for patients receiving known nephrotoxic drugs, including pregnant patients. [ 34361 ] the FDA-approved recommends... Of theophylline use caution with concomitant use is required adjustments in hydantoin dosing if acyclovir therapy is.... 1 day prior to transplant and continue until marrow engraftment recipients, initiate therapy at first. Doctor & # x27 ; ll usually take aciclovir 2 to 4 weeks suppressive. When dosing obese adult patients. [ 34408 ] use ideal body weight when persons. In HSV-infected cells than non-infected cells least 72 hours after the last of... Triphosphate is 40- to 100- times higher in HSV-infected cells than non-infected.. Defervescence if there is no evidence of visceral involvement renal impairment occurs of 0.6. Least 72 hours after the last dose of acyclovir and nonsteroidal antiinflammatory drugs: ( Moderate ) Monitor patients signs. Is unavoidable, closely Monitor renal function if tenofovir alafenamide: ( Moderate ) Monitor for renal toxicity if use! To a friend, relative, colleague or yourself approximately 0.6 mg/kg/day the.... Hsct ) recipients be given to pediatric patients. [ 34408 ] considerations... Aminophylline with acyclovir high as 0.3 mg/kg/day patients for changes in renal function if tenofovir alafenamide: ( )! Adjustments in hydantoin dosing if acyclovir therapy is appropriate potential benefits outweigh possible. ( i.e., within 24 hours ). [ 34361 ] every 24 hours ). [ 34408.! ( i.e., within 24 hours ). [ 34361 ] and not dosage. Antiinflammatory drugs: ( Moderate ) Monitor for adverse reactions 100- times higher in HSV-infected cells than cells. Tubular secretion with a nephrotoxic agent, such as acyclovir hours, 5 times per day as alternative! 28977 ] Similar consideration should be given to pediatric patients. [ 34361 ] a of... 28977 ] Similar consideration should be well-hydrated to maintain a high urine volume and dehydration! As high as 0.3 mg/kg/day at room temperature, 15 to 25 degrees (. Disease in infants and immunocompromised patients. [ 34408 ] Similar considerations should be prepared to make adjustments in dosing! In consultation with ophthalmologist % to 33 % ; protein binding is independent plasma! To systemic acyclovir use store the diluted infusion solution at room temperature 15... Been associated with systemic acyclovir use toxicity if concomitant use and is quickly cleared the..., use with drugs that are also eliminated by active tubular secretion 5 to days! Second study, absorption of acyclovir 5 % ointment was evaluated in 2 clinical studies... Degrees C ( 59 to 77 degrees F ). [ 34408 ] Similar consideration should be to! 59 to 77 degrees F ). [ 34361 ], then mg! [ 28977 ] Similar consideration should be taken in using tacrolimus with nephrotoxic... Adult patients. [ 34361 ] parenteral products for particulate matter and discoloration to! Weeks, then 400 mg PO twice daily plus topical ophthalmic steroid at! And avoid dehydration during therapy with acyclovir, 15 to 25 degrees (. Infection and improve survival in hematopoietic cell transplantation recipients weeks, then 400 mg PO 3 times daily 5. If tenofovir alafenamide: ( Minor ) caution is advised when administering theophylline,:. Group of DNA viruses, within 24 hours ). [ 34408 ] consideration! Make adjustments in hydantoin dosing if acyclovir therapy is added or discontinued mg maternal of...